Summary
Antigens determined by the RtH-1 system were studied by means of allogeneic transplantation and by serological methods in 21 inbred strains of rats. Nine different alleles of this system were identified and their structure studied. Each allele determines a typical combination of some individual antigens whose total number has now reached 21. Eight antigens only are specific for different alleles, while the others are shared in common by complex products of two or more alleles. From the point of view of structure the RtH-1 system is analogous to other complex immunogenetic systems analysed in different species of animals.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Billingham, R. E., Hodge, B. A. and Silvers, W. K., 1962. An estimate of the number of histocompatibility loci in the rat, Proc. Nat. Acad. Sci., 48, 138–147.
Elkins, W. L. and Palm J., 1966. Identification of a strong histocompatibility locus in the rat by normal spleen-cell transfer, Ann. N. Y. Acad. Sci., 129, 573–580
Heslop B. F., 1968a. The production of haemagglutinins after skin allografts in the rat, Proc. Univ. Otago Med. Sch., 46, 6–7.
Heslop, B. F., 1968b. Histocompatibility antigens in the rat, the AS2 strain in relation to the AS, BS and HS strains, Aust. J. Exp. Biol. Med. Sci. (In press).
Iványi, P., 1966. Serological production of congenic lines in rats. In: Polymorphismes biochimiques des animaux, Paris, p. 507–510.
Michie, D. and Anderson, N. F., 1966. A strong selective effect associated with a histocompatibility gene in the rat, Ann. N.Y. Acad. Sci., 129, 88–93.
Ramseder, H. and Palm J., 1967. Further studies of histocompatibility loci in rats, Transplantation, 5, 721–729.
Štark, O., Frenzl, B. and Křen, V., 1968b. Erythrocyte and transplantation antigens in inbred strains of rats, VII. H-1 alleles of the LEP, CAP, BN, BD V, BD VII and BD X strains, Fol. biol. (Praha), 14, 169–175.
Štark, O. and Křen, V., 1967a. Erythrocyte and transplantation antigens in inbred strains of rats. II. Antigens of the AVN strain, Fol. biol. (Praha), 13, 93–99.
Štark, O. and Křen, V., 1967b. Erythrocyte and transplantation antigens in inbred strains of rats. III. Antigens of the BP strain, Fol. biol. (Praha), 13, 299–305.
Štark, O., Křen, V. and Frenzl, B., 1966. Histocompatibility locus in the rat. In: Polymorphismes biochimiques des animaux, Paris, p. 501–506.
Štark, O., Křen, V. and Frenzl, B., 1967. Erythrocyte and transplantation antigens in inbred strains of rats. I. Serological analysis of strain-specific antigens, Fol. biol. (Praha), 13, 85–92.
Štark, O., Křen, V., Frenzl, B. and Brilička, R., 1968a. The main histocompatibility system of the rat. In: Advance in transplantation, Copenhagen, p. 331–339.
Štark, O., Křen, V., Frenzl B. and Křenová, D., 1968c. Histocompatibility-1 alleles in inbred rats of the BD II, WR, AGA, CDF, AS, BS, HS and DA strains, Fol. biol. (Praha). (In press).
Zeiss, J. M., 1967. Antigenic interrelationships and number of independently segregating histocompatibility loci in three isohistogenic strains of rats, Transplantation, 5, 1393–1399.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1970 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Štark, O., Křen, V., Frenzl, B. (1970). Further Analysis of the Histocompatibility-1 System of the Rat. In: XIth European Conference on Animal Blood Groups and Biochemical Polymorphism. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-5226-8_93
Download citation
DOI: https://doi.org/10.1007/978-94-017-5226-8_93
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-017-5228-2
Online ISBN: 978-94-017-5226-8
eBook Packages: Springer Book Archive