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Diabetes

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Neurourology

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Abstract

Changes in environmental and behavioral factors such as a sedentary life style and obesity over the previous years have resulted in a dramatic increase in the incidence of diabetes worldwide [1]. Urological manifestations of Diabetic patients include: Diabetic Nephropathy, Renal Vascular disease, Urinary Tract Infections, Emphysematous Complications, Infertility, Erectile dysfunction, and Diabetic bladder dysfunction which we will talk about it in details in this section [2, 3].

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References

  1. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001;414:782–7.

    Article  CAS  PubMed  Google Scholar 

  2. Boulton AJ, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, Malik RA, Maser RE, Sosenko JM, Ziegler D, American Diabetes Association. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care. 2005;28(4):956–62.

    Article  PubMed  Google Scholar 

  3. Davies M, Brophy S, Williams R, Taylor A. The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes Care. 2006;29:1518–22.

    Article  PubMed  Google Scholar 

  4. Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010;33:2285–93.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Daneshgari F, Moore C. Diabetic uropathy. Semin Nephrol. 2006;26:182.

    Article  PubMed  Google Scholar 

  6. Olapade-Olaopa EO, Morley RN, Carter CJ, Walmsley BH. Diabetic cystopathy presenting as primary acute urinary retention in a previously undiagnosed young male diabetic patient. J Diabetes Complicat. 1997;11:350–1.

    Article  CAS  Google Scholar 

  7. Yuan Z, Tang Z, He C, Tang W. Diabetic cystopathy: a review. J Diabetes. 2015;7:442–7.

    Article  PubMed  Google Scholar 

  8. Siracusano S, d’Aloia G, Lentini MG, Silvestre G. Diabetic cystopathy. J Diabetes Nutr Meta. 2015;15:41–4.

    Google Scholar 

  9. Zderic SA, Chacko S, Disanto ME, Wein AJ. Voiding function: relevant anatomy, physiology, pharmacology, and molecular aspects. Philadelphia: Williams & Wilkins; 2002.

    Google Scholar 

  10. Burakgazi AZ, Alsowaity B, Burakgazi ZA, Unal D, Kelly JJ. Bladder dysfunction in peripheral neuropathies. Muscle Nerve. 2012;45:2–8.

    Article  PubMed  Google Scholar 

  11. Daneshgari F, Liu G. Diabetic bladder dysfunction: current translational knowledge. J Urol. 2009;182:S18–26.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ueda T, Tamaki M, Kageyama S, Yoshimura N, Yoshida O. Urinary incontinence among community-dwelling people aged 40 years or older in Japan: prevalence, risk factors, knowledge and self-perception. Int J Urol. 2000;7:95.

    Article  CAS  PubMed  Google Scholar 

  13. Kaplan SA, Te AE, Blaivas JG. Urodynamic findings in patients with diabetic cystopathy. J Urol. 1995;153:342.

    Article  CAS  PubMed  Google Scholar 

  14. Brown JS, Nyberg LM, Kusek JW, Burgio KL, Diokno AC, Foldspang A, et al. Proceedings of the National Institute of Diabetes and Digestive and Kidney Diseases International Symposium on Epidemiologic Issues in Urinary Incontinence in Women. Am J Obstet Gynecol. 2003;188(6):S77.

    Article  PubMed  Google Scholar 

  15. Frimodt-Moller C. Diabetic cystopathy: epidemiology and related disorders. Ann Intern Med. 1980;92:318–21.

    Article  CAS  PubMed  Google Scholar 

  16. Yoshimura N, Chancellor MB, Andersson KE, Christ GJ. Recent advances in understanding the biology of diabetes-associated bladder complications and novel therapy. BJU Int. 2005;95:733.

    Article  PubMed  Google Scholar 

  17. Liu G, Daneshgari F. Alterations in neurogenically mediated contractile responses of urinary bladder in rats with diabetes. Am J Physiol Renal Physiol. 2005;288:F1220.

    Article  CAS  PubMed  Google Scholar 

  18. Liu G, Daneshgari F. Temporal diabetes- and diuresis-induced remodeling of the urinary bladder in the rat. Am J Physiol Regul Integr Comp Physiol. 2006;291:R837.

    Article  CAS  PubMed  Google Scholar 

  19. Christ GJ, Hsieh Y, Zhao W, Schenk G, Venkateswarlu K, Wang HZ, et al. Effects of streptozotocin-induced diabetes on bladder and erectile (dys)function in the same rat in vivo. BJU Int. 2006;97:1076.

    Article  PubMed  Google Scholar 

  20. Tammela TL, Leggett RE, Levin RM, Longhurst PA. Temporal changes in micturition and bladder contractility after sucrose diuresis and streptozotocin-induced diabetes mellitus in rats. J Urol. 1995;153:2014.

    Article  CAS  PubMed  Google Scholar 

  21. Poladia DP, Bauer JA. Functional, structural, and neuronal alterations in urinary bladder during diabetes: investigations of a mouse model. Pharmacology. 2005;74:84.

    Article  CAS  PubMed  Google Scholar 

  22. Liu G, Lin Y, Yamada Y, Daneshgari F. External urethral sphincter activity in diabetic rats. Neurourol Urodyn. 2008;27:429.

    Article  PubMed  Google Scholar 

  23. Torimoto K, Fraser MO, Hirao Y, De Groat WC, Chancellor MB, Yoshimura N. Urethral dysfunction in diabetic rats. J Urol. 2004;171:1959.

    Article  PubMed  Google Scholar 

  24. Ueda T, Yoshimura N, Yoshida O. Diabetic cystopathy: relationship to autonomic neuropathy detected by sympathetic skin response. J Urol. 1997;157:580.

    Article  CAS  PubMed  Google Scholar 

  25. Stohrer M, Blok B, Castro-Diaz D, Chartier-Kastler E, del Popolo G, Kramer G, et al. EAU guidelines on neurogenic lower urinary tract dysfunction. Eur Urol. 2009;56:81–8.

    Article  PubMed  Google Scholar 

  26. Niu X, Wang X, Huang H, Ni P, Lin Y, Shao B. Bulbocavernosus reflex test for diagnosis of pudendal nerve injury in female patients with diabetic neurogenic bladder. Aging Dis. 2016;6:715–20.

    Article  Google Scholar 

  27. Hellweg R, Raivich G, Hartung HD, Hock C, Kreutzberg GW. Axonal transport of endogenous nerve growth factor (NGF) and NGF receptor in experimental diabetic neuropathy. Exp Neurol. 1994;130:24.

    Article  CAS  PubMed  Google Scholar 

  28. Hellweg R, Hartung HD. Endogenous levels of nerve growth factor (NGF) are altered in experimental diabetes mellitus: a possible role of NGF in the pathogenesis of diabetic neuropathy. J Neurosci Res. 1990;26:258.

    Article  CAS  PubMed  Google Scholar 

  29. Steinbacher BC Jr, Nadelhaft I. Increased level of nerve growth factor in the urinary bladder and hypertrophy of dorsal root ganglion neurons in the diabetic rat. Brain Res. 1988;782:255.

    Article  Google Scholar 

  30. Sasaki K, Michael B. Diabetic cystopathy correlates with a long-term decrease in nerve growth factor levels in the bladder and lumbosacral dorsal root ganglia. J Urol. 2002;168:1259–64.

    Article  PubMed  Google Scholar 

  31. Cheng JT, Yu BC, Tong YC. Changes of M3-muscarinic receptor protein and mRNA expressions in the bladder urothelium and muscle layer of streptozotocininduced diabetic rats. Neurosci Lett. 2007;423:1–5.

    Article  CAS  PubMed  Google Scholar 

  32. Tong YC, Cheng JT, Wan WC. Effects of Ba-Wei-Die-Huang-Wan on the cholinergic function and protein expression of M2 muscarinic receptor of the urinary bladder in diabetic rats. Neurosci Lett. 2002;330:21–4.

    Article  CAS  PubMed  Google Scholar 

  33. Kubota Y, Nakahara T, Mitani A, Maruko T, Sakamoto K, Ishii K. Augmentation of rat urinary bladder relaxation mediated by beta1-adrenoceptors in experimental diabetes. Eur J Pharmacol. 2003;467:191–5.

    Article  CAS  PubMed  Google Scholar 

  34. Edwards JL, Vincent AM, Cheng HT, Feldman EL. Diabetic neuropathy: mechanisms to management. Pharmacol Ther. 2008;120:1–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Daneshgari F, Huang X, Liu G, Bena J, Saffore L, Powell CT. Temporal differences in bladder dysfunction caused by diabetes, diuresis, and treated diabetes in mice. Am J Physiol Regul Integr Comp Physiol. 2006;290:R1728.

    Article  CAS  PubMed  Google Scholar 

  36. Daneshgari F, Liu G, Imrey PB. Time dependent changes in diabetic cystopathy in rats include compensated and decompensated bladder function. J Urol. 2006;176:380.

    Article  PubMed  Google Scholar 

  37. Beshay E, Carrier S. Oxidative stress plays a role in diabetes-induced bladder dysfunction in a rat model. Urology. 2004;64:1062.

    Article  PubMed  Google Scholar 

  38. Rolo AP, Palmeira CM. Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicol Appl Pharmacol. 2006;212:167.

    Article  CAS  PubMed  Google Scholar 

  39. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813.

    Article  CAS  PubMed  Google Scholar 

  40. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005;54:1615.

    Article  CAS  PubMed  Google Scholar 

  41. Pinna C, Zanardo R, Puglisi L. Prostaglandin-release impairment in the bladder epithelium of streptozotocin-induced diabetic rats. Eur J Pharmacol. 2000;388:267.

    Article  CAS  PubMed  Google Scholar 

  42. Pitre DA, Ma T, Wallace LJ, Bauer JA. Time-dependent urinary bladder remodeling in the streptozotocin-induced diabetic rat model. Acta Diabetol. 2002;39:23.

    Article  CAS  PubMed  Google Scholar 

  43. Berger P, Deibl M, Halpern EJ, Lechleitner M, Bektic J, Horninger W, et al. Vascular damage induced by type 2 diabetes mellitus as a risk factor for benign prostatic hyperplasia. Diabetologia. 2005;48:784–9.

    Article  CAS  PubMed  Google Scholar 

  44. Ikeda K, Wada Y, Foster HE, Wang Z, Weiss RM, Latifpour J. Experimental diabetes-induced regression of the rat prostate is associated with an increased expression of transforming growth factor-beta. J Urol. 2000;164:180–5.

    Article  CAS  PubMed  Google Scholar 

  45. Vikram A, Jena GB, Ramarao P. Increased cell proliferation and contractility of prostate in insulin resistant rats: linking hyperinsulinemia with benign prostate hiperplasia. Prostate. 2010;1(70):79–89.

    Article  Google Scholar 

  46. Longhurst PA. In vivo urinary bladder function in rats following prolonged diabetic and non-diabetic diuresis. Neurourol Urodyn. 1990;9:171.

    Article  Google Scholar 

  47. Satriano J. Kidney growth, hypertrophy and the unifying mechanism of diabetic complications. Amino Acids. 2007;33:331.

    Article  CAS  PubMed  Google Scholar 

  48. Brown JS, Barrett-Connor E, Nyberg LM, Kusek JW, Orchard TJ, Ma Y. Incontinence in women with impaired glucose tolerance: results of the Diabetes Prevention Program. J Urol. 2004;171:325–6.

    Article  Google Scholar 

  49. Jackson RA, Vittinghoff E, Kanaya AM, Resnick HE, Kritchevsky S, Miles T, Simonsick E, et al. Aging and body composition. Obstet Gynecol. 2004;104:301–7.

    Article  CAS  PubMed  Google Scholar 

  50. Fayyad AM, Hill SR, Jones G. Prevalence and risk factors for bothersome lower urinary tract symptoms in women with diabetes mellitus from hospital-based diabetes clinic. Int Urogynecol J Pelvic Floor Dysfunct. 2009;20:1339–44.

    Article  PubMed  Google Scholar 

  51. Kebapci N, Yenilmez A, Efe B, Entok E, Demirustu C. Bladder dysfunction in type 2 diabetic patients. Neurourol Urodyn. 2007;26:814–9.

    Article  PubMed  Google Scholar 

  52. Agency for Health Care Policy and Research. Urinary incontinence in adults: acute and chronic management. Clinical practice guideline, vol. 7. Washington, DC: U.S. Public Health Service, Department of Health and Human Services, AHCPR; 1996. p. 19–71.

    Google Scholar 

  53. Subak LL, Johnson C, Whitcomb E, Boban D, Saxton J, Brown JS. Does weight loss improve incontinence in moderately obese women? Int Urogynecol J Pelvic Floor Dysfunct. 2002;13:40–3.

    Article  CAS  PubMed  Google Scholar 

  54. Brown JS, Wing R, Barrett-Connor E, et al. Lifestyle intervention is associated with lower prevalence of urinary incontinence: the Diabetes Prevention Program. Diabetes Care. 2006;29:385–90.

    Article  PubMed  Google Scholar 

  55. Novara G, Galfano A, Secco S, et al. A systematic review and meta-analysis of randomized controlled trials with antimuscarinic drugs for overactive bladder. Eur Urol. 2008;54:740–63.

    Article  CAS  PubMed  Google Scholar 

  56. Chapple C, Khullar V, Gabriel Z, Dooley JA. The effects of antimuscarinic treatments in overactive bladder: a systematic review and meta-analysis. Eur Urol. 2005;48:5–26.

    Article  CAS  PubMed  Google Scholar 

  57. Wein AJ, Van Arsdalen K, Levin RM. Pharmacologic therapy. In: Krane RJ, Siroky MB, editors. Clinical neuro-urology. Boston: Little Brown; 1992. p. 523–57.

    Google Scholar 

  58. Lucas. http://www.uroweb.org/gls/pdf/19_Urinary_Incontinence_LR.pdf.

  59. Burton C, Sajja A, Latthe PM. Effectiveness of percutaneous posterior tibial nerve stimulation for overactive bladder: a systematic review and meta-analysis. Neurourol Urodyn. 2012;31:1206.

    Article  CAS  PubMed  Google Scholar 

  60. Daniels DH, Powell CR, Braasch MR, Kreder KJ. Sacral neuromodulation in diabetic patients: Success and complications in the treatment of voiding dysfunction. Neurourol Urodyn. 2010;29:578–81.

    PubMed  Google Scholar 

  61. van Kerrebroeck PE, van Voskuilen AC, Heesakkers JP, et al. Results of sacral neuromodulation therapy for urinary voiding dysfunction: outcomes of a prospective, worldwide clinical study. J Urol. 2007;178:2029–34.

    Article  PubMed  Google Scholar 

  62. Zincke H, Campbell JT, Palumbo PJ, Furlow WL. Neurogenic vesical dysfunction in diabetes mellitus: another look at vesical neck resection. J Urol. 1974;111:488–90.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. King Fahad Specialist Hospital, Dammam, Saudi Arabia

    Abdulrahman Almuhrij & Riyad Al Mousa

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  1. Abdulrahman Almuhrij
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  2. Riyad Al Mousa
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Editors and Affiliations

  1. Department of Urology, China Rehabiliation Research Center Capital Medical University, Beijing, China

    Limin Liao

  2. Department of Urology, University Hospital, Innsbruck, Austria

    Helmut Madersbacher

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Almuhrij, A., Al Mousa, R. (2019). Diabetes. In: Liao, L., Madersbacher, H. (eds) Neurourology. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7509-0_67

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  • DOI: https://doi.org/10.1007/978-94-017-7509-0_67

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