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Principles of Cancer Biotherapy pp 111–161Cite as

Therapeutic approaches to cancer-associated immune suppression

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Abstract

It is now well established that many cancer patients exhibit in-vivo and in-vitro evidence of immune suppression, which often correlates with tumor-cell burden, stage of disease, and prognosis. Cancer-associated immune suppression appears to be a direct result of the presence of disease, or follows treatment for it, rather than being an antecedent or predisposing condition. However, the precise role that nonspecific and/or specific antitumor immunity plays in the control of human cancer remains controversial. Indeed, there is some evidence that suggests that the development of certain antitumor immune responses may lead to augmented tumor cell growth rather than tumor regression [314, 442, 443].

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References

  1. Addison I, Baggage J, Gandossini M, Souhami R. Assess- ment of host defense against infection during chemotherapy of Hodgkin’s disease. Cancer Chemother Pharmacol 1978; 1: 129–33.

    CAS  PubMed  Google Scholar 

  2. Adler A, Stein JA, Ben-Efraim S. Immunocompetence, immunosuppression, and human breast cancer. II. Further evidence of initial immune impairment by integrated assessment effect of nodal involvement (N) and of primary tumor size (T). Cancer 1980; 45: 2061–73.

    CAS  PubMed  Google Scholar 

  3. Adler A, Stein JA, Ben-Efraim S. Immunocompetence, immunosuppression, and human breast cancer. III. Prognostic significance of initial level of immunocompetence in early and advanced disease. Cancer 1980; 45: 2074–83.

    CAS  PubMed  Google Scholar 

  4. Ahmed K, Turk JL. Effect of anticancer agents neothra- mycin, aclacinomycin, FK- 565 and FK- 156 on the release of interleukin-2 and interleukin-1 in vitro. Cancer Immunol Immunother 1989; 28: 87–92.

    CAS  PubMed  Google Scholar 

  5. Alberola V, Gonzalez-Molina A, Trenor A et al. Mechan- ism of suppression of the depressed lymphocyte response in lung cancer patients. Allergol Immunopathol (Madr) 1985; 13: 213–19.

    Google Scholar 

  6. Albin RJ, Gordon MJ, Soane WA. Levels of immunoglobulins in the serum of patients with carcinoma of the prostate. Neoplasma 1972; 19: 57–60.

    Google Scholar 

  7. Alexopoulos LG, Wiltshaw E. Immunological monitoring during chemotherapy for advanced Hodgkin’s disease. Cancer 1978; 42: 2631–40.

    CAS  PubMed  Google Scholar 

  8. Alsabti EA. In vivo and in vitro assays of incompetence in bronchogenic carcinoma. Oncology 1979; 36: 171–5.

    CAS  PubMed  Google Scholar 

  9. Amery WK, Butterworth BS. The dosage regimen of levamisole in cancer: is it related to efficacy and safety? Int J Immunopharmacol 1983; 5: 1–9.

    CAS  PubMed  Google Scholar 

  10. Amery WK, Cosemans J, Gooszen HC et al. Four-year results from double-blind study of adjuvant levamisole treatment in resectable lung cancer. In: Terry WD, Rosenberg SA, eds. Immunotherapy of Human Cancer. New York: Elsevier/North-Holland, 1982: 123–33.

    Google Scholar 

  11. Amlot PL, Anger A. Binding of phytohaemagglutinin to serum substances and inhibition of lymphocyte transformation in Hodgkin’s disease. Clin Exp Immunol 1976; 26: 520–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  12. Anderson TC, Jones SE, Sochnlen BJ et al. Immunocompetence and malignant lymphomas: immunologic status before therapy. Cancer 1981; 48: 2702–9.

    CAS  PubMed  Google Scholar 

  13. Anderson TM, Ibayashi Y, Tokuda Y et al. Natural killer activity of lymphocytes infiltrating human lung cancers following preoperative systemic recombinant interleukin2. Arch Surg 1987; 122: 1446–50.

    CAS  PubMed  Google Scholar 

  14. Anderson TM, Ibayashi Y, Holmes EC, Golub SH. Modification of natural killer activity of lymphocytes infiltrating human lung cancers. Cancer Immunol Immunother 1987;25:65–8

    Google Scholar 

  15. Anthony HM, Templeman GH, Madsen KE, Mason MK. The prognostic significance of DHS skin tests in patients with carcinoma of bronchus. Cancer 1974; 34: 1901–6.

    CAS  PubMed  Google Scholar 

  16. Anthony HM. Yorkshire trial of adjuvant therapy with levamisole in surgically treated lung cancer. In: Terry WD, Rosenberg SA, eds. Immunotherapy of Human Cancer. New York: Elsevier/North-Holland, 1982: 135–440.

    Google Scholar 

  17. Aparicio-Pages NM, Verspaget HW, Pena SA, Lamers CB. Impaired local natural killer-cell activity in human colorectal carcinomas. Cancer Immunol Immunother 1989; 28: 301–4.

    CAS  PubMed  Google Scholar 

  18. Aparicio-Pages NM, Verspaget HW, Pena SA, Lamers CB. Impaired local natural killer-cell activity in human colorectal carcinomas. Cancer Immunol Immunother 1989; 28: 301–4.

    CAS  PubMed  Google Scholar 

  19. Aranha GV, McKhann CF, Simmons RL, Grage TB. Recall skin test antigens and the prognosis of stage I melanoma. J Surg Oncol 1976; 11: 13–16.

    Google Scholar 

  20. Arinaga S, Akiyoshi T, Tsuji H. Augmentation of the generation of cell mediated cytotoxicity after a single dose of adriamycin in cancer patients. Cancer Res 1986; 46: 4213–6.

    CAS  PubMed  Google Scholar 

  21. Arinaga S, Akiyoshi T, Tsuji H. Augmentation of the cell-mediated cytotoxic response induced in mixed cell culture by adriamycin. Jpn J Cancer Res 1985; 76: 414–19.

    CAS  PubMed  Google Scholar 

  22. Armstrong D, Chmel M. Infectious complications of Hodgkin’s disease. In: Lacher MJ, ed. Hodgkin’s Disease. New York: Wiley, 1976: 267–90.

    Google Scholar 

  23. Arnaud JP, Buyse M, Nordlinger B et al. Adjuvant therapy of poor prognosis colon cancer with levamisole: results of an EORTC double-blind randomized clinical trial. Br J Surg 1989; 76: 284–9.

    CAS  PubMed  Google Scholar 

  24. Ascher MS, Schneider WJ, Valentine FT, Lawrence HS. In vitro properties of leukocyte dialysates containing transfer factor. Proc Natl Acad Sci USA 1974; 74: 1178–82.

    Google Scholar 

  25. Ashorn RG, Vandenbard AA, Acott KM, Krohn KJ. Dialysable leukocyte extracts (transfer factor) augment non-specifically keyhole limpet haemocyanin and horseshoe crab haemocyanin skin reactivity in immunized human recipients. Scand J Immunol 1976; 23: 161–7.

    Google Scholar 

  26. Aymard JP, Janot C, Thibaut G et al. Levamisole in chronic lymphocytic leukaemia: a prospective study of 15 patients. Acta Haematol (Basel) 1984; 71: 316–21.

    CAS  Google Scholar 

  27. Balaram P, Remani P, Padmanabhan TK, Vasudevan DM. Role of levamisole immunotherapy as an adjuvant to radiotherapy in oral cancer: immune responses. Neoplasma 1988; 35: 6; 617–25.

    CAS  PubMed  Google Scholar 

  28. Balaram P, Padmanabhan TK, Vasudevan DM. Role of levamisole immunotherapy as an adjuvant to radiotherapy in oral cancer. II. Lymphocyte subpopulations. Neoplasma 1988; 35: 2; 235–42.

    CAS  PubMed  Google Scholar 

  29. Balch CM, Doughtery PA, Cloud GA, Tilden AB. Prostaglandin E2-mediated suppression of cellular immunity in colon cancer patients. Surgery 1984; 95: 71–7.

    CAS  PubMed  Google Scholar 

  30. Balch CM, Tilden AB, Dougherty PA, Cloud GA. Depressed levels of granular lymphocytes with natural killer (NK) cell function in 247 cancer patients. Ann Surg 1983; 198: 192–9.

    CAS  PubMed  Google Scholar 

  31. Balch CM, Dougherty PA, Tilden AB. Excessive prostaglandin E2 production by suppressor monocytes in head and neck cancer patients. Ann Surg 1982; 196: 645–50.

    CAS  PubMed  Google Scholar 

  32. Balm FA, Drexhage HA, von Blomberg M et al. Mononuclear phagocytic function in head and neck cancer. Cancer 1984; 54: 1010–15.

    CAS  PubMed  Google Scholar 

  33. Bancewicz J, Calman K, MacPherson SG et al. Adjuvant chemotherapy and immunotherapy for colorectal cancer; preliminary communication. J R Soc Med 1980; 73: 197–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  34. Baral E, Blomgren H, Petrini B, Wasserman J. Blood lymphocytes in breast cancer patients following radiotherapy and surgery. Int J Radiat Oncol Biol Phys 1977; 2: 289–95.

    CAS  PubMed  Google Scholar 

  35. Baral E, Blomgren H, Petrini B et al. Prognostic relevance of immunologic variables in breast carcinoma. Acta Radiol Ther Phys Biol 1977; 16: 417–26.

    CAS  PubMed  Google Scholar 

  36. Baseler MW, Maxim PE, Veltri RW. Circulating IgA immune complexes in head and neck cancer, nasopharyngeal carcinoma, lung cancer, and colon cancer. Cancer 1987; 59: 1727–31.

    CAS  PubMed  Google Scholar 

  37. Baskies AM, Chretien PB, Weiss JF et al. Serum glycoproteins in cancer patients: first report of correlations with in vitro and in vivo parameters and cellular immunity. Cancer 1980; 45: 3050–60.

    CAS  PubMed  Google Scholar 

  38. Bast RC, Reinherz EL, Maven C et al. Contrasting effects of cyclophosphamide and prednisolone on the phenotype of human peripheral blood leukocytes. Clin Immunol Immunopathol 1983; 28: 101–14.

    PubMed  Google Scholar 

  39. Baumann MA, Milson TJ, Patrick CW et al. Correlation of circulating natural killer cell count with prognosis in large cell lymphoma. Cancer 1986; 57: 2309–12.

    CAS  PubMed  Google Scholar 

  40. Bean MA, Schelhammer PS, Her HW et al. Immunocompetence of patients with transitional cell carcinoma as measured by DNCB skin tests and in vitro lymphocyte function. Natl Cancer Inst Monogr 1978; 49: 111–14.

    PubMed  Google Scholar 

  41. Bedikian AY, Patt YZ, Murphy WK et al. Prospective evaluation of thymosin fraction V immunotherapy in patients with non-small cell lung cancer receiving vindesine, doxorubicin, and cisplatin (VAP) chemotherapy. Am J Clin Oncol 1984; 7: 399–404.

    CAS  PubMed  Google Scholar 

  42. Benkovic B, Burek B, Jaksic B, Vitale B. Modulation of chronic lymphocytic leukemia (CLL) lymphocyte phenotypes by in vitro incubation with alpha-1 thymosin. Blood Cells 1987; 12: 441–55.

    CAS  PubMed  Google Scholar 

  43. Bennett A, Berstock A, Harris M et al. Prostaglandins and their relationship to malignant and benign breast tumors. In: Sammuelsson B, Ramuell PW, Paoletti R, eds. Advances in Prostaglandin and Thromboxane Research, vol. 6. New York: Raven Press, 1980: 595–9.

    Google Scholar 

  44. Berd D, Macguire HC Jr, Mastrangelo MJ. Induction of cell-mediated immunity to autologous melanoma cells and regression of metastases after treatment with a melanoma cell vaccine preceded by cyclophosphamide. Cancer Res 1986; 46: 2572–7.

    CAS  PubMed  Google Scholar 

  45. Berd D, Mastrangelo MJ, Enstron PF et al. Augmentation of the human immune response by cyclophosphamide. Cancer Res 1982; 42: 4862–6.

    CAS  PubMed  Google Scholar 

  46. Berd D, Wilson EJ, Bellet RE, Mastrangelo MJ. Effect of 1-(2-chlorethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea adjuvant therapy on the immune response of patients with malignant melanoma. Cancer Res 1979; 39: 4472–6.

    CAS  PubMed  Google Scholar 

  47. Berd D, Mastrangelo MJ. Effect of low dose cyclopho- sphamide on the immune system of cancer patients: reduction of T-suppressor function without depletion of the CD8+ subset. Cancer Res 1987; 47: 3317–21.

    CAS  PubMed  Google Scholar 

  48. Berd D, Maguire HC, Mastrangelo MJ. Impairment of concanavalin A-inducible suppressor activity following administration to patients with advanced cancer. Cancer Res 1984; 44: 1275–80.

    CAS  PubMed  Google Scholar 

  49. Berenbaum MC, Fluck PA, Hurst NP. Depression of lymphocyte responses after surgical trauma. Br J Exp Pathol 1973; 54: 597–607.

    CAS  PubMed Central  PubMed  Google Scholar 

  50. Berenyl E, Kavai M, Szabolcsi M, Szegedi G. Levamisole in the treatment of Hodgkin’s disease. Acta Med Acad Sci Hung 1979; 36: 177–85.

    Google Scholar 

  51. Bergman S, Borgstrom S, Tarnik A. Lymphocyte response to phytohaemagglutinin following cholecystectomy. Acta Pathol Microbiol Scand 1969; 75: 363–6.

    CAS  PubMed  Google Scholar 

  52. Bergmann L, Mitrou PS, Demmer-Dieckmann M et al. Impaired T- and B-cell functions in patients with Hodgkin’s disease. Cancer Immunol Immunother 1987; 25: 59–64.

    CAS  PubMed  Google Scholar 

  53. Berkarda B, Bouffard-Eyaboglu H, Derman U. The effect of coumarin derivatives on the immunological system of man. Agents Actions 1983; 13: 50–2.

    CAS  PubMed  Google Scholar 

  54. Berlinger NT. Deficient immunity in head and neck cancer due to excessive monocyte production of prostaglandins. Laryngoscope 1984; 94: 1407–10.

    CAS  PubMed  Google Scholar 

  55. Bernengo MG, Fra P, Lisa F, Meregilli M, Zina G. Thymostimulin therapy in melanoma patients: correlation of immunologic effects with clinical course. Clin Immunol Immunopathol 1983; 28: 311–24.

    CAS  PubMed  Google Scholar 

  56. Bernengo MG, Lisa F, Meregalli M et al. The prognostic value of T-lymphocyte levels in malignant melanoma. A five year follow-up. Cancer 1983; 52: 1841–98.

    CAS  PubMed  Google Scholar 

  57. Bernengo MG, Lisa F, Meregalli M, Doveil GC. Changes in T- and B-lymphocyte subpopulations before, during and after chemotherapy for malignant melanoma. Int J Tissue React 1984; 6: 505–11.

    CAS  PubMed  Google Scholar 

  58. Bicker U. Immunomodulation by 2-cyanaziridine deriva- tives. In: Serrou B, Rosenfeld C, Daniels JC, Saunder JP, eds. Current Concepts in Human Immunology and Cancer Immunomodulation. Amsterdam: Elsevier, 1982: 521–34.

    Google Scholar 

  59. Bier J, Nicklisch U, Platz H. The doubtful relevance of nonspecific immune reactivity in patients with squamouscell carcinoma of the head and neck region. Cancer 1983; 52: 1165–72.

    CAS  PubMed  Google Scholar 

  60. Bjorkholm M, Wedelin C, Holm G et al. Lymphocytotoxic serum factors and lymphocyte functions in untreated Hodgkin’s disease. Cancer 1982; 50: 2044–8.

    CAS  PubMed  Google Scholar 

  61. Bjorkholm M, Holm G, Mellstedt H. Persisting lymphocyte deficiencies during remission in Hodgkin’s disease. Clin Exp Immunol 1977; 28: 389–93.

    CAS  PubMed Central  PubMed  Google Scholar 

  62. Bjorkholm M, Holm G, Mellstedt H. Immunologic profile of patients with cured Hodgkin’s disease. Scand J Hematol 1977; 18: 361–8.

    CAS  Google Scholar 

  63. Bjorkholm M, Holm G, Mellsted H, Johansson B. Immunodeficiency and prognosis in Hodgkin’s disease. Acta Med Scand 1975; 198: 275–9.

    CAS  PubMed  Google Scholar 

  64. Block JB, Haynes HA, Thompson WL, Neiman PE. Delayed hypersensitivity in chronic lymphocytic leukemia. J Natl Cancer Inst 1969; 42: 973–80.

    CAS  PubMed  Google Scholar 

  65. Blomgren H, Edsmyr F, Esposti PL et al. Influence of bestatin, a new immunomodifier, on human lymphoid cells. In: Serrou B, Rosenfeld C, Daniels JC, Saunders JP, eds. Current Concepts in Human Immunology and Cancer Immunomodulation. Amsterdam: Elsevier, 1982: 593–610.

    Google Scholar 

  66. Blomgren H, Edsmyr F, Esposti PL, Naslund I. Immunological and haematological monitoring in bladder cancer patients receiving adjuvant bestatin treatment following radiation therapy. A prospective randomized trial. Biomed Pharmacother 1984; 38: 143–9.

    CAS  PubMed  Google Scholar 

  67. Blomgren SE, Wolberg WH, Kisken WA. Effect of fluoropyrimidines on delayed cutaneous hypersensitivity. Cancer Res 1965; 25: 977–9.

    CAS  PubMed  Google Scholar 

  68. Blomgren H, Wasserman J, Rotstein S et al. Possible role of prostaglandin-producing monocytes in the depression of mitogenic response of blood lymphocytes following radiation therapy. Radiother Oncol 1984; 1: 255–61.

    CAS  PubMed  Google Scholar 

  69. Blomgren H, Baral E, Edsmyr F et al. Natural killer activity in peripheral blood lymphocyte populations following local radiation therapy. Acta Radiol Oncol 1980; 2: 139–43.

    Google Scholar 

  70. Blomgren H, Wasserman J, Littbrand B. Blood lymphocytes after radiation therapy of carcinoma of prostate and urinary bladder. Acta Radiol Ther Phys Biol 1974; 13: 357–67.

    CAS  PubMed  Google Scholar 

  71. Blomgren H, Naslund I, Esposti PL et al. Adjuvant bestatin immunotherapy in patients with transitional cell carcinoma of the bladder. Clinical results of a randomized trial. Cancer Immunol Immunother 1987; 25: 46.

    Google Scholar 

  72. Blomgren H, Strender LE, Petrini B, Wasserman J. Changes of the spontaneous cytotoxicity of the blood lymphocyte population following local radiation therapy for breast cancer. Eur J Cancer Clin Oncol 1982; 18: 637–43.

    CAS  PubMed  Google Scholar 

  73. Blomgren H, Wasserman J, Baral E, Petrini B. Evidence for the appearance of non-specific suppressor cells in the blood after local irradiation therapy. Int J Radiol Oncol Biol Phys 1978; 4: 249–53.

    CAS  Google Scholar 

  74. Blomgren H, Strender LE, Edsmyr F. Bestatin treatment and the peripheral lymphocyte population in cancer patients. Recent Results Cancer Res 1980; 75: 133–8.

    CAS  PubMed  Google Scholar 

  75. Blomgren H, Edsmyr F, von Stedingk L -~, Wasserman J. Bestatin treatment enhances the recovery of radiation-induced impairments of the immunological reactivity of the blood lymphocyte population in bladder and cancer patients. Biomed Pharmacother 1986; 40: 50–4.

    CAS  Google Scholar 

  76. Bobrove AM, Fuks Z, Strober S. Quantitation of T- and B-lymphocytes and cellular immune function in Hodgkin’s disease. Cancer 1975; 36: 169–79.

    CAS  PubMed  Google Scholar 

  77. Bockman RS. Prostaglandins in cancer: a review. Cancer Invest 1983; 1: 485–93.

    CAS  PubMed  Google Scholar 

  78. Boetcher DA, Leonard EJ. Abnormal monocyte chemotactic response in cancer patients. J Natl Cancer Inst 1974; 52: 1091–8.

    CAS  PubMed  Google Scholar 

  79. Bollag W, Matta A. From vitamin A to retinoids in experimental and clinical oncology: achievements, failures, and outlook. Ann NYAcad Sci 1981; 359: 9–23.

    CAS  Google Scholar 

  80. Bolton PM, Teasdale C, Mander AM et al. Immune competence in breast cancer: relationships of pretreatment immunologic tests to diagnosis and tumor stage. Cancer Immunol Immunother 1976; 1: 251–8.

    Google Scholar 

  81. Bolton PM, Mander AM, Davidson JM et al. Cellular immunity in cancer: comparison of delayed hypersensitivity skin tests in three common cancers. Br J Med 1975; 3: 18–20.

    CAS  Google Scholar 

  82. Bone G, Appleton DR, Venebles CW. The prognostic value of the cutaneous delayed hypersensitivity response to 2,4-dinitrochlorobenzene in gastrointestinal cancer. Br J Cancer 1974; 29: 403–6.

    CAS  PubMed Central  PubMed  Google Scholar 

  83. Borden EC, Davis TE, Crowley JJ et al. Interim analysis of trial of levamisole and 5-fluorouracil in metastatic colorectal carcinoma. In: Terry WD, Rosenberg SA, eds. Immunotherapy of Human Cancer. New York: Elsevier/ North-Holland, 1982: 231–5.

    Google Scholar 

  84. Bosworth JL, Ghossein NA, Brooks TL. Delayed hypersensitivity in patients treated by curative radiotherapy. Its relation to tumor response and short-term survival. Cancer 1975; 36: 353–8.

    CAS  PubMed  Google Scholar 

  85. Braun DP, Nisius S, Hollinshead A, Harris JE. Serial immune testing in surgically resected lung cancer patients. Cancer Immunol Immunother 1983; 15: 114–20.

    CAS  PubMed  Google Scholar 

  86. Braun DP, Harris JE, Rugenstein M. Relationships of arachidonic acid metabolism to indomethacin-sensitive immunoregulatory function and lymphocyte PGE sensitivity in peripheral blood mononuclear cells of disseminated solid-tumor cancer patients. J Immunopharmacol 1984; 6: 227–36.

    CAS  Google Scholar 

  87. Braun DP, Harris JE. Effects of combination chemother- apy on immunoregulatory cells in peripheral blood of solid-tumor cancer patients: correlation with rebound overshoot immune function recovery. Clin Immunol Immunopathol 1981; 20: 193–214.

    CAS  PubMed  Google Scholar 

  88. Braun DP, Harris JE. Modifications of the effects of cytotoxic chemotherapy on the immune responses of cancer patients with a non-steroidal, anti-inflammatory drug, piroxicam. Proc Am Soc Clin Oncol 1985; 4: 223 (abstract).

    Google Scholar 

  89. Brenner BG, Friedman G, Margolese RG. The relationship of clinical status and therapeutic modality to natural killer cell activity in human breast cancer. Cancer 1985; 56: 1543–8.

    CAS  PubMed  Google Scholar 

  90. Brooks WH, Caldwell HD, Mortara RH. Immune responses in patients with gliomas. Surg Neurol 1974; 2: 419–23.

    CAS  PubMed  Google Scholar 

  91. Brosman S, Elhilali M, Vescura C, Fahey J. Immune response in bladder cancer patients. J Urol 1979; 121: 162–9.

    CAS  PubMed  Google Scholar 

  92. Brosman S, Hausman M, Shacks SJ. Studies on the immune status of patients with renal adenocarcinoma. J Urol 1975; 114: 375–80.

    CAS  PubMed  Google Scholar 

  93. Browder JP, Cretien PB. Immune reactivity in head and neck squamous carcinoma and relevance to the design of immunotherapy trials. Semin Oncol 1977; 4: 431–9.

    CAS  PubMed  Google Scholar 

  94. Brown AE, Badger AM, Poste G. The effects of cimetidine on immune cell function and host response to tumors. In: Serrou B, Rosenfeld C, Daniels JC, and Sanders JP, eds. Current Concepts of Human Immunology and Cancer Immunomodulation. Amsterdam: Elsevier, 1982: 513–19.

    Google Scholar 

  95. Bruckner HW, Mokyr MB, Mitchell MS. Effect of imidazole-4-carboxamide-5-(3,3-dimethyl-1-triazeno) on immunity in patients with malignant melanoma. Cancer Res 1974; 34: 181–3.

    CAS  PubMed  Google Scholar 

  96. Bukowski RM, Deodhar S, Hewlett JS, Greenstreet R. Randomized controlled trial of transfer factor in stage II malignant melanoma. Cancer 1983; 51: 269–72.

    CAS  PubMed  Google Scholar 

  97. Buroker TR, Moertel CG, Fleming TR et al. A controlled evaluation of recent approaches to biochemical modulation or enhancement of 5-fluorouracil therapy in colorectal carcinoma. J Clin Oncol 1985; 3: 1624–31.

    CAS  PubMed  Google Scholar 

  98. Burtin C, Noirot C, Scheinmann P et al. Clinical improvement in advanced cancer disease after treatment combining histamine and H2-antihistaminics (rantidine or cimetidine). Eur J Cancer Clin Oncol 1988; 24: 161–7.

    CAS  PubMed  Google Scholar 

  99. Busutti L, Blotta A, Mastrorilli M et al. Transfer factor adjuvant therapy in non-small-cell lung carcinoma (NSCLC) after surgery and radiotherapy. J Exp Pathol 1987; 3: 565–8.

    CAS  PubMed  Google Scholar 

  100. Butterworth C, Oon CJ, Westbury G, Hobbs JR. T-lymphocyte response in patients with malignant melanoma. Eur J Cancer 1977; 10: 639–46.

    Google Scholar 

  101. Cairo MS, Mallett C, Vande Ven C et al. Impaired in vitro polymorphonuclear function secondary to the chemotherapeutic effects of vincristine, adriamycin, cyclophosphamide, and actinomycin D. J Clin Oncol 1986; 5: 798–804.

    Google Scholar 

  102. Cameron DJ. A comparison of the cytotoxic potential in polymorphonuclear leukocytes obtained from normal donors and cancer patients. Clin Immunol Immunopathol 1983; 28: 115–24.

    CAS  PubMed  Google Scholar 

  103. Cameron DJ, O’Brien P, Majeski JA. Effects of in vivo treatment with ibuprofen on macrophage function in breast and colon cancer patients. J Clin Lab Immunol 1986; 20: 23–8.

    CAS  PubMed  Google Scholar 

  104. Cannon GB, Dean JH, Herberman RB et al. Association of depressed postoperative lymphoproliferative responses to alloantigens with poor prognosis in patients with stage I lung cancer. Int J Cancer 1980; 25: 9–17.

    CAS  PubMed  Google Scholar 

  105. Carmignani G, Belgrano E, Puppo P, Cornaglia P. Tlymphocyte-inhibiting factors in renal cancer: evaluation of differences between arterial and renal venous blood levels of E-rosette-forming cells. J Urol 1978; 120: 673–5.

    CAS  PubMed  Google Scholar 

  106. Carpenter JT Jr, Smalley RV, Raney M et al. Ineffectiveness of levamisole in prolonging remission or survival of women treated with cyclophosphamide, doxorubicin, and 5-fluorouracil for good-risk metastatic breast carcinoma: a Southeastern Cancer Study Group Trial. Cancer Treat Rep 1986; 70: 1073–9.

    PubMed  Google Scholar 

  107. Case DC, Hansen JA, Corrales E et al. Depressed in vitro lymphocyte responses to PHA in patients with Hodgkin’s disease in continuous long remissions. Blood 1977; 49: 771–8.

    PubMed  Google Scholar 

  108. Catalona WJ, Ratliff TL, McCool RE. Discordance among cell-mediated cytolytic mechanisms in cancerous patients: importance of the assay system. J Immunol 1979; 122: 1009–14.

    CAS  PubMed  Google Scholar 

  109. Catalona WJ, Tarpley JL, Potvin C, Chretien PB. Host immunocompetence in genitourinary cancer: relationship to tumor stage and prognosis. Natl Cancer Inst Monogr 1978; 49: 105–10.

    PubMed  Google Scholar 

  110. Catalona WJ, Chretien PB. Abnormalities of quantitative dinitrochlorobenzine sensitization in cancer patients: correlation with tumor stage and histology. Cancer 1973; 31: 353–6.

    CAS  PubMed  Google Scholar 

  111. Catalona WJ, Sample WF, Chretien PB. Lymphocyte reactivity in cancer patients: correlation with tumor histology and clinical stage. Cancer 1973; 31: 65–71.

    CAS  PubMed  Google Scholar 

  112. Catalona WJ, Tarpley JL, Potvin C, Chretien PB. Correlations among cutaneous reactivity to DNCB, PHA-induced lymphocyte blastogenesis and peripheral blood E-rosettes. Clin Exp Immunol 1975; 19: 327–32.

    CAS  PubMed Central  PubMed  Google Scholar 

  113. Catalona WJ, Ratliff TL, McCool R. Concanavalin-Aactivated suppressor cell activity in peripheral blood

    Google Scholar 

  114. lymphocytes of urologic cancer patients. J Natl Cancer Inst 1980; 65: 553–7.

    Google Scholar 

  115. Caulfield MJ, Luce KJ, Proffitt MR, Cevy J. Induction of idiotype-specific suppressor T-cells with antigen/antibody complexes. J Exp Med 1983; 157: 1713–25.

    CAS  PubMed  Google Scholar 

  116. Cervical Cancer Immunotherapy Study Group. Immunotherapy using the streptococcal preparation OK-432 for the treatment of uterine cervical cancer. Cancer 1987; 60: 2394–402.

    Google Scholar 

  117. Chahinian AP, Goldberg J, Holland JF et al. Chemotherapy vs. chemoimmunotherapy with levamisole or Corynebacterium parvum in advanced lung cancer. Cancer Treat Rep 1982; 66: 1291–7.

    CAS  PubMed  Google Scholar 

  118. Chang TC, Statzman L, Sokal JE. Correlation of delayed hypersensitivity responses with chemotherapeutic results in advanced Hodgkin’s disease. Cancer 1975; 36: 950–5.

    CAS  PubMed  Google Scholar 

  119. Cheema AR, Hersh EM. Patient survival after chemotherapy and its relationship to in vitro lymphocyte blastogenesis. Cancer 1971; 28: 851–5.

    CAS  PubMed  Google Scholar 

  120. Chihara G, Hamuro J, Maeda YY et al. Antitumor and metastasis-inhibitory activities of lentinan as an immunomodulator: an overview. Cancer Detect Prev Suppl 1987; 1: 423–43.

    CAS  PubMed  Google Scholar 

  121. Chirhara G. The antitumor polysaccharide lentinan: an overview. In: Aoki T, Urushizaki I, and Tsubara E, eds. Manipulation of Host Defense Mechanisms. Amsterdam: Excerpta Medica, 1981: 1–16.

    Google Scholar 

  122. Chirigos MA, Mastrangelo MJ. Immunorestoration by chemicals. In: Milhich E, ed. Immunological Approaches to Cancer Therapeutics. New York: Wiley, 1982: 191–239.

    Google Scholar 

  123. Chisesi T, Capnist G, Rancan L et al. The effect of thymic substances on T-circulating cells of patients treated for Hodgkin’s disease. J Biol Regul Homeost Agents 1988; 2: 193–8.

    CAS  PubMed  Google Scholar 

  124. Chlebowski RT, Nystrom S, Reynolds R et al. Long-term survival following levamisole or placebo adjuvant treatment of colorectal cancer: a Western Cancer Study Group trial. Oncology 1988; 45: 141–3.

    CAS  PubMed  Google Scholar 

  125. Clemens LE, Siiteri PK, Stities DP. Mechanism of immunosuppression of progesterone of natural lymphocyte activation during pregnancy. J Immunol 1979; 122: 1978–85.

    CAS  PubMed  Google Scholar 

  126. Cochran AJ, Mackie RM, Grant RM et al. An examination of the immunology of cancer patients. Int J Cancer 1976; 18: 298–309.

    CAS  PubMed  Google Scholar 

  127. Cohen MH, Chretien PB, Johnston-Early A et al. Thymosin fraction V prolongs survival of intensively treated small-cell lung cancer patients. In: Terry WD, Rosenberg SA, eds. Immunotherapy of Human Cancer. New York: Elsevier/North-Holland, 1982: 141–5.

    Google Scholar 

  128. Cohen JHD, Danel L, Cordier G et al. Sex steroid receptors in peripheral T-cell: absence of androgen receptors to OKT8-positive cells. J Immunol 1983; 131: 2767–71.

    CAS  PubMed  Google Scholar 

  129. Cohen MH, Chretien PB, Indo DC et al. Thymosin fraction V and intensive combination chemotherapy prolonging the survival of patients with small-cell lung cancer. J Am Med Assoc 1979; 241: 1813–15.

    CAS  Google Scholar 

  130. Colozza M, Tonato M, BelsantiV et al. 5-Fluorouracil and isoprinosine in the treatment of advanced colorectal cancer: a limited phase I, II evaluation. Cancer 1988; 62: 1049–52.

    CAS  PubMed  Google Scholar 

  131. Cone L, Uhr JW. Immunological deficiency disorders associated with chronic lymphocyte leukemia and multiple myeloma. J Clin Invest 1964; 43: 2241–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  132. Consolini R, Cei B, Cini P et al. Circulating thymic hormone activity in young cancer patients. Clin Exp Immunol 1986; 66: 173–80.

    CAS  PubMed Central  PubMed  Google Scholar 

  133. Corder MP, Young RC, Brown RS, DeVita VT. Phytohemagglutinin-induced lymphocyte transformation: the relationship to prognosis of Hodgkin’s disease. Blood 1972; 39: 595–601.

    CAS  PubMed  Google Scholar 

  134. Costanzi JJ, Fletcher WS, Balcerzak SP et al. Combination chemotherapy plus levamisole in the treatment of disseminated malignant melanoma. A Southwest Oncology Group Study. Cancer 1984; 53: 833–6.

    CAS  PubMed  Google Scholar 

  135. Cozzolino F, Torcia M, Carossino AM et al. Characterization of cells from invaded lymph nodes in patients with solid tumors. J Exp Med 1987; 166: 303–18.

    CAS  PubMed  Google Scholar 

  136. Cullen BF, Van Belle G. Lymphocyte transformation and changes in leukocyte count. Effect of anesthesia and operation. Anesthesiology 1975; 43: 563–9.

    CAS  PubMed  Google Scholar 

  137. Cunningham-Rundles S, Filippa A, Braun DW et al. Natural cytotoxicity of peripheral blood lymphocytes and regional lymph node cells in breast cancer in women. J Natl Cancer Inst 1981; 67: 585–90.

    CAS  PubMed  Google Scholar 

  138. Dagan S, Tzehoval E, Fridkin M, Feldman M. Tuftsin and tuftsin conjugates potentiate immunogenic processes: effects and possible mechanisms. J Biol Response Mod 1987; 6: 625–36.

    CAS  PubMed  Google Scholar 

  139. Dalbow MH, Concannon JP, Eng CP et al. Lymphocyte mitogen stimulation studies for patients with lung cancer: evaluation of prognostic significance of preirradiation therapy studies. J Lab Clin Med 1977; 90: 295–302.

    CAS  PubMed  Google Scholar 

  140. Danel L, Sonweine G, Monier JC, Saez S. Specific estrogen binding sites in human lymphoid cells and thymic cells. J Steroid Biochem 1983; 18: 559–63.

    CAS  PubMed  Google Scholar 

  141. Danish Breast Cancer Cooperative Group. Increased breast cancer recurrence rate after adjuvant therapy with levamisole. Lancet 1980; 2: 824–7.

    Google Scholar 

  142. Das SN, Khanna NN, Khanna S. A multiparametric observation of immune competence in breast cancer and its correlation with tumor load and prognosis. Ann Acad Med Singapore 1985; 14: 374–81.

    CAS  PubMed  Google Scholar 

  143. Davis S, Mietlowski W, Rohweder JJ et al. Levamisole as an adjuvant to chemotherapy in extensive bronchogenic carcinoma. A Veterans Administration Lung Cancer Group study. Cancer 1982; 50: 646–51.

    CAS  PubMed  Google Scholar 

  144. Dawson DE, Everts EC, Vetto RM, Burger DR. Assessment of immunocompetent cells in patients with head and neck squamous-cell carcinoma. Ann Otol Rhinol Laryngol 1985; 94: 342–5.

    CAS  PubMed  Google Scholar 

  145. DeBoer KP, Braun DP, Harris JE. Natural cytotoxicity and antibody-dependent cytotoxicity in solid-tumor cancer patients: regulation by adherent cells. Clin Immunol Immunopathol 1982; 23: 133–44.

    CAS  PubMed  Google Scholar 

  146. Del Giacco GS, Cengiarotti L, Mantovani G et al. Advanced lung cancer treated with combination chemotherapy with or without thymostimulin. In: Byrom NA, Hobbs JR, eds. Thymic Factor Therapy Serono Symposium Publications: New York: Raven Press, 1982: 321–8.

    Google Scholar 

  147. Dellon AL, Potvin C, Chretien PB. Thymus-dependent lymphocyte levels during radiation therapy for bronchogenic and esophageal carcinoma: correlations with clinical course in responders and nonresponders. Am J Roentgenol Radiat Ther Nucl Med 1975; 123: 500–11.

    CAS  Google Scholar 

  148. Dellon AL, Potvin C, Chretien PB. Thymus-dependent lymphocyte levels in bronchogenic carcinoma: correlations with histology, clinical stage, and clinical course after surgical treatment. Cancer 1975; 35: 687–94.

    CAS  PubMed  Google Scholar 

  149. Dillman RO, Beauregard JC, Zavanelli MI et al. In vivo immune restoration in advanced cancer patients after administration of thymosin fraction V or thymosin alpha-1. J Biol Response Mod 1983; 2: 139–47.

    CAS  PubMed  Google Scholar 

  150. Dimitrov NV, Arnold D, Munson J et al. Phase II study of thymosin fraction 5 in the treatment of metastatic renal cell carcinoma. Cancer Treat Rep 1985; 69: 137–8.

    CAS  PubMed  Google Scholar 

  151. Dizon QS, Southam CM. Abnormal cellular response in skin abrasion in cancer patients. Cancer 1963; 16: 1288–92.

    CAS  PubMed  Google Scholar 

  152. Domellof L. Athlin L, Berghem L. Effects of long-term combination chemotherapy on the reticuloendothelial system. Cancer 1984; 53: 2073–8.

    PubMed  Google Scholar 

  153. Donoran AJ. Reticuloendothelial function in patients with cancer: initial observations. Am J Surg 1967; 111: 230–8.

    Google Scholar 

  154. Droller MJ, Schneider MU, Perlmann P. A possible role of prostaglandins in the inhibition of natural and antibody-dependent cell-mediated cytotoxicity against tumor cells. Cell Immunol 1978; 39: 165–77.

    CAS  PubMed  Google Scholar 

  155. Droller MJ, Perlmann P, Schneider MU. Enhancement of natural and antibody-dependent lymphocyte cytotoxicity by drugs which inhibit prostaglandin production by tumor target cells. Cell Immunol 1978; 39: 154–64.

    CAS  PubMed  Google Scholar 

  156. Ducos J, Mingueres J, Colombio P et al. Lymphocyte response to PHA in patients with lung cancer. Lancet 1970; 1: 111–12.

    Google Scholar 

  157. Dupont B, Ballon M, Hansen JA et al. Effects of transfer factor therapy on mixed lymphocyte culture reactivity. Proc Natl Acad Sci USA 1974; 71: 867–71.

    CAS  PubMed  Google Scholar 

  158. Edelman GM, Cunningham BA, Gall WE et al. The covalent structure of and entire gamma G immunoglobulin molecule. Proc Natl Acad Sci USA 1969; 63: 78–85.

    CAS  PubMed  Google Scholar 

  159. Ehrke MJ, Mihich E, Berd D, Mastrangelo MJ. Effects of anticancer drugs on the immune system in humans. Semin Oncol 1989; 16: 230–53.

    CAS  PubMed  Google Scholar 

  160. Eilber FR, Nizze HA, Morton DL. Sequential evaluation of general immune competence in cancer patients: correlation with clinical course. Cancer 1975; 35: 660–5.

    CAS  PubMed  Google Scholar 

  161. Eilber FR, Morton DL. Impaired immunologic reactivity and recurrence following cancer surgery. Cancer 1970; 25: 362–7.

    CAS  PubMed  Google Scholar 

  162. Eilber FR, Morton DL, Ketcham AS. Immunologic abnormalities in head and neck cancer. Am J Surg 1974; 128: 534–8.

    CAS  PubMed  Google Scholar 

  163. Eisenthal A, Monselise J, Zinger R, Adler A. The effect of cimetidine on PBL from healthy donors and melanoma patients: augmentation of T-cell responses to TCGF mito-gens and alloantigens and of TCGF production. Cancer Immunol Immunother 1986; 21: 141–7.

    CAS  PubMed  Google Scholar 

  164. Eremin O, Ashby J, Franks D. Killer (K) cell activity in human normal lymph node, regional tumor lymph node, and inflammatory lymph node. Int Arch Allergy Appl Immunol 1977; 54: 210–20.

    CAS  PubMed  Google Scholar 

  165. Eremin O, Ashby J, Stephens JP. Human natural cytotoxicity in the blood and lymphoid organs of healthy donors and patients with malignant disease. Int J Cancer 1978; 21: 35–41.

    CAS  PubMed  Google Scholar 

  166. Ershler WB, Hacker MP, Burroughs BJ et al. Cimetidine and the immune response. In vivo augmentation of nonspecific and specific immune response. Clin Immunol Immunopathol 1983; 26: 10–17.

    CAS  PubMed  Google Scholar 

  167. Eskinazi DP, Perna JJ, Mihail R. Mononuclear cell subsets in patients with oral cancer. Cancer 1987; 60: 376–81.

    CAS  PubMed  Google Scholar 

  168. Estervez ME, Ballart IJ, Diez RA et al. Normalization of monocyte candidacidal deficiency by cyclooxygenase inhibitors in Hodgkin’s disease. Cancer 1985; 55: 2774–8.

    Google Scholar 

  169. Eura M, Maehara T, Tsutomo I, Ishikawa T. Suppressor cells in the effector phase of autologous cytotoxic reactions in cancer patients. Cancer Immunol Immunother 1988; 27: 147–53.

    CAS  PubMed  Google Scholar 

  170. Ezdinli EZ, Simonson KL, Smith RA. Comparison of the effects of single vs. multiple agent chemotherapy on

    Google Scholar 

  171. lymphocytes assayed by the rosette techniques. Cancer 1978; 42: 2234–43.

    Google Scholar 

  172. Faguet GB, Davis HC. Survival in Hodgkin’s disease: the role of immunocompetence and other major risk factors. Blood 1982; 59: 938–45.

    CAS  PubMed  Google Scholar 

  173. Fisher RI, Bostick-Bruton F. Depressed T-cell proliferative responses in Hodgkin’s disease: role of monocyte-mediated suppression via prostaglandins and hydrogen peroxide. J Immunol 1982; 129: 1770–4.

    CAS  PubMed  Google Scholar 

  174. Fisherman EW. Does the allergic diathesis influence malignancy? J Allergy 1960; 31: 74–8.

    CAS  PubMed  Google Scholar 

  175. Flodgren P, Sjogren HO. Influence in vitro on NK and K-cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon. Cancer Immunol Immunother 1985; 19: 28–34.

    CAS  PubMed  Google Scholar 

  176. Florentin I, Kraus L, Mathe~ G, Hadden JW. In vivo study in mice of the immunopharmacological properties of NPT-15392. In: Serrou B, Rosenfeld C, Daniels JB, Saunders JP, eds. Current Concepts of Human Immunology and Cancer Immodulation. Amsterdam: Elsevier, 1982: 463–9.

    Google Scholar 

  177. Forbes JT, Greco FA, Oldham RK. Human natural cell-mediated cytotoxicity. II. Levels in neoplastic disease. Cancer Immunol Immunother 1982; 11: 147–53.

    Google Scholar 

  178. Ford RJ, Tsao J, Kouttab NM et al. Association of an interleukin abnormality with the T-cell defect in Hodgkin’s disease. Blood 1984; 64: 386–92.

    CAS  PubMed  Google Scholar 

  179. Fracchia A, Pacetti M, Barberis M et al. Determination of T-lymphocyte subpopulations in patients with lung cancer. A comparison between lung lavage and peripheral blood by monoclonal antibodies and flow cytometry. Respiration 1987; 51: 161–9.

    CAS  PubMed  Google Scholar 

  180. Frydecka I. Natural killer-cell activity during the course of disease in patients with Hodgkin’s disease. Cancer 1985; 56: 2799–803.

    CAS  PubMed  Google Scholar 

  181. Fujisama T, Yamaguchi Y, Kimura H et al. Adjuvant immunotherapy of primary resected lung cancer with transfer factor. Cancer 1984; 54: 663–9.

    Google Scholar 

  182. Fujisawa T, Yamaguchi Y, Kimura H. Transfer factor in restoration and cell-mediated immunity in lung cancer patients. Jpn J Surg 1983; 13: 304–11.

    CAS  PubMed  Google Scholar 

  183. Fuks Z, Strober S, Kaplan HS. Interaction between serum factors and T-lymphocytes in Hodgkin’s disease. N Engl J Med 1976; 295: 1273–8.

    CAS  PubMed  Google Scholar 

  184. Fuks Z, Strober W, Bobrove AM et al. Long-term effects of radiation on T- and B-lymphocytes in peripheral blood of patients with Hodgkin’s disease. J Clin Invest 1976; 58: 803–14.

    CAS  PubMed Central  PubMed  Google Scholar 

  185. Garay GE, Pavlovsky S, Sasiain MC et al. Immunocompetence and prognosis in children with acute lymphoblastic leukemia: combination of two different maintenance therapies. Med Pediatr Oncol 1976; 2: 403–15.

    CAS  PubMed  Google Scholar 

  186. Gatti RA, Good RA. Occurrence of malignancy in immunodeficiency disease: a literature review. Cancer 1971; 28: 89–98.

    CAS  PubMed  Google Scholar 

  187. Geffner JR, Serebrinsky G, Isturiz MA. Normal human serum restores the expression of Fc8 receptors in immune complex: blocked human mononuclear cells. Immunology 1986; 59: 239–43.

    CAS  PubMed  Google Scholar 

  188. Gilbert HA, Kagan AR, Miles J et al. Delayed hypersensitivity in patients treated by curative radiotherapy. Its relation to tumor response and short-term survival. J Surg Oncol 1978; 10: 73–7.

    CAS  PubMed  Google Scholar 

  189. Giulivi A, Cilano L, Roncoroni L et al. Effects of cimetidine on in vitro transformation of peripheral monocytes to macrophages in healthy volunteers and cancer patients. Int J Immunopharmacol 1986; 8: 517–23.

    CAS  PubMed  Google Scholar 

  190. Goldenberg GJ, Brandes LJ, Lau WH et al. Cooperative trial of immunotherapy for nasopharyngeal carcinoma with transfer factor from donors with Epstein-Barr virus antibody activities. Cancer Treat Rep 1985; 69: 761–7.

    Google Scholar 

  191. Goldrosen MH, Han T, Jung D et al. Impaired lymphocyte blastogenic response in patients with colon adenocarcinoma: effects of disease and age. J Surg Oncol 1977; 9: 229–34.

    CAS  PubMed  Google Scholar 

  192. Goldsmith HS, Levin AG, Southam CM. A study of cellular responses in cancer patients by quantitative and qualitative Rebuck tests. Surg Forum 1965; 16: 102–4.

    CAS  PubMed  Google Scholar 

  193. Goldstein AL, Low TLK, Thurman GB et al. Thymosins and other hormone-like factors of the thymus gland. In: Mihich E, ed. Immunological Cancer Therapeutics. New York: Wiley, 1982: 137–90.

    Google Scholar 

  194. Golub SH, Rangel DM, Morton D. In vitro assessment of immunocompetence in patients with malignant melanoma. Int J Cancer 1977; 20: 873–80.

    CAS  PubMed  Google Scholar 

  195. Goodwin JS, Messner RP, Bankhurst AD et al. Prostaglandin-producing suppressor cells in Hodgkin’s disease. N Engl J Med 1977; 297: 963–8.

    CAS  PubMed  Google Scholar 

  196. Gottlieb AA, Farmer JL, Matzura CT et al. Modulation of human T-cell production of migration inhibitory lymphocytes by cytokines derived from human leukocyte dialysates. J Immunol 1984; 132: 256–60.

    CAS  PubMed  Google Scholar 

  197. Green AA, Borella L. Immunologic rebound after cessation of long-term chemotherapy in acute leukemia. II. In vitro response to phytohemagglutinin and antigens by peripheral blood and bone marrow lymphocytes. Blood 1973; 42: 99–10.

    CAS  PubMed  Google Scholar 

  198. Grohn P, Heinonen E, Klefstrom P, Tarkkanen J. Adjuvant postoperative radiotherapy, chemotherapy and immunotherapy in stage III breast cancer. Cancer 1985; 54: 670–4.

    Google Scholar 

  199. Groveman DS, Borden EC. In vitro and in vivo effects of levamisole on monocyte chemotaxis in normal donors and patients with colorectal carcinoma. J Biol Response Mod 1983; 2: 167–74.

    CAS  PubMed  Google Scholar 

  200. Grzelak I, Olszewski WL, Engeset A. Decreased suppressor cell activity after surgery. J Clin Lab Immunol 1985; 16: 201–5.

    CAS  PubMed  Google Scholar 

  201. Grzelak I, Olszewski WL, Engeset A. Suppressor cell activity in peripheral blood in cancer patients after surgery. Clin Exp Immunol 1983; 51: 149–56.

    CAS  PubMed Central  PubMed  Google Scholar 

  202. Guiliano AE, Rangel D, Golub SH et al. Serum-mediated immunosuppression in lung cancer. Cancer 1979; 43: 917–24.

    Google Scholar 

  203. Gupta S, Cunningham-Rundles S. Deficient concanavalinA-induced suppressor cell activity in women with untreated breast cancer. J Clin Lab Immunol 1982; 9: 159–61.

    CAS  PubMed  Google Scholar 

  204. Gupta S, Good RA. Subpopulations of human T-lymphocytes. II. Effect of thymopoietin, corticosteroids, and irradiation. Cell Immunol 1977; 34: 10–18.

    CAS  PubMed  Google Scholar 

  205. Haas GS, Halperin E, Doseretz D et al. Differential recovery of circulating T-cell subsets after nodal irradiation for Hodgkin’s disease. J Immunol 1984; 132: 1026–30.

    CAS  PubMed  Google Scholar 

  206. Hadden JW. Chemically-defined immunotherapeutic drugs under development for the treatment of cancer. In: Serrou B, Rosenfeld C, Daniels JC, and Saunders JP, eds. Current Concepts in Human Immunology and Cancer Immunomodulation. Amsterdam: Elsevier, 1982: 439–48.

    Google Scholar 

  207. Hadden JW. Recent advances in the preclinical and clinical immunopharmacology of interleukin-2: emphasis on IL-2 as an immunorestorative agent. Cancer Detect Prev 1988; 12: 537–52.

    CAS  PubMed  Google Scholar 

  208. Hadjipetrou-Kourounakis L, Manikou H, Tsougranis A. Restoration of immunosuppression in lung cancer by normal sera. J Clin Lab Immunol 1985; 16: 149–53.

    CAS  PubMed  Google Scholar 

  209. Haim N, Meidav A, Samuelly B et al. Prostaglandin-related and adherent cell suppressor system in apparently cured Hodgkin’s disease patients. J Biol Response Mod 1984; 3: 219–25.

    CAS  PubMed  Google Scholar 

  210. Hakim AA. Peripheral blood lymphocytes from patients with cancer lack interleukin-2 receptors. Cancer 1988; 61: 689–701.

    CAS  PubMed  Google Scholar 

  211. Halili M, Bosworth J, Romney S et al. The long-term effect of radiotherapy on the immune status of patients cured of a gynecologic malignancy. Cancer 1976; 37: 2875–8.

    CAS  PubMed  Google Scholar 

  212. Hall HRS, Goldstein AL. The endocrine thymus. In: Becker KC, ed. Principles and Practice of Endocrinology and Metabolism. New York: Lippincott, 1990.

    Google Scholar 

  213. Han T, Takita H. Indomethacin-mediated enhancement of lymphocyte response to mitogens in healthy subjects and lung cancer patients. Cancer 1980; 46: 2416–20.

    CAS  PubMed  Google Scholar 

  214. Han T. Studies of correlation of lymphocyte response to phytohemagglutinin with the clinical and immunologic status in chronic lymphocytic leukemia. Cancer 1973; 31: 280–5.

    CAS  PubMed  Google Scholar 

  215. Han T, Nemoto T, Ledesma EJ, Bruno S. Enhancement of T-lymphocyte response to mitogens by indomethacin in breast and colorectal cancer patients. Int J Immunopharmacol 1983; 5: 11–15.

    CAS  PubMed  Google Scholar 

  216. Herr HW. Adherent suppressor cells in the blood of patients with bladder cancer. J Urol 1981; 126: 457–60.

    CAS  PubMed  Google Scholar 

  217. Hakim AA. Lipid-like agent from human neoplastic cells suppresses cell-mediated immunity. Cancer Immunol Immunother 1980; 8: 1330.

    Google Scholar 

  218. Han T, Takita H. Immunologic impairment in bronchogenic carcinoma: a study of lymphocyte response to phytohemagglutinin. Cancer 1972; 30: 616–20.

    CAS  PubMed  Google Scholar 

  219. Hanaue H, Kim DY, Machimura T et al. Hemolytic Streptococcus preparation Ok-432: beneficial adjuvant therapy in recurrent gastric carcinoma. Tokai J Exp Clin Med 1987; 12: 209–14.

    CAS  PubMed  Google Scholar 

  220. Hancock BW, Bruce L, Sokol RJ, Clark A. Transfer factor in Hodgkin’s disease: a randomized clinical and immunological study. Eur J Cancer Clin Oncol 1988; 24: 929–33.

    CAS  PubMed  Google Scholar 

  221. Hancock BW, Bruce L, Whitham MD, Ward AM. The effects of radiotherapy on immunity in patients with cured localized carcinoma of the cervix uteri. Cancer 1984; 53: 884–7.

    CAS  PubMed  Google Scholar 

  222. Harris J, Copeland D. Impaired imunoresponsiveness in tumor patients. Ann NY Acad Sci 1974; 230: 56–85.

    CAS  PubMed  Google Scholar 

  223. Harris JE, DeBoer KP, Vahey AC, Braun DP. The measurement of leukocyte subsets in the peripheral blood of cancer patients using monoclonal antibody reagents. Med Pediatr Oncol 1982; 10: 185–94.

    CAS  PubMed  Google Scholar 

  224. Harris JE, Stewart THM. Recovery of mixed lymphocyte reactivity (MLR) following cancer chemotherapy in man. In: Schwartz MR, ed. Proceedings of the Sixth Leukocytes Culture Conference. New York: Academic Press, 1979: 555–80.

    Google Scholar 

  225. Haskell CM. Immunologic aspects of cancer chemotherapy. Ann Rev Pharmacol Toxicol 1977; 17: 179–95.

    CAS  Google Scholar 

  226. Hausman MS, Brossman SA, Snyderman R et al. Defective monocyte function in patients with genitourinary carcinoma. J Natl Cancer Inst 1975; 55: 1047–54.

    CAS  PubMed  Google Scholar 

  227. Hayashi Y, Nishida T, Yoshida H et al. Peripheral T-gamma lymphocyte population in head and neck cancer. Cancer Immunol Immunother 1984; 17: 160–4.

    CAS  PubMed  Google Scholar 

  228. Heal JM, Chuang C, Blumberg N. Perioperative blood transfusions and prostate cancer recurrence and survival. Am J Surg 1988; 156: 374–9.

    CAS  PubMed  Google Scholar 

  229. Hellstrand K, Hermodsson S, Naredi P et al. Histamine and cytokine therapy. Acta Oncol 1998; 37: 347–53.

    CAS  PubMed  Google Scholar 

  230. Hernandez JL, Sanz M, Crisi CD et al. Lymphocyte subpopulations in colorectal cancer-postoperative evaluation. Allergy Immunopathol 1978; 6: 339–44.

    CAS  Google Scholar 

  231. Hersey P, Bindon C, Czerniecki M et al. Inhibition of interleukin-2 production by factors released from tumor cells. J Immunol 1983; 131: 2837–42.

    CAS  PubMed  Google Scholar 

  232. Hersh EM, Gutterman JU, Mavligit GM, Reed RC. Immunologic aspects of chemotherapy. In: Cancer Chemotherapy–Fundamental Concepts and Recent Advances. Chicago: Yearbook Medical, 1975: 279–94;

    Google Scholar 

  233. Hersh EM. Vinca alkaloids. In: Sartorelli AC, Johns DG, eds. Antineoplastic and Immunosuppressive Agents, Part

    Google Scholar 

  234. I. New York: Springer Verlag, 1974: 601–2.

    Google Scholar 

  235. Hersh EM, Gutterman JU, Mavligit GM. Immunotherapy of leukemia. Med Clin N Am 1976; 60: 1019–42.

    CAS  PubMed  Google Scholar 

  236. Hersh EM, Gutterman JU, Mavligit GM et al. Serial studies of immunocompetence of patients undergoing chemotherapy for acute leukemia. J Clin Invest 1974; 54: 401–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  237. Hersh EM, Whitecan JP Jr, McCredie JB et al. Chemotherapy, immunocompetence, immunosuppression and prognosis in acute leukemia. N Engl J Med 1971; 285: 1211–16.

    CAS  PubMed  Google Scholar 

  238. Hersh EM, Irwin WS. Blastogenic responses of lymphocytes from patients with untreated and treated lymphomas. Lymphology 1969; 2: 150–60.

    CAS  PubMed  Google Scholar 

  239. Hersh EM. Immunosuppressive agents. In: Sartorelli AC, Johns DG, eds. Antineoplastic and Immunosuppressive Agents, Part I. New York: Springer Verlag, 1974: 555–76.

    Google Scholar 

  240. Hersh EM, Oppenheim J. Inhibition of in vitro lymphocyte transformation during chemotherapy in man. Cancer Res 1979; 27: 98–105.

    Google Scholar 

  241. Herskovic A, Bauer M, Seydel G et al. Postoperative thoracic irradiation with or without levamisole in nonsmall-cell lung cancer: results of a radiation therapy oncology group study. Int J Radiat Oncol Biol Phys 1988; 14: 37–42.

    CAS  PubMed  Google Scholar 

  242. Hilal EY, Wanebo HJ, Pinsky CM et al. Immunologic evaluation and prognosis in patients with head and neck cancer. Am J Surg 1977; 134: 68–73.

    Google Scholar 

  243. Hilgard P, Pohl J, Stekar J, Voegeli R. Oxazaphosphorines as biological response modifiers: experimental and clinical perspective. Cancer Treat Rev 1985; 12: 155–62.

    CAS  PubMed  Google Scholar 

  244. Hillinger SM, Herzig GP. Impaired cell-mediated immunity in Hodgkin’s disease mediated by suppressor lymphocytes and monocytes. J Clin Invest 1978; 61: 1620–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  245. Hirsh B, Johnson JT, Rabin BS, Thearle PB. Immunostimulation of patients with head and neck cancer. In vitro and preliminary clinical experience. Arch Otolaryngol 1983; 109: 298–301.

    Google Scholar 

  246. Hirshaut Y, Pinsky CM, Frydecka I et al. Effect of short-term levamisole therapy on delayed hypersensitivity. Cancer 1980; 45: 362–6.

    CAS  PubMed  Google Scholar 

  247. Hoagland JG, Scoggin S, Giavazzi R et al. Tumor-derived suppressor factors (TDSFs) in normal and neoplastic colon and rectum. J Surg Res 1986; 40: 467–74.

    CAS  PubMed  Google Scholar 

  248. Hodgson WJB, Lowenfels AB. Blood transfusion and recurrence rates in colonic malignancy. Lancet 1982; 2: 1047.

    CAS  PubMed  Google Scholar 

  249. Hojo H, Hashimoto Y. Cytotoxic cells induced in tumor-bearing rats by a streptococcal preparation (OK-432). Gann 1981; 72: 62–9.

    Google Scholar 

  250. Holm G, Mellstedt H, Bjorkholm M et al. Lymphocyte abnormalities in untreated patients with Hodgkin’s disease. Cancer 1976; 37: 751–62.

    CAS  PubMed  Google Scholar 

  251. Holmes EC. Immunology of tumor-infiltrating lymphocytes. Ann Surg 1985; 201: 158–63.

    CAS  PubMed  Google Scholar 

  252. Holmes E, Sibbitt WL, Bankhurst AD. Serum factors which suppress natural cytotoxicity in cancer patients. Int Arch Allergy Appl Immunol 1986; 80: 39–43.

    CAS  PubMed  Google Scholar 

  253. Holmes EC, Golub SH. Immunologic defects in lung cancer patients. J Thorac Cardiovasc Surg 1976; 71: 161–8.

    CAS  PubMed  Google Scholar 

  254. Hoon DSB, Bowker RJ, Cochran AJ. Suppressor-cell activity in melanoma-draining lymph nodes. Cancer Res 1987; 47: 1529–33.

    CAS  PubMed  Google Scholar 

  255. Hoon DSB, Korn EL, Cochran AJ. Variations in functional immunocompetence of individual tumor-draining lymph nodes in humans. Cancer Res 1987; 47: 1740–4.

    CAS  PubMed  Google Scholar 

  256. Hoon DS, Irie RF, Cochran AJ. Gangliosides from human melanoma immunomodulate responses of T-cells to interleukin-2. Cell Immunol 1988; 111: 410–19.

    CAS  PubMed  Google Scholar 

  257. Horiguchi M, Saito A, Sonoda H. A gastric cancer showing marked improvement (stage IV) with lentinan immunotherapy and 5-FU, MMC-chemotherapy. Gan To Kagaku Ryoho 1988; 15: 1973–7.

    CAS  PubMed  Google Scholar 

  258. Horrino N. Impaired PWM-induced polyclonal B-cell activation in patients with malignancies treated with various intermittent combination chemotherapies including doxorubicin. Cancer 1982; 50: 659–67.

    Google Scholar 

  259. Hortobagyi GN, Hersh EM, Papadopoulos EJ et al. Initial clinical studies with copovithane. J Biol Response Mod 1986; 5: 319–29.

    CAS  PubMed  Google Scholar 

  260. Hsu CC, Logerfo P. Correlation between serum alpha globulin and plasma inhibitory effect of PHA-stimulated lymphocytes in colon cancer patients. Proc Soc Exp Biol Med 1972; 139: 575–8.

    CAS  PubMed  Google Scholar 

  261. Huang AT, Mold NG, Fisher SR et al. A prospective study of squamous head and neck carcinoma. Cancer 1987; 59: 1721–6.

    CAS  PubMed  Google Scholar 

  262. Hubbard GW, Wanebo H, Fukuda M, Pace R. Defective suppressor-cell activity in cancer patients: a defect in immune regulation. Cancer 1981; 47: 2177–84.

    CAS  PubMed  Google Scholar 

  263. Ninneman JL. Melanoma-associated immunosuppression through B-cell activation of suppressor T-cells. J Immunol 1978; 120: 1573–9.

    Google Scholar 

  264. Hughes NR. Serum concentrations of gamma G, gamma A and gamma M immunoglobulins in patients with carcinoma, melanoma, and sarcoma. J Natl Cancer Inst 1971; 46: 1015–28.

    CAS  PubMed  Google Scholar 

  265. Humphrey LJ, Humphrey MA, Singla O, Volenec FJ. Immunologic responsiveness of patients with cancer: relationship to tumor type, stage and prognosis. Ann Surg 1981; 193: 574–8.

    CAS  PubMed  Google Scholar 

  266. Hyman GA. Increased incidence of neoplasia in association with chronic lymphocytic leukemia. Scand J Haematol 1969; 6: 99–104.

    CAS  PubMed  Google Scholar 

  267. Iaffaioli RV, Frasci G, Tortora G et al. Effect of thymic extract `thymostimulin’ on the incidence of infections and myelotoxicity during adjuvant chemotherapy for breast cancer. Thymus 1988; 12: 69–75.

    PubMed  Google Scholar 

  268. Ichimura O, Suzuki S, Saito M et al. Augmentation of interleukin-1 and interleukin-2 production by OK-432. Int J Immunopharmacol 1985; 7: 263–70.

    CAS  PubMed  Google Scholar 

  269. Inagaki T, Morise K, Matsunaga H. Effects of endoscopic intratumoral injection of lentinan in patients with gastric cancer. Gan To Kagaku Ryoho 1988; 15: 319–24.

    CAS  PubMed  Google Scholar 

  270. Intergroup 5-FU/levamisole study positive; untreated arms stopped, clinical alert sent. Clin Trials–Clin Cancer Lett 1989; October.

    Google Scholar 

  271. Israel L, Mugica J, Chahinian PH. Prognosis of early bronchogenic carcinoma: survival cures of 451 patients after resection of lung cancer in relation to the results of preoperative tuberculin skin test. Biomed Exp 1973; 19: 68–72.

    CAS  Google Scholar 

  272. Itoh K, Pellis NR, Balch C. Monocyte-dependent serum-borne suppressor of induction of lymphokine-activated killer cells in lymphocytes from melanoma patients. Cancer Immunol Immunother 1989; 29: 57–62.

    CAS  PubMed  Google Scholar 

  273. Jacobs D, Houri M, Landon J, Merret TG. Circulating levels of immunoglobulin E in patients with cancer. Lancet 1972; 2: 1059–61.

    CAS  Google Scholar 

  274. Jacobson DR, Zolla-Pazner S. Immunosuppression and infection in multiple myeloma. Semin Oncol 1986; 13: 282–90.

    CAS  PubMed  Google Scholar 

  275. Jansen HM, The TH, deGast GC et al. The primary immune response of patients with different stages of squamous-cell bronchial carcinoma. Thorax 1978; 33: 755–60.

    CAS  PubMed  Google Scholar 

  276. Jenkins VK, Ray P, Ellis HN et al. Lymphocyte response in patients with head and neck cancer: effect of clinical stage and radiotherapy. Arch Otolaryngol 1976; 102: 596–600.

    CAS  PubMed  Google Scholar 

  277. Jenkins VK, Griffiths CM, Ray P et al. Radiotherapy and head and neck cancer. Role of lymphocyte response and clinical stage. Arch Otolaryngol 1980; 106: 414–18.

    CAS  PubMed  Google Scholar 

  278. Jerrells TR, Dean JH, Richardson GL et al. Role of suppressor cells in depression of in vitro lymphoproliferative responses of lung cancer and breast cancer patients. J Natl Cancer Inst 1978; 61: 1001–9.

    CAS  PubMed  Google Scholar 

  279. Jerrells TR, Dean JH, Herberman RB. Relationship between T-lymphocyte levels and lymphoproliferative responses to mitogens and alloantigens in lung and breast cancer patients. Int J Cancer 1978; 21: 282–90.

    CAS  PubMed  Google Scholar 

  280. Job G, Pfeundschuh M, Bauer M et al. The influence of radiation therapy on T-lymphocyte subpopulations defined by monoclonal antibodies. Int J Radiat Oncol Biol Phys 1984; 10: 2077–81.

    CAS  PubMed  Google Scholar 

  281. Joensun H, Nordman E, Toivanen A. Long-term effect of levamisole on the immune functions in melanoma patients. Strahlenther Onkol 1986; 162: 753–6.

    Google Scholar 

  282. Joensun H, Toivanen A, Nordman E. Effect of tamoxifen on immune function. Cancer Treat Rep 1986; 7: 381–2.

    Google Scholar 

  283. Johnson JD, Summersgill JT, Raff MJ. The in vitro effects of methotrexate on the phagocytosis and intracellular killing of Staphylococcus aureus by human neutrophils. Cancer 1986; 57: 2343–5.

    CAS  PubMed  Google Scholar 

  284. Johnston-Early A, Cohen MH, Fossieck BE et al. Delayed hypersensitivity skin testing as a prognostic indicator in patients with small-cell lung cancer. Cancer 1983; 52: 1395–400.

    CAS  PubMed  Google Scholar 

  285. Jondal M, Merrill J, Ullberg M. Monocyte-induced human natural killer cell suppression followed by increased cytotoxic activity during short-term in vitro culture in autologous serum. Scand J Immunol 1981; 14: 555–63.

    CAS  PubMed  Google Scholar 

  286. Jones KD, Whitehead RH, Grimshaw D, Hughes LE. Lymphocyte response to PHA and patient response to chemotherapy in breast cancer. Clin Oncol 1980; 6: 159–66.

    CAS  PubMed  Google Scholar 

  287. Jones SE, Griffith K, Dombrowski P, Gaines JA. Immunodeficiency in patients with non-Hodgkin’s lymphomas. Blood 1977; 49: 335–44.

    CAS  PubMed  Google Scholar 

  288. Jose DG, Seshadri R. Circulating immune complexes in neuroblastoma: direct assay and role in blocking specific cellular immunity. Int J Cancer 1974; 13: 824–38.

    CAS  PubMed  Google Scholar 

  289. Jubert AV, Lee ET, Hersh EM, McBridge CM. Effects of surgery, anesthesia and intraoperative blood loss on immunocompetence. J Surg Res 1973; 15: 399–403.

    CAS  PubMed  Google Scholar 

  290. Jung TT, Berlinger NT, Juhn SK. Prostaglandins in squamous-cell carcinoma of the head and neck: a preliminary study. Laryngoscope 1985; 95: 307–12.

    CAS  PubMed  Google Scholar 

  291. Kadish AS, Doyle AT, Steinhaur EH, Ghossein NA. Natural cytotoxicity and interferon production in human cancer: deficient natural killer activity and normal inter-

    Google Scholar 

  292. feron production in patients with advanced disease. J Immunol 1981; 127: 1817–22.

    Google Scholar 

  293. Kaneko T. Effects of lentinan on cytotoxic functions of human lymphocytes. Immunopharmacol Immunotoxicol 1988; 10: 157–63.

    PubMed  Google Scholar 

  294. Kaplan HS. Hodgkin’s Disease. Cambridge, MA: Harvard University Press, 1980.

    Google Scholar 

  295. Kaplan HS. Hodgkin’s Disease. Cambridge, MA. Harvard University Press, 1980.

    Google Scholar 

  296. Karavodin LM, Guilliano AE, Golub SH. T-lymphocyte subsets in patients with malignant melanoma. Cancer Immunol Immunother 1981; 11: 251–4.

    Google Scholar 

  297. Kaszubowski PA, Husky G, Tung KS, Williams RC Jr. T-lymphocyte subpopulations in peripheral blood and tissues of cancer patients. Cancer Res 1980; 40: 4684–87.

    Google Scholar 

  298. Katz AE. Immunobiologic staging of patients with carcinoma of the head and neck. Laryngoscope 1983; 93: 445–63.

    CAS  PubMed  Google Scholar 

  299. Kawaguchi T, Suematsu M, Koizumi HM et al. Activation of macrophage function by intraperitoneal administration of the streptococcal anti-tumor agent OK-432. Immunopharmacology 1983; 6: 1077–89.

    Google Scholar 

  300. Kay RG, Mason BH, Stephans EJ et al. Levamisole in primary breast cancer: a controlled study in conjunction with L-phenylalanine mustard. Cancer 1983; 51: 1992–7.

    CAS  PubMed  Google Scholar 

  301. Keller SM, Groshen S, Martini N, Kaiser LR. Blood transfusion and lung cancer recurrence. Cancer 1988; 62: 606–10.

    CAS  PubMed  Google Scholar 

  302. Kenady DE, Chretien PB, Potvin C et al. Effect of thymosin in vitro on T-cell levels during radiation therapy. Cancer 1972; 39: 642–52.

    Google Scholar 

  303. Kerman RH, Stefani SS. Phytohemagglutinin stimulation of lymphocytes in lung cancer patients. Oncology 1977; 34: 10–12.

    CAS  PubMed  Google Scholar 

  304. Kerman RH, Smith R, Stefani SS. Active T-rosette forming cells in the peripheral blood of cancer patients. Cancer Res 1976; 36: 3274–80.

    CAS  PubMed  Google Scholar 

  305. Khoo SK, Whitaker SV, Jones IS, Thomas DA. Levami-sole as adjuvant to chemotherapy of ovarian cancer. Results of a randomized trial and 4-year follow-up. Cancer 1984; 54: 986–990.

    CAS  PubMed  Google Scholar 

  306. Kikuchi Y, Kizawa I, Oomori K et al. Effects of cimetidine on interleukin-2 production by peripheral blood lymphocytes in advanced ovarian carcinoma. Eur J Cancer Clin Oncol 1988; 24: 1185–90.

    CAS  PubMed  Google Scholar 

  307. Kirsh MM, Orringer MB, McAuliffe S et al. Transfer factor in the treatment of carcinoma of the lung. Ann Thorac Surg 1984; 38: 140–145.

    CAS  PubMed  Google Scholar 

  308. Klefstrom P, Holsti P, Grohn P et al. Levamisole in the treatment of stage II breast cancer. Five-year follow-up of a randomized double-blind study. Cancer 1985; 55: 2753–7.

    CAS  PubMed  Google Scholar 

  309. Klefstrom P. Combination of levamisole immunotherapy and polychemotherapy in advanced breast cancer. Cancer Treat Rep 1980; 64: 65–72.

    CAS  PubMed  Google Scholar 

  310. Klefstrom P, Nuortio L, Taskinen E. Post-operative radiation therapy and adjuvant chemoimmunotherapy in breast cancer. Aspects of timing and immune competence. Acta Radiol (Oncol) 1986; 25: 161–6.

    CAS  Google Scholar 

  311. Klefstrom P, Grohn P, Heinonen E et al. Adjuvant postoperative radiotherapy, chemotherapy, and immunotherapy in stage III breast cancer. II. Five-year results and influence of levamisole. Cancer 1987; 60: 936–42.

    CAS  PubMed  Google Scholar 

  312. Klefstrom P, Holsti P, Grohn P, Heinonem E. Combination of levamisole immunotherapy with conventional treatments in breast cancer. In: Terry WD, ed. Proceedings of Second International Conference on Immunotherapy of Cancer. Bethesda, MD. 1982: 4128–30.

    Google Scholar 

  313. Kleinerman ES, Zwelling LA, Schwartz R et al. Effect of L-phenylalanine mustard, adriamycin and actinomycin D, and 4’-(9-acridinylamino) methanesulfon-m-anisidide on naturally occurring human spontaneous monocyte-mediated cytotoxicity. Cancer Res 1982; 42: 1692–5.

    CAS  PubMed  Google Scholar 

  314. Koba F, Akiyoshi T, Tsuji H. Natural killer-cell activity in the perigastric lymph nodes from patients with gastric carcinoma or benign lesions. J Clin Lab Immunol 1987; 23: 191–5.

    CAS  PubMed  Google Scholar 

  315. Kova J, Ninger E, Zemanov D, Lauerov P. A prospective study of lymphocyte responses to phytohemagglutinin in melanoma (lack of prognostic value of correlation with minimal tumor burden). Neoplasma 1980; 27: 575–82.

    Google Scholar 

  316. Kratikanont P, deShazo RD, Banks DE, Chapman Y. Cytotoxic cell function in bronchogenic carcinoma. Chest 1998; 92: 90–4.

    Google Scholar 

  317. Kraus S, Comas F, Perez C et al. Treatment of inoperable non-small-cell carcinoma of the lung with radiation therapy, with or without levamisole. Am J Clin Oncol 1984; 7: 405–12.

    Google Scholar 

  318. Kreienberg R, Boerner D, Melchert F, Lemmell EM. Reduction of the immunosuppressive action of chemotherapeutics in patients with mammary carcinoma by Azimexon. J Immunopharmacol 1983; 5: 49–64.

    CAS  PubMed  Google Scholar 

  319. Kripke ML. Immunoregulation of carcinogenesis: past, present, and future. J Natl Cancer Inst 1988; 80: 722–7.

    CAS  PubMed  Google Scholar 

  320. Krown S, Pinsky CM, Wanebo HJ et al. Immunologic reactivity and prognosis in breast cancer. Cancer 1980; 46: 1746–52.

    CAS  PubMed  Google Scholar 

  321. Kumano N, Suzuki S, Oizumi K et al. Imbalance of T-cell subsets in cancer patients and its modification with bestatin, a small molecular immunomodifier. Tohoku J Exp Med 1985; 147: 125–33.

    CAS  PubMed  Google Scholar 

  322. Kurosu Y, Tanaka N, Furusho Y, Morita K. Cimetidinemediated augmentation of lymphocyte responses to phytohemagglutinin in gastric cancer patients. Jpn J Clin Oncol 1989; 19: 56–61.

    CAS  PubMed  Google Scholar 

  323. Lauria F, Raspadori D, Tura S. Effect of a thymic factor on T-lymphocytes in B-cell chronic lymphocytic leukemia: in vitro and in vivo studies. Blood 1984; 64: 667–71.

    CAS  PubMed  Google Scholar 

  324. Lauria F, Foa R, Gobbi M et al. Increased proportion of suppressor/cytotoxic (OKT8+) cells in patients with Hodgkin’s disease in long-lasting remission. Cancer 1983; 52: 1385–8.

    CAS  PubMed  Google Scholar 

  325. Lauria JA, Moertel CG, Fleming TR et al. Surgical adjuvant therapy of large-bowel carcinoma: an evaluation of levamisole and the combination of levamisole and fluorouracil. J Clin Oncol 1989; 7: 1447–56.

    Google Scholar 

  326. Laurie J, Moertel C, Fleming T et al. Surgical adjuvant therapy of poor prognosis colorectal cancer with levami-sole alone or combined levamisole and 5-fluorouracil (5- FU). Proc ASCO 1986; 5: 81 (abstract).

    Google Scholar 

  327. Lawrence HS. The transfer in humans of delayed skin sensitivity to streptococcal M substance and to tuberculin with disrupted leukocytes. J Clin Invest 1955; 34: 219–30.

    CAS  PubMed Central  PubMed  Google Scholar 

  328. Lee ET, Ishmael R, Bottomley RH, Murray JL. An analysis of skin tests and their relationship to recurrence and survival in stage III and stage IV melanoma patients. Cancer 1982; 49: 2336–41.

    CAS  PubMed  Google Scholar 

  329. Lee YT. Delayed cutaneous hypersensitivity, lymphocyte count, and blood tests, in patients with breast carcinoma. J Surg Oncol 1984; 27: 135–40.

    CAS  PubMed  Google Scholar 

  330. Lee AK, Rowley M, MacKay IR. Antibody-producing capacity in human cancer. Br J Cancer 1970; 24: 454–63.

    CAS  PubMed Central  PubMed  Google Scholar 

  331. Lee YT, Sparks FC, Eilber FR, Morton DL. Delayed cutaneous hypersensitivity and peripheral lymphocyte counts in patients with advanced cancer. Cancer 1975; 35: 748–55.

    CAS  PubMed  Google Scholar 

  332. Leibler GA, Concannon JP, Magorern GJ et al. Immunoprofile studies for patients with bronchogenic carcinoma. J Thorac Cardiovasc Surg 1977; 74: 506–18.

    Google Scholar 

  333. Levin RH, Landy M, Frei E. The effect of 6-mercaptopurine on immune response in man. N Engl J Med 1964; 271: 16–22.

    CAS  PubMed  Google Scholar 

  334. Levo Y, Rotter V, Ramot B. Restoration of cellular immune response by levamisole in patients with Hodgkin’s disease. Biomedicine 1975; 23: 198–200.

    CAS  PubMed  Google Scholar 

  335. Levy S, Herberman R, Lippman M, d’Angelo T. Correlation of stress factors with sustained depression of natural killer cell activity and predicted prognosis in patients with breast cancer. J Clin Oncol 1987; 5: 348–53.

    CAS  PubMed  Google Scholar 

  336. Lewinski UH, Mavligit GM, Hersh EM. Cellular immune modulation after a single high dose of levamisole. Cancer 1980; 46: 2185–94.

    CAS  PubMed  Google Scholar 

  337. Liberati AM, Bragia M, Edwards BS et al. Immunorestorative properties of thymostimulin (TS) in patients with Hodgkin’s disease in clinical remission. Cancer Immunol Immunother 1985; 19: 136–41.

    CAS  PubMed  Google Scholar 

  338. Liberata AM, Ballatori E, Fizzotti M et al. A randomized trial to evaluate the immunorestorative properties of thymostimulin in patients with Hodgkin’s disease in complete remission. Cancer Immunol Immunother 1988; 26: 87–93.

    Google Scholar 

  339. Liberata AM, Voekel JG, Borden EC et al. Influence of non-specific immunologic factors on prognosis in advanced bronchogenic carcinoma. Cancer Immunol Immunother 1982; 13: 140–4.

    Google Scholar 

  340. Lichtenstein A, Zighelboim J, Dorey R et al. Comparison of immune derangements in patients with different malignancies. Cancer 1980; 45: 2090–5.

    CAS  PubMed  Google Scholar 

  341. Lin CC, Kuo YC, Huang WC, Lin CY. Natural killer-cell activity in lung cancer patients. Chest 1987; 92: 1022–4.

    CAS  PubMed  Google Scholar 

  342. Lotan R. Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochim Biophys Acta 1980; 605: 33–91.

    CAS  PubMed  Google Scholar 

  343. Loutfi A, Shakr A, Jerry M et al. Double-blind randomized prospective trial of levamisole/placebo in stage I cutaneous malignant melanoma. Clin Invest Med 1987; 10: 325–8.

    CAS  PubMed  Google Scholar 

  344. Ludwig CU, Hartmann D, Landmann R et al. Unaltered immunocompetence in patients with nondisseminated breast cancer at the time of diagnosis. Cancer 1985; 55: 1673–8.

    CAS  PubMed  Google Scholar 

  345. Lundy J, Raaf JH, Deakins S, Wanebo HJ. The acute and chronic effects of alcohol on the human immune system. Surg Gynecol Obstet 1975; 141: 212–18.

    CAS  PubMed  Google Scholar 

  346. Luzi G, Troopea F, Seminara R et al. Clinical and immunological evaluation in non-resectable lung cancer patients treated with thymostimulin. In: Byrom NA, Hobbs JR, eds. Thymic Factor Therapy. New York: Raven Press, 1984: 309–20.

    Google Scholar 

  347. Maca RM, Panje WR. Indomethacin-sensitive suppressor-cell activity in head and neck cancer patients pre-and post-irradiation therapy. Cancer 1982; 50: 483–9.

    CAS  PubMed  Google Scholar 

  348. Macchiarini P, Danesi R, Del Tacca M, Angeletti CA. Effects of thymostimulin on chemotherapy-induced toxicity and long-term survival in small-cell lung cancer patients. Anticancer Res 1989; 9: 193–6.

    CAS  PubMed  Google Scholar 

  349. Mackay JR, Goodyear MD, Riglar C et al. Effect on immunologic and other indices of adjuvant cytotoxic chemotherapy including melphalan in breast cancer. Cancer 1984; 53: 2619–27.

    CAS  PubMed  Google Scholar 

  350. Maguire LC, Roszman TL, Lackey S. Failure of cimetidine as an immunomodulator in cancer patients and normal subjects. South Med J 1985; 78: 1078–80.

    CAS  PubMed  Google Scholar 

  351. Mahaley MS Jr, Brooks WH, Roszman TL et al. Immunobiology of primary intracranial tumors. I. Studies of the

    Google Scholar 

  352. cellular immunity of brain tumor patients. J Neurosurg 1977; 46: 467–76.

    Google Scholar 

  353. Maisel RH, Ogura JH. Dinitrochlorobenzene skin sensitization and peripheral lymphocyte count: predictors of survival in head and neck cancer. Ann Otol Rhinol Laryngol 1976; 85: 517–22.

    CAS  PubMed  Google Scholar 

  354. Mandel MA, Dvorak K, Decasse JJ. Salivary immunoglobulins in patients with oropharyngeal and bronchopulmonary cancer. Cancer 1973; 31: 1408–13.

    CAS  PubMed  Google Scholar 

  355. Mandeville R, Lamoureux G -T, Poisson SL, Poisson R. Biological markers and breast cancer: a multiparameter study. II. Depressed immune competence. Cancer 1982; 50: 1280–8.

    CAS  PubMed  Google Scholar 

  356. Mantovani G, Floris C, Maccio A et al. Role of interleukin-2 (IL-2) in cancer-related immune deficiency: in vitro response to IL-2, production of IL-2, and IL-2 receptor expression in patients with advanced cancer. Cancer Detect Prev 1988; 12: 149–59.

    CAS  PubMed  Google Scholar 

  357. Marshall ME, Mendelsohn L, Butler K et al. Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopyrone) and cimetidine: a pilot study. J Clin Oncol 1987; 5: 862–6.

    CAS  PubMed  Google Scholar 

  358. Marshall ME, Riley LK, Rhoades J et al. Effects of coumarin (1,2-benzopyrone) and cimetidine on peripheral blood lymphocytes, natural killer cells, and monocytes in patients with advanced malignancies. J Biol Response Mod 1989; 8: 62–9.

    CAS  PubMed  Google Scholar 

  359. Martelli MF, Velardi A, Rambotti P et al. The in vivo effect of a thymic factor (thymostimulin) in immunologic parameters of patients with untreated Hodgkin’s disease. Cancer 1982; 50: 490–7.

    CAS  PubMed  Google Scholar 

  360. Mastrangelo MJ, Berd D, Maguire H Jr. Cell-mediated immunity: the immunoaugmenting effects of cancer chemotherapeutic agents. Semin Oncol 1986; 13: 186–94.

    CAS  PubMed  Google Scholar 

  361. Math G, Amiel JL, Schwarzenberg L et al. Active immunotherapy for acute lymphoblastic leukemia. Lancet 1969; 1: 697–9.

    Google Scholar 

  362. Math G. Do tuftsin and bestatin constitute a biopharmacological immunoregulatory system? Cancer Detect Prev Suppl1987; 1: 445–55.

    Google Scholar 

  363. Math G, Umezawa H, Misset JL et al. Immunomodulating properties of bestatin in cancer patients. A phase II trial. Biomed Pharmacother 1986; 40: 379–82.

    Google Scholar 

  364. Mavligit GM. Immunologic effects of cimetidine: potential uses. Pharmacotherapy 1987; 7: 120S–4S.

    CAS  PubMed  Google Scholar 

  365. Mavligit GM, Raphael LS, Calvo DB III, Wong WL. Indomethacin-induced monocyte-dependent restoration of local graft-versus-host reaction among cells from cancer patients. J Natl Cancer Inst 1980; 65: 317–20.

    CAS  PubMed  Google Scholar 

  366. McCredie JA, Macdonald HR. Antibody-dependent cellular cytotoxicity in cancer patients: lack of prognostic value. Br J Cancer 1980; 41: 880–5.

    CAS  PubMed Central  PubMed  Google Scholar 

  367. McGeorge MB, Russel EC, Mohanakumar T. Immunologic evaluation of long-term effects of childhood ALL chemotherapy: analysis of in vitro NK- and K- cell activities of peripheral blood lymphocytes. Am J Hematol 1982; 12: 19–27.

    CAS  PubMed  Google Scholar 

  368. McGinnes K, Florence J, Penny R. The effect of radiotherapy on the natural killer (NK) cell activity of cancer patients. J Clin Immunol 1987; 7: 210–17.

    CAS  PubMed  Google Scholar 

  369. Menconi E, Barzi A, Greco M et al. Immunological profile of breast cancer patients in early or advanced disease. Experientia 1979; 35: 820–2.

    CAS  PubMed  Google Scholar 

  370. Merrin C, Han T. Immune responses in bladder cancer. J Urol 1974; 111: 170–2.

    CAS  PubMed  Google Scholar 

  371. Messerschmidt GL, Henry DH, Snyder HW Jr et al. Protein A immunoadsorption in the treatment of malignant disease. J Clin Oncol 1988; 6: 203–12.

    CAS  PubMed  Google Scholar 

  372. Metzher Z, Hoffeld JT, Oppenheim JJ. Evidence for the involvement of monocyte-derived toxic oxygen metabolites in the lymphocyte dysfunction of Hodgkin’s disease. Clin Exp Immunol 1981; 46: 313–20.

    Google Scholar 

  373. Micksche M, Cerni C, Kokron K et al. Stimulation of the immune response in lung cancer patients by vitamin A. Oncology 1977; 34: 234–9.

    CAS  PubMed  Google Scholar 

  374. Micksche M, Colot M, Kucera H. Radioimmunotherapy in advanced cervical cancer. In: Dubois JB, Serrou B, Rosenfeld C, eds. Immunopharmacologic Effects of Radiation Therapy. New York: Raven Press, 1981: 499–518.

    Google Scholar 

  375. Mihich E. Biological response modifiers in cancer therapeutics: potentialities and limitations. Cancer Detect Prev 1988; 12: 531–5.

    CAS  PubMed  Google Scholar 

  376. Mihich E, Ehreke MJ, Ishizuka M. Immunomodulation by antibiotics. In: Mihich E, Sakurai Y, eds. Biological Responses in Cancer, vol. 3: Immunomodulation by Anticancer Drugs. New York: Plenum Press, 1985: 71–3.

    Google Scholar 

  377. Miller HC, Vito C. Action of a thymic cytokine TsIF in reversing the autoimmune disease state of the MRL/1pr mouse. Mol Biother 1989; 1: 213–17.

    CAS  PubMed  Google Scholar 

  378. Miller LL, Spitler LE, Allen RE, Minot DR. A randomized, double-blind, placebo-controlled trial of transfer factor as adjuvant therapy for malignant melanoma. Cancer 1988; 61: 1543–9.

    CAS  PubMed  Google Scholar 

  379. Miller FR, Kataoka T. Interactions of antimetabolites with tumors and the immune system. In: Mihich E, Sakurai Y, eds. Biological Responses in Cancer, vol. 3: Immunomodulation by Anti-cancer Drugs. New York: Plenum Press, 1985: 33–69.

    Google Scholar 

  380. Mitchell MS, Kempf RA, Harel W et al. Effectiveness and tolerability of low-dose cyclophosphamide and low-dose intravenous interleukin-2 in disseminated melanoma. J Clin Oncol 1988; 6: 409–24.

    CAS  PubMed  Google Scholar 

  381. Mitchell MS, Defonti RC. Immunosuppression by 5- fluorouracil. Cancer 1970; 26: 884–9.

    CAS  PubMed  Google Scholar 

  382. Mitchell MS, Wade ME, Deconti RC et al. Immunosuppressive effects of cytosine arabinoside and methotrexate in man. Ann Intern Med 1969; 70: 535–47.

    CAS  PubMed  Google Scholar 

  383. Miwa H, Orita K. Immunotherapy of gastrointestinal cancer patients with levamisole. Acta Med Okayama 1979; 33: 29–42.

    CAS  PubMed  Google Scholar 

  384. Miwa H, Orita K. Cancer immunotherapy with levami-sole. Acta Med Okayama 1978; 32: 239–45.

    CAS  PubMed  Google Scholar 

  385. Miwa H, Orita K. Reactivating effect of levamisole on cell-mediated immunity in gastrointestinal cancer patients. Acta Med Okayama 1977; 31: 325–9.

    CAS  PubMed  Google Scholar 

  386. Modini C, Ziparo V, Cicconetti F et al. Role of delayed cutaneous hypersensitivity reaction in classifying patients with bronchial carcinoma. Tumori 1985; 71: 277–81.

    CAS  PubMed  Google Scholar 

  387. Moertel CG, Fleming TR, MacDonald JS et al. Levami-sole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med 1990; 322: 352–8.

    CAS  PubMed  Google Scholar 

  388. Moertel CG, Ritts RE, O’Connell MJ, Silvers A. Nonspecific immune determinants in the patient with unresectable gastrointestinal carcinoma. Cancer 1979; 43: 1483–92.

    CAS  PubMed  Google Scholar 

  389. Monson JR, Ramsden C, Guillou PJ. Decreased interleukin-2 production in patients with gastrointestinal cancer. Br J Surg 1986; 73: 483–6.

    CAS  PubMed  Google Scholar 

  390. Monte JE, Bukowski RM, James RE et al. A critical review of immunotherapy of disseminated renal adenocarcinoma. J Surg Oncol 1982; 21: 5–8.

    Google Scholar 

  391. Morales A, Eidinger D. Immune reactivity in renal cancer. J Urol 1976; 115: 510–13.

    CAS  PubMed  Google Scholar 

  392. Morin A, Ballet J, Touraine J, Hadder JW. Current status of isoprinosine. In: Serrou B, Rosenfeld C, Daniels JC, Saunders JP, eds. Current Concepts in Human Immunol-

    Google Scholar 

  393. ogy and Cancer Immunomodulation. Amsterdam: Elsevier, 1982: 479–89.

    Google Scholar 

  394. Morton DL, Eilber FR, Malmgren RA, Wood WC. Immunological factors which influence response to immunotherapy in malignant melanoma. Surgery 1970; 68: 158–64.

    CAS  PubMed  Google Scholar 

  395. Mukherji B, Guha A, Loomis R, Ergin MT. Cell-mediated amplification and down regulation of cytotoxic immune response against autologous human cancer. J Immunol 1987; 138: 1987–91.

    CAS  PubMed  Google Scholar 

  396. Mukhopadhyaya R, Advani SH, Gangal SG. Functional evaluation of T-lymphocytes from peripheral blood and spleens in Hodgkin’s disease. Br J Cancer 1987; 56: 800–2.

    CAS  PubMed Central  PubMed  Google Scholar 

  397. Munster AM. Post-traumatic immunosuppression is due to activation of suppressor T-cells. Lancet 1976; 1: 1329.

    CAS  PubMed  Google Scholar 

  398. Munzarova M, Mechl Z, Kovarik J, Kolcova V. Skin tests with autologous cholesteryl hemisuccinate-treated tumor cells, DNCB and PPD and their relationship to prognosis in malignant melanoma patients. Neoplasma 1988; 35: 229–34.

    CAS  PubMed  Google Scholar 

  399. Murphy RM, Colton CK, Yarmush ML. Staphylococcal protein A adsorption in neoplastic disease: Analysis of physiochemical aspects. Mol Biother 1989; 1: 186–207.

    CAS  PubMed  Google Scholar 

  400. Murray JL, Kollmorgen GM. Inhibition of lymphocyte response by prostaglandin-producing suppressor cells in patients with melanoma. J Clin Immunol 1983; 3: 268–76.

    CAS  PubMed  Google Scholar 

  401. Murray JL, Reuben JM, Smith TL et al. A pilot clinical trial of the toxicity and immunorestorative effects of T-cell reconstituting factor (SR 270258) in immunosuppressed cancer patients. J Biol Response Mod 1987; 6: 56–68.

    CAS  PubMed  Google Scholar 

  402. Najjar VA. Biochemistry and physiology of tuftsin–ThrLys-Pro-Arg. In: Sbarra S, Strauss R, eds. The Reticuloendothelial System. New York: Plenum Press, 1980: 45–71.

    Google Scholar 

  403. Nathanson SD, Zamfirescu PL, Portaro JK et al. Acute effects of orally administered levamisole on random monocyte motility and chemotaxis in man. J Natl Cancer Inst 1978; 61: 301–6.

    CAS  PubMed  Google Scholar 

  404. Nemoto T, Han T, Minowada J et al. Cell-mediated immune status of breast cancer patients: evaluation by skin tests, lymphocyte stimulation and counts of rosette-forming cells. J Natl Cancer Inst 1974; 53: 641–5.

    CAS  PubMed  Google Scholar 

  405. Niimoto M, Hattori T, Ito I et al. Levamisole as postoperative adjuvant immunochemotherapy for gastric cancer. A randomized controlled study of the MMC + Tegafur regimen with or without levamisole. Report I. Cancer Immunol Immunother 1984; 18: 13–18.

    CAS  PubMed  Google Scholar 

  406. Noda T, Asano M, Yoshie O et al. Interferon-y induction of human peripheral blood mononuclear cells by OK-432, a killed preparation of Streptococcus pyogenes. Microbiol Immunol 1985; 30: 81–8.

    Google Scholar 

  407. Noma T, Yoshimura N, Yata J. Depressed lymphocyte functions of cancer patients and their correlation by bestatin (product of Streptomyces olivereticuli). In: Serrou S, Rosenfeld C, Daniels JC, Saunders JP, eds. Current Concepts in Human Immunology and Cancer Immunomodulation. Amsterdam: Elsevier, 1982: 611–16.

    Google Scholar 

  408. Nordman E, Saarimaa H, Tolvanen A. The influence of 5- fluorouracil on cellular and humoral immunity in cancer patients. Cancer 1978; 41: 64–9.

    CAS  PubMed  Google Scholar 

  409. Nordman E, Tolvanen A. Effects of irradiation of the immune function in patients with mammary, pulmonary or head and neck carcinoma. Acta Radiol Oncol Radiat Phys Biol 1978; 17: 3–9.

    CAS  PubMed  Google Scholar 

  410. Norris RW, Byrom NA, Nagvekar NM et al. Thymostimulin plus surgery in the treatment of primary truncal malignant melanoma: preliminary results of a U.K. multi-centre clinical trial. In: Byrom NA, Hobbs JR, eds. Thymic Factor Therapy. New York: Raven Press, 1984: 341–8.

    Google Scholar 

  411. Oka S. A review of clinical studies of bestatin. Recent results. Cancer Res 1980; 75: 126–32.

    CAS  Google Scholar 

  412. Olivari A, Pradier R, Feierstein H et al. Cell-mediated immune response in head and neck cancer patients. J Surg Oncol 1976; 8: 287–94.

    CAS  PubMed  Google Scholar 

  413. Olivari AJ, Glait HM, Guardo A et al. Levamisole in squamous-cell carcinoma of the head and neck. Cancer Treat Rep 1979; 63: 983–90.

    CAS  PubMed  Google Scholar 

  414. Onsrud M. Whole pelvic irradiation in stage I endometrial carcinoma: changes in numbers and reactivities of some blood lymphocyte subpopulations. Gynecol Oncol 1982; 13: 283–92.

    CAS  PubMed  Google Scholar 

  415. Orita K, Miwa H, Fukuda H et al. Preoperative cell-mediated immune status of gastric cancer patients. Cancer 1976; 38: 2343–8.

    CAS  PubMed  Google Scholar 

  416. Osband M, Shen Y, Schlesinger M et al. Successful tumor immunotherapy with cimetidine in mice. Lancet 1981; 1: 636–8.

    CAS  PubMed  Google Scholar 

  417. Oshimi K, Kano S, Takaku F, Okumura K. Augmentation of mouse natural killer cell activity by a streptococcal preparation OK-432. J Natl Cancer Inst 1980; 65: 1265–9.

    CAS  PubMed  Google Scholar 

  418. Ota K, Kurita S, Yamada K et al. Immunotherapy with bestatin for acute non-lymphocytic leukemia in adults. Cancer Immunol Immunother 1986; 23: 5–10.

    CAS  PubMed  Google Scholar 

  419. Ozer H. Effects of alkylating agents on immunoregulatory mechanisms. In: Mihich E, Sakurai Y, eds. Biological Responses in Cancer, vol. 3: Immunomodulation by Anti-cancer Drugs. New York: Plenum Press, 1985: 95–129.

    Google Scholar 

  420. Paavonen T, Anderson LC, Adlercrentz H. Estradiol enhances human B-cell maturation via inhibition of suppressor T-cells in pokeweed mitogen-stimulated cultures. J Exp Med 1981; 154: 1935–45.

    CAS  PubMed  Google Scholar 

  421. Padmanabhan TK, Balaram P, Vasudevan DM. Role of levamisole immunotherapy as an adjuvant to radiotherapy in oral cancer. I. A three-year clinical follow-up. Neoplasma 1987; 34: 627–32.

    CAS  PubMed  Google Scholar 

  422. Paik YK, Kimura L, Yanagihora E et al. Inhibition of the phytohemagglutinin stimulation of leukocytes by C-reactive protein. J Reticuloendothel Soc 1972; 11: 420.

    Google Scholar 

  423. Papatestas AE, Kark AE. Peripheral lymphocyte counts in breast carcinoma: an index of immune competence. Cancer 1978; 34: 2014–17.

    Google Scholar 

  424. Papenhausen PR, Kukwa A, Croft CB et al. Cellular immunity in patients with epidermoid cancer of the head and neck. Laryngoscope 1979; 89: 538–49.

    CAS  PubMed  Google Scholar 

  425. Park SK, Brody JL, Wallace HA, Blakemore WS. Immunosuppressive effect of surgery. Lancet 1971; 1: 53–5.

    CAS  PubMed  Google Scholar 

  426. Parkinson DR, Cano PO, Jerry LM et al. Complications of cancer immunotherapy with levamisole. Lancet 1977; 1: 1129–32.

    CAS  PubMed  Google Scholar 

  427. Passwell J, Lavanon M, Davidsohn J, Ramot B. Monocyte PG E2 secretion in Hodgkin’s disease and its relation to decreased cellular immunity. Clin Exp Immunol 1983; 51: 61–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  428. Paterson AHG, Natting M, Takata L et al. Chemoimmunotherapy with levamisole in metastatic breast carcinoma: a controlled clinical trial. Cancer Clin Trials 1980; 3: 5–10.

    CAS  PubMed  Google Scholar 

  429. Patt YZ, Hersh EM, Reuben J et al. A phase-I study of intravenous azimexon therapy in human cancer. J Biol Response Mod 1986; 5: 313–18.

    CAS  PubMed  Google Scholar 

  430. Pauwels R, Van der Straeter M. Delayed hypersensitivity in patients with bronchial carcinoma. Scand J Resp 1975; 56: 160–4.

    CAS  Google Scholar 

  431. Pavlovsky S, Muriel FS, Garay G et al. Chemoimmunotherapy with levamisole in acute lymphoblastic leukemia. Cancer 1981; 48: 1500–7.

    CAS  PubMed  Google Scholar 

  432. Pavlovsky S, Garay G, Sackman MF, Svarch E. Levami-sole therapy during maintenance of remission in patients

    Google Scholar 

  433. with acute lymphoblastic leukemia. In: Terry WD, ed. Proceedings of Second International Conference on Immunotherapy of Cancer. Amsterdam: Elsevier/NorthHolland, 1980: 47–54.

    Google Scholar 

  434. Payne JE, Meyer JH, Macpherson JG et al. The value of lymphocyte transformation in carcinoma of the colon and rectum. Surg Gynecol Obstet 1980; 150: 687–93.

    CAS  PubMed  Google Scholar 

  435. Penn I. Tumors of the immunocompromised patient. Annu Rev Med 1988; 39: 63–73.

    CAS  PubMed  Google Scholar 

  436. Penn I. Occurrence of cancer in immune deficiency. Cancer 1974; 34: 858–66.

    PubMed  Google Scholar 

  437. Perez CA, Bauer M, Emami BN et al. Thoracic irradiation with or without levamisole (NSC ##177023) in unresectable non-small-cell carcinoma of the lung: a phase III randomized trial of the RTOG. Int J Radiat Oncol Biol Phys 1988; 15: 1337–46.

    CAS  PubMed  Google Scholar 

  438. Petrini B, Wasserman J, Blomgren H, Rotstein S. T-helper/suppressor ratios in chemotherapy and radiotherapy. Clin Exp Immunol 1983; 53: 255–6.

    CAS  PubMed Central  PubMed  Google Scholar 

  439. Petrini B, Wasserman J, Glas U, Blomgren H. T-lymphocyte subpopulations in blood following radiation therapy for breast cancer. Eur J Cancer Clin Oncol 1982; 18: 921–4.

    CAS  PubMed  Google Scholar 

  440. Petrini B, Wasserman J, Biberfeld G et al. The effect of in vitro irradiation on PHA-mediated cytotoxicity and lymphocytes with receptors for the Fc pat of Ig. J Clin Lab Immunol 1979; 2: 333–6.

    CAS  PubMed  Google Scholar 

  441. Pierri I, Cordone G, Rogna S et al. T-lymphocyte phenotype and functions in patients with head and neck cancer. Laryngoscope 1985; 95: 577–81.

    CAS  PubMed  Google Scholar 

  442. Pines A. BCG plus levamisole following irradiation of advanced squamous bronchial carcinoma. Int J Radiat Oncol Biol Phys 1980; 6: 1041–2.

    CAS  PubMed  Google Scholar 

  443. Pinsky CM, El-Domeiri A, Caron AA et al. Delayed hypersensitivity reactions in patients with cancer. In: Mathe~ G, Weiner R, eds. Recent Results in Cancer Research. Berlin: Springer-Verlag, 1973: 37–41.

    Google Scholar 

  444. Pinsky CM, Wanebo H, Mike V, Oettgen H. Delayed cutaneous hypersensitivity reactions and prognosis in patients with cancer. Ann NY Acad Sci 1976; 276: 407–10.

    CAS  PubMed  Google Scholar 

  445. Pitchenik AE, Guffee J, Stein-Streilein J. Lung natural killer and interleukin-2 activity in lung cancer. A pulmonary compartment of augmented natural killer activity occurs in patients with bronchogenic carcinoma. Am Rev Respir Dis 1987; 136: 1327–32.

    CAS  PubMed  Google Scholar 

  446. Plesnicar S. Immunoglobulins in carcinoma of the uterine cervix. Acta Radiol 1972; 11: 37–47.

    CAS  Google Scholar 

  447. Pompidou A, Soubrane C, Cour V et al. Immunological effects of isoprinosine as a pulse immunotherapy in melanoma and ARC patients. Cancer Detect Prev Suppl 1987; 1: 457–62.

    CAS  PubMed  Google Scholar 

  448. Posner MR, Reinherz E, Lane H et al. Circulating lymphocyte populations in Hodgkin’s disease after mantle and para-aortic irradiation. Blood 1983; 61: 705–8.

    CAS  PubMed  Google Scholar 

  449. Powles TJ, Dady DJ, Williams J et al. Use of inhibitor of prostaglandin synthesis and patients with breast cancer. In: Sammuelsson B, Ramwel PW, Paoletti R, eds. Advances in Prostaglandin and Thromboxane Research, vol. 6. New York: Raven Press, 1980: 511–16.

    Google Scholar 

  450. Prehn RT, Prehn LM. The flip side of tumor immunity. Arch Surg 1989; 124: 102–6.

    CAS  PubMed  Google Scholar 

  451. Prehn RT, Prehn LM. The autoimmune nature of cancer. Cancer Res 1987; 47: 927–32.

    CAS  PubMed  Google Scholar 

  452. Pritchard DJ, Ritts RE Jr, Taylor WF, Miller GC. A prospective study of immune responsiveness in humans.

    Google Scholar 

  453. I. Assessment of initial pretreatment status with stage of disease. Cancer 1978; 41: 2165–73.

    Google Scholar 

  454. Pross HF, Baines MG. Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. I. The

    Google Scholar 

  455. effect of malignant disease. Int J Cancer 1976; 18: 593–604.

    Google Scholar 

  456. Pui C-H, Ip SH, Kung P et al. High serum interleukin-2 receptor levels are related to advanced disease and a poor outcome in childhood non-Hodgkin’s lymphoma. Blood 1987; 70: 3; 624–8.

    CAS  PubMed  Google Scholar 

  457. Pulay TA, Csomor S. Effect of levamisole treatment on immunological parameters and the early course of cervical cancer. Neoplasia 1980; 29: 81–6.

    Google Scholar 

  458. Quirt I, Shelley W, Bodurtha A et al. Adjuvant levamisole improves survival and disease-free survival in patients with poor prognostics with malignant melanoma. Proc ASCO 1986; 5: 130 (abstract).

    Google Scholar 

  459. Raben M, Walch N, Galili U, Schlesinger M. The effect of radiation therapy on lymphocyte subpopulations in cancer patients. Cancer 1976; 37: 1417–21.

    CAS  PubMed  Google Scholar 

  460. Ramot B, Biniaminov M, Shoham C, Rosenthal E. The effect of levamisole on E-rosette-forming cells in vivo and in vitro in Hodgkin’s disease patients. N Engl J Med 1976; 194: 809–11.

    Google Scholar 

  461. Ramot B, Rosenthal E, Biniaminov M, Ben-Bassat I. Effect of levamisole, thymic humoral factor, and indomethacin on E-rosette formation of lymphocytes in Hodgkin’s disease. Israel J Med Sci 1981; 17: 232–5.

    CAS  PubMed  Google Scholar 

  462. Rand RJ, Jenkins DM, Bulmer R. T and B lymphocyte subpopulations in pre-invasive and invasive carcinoma of the cervix. Clin Exp Immunol 1977; 30: 421–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  463. Rangel DM, Golub SH, Morton DL. Demonstration of lymphocyte blastogenesis-inhibiting factors in sera of melanoma patients. Surgery 1977; 82: 224–32.

    CAS  PubMed  Google Scholar 

  464. Rapson NT, Cornbleet MA, Chessells JM, Hardisity RM. Immunosuppression and serious infections in children with acute lymphoblastic leukemia: a comparison of the three chemotherapy regimens. Br J Hematol 1980; 45: 41–52.

    CAS  Google Scholar 

  465. Ravikumar T, Steele G, Rodrick M et al. Effects of tumor growth on interleukins and circulating immune complexes. Cancer 1984; 53: 1373–8.

    CAS  PubMed  Google Scholar 

  466. Reed DM. On the pathological changes in Hodgkin’s disease with special references to its relation to tuberculosis. Johns Hopkins Hosp Rep 1902: 10: 133–98.

    Google Scholar 

  467. Rees JC, Rossio JL, Wilson HG et al. Cellular immunity in neoplasia. Antigen and mitogen responses in patients with bronchogenic carcinoma. Cancer 1975; 36: 2010–15.

    CAS  PubMed  Google Scholar 

  468. Remacle-Bonnet MM, Rommier GJ, Luc C et al. Nonspecific suppressive and cytostatic activities mediated by human colonic carcinoma tissue or cultured cell extract. J Immunol 1978; 121: 44–52.

    CAS  PubMed  Google Scholar 

  469. Renoux G, Renoux M. DTC. A summary of current status. In: Serrou B, Rosenfeld C, Daniels JC, Saunder JP, eds. Current Concepts in Human Immunology and Cancer Immunomodulation. Amsterdam: Elsevier, 1982: 575–84.

    Google Scholar 

  470. Renoux G, Renoux M. Effect immunostimulant d’un imidothiazole dans l’immunization des souris contre l’infecction par Brucella abortus. CR Acad Sci (Paris) 1971; 272; 349–50.

    CAS  Google Scholar 

  471. Ress JC, Rossio HL, Wilson HE et al. Cellular immunity in neoplasia. Antigen and mitogen response in patients with bronchogenic carcinoma. Cancer 1975; 36: 2010–15.

    Google Scholar 

  472. Retsas S, Thomas C, Hobbs JR. The effect of vindesine therapy on the in vitro immune response of patients with advanced malignant melanoma. Clin Oncol 1981; 7: 33–7.

    CAS  PubMed  Google Scholar 

  473. Richtsmeier WJ, Eisele D. In vivo anergy reversal with cimetidine in patients with cancer. Arch Otolaryngol Head Neck Surg 1986; 112: 1074–7.

    CAS  PubMed  Google Scholar 

  474. Riddle PR. Disturbed immune reactions following surgery. Br J Surg 1967; 54: 882–6.

    CAS  PubMed  Google Scholar 

  475. Riddle PR, Berenbaum MC. Postoperative depression of the lymphocyte response to phytohemagglutinin. Lancet 1967; 1: 746–8.

    CAS  PubMed  Google Scholar 

  476. Rijswijk REN, Sybesma JPH, Kater L. A prospective study of the changes in the immune status before, during and after multiple agent chemotherapy for Hodgkin’s disease. Cancer 1983; 51: 637–44.

    PubMed  Google Scholar 

  477. Rijswijk REN, Sybesma JPH, Kater L. A prospective study of the changes in immune status following radiotherapy for Hodgkin’s disease. Cancer 1984; 53: 62–9.

    PubMed  Google Scholar 

  478. Roberts MM. Lymphocyte transformation in breast cancer. Br J Surg 1970; 57: 381.

    CAS  PubMed  Google Scholar 

  479. Robinson BW. Asbestos and cancer: human natural killer cell activity is suppressed by asbestos fibers but can be restored by recombinant interleukin-2. Am Rev Respir Dis 1978; 139: 897–901.

    Google Scholar 

  480. Rojas AF, Feirstan JN, Glait HM, Olivari AJ. Levamisole action in breast cancer. In: Terry WD, Windhorst D, eds. Immunotherapy of Cancer: Present Status on Trials in Man. New York: Raven Press, 1978: 635–46.

    Google Scholar 

  481. Romagnani S, Maggi E, Del Prete G et al. Short-and longterm effects of radiation on T-cell subsets in peripheral blood of patients with Hodgkin’s disease. Cancer 1980; 46: 2590–5.

    CAS  PubMed  Google Scholar 

  482. Romagnani S, Ferrini PLR, Ricci M. The immune derangement in Hodgkin’s disease. Semin Oncol 1985; 22: 41–55.

    CAS  Google Scholar 

  483. Rosenberg SA, Seipp CA, White DE, Wesley R. Perioperative blood transfusions are associated with increased rates of recurrence and decreased survival in patients with high-grade soft-tissue sarcomas of the extremities. J Clin Oncol 1985; 3: 698–709.

    CAS  PubMed  Google Scholar 

  484. Roses DF, Campion JF, Harris MN, Gumport SL. Malignant melanoma. Delayed hypersensitivity skin testing. Arch Surg 1979; 114: 35–8.

    CAS  PubMed  Google Scholar 

  485. Rossen RD, Morgan AC. Blockage of the humoral immune response: immune complexes in cancer. Cancer Immunol 1980: 210–80.

    Google Scholar 

  486. Roth JA, Osborne BA, Ames RS. Immunoregulatory factors derived from human tumors. II. Partial purification and further immunobiochemical characterization of a human sarcoma-derived immunosuppressive factor expressing HLA-DR and immunoglobulin-related determinants. J Immunol 1983; 130: 303–8.

    CAS  PubMed  Google Scholar 

  487. Roth JA, Golub SH, Grimm EA et al. Effects of operation on immune response in cancer patients: sequential evaluation of in vitro lymphocyte function. Surgery 1976; 79: 47–51.

    Google Scholar 

  488. Rotstein S, Blomgren H, Petrini B et al. Long-term effects on the immune system following local radiation for breast cancer. I. Cellular composition of the peripheral blood lymphocyte population. Int J Radiat Oncol Biol Phys 1985; 11: 921–5.

    CAS  PubMed  Google Scholar 

  489. Rotstein S, Blomgren H, von Stedingk LV et al. Long-term effects on the immune system following local irradiation for breast cancer. Pokeweed mitogen-induced immunoglobulin secretion by blood lymphocytes and serum immunoglobulin levels. Eur J Surg Oncol 1985; 11: 137–41.

    CAS  PubMed  Google Scholar 

  490. Rotstein S, Blomgren H, Nilsson B et al. Prognostic value of various immunological tests in breast cancer patients treated with adjuvant postoperative chemotherapy. Chemotherapy 1984; 3: 227–31.

    CAS  Google Scholar 

  491. Rotstein S, Blomgren H, Petrini et al. Blood lymphocyte counts with subset analysis in operable breast cancer. Cancer 1985; 56: 1413–19.

    CAS  PubMed  Google Scholar 

  492. Ruco LP, Procopio A, Valtieri M et al. Increased monocyte phagocytosis and decreased lymphocyte mitogen reactivity in colorectal cancer patients. Appl Pathol 1983; 1: 149–56.

    CAS  PubMed  Google Scholar 

  493. Ryan RE Jr, Neel HB, Ritts RE. Correlation of preoperative immunologic test results with recurrence in patients with head and neck cancer. Otolaryngol Head Neck Surg 1980; 88: 58–63.

    PubMed  Google Scholar 

  494. Saijo N, Shimizu E, Irimajiri N et al. Analysis of NK activity and ADCC in healthy volunteers and in patients with primary lung carcinoma and metastatic pulmonary tumors. J Cancer Reg Clin Oncol 1982; 102: 195–214.

    CAS  Google Scholar 

  495. Saijo N, Shimizu E, Shibuya M et al. Effect of chemotherapy on natural killer (NK) activity and antibody-dependent cell-mediated cytotoxicity in carcinoma of the lung. Br J Cancer 1982; 46: 180–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  496. Saito M, Ebina T, Koi M et al. Induction of interferon-gamma in mouse spleen cells by OK-432, a preparation of Streptococcus pyogenes. Cell Immunol 1982; 68: 187–92.

    CAS  PubMed  Google Scholar 

  497. Salmon SE, Hunt A, Bonnet JD et al. Alternating combination chemotherapy and levamisole improves survival in multiple myeloma: a Southwest Oncology Group study. J Clin Oncol 1983; 1: 453–61.

    CAS  PubMed  Google Scholar 

  498. Sample WF, Gertner HR, Chretien PB. Inhibition of phytohemagglutinin-induced in vitro lymphocyte transformation by serum from patients with carcinoma. J Natl Cancer Inst 1971; 46: 1291–7.

    CAS  PubMed  Google Scholar 

  499. Santos GW, Owens AH, Sensenbrenner LL. Effects of selected cytotoxic agents on antibody production in man: a preliminary report. Ann NY Acad Sci 1964; 114: 404–23.

    CAS  PubMed  Google Scholar 

  500. Santos LB, Yamada FT, Scheinberg MA. Monocyte and lymphocyte interaction in patients with advanced cancer. Evidence for deficient IL-1 production. Cancer 1985; 56: 1553–8.

    CAS  PubMed  Google Scholar 

  501. Sarin PS, San DK, Thornton AH et al. Neutralization of HTLV-III/LAV replication by antiserum to thymosinalpha-one. Science 1986; 232: 1135–7.

    CAS  PubMed  Google Scholar 

  502. Scambia G, Panici PB, Mancuso S et al. Effects of antiestrogen and progestin on immune functions in breast cancer patients. Cancer 1988; 61: 2214–18.

    CAS  PubMed  Google Scholar 

  503. Schantz SP, Romsdahl MM, Babcock GF et al. The effect of surgery on natural killer cell activity in head and neck cancer patients: in vitro reversal of a postoperatively suppressed immunosurveillance system. Laryngoscope 1985; 95: 588–94.

    CAS  PubMed  Google Scholar 

  504. Schantz SP, Savage HE, Racz T et al. Immunologic determinants of head and neck cancer response to induction chemotherapy. J Clin Oncol 1989; 7: 857–64.

    CAS  PubMed  Google Scholar 

  505. Schlechter GP, Wahl LM, Oppenheim JJ. Suppressor monocytes in human disease: a review. Adv Exp Med Biol 1979; 121B: 283–98.

    Google Scholar 

  506. Schechter GP, Soehlen F. Monocyte-mediated inhibition of lymphocyte blastogenesis in Hodgkin’s disease. Blood 1978; 52: 261–71.

    CAS  PubMed  Google Scholar 

  507. Scher HI, Shank B, Chapman R et al. Randomized trial of combined modality therapy with and without thymosin fraction V in the treatment of small cell lung cancer. Cancer Res 1988; 48: 1663–70.

    CAS  PubMed  Google Scholar 

  508. Schindler L, Leroux M, Zimmerman GF et al. Reversal of defective lymphoproliferation in postoperative patients with colon cancer. J Cancer Res Clin Oncol 1987; 113: 166–70.

    CAS  PubMed  Google Scholar 

  509. Schlelhammer PF, Bracken RB, Bean M et al. Immune evaluator with skin testing. A study of testicular, prostatic, and bladder neoplasms. Cancer 1976; 38: 149–56.

    Google Scholar 

  510. Schlumberger HD. BAY I7433: a synthetic polymer with antitumor activity. In: Hersh EM, Cirigos MA, Mastrangelo, MJ, eds. Augmenting Agents in Cancer Therapy. New York: Raven Press, 1981: 373–90.

    Google Scholar 

  511. Schulof RS, Lloyf MJ, Cleary PA et al. A randomized trial to evaluate the immunorestorative properties of thymosin-

    Google Scholar 

  512. alpha-one in patients with lung cancer. J Biol Response Mod 1985; 4: 147–58.

    Google Scholar 

  513. Schulof RS, Bockman RS, Garofalo JA et al. Multivariate analysis of T-cell functional defects and circulating serum factors in Hodgkin’s disease. Cancer 1981; 48: 964–73.

    CAS  PubMed  Google Scholar 

  514. Schulof RS, Michitsch RW, Livingston PO, Gupta S. Monocyte-mediated suppression on lymphocyte cytotoxic activity for cultured autologous melanoma cells. Cell Immunol 1981; 57: 529–32.

    CAS  PubMed  Google Scholar 

  515. Schulof RS, Chorba TC, Cleary PA et al. T-cell abnormalities after mediastinal irradiation for lung cancer. The in vitro influence of synthetic thymosin alpha-1. Cancer 1985; 55: 974–83.

    CAS  PubMed  Google Scholar 

  516. Schulof RS. Thymic peptide hormones: basic properties and clinical applications in cancer. CRC Crit Rev Oncol Hematol 1985; 3: 309–76.

    CAS  Google Scholar 

  517. Schulof RS, Lee BJ, Lacher MJ et al. Concanavalin-Ainduced suppressor cell activity in Hodgkin’s disease. Clin Immunol Immunopathol 1980; 16: 454–62.

    CAS  PubMed  Google Scholar 

  518. Schulof RS, Lloyd MJ, Ueno WM et al. Phase II trial of thymosin fraction 5 in advanced renal cancer. J Biol Response Mod 1984; 3: 151–9.

    CAS  PubMed  Google Scholar 

  519. Schulof RS, Lacher MJ, Gupta S. Abnormal phytohemagglutinin-induced T-cell proliferative responses in Hodgkin’s disease. Blood 1981; 57: 607–13.

    CAS  PubMed  Google Scholar 

  520. Sears HF, Simon R, Rosenberg SA. Longitudinal studies of cellular immunity of patients with osteogenic sarcoma during chemoimmunotherapy. Cancer Treat Rep 1980; 64: 589–97.

    CAS  PubMed  Google Scholar 

  521. Seder RH, Katz AE, Keggins JJ et al. Plasma exchange in six patients with advanced cancers of the head and neck. J Clin Apheresis 1985; 2: 238–49.

    CAS  PubMed  Google Scholar 

  522. Seder RH, Katz AE, Keggins JJ et al. Plasma exchange in six patients with advanced cancers of the head and neck. J Clin Apheresis 1985; 2: 238–49.

    CAS  PubMed  Google Scholar 

  523. Seder RH, Vaughn CW, Oh S-K et al. Tumor regression and temporary restoration of immune response after plasmapheresis in a patient with recurrent oral cancer. Cancer 1987; 60: 318–25.

    CAS  PubMed  Google Scholar 

  524. Sedman PC, Ramsden CW, Brennan TG et al. Effects of low-dose perioperative interferon on the surgically induced suppression of antitumor immune response. Br J Surg 1988; 75: 976–81.

    CAS  PubMed  Google Scholar 

  525. Sen L, Borella L. Expression of cell surface markers on Tand B-lymphocytes after long-term chemotherapy of acute leukemia. Cell Immunol 1973; 9: 84–95.

    CAS  PubMed  Google Scholar 

  526. Serdengecti S, Buyukunal E, Molinas N et al. Overall survival results of non-small cell lung cancer patients: chemotherapy alone versus chemotherapy with combined immunomodulation. Chemioterapia 1988; 7: 122–6.

    CAS  PubMed  Google Scholar 

  527. Sertoli MR, Guarneri D, Rubagotti A et al. Adjuvant immunochemotherapy in colorectal cancer. Dukes C. Oncology 1987; 44: 78–81.

    CAS  PubMed  Google Scholar 

  528. Shafir M, Bekesi JG, Papatestas A et al. Preoperative and postoperative immunological evaluation of patients with colorectal cancer. Cancer 1980; 46: 700–5.

    CAS  PubMed  Google Scholar 

  529. Shank B, Scher H, Hilaris BS et al. Increased survival with high-dose multified radiotherapy and intensive chemotherapy in limited small cell carcinoma of the lung. Cancer 1985; 56: 2771–8.

    CAS  PubMed  Google Scholar 

  530. Shiraki S, Mori H, Kadomoto N et al. Adjuvant immunotherapy of carcinoma colon with levamisole. Prevention of immunological depression following surgical therapy and radiotherapy. Int J Immunopharmacol 1982; 4: 73–80.

    CAS  PubMed  Google Scholar 

  531. Shoham J, Theodore E, Brenner HJ et al. Enhancement of the immune system of chemotherapy-treated cancer patients by simultaneous treatment with thymic extract, TP-1. Cancer Immunol Immunother 1980; 9: 173–80.

    Google Scholar 

  532. Shukla HS, Hughes LE, Whitehead RH, Newcombe RG. Long-term (5–11 years) follow-up of general immune competence in breast cancer. I. Pretreatment levels with reference to micrometastasis. Cancer Immunol Immun-other 1986; 21: 1–5.

    CAS  Google Scholar 

  533. Shukla HS, Hughes LE, Whitehead RH, Newcomb RG. Long-term follow-up of general immune competence in breast cancer. II. Sequential pre-and post-treatment levels: a 10-year study. Cancer Immunol Immunother 1986; 21: 6–11.

    CAS  PubMed  Google Scholar 

  534. Sibbit WL, Bankhurst AD, Williams RC. Studies of cell subpopulations mediating mitogen hyporesponsiveness in patients with Hodgkin’s disease. J Clin Invest 1978; 61: 55–63.

    Google Scholar 

  535. Silverman NA, Alexander JC, Potvin C, Chretien PB. In vitro lymphocyte reactivity and T-cell levels in patients with melanoma: correlations with clinical and pathological stage. Surgery 1976; 79: 332–9.

    CAS  PubMed  Google Scholar 

  536. Silverman NA, Alexander JC, Potvin C, Chretien PB. Effect of nonthymic irradiation on cellular immunocompetence. Surg Forum 1975; 26: 345–6.

    CAS  PubMed  Google Scholar 

  537. Sinclair T, Ezdinli EZ, Boonlayangoor Petal. Rosette and blastogenesis inhibition by plasma from Hodgkin’s disease and other malignancies. Positive correlation in stage I and II Hodgkin’s disease. Cancer 1983; 51: 238–44.

    CAS  PubMed  Google Scholar 

  538. Slade MS, Simmons RL, Yunis E, Greenberg LJ. Immunodepression after major surgery in normal patients. Surgery 1975; 78: 363–72.

    CAS  PubMed  Google Scholar 

  539. Slater JM, Ngo E, Lau BHS. Effect of therapeutic irradiation on the immune response. Am J Roentgenol Radium Ther Nucl Med 1976; 126: 313–20.

    CAS  Google Scholar 

  540. Smalley RV, Talmadge J, Oldham RK, Thurman GB. The thymosins: preclinical and clinical studies with fraction V and alpha-1. Cancer Treat Rev 1984; 11: 69–84.

    CAS  PubMed  Google Scholar 

  541. Smith RB, Dekernion J, Baron B et al. Levamisole in the treatment of non-invasive and invasive bladder cancer: a preliminary report. J Urol 1978; 119: 347–9.

    CAS  PubMed  Google Scholar 

  542. Snyderman R, Siegler HF, Meadew R. Abnormalities of monocyte chemotaxis in patients with melanoma: effects of immunotherapy and tumor removal. J Natl Cancer Inst 1977; 58: 37–41.

    CAS  PubMed  Google Scholar 

  543. Sokal JE, Aungst CW. Response to BCG vaccination and survival in advanced Hodgkin’s disease. Cancer 1969; 24: 128–34.

    CAS  PubMed  Google Scholar 

  544. Soto A, Hall T, Reed S. Trial of antiviral action of isoprinosine against rhinovirus infection of volunteers. Antimicrob Agent Chemother 1973; 3: 332–4.

    CAS  Google Scholar 

  545. Soulillou JP, Douillard JU, Vie H et al. Defects in lectininduced interleukin-2 (IL-2) production by peripheral blood lymphocytes of patients with Hodgkin’s disease. Eur J Cancer Clin Oncol 1985; 21: 935.

    CAS  PubMed  Google Scholar 

  546. Spitler LE, Sagebiel R. A randomized trial of levamisole versus placebo as adjuvant therapy in malignant melanoma. N Engl J Med 1980; 303: 1143–7.

    CAS  PubMed  Google Scholar 

  547. Spreafico F, Vecchi A. The imunomodulatory activity of certain cancer chemotherapeutic agents. In: Mihich E, Sakurai Y, eds. Biological Responses in Cancer, vol. 3: Immunomodulation by Anti-cancer Drugs. New York: Plenum Press, 1985: 131–49.

    Google Scholar 

  548. Steele G, Wang BS, Mannick JA. Immune RNA and transfer factor. In: Mihich E, ed. Immunological Approaches to Cancer Therapeutics. New York: Wiley, 1982: 257–76.

    Google Scholar 

  549. Stefani S, Kerman R, Abbate J. Serial studies of immunocompetence in head and neck cancer patients undergoing radiation therapy. Am J Roentgenol Radium Ther Nucl Med 1976; 126: 880–6.

    Google Scholar 

  550. Stefano S, Kerman R, Abbate J. Serial studies of immunocompetence in head and neck cancer patients under-

    Google Scholar 

  551. going radiation therapy. Am J Roentgenol 1976; 126: 880–6.

    Google Scholar 

  552. Stein JA, Adler A, Efraim SB, Maor M. Immunocompetence, immunosuppression and human breast cancer. Cancer 1976; 38: 1171–87.

    CAS  PubMed  Google Scholar 

  553. Stephens EJW, Wood HF, Mason B. Levamisole as adjuvant to cyclic chemotherapy in end-stage mammary carcinoma. Recent Results Cancer Res 1978; 68: 139–45.

    CAS  PubMed  Google Scholar 

  554. Stratton JA, Byfield PE, Byfield JE et al. A comparison of the acute effects of radiation therapy, including or excluding the thymus, on the lymphocyte subpopulations of cancer patients. J Clin Invest 1975; 56: 88–97.

    CAS  PubMed Central  PubMed  Google Scholar 

  555. Stratton JA, Fast PE, Weintraub I. Recovery of lymphocyte function after radiation therapy for cancer in relationship to prognosis. J Clin Lab Immunol 1982; 7: 147–53.

    CAS  PubMed  Google Scholar 

  556. Strender LE, Blomgren H, Wasserman J et al. Influence of adjuvant radiation therapy in breast cancer on PWMinduced Ig secretion by blood lymphocytes in vitro. Anticancer Res 1983; 3: 41–5.

    CAS  PubMed  Google Scholar 

  557. Strender LE, Blomgren H, Petrini B et al. Immunologic monitoring in breast cancer patients receiving postoperative adjuvant chemotherapy. Cancer 1981; 48: 1996–2002.

    CAS  PubMed  Google Scholar 

  558. Sugden PJ, Lilleyman JS. Impairment of lymphocyte transformation by plasma from patients with advanced Hodgkin’s disease. Cancer 1980; 45: 899–905.

    CAS  PubMed  Google Scholar 

  559. Symoens J, Veys E, Mielants W, Pinals R. Adverse reactions to levamisole. Cancer Treat Rep 1978; 62: 1721–30.

    CAS  PubMed  Google Scholar 

  560. Taguchi T. Clinical efficacy of lentinan on patients with stomach cancer: endpoint results of a four-year follow-up survey. Cancer Detect Prev Suppl 1987; 1: 333–49.

    CAS  PubMed  Google Scholar 

  561. Takusugi M, Ramseyer A, Takasugi J. Decline of natural non-selective cell-mediated cytotoxicity in patients with tumor progression. Cancer Res 1977; 37: 413–18.

    Google Scholar 

  562. Talmadge JE, Lenz BF, Pennington R et al. Immunomodulatory and therapeutic properties of bestatin in mice. Cancer Res 1986; 46: 4505–10.

    CAS  PubMed  Google Scholar 

  563. Talmadge JE, Lenz B, Schneider M et al. Immunomodulatory and therapeutic properties of FK- 565 in mice. Cancer Immunol Immunother 1989; 28: 93–100.

    CAS  PubMed  Google Scholar 

  564. Talpaz M, Medina JE, Patt YZ et al. The immune restorative effect of cimetidine administration in vivo on the local graft-vs-host reaction of cancer patients. Clin Immunol Immunopathol 1982; 24: 155–60.

    CAS  PubMed  Google Scholar 

  565. Tamura K, ShibataY, Matsuda Y, Ishida N. Isolation and characterization of an immunosuppressive acidic protein from ascitic fluids of cancer patients. Cancer Res 1981; 41: 3244–52.

    CAS  Google Scholar 

  566. Taramelli D, Mazzocchi A, Clemente C et al. Lack of suppressive activity of human primary melanoma cells on the activation of autologous lymphocytes. Cancer Immunol Immunother 1988; 26: 61–6.

    CAS  PubMed  Google Scholar 

  567. Tarpley JL, Potvin C, Chretien PB. Prolonged depression of cellular immunity in cured laryngopharyngeal cancer patients treated with radiation therapy. Cancer 1975; 35: 638–44.

    CAS  PubMed  Google Scholar 

  568. Tarpley JL, Twomey PL, Catalona WJ, Cretien PB. Suppression of cellular immunity by anesthesia and operation. J Surg Res 1977; 22: 195–201.

    CAS  PubMed  Google Scholar 

  569. Tartter PI, Burrows L, Kirshner P. Perioperative blood transfusion adversely affects prognosis after resection in stage I (subset No) non-oat cell lung cancer. J Thorac Cardiovasc Surg 1984; 88: 659–62.

    CAS  PubMed  Google Scholar 

  570. Tartter PI, Martinelli G. Lymphocyte subsets, natural killer cytotoxicity, and perioperative blood transfusion for elective colorectal cancer surgery. Cancer Detect Prev (Suppl) 1987; 1: 571–6.

    CAS  Google Scholar 

  571. Tartter PI, Martinelli G, Steinberg B, Barron D. Changes in peripheral T-cell subsets and natural killer cytotoxicity

    Google Scholar 

  572. in relation to colorectal cancer surgery. Cancer Detect Prev 1986; 9: 359–64.

    Google Scholar 

  573. Tartter PI, Burrows L, Papatestas AE et al. Perioperative blood transfusion has prognostic significance for breast cancer. Surgery 1985; 97: 225–30.

    CAS  PubMed  Google Scholar 

  574. Taylor SA, Gordon MY, Currie GA, Shepherd VB. Irradiation and monocyte function in patients with breast cancer. Int J Radiat Oncol 1979; 5: 2063–7.

    CAS  Google Scholar 

  575. Thatcher N, Palmer MK, Swindell R, Crowther D. Lymphocyte function related to survival curves in patients with metastatic melanoma were evaluated immunologically prior to chemoimmunotherapy. Med Pediatr Oncol 1978; 4: 49–70.

    Google Scholar 

  576. Theofilopoulos A, Dixon FJ. The biology and detection of immune complexes. Adv Immunol 1979; 28: 89–220.

    CAS  PubMed  Google Scholar 

  577. Thienpont D, Vanparjis OFJ, Racymakers AHM et al. Tetramasole (R8299): a new potent broad spectrum anthelmintic. Nature 1966; 209: 1084–6.

    CAS  PubMed  Google Scholar 

  578. Thornes RD, Lynch G, Sheehan MV. Cimetidine and coumarin therapy of melanoma. Lancet 1982; 2: 328.

    CAS  PubMed  Google Scholar 

  579. Thornes RD, Lynch G. Combination of cimetidine with other drugs for the treatment of cancer. N Engl J Med 1983; 308: 591.

    Google Scholar 

  580. Tilden AB, Balch CM. Immune modulatory effects of indomethacin in melanoma patients are not related to prostaglandin E2-mediated suppression. Surgery 1982; 92: 528–32.

    CAS  PubMed  Google Scholar 

  581. Ting A, Terasaki PI. Depressed lymphocyte-mediated killing sensitized targets in cancer patients. Cancer Res 1974; 34: 2694–8.

    CAS  PubMed  Google Scholar 

  582. Toge T, Hamamoto S, Itagaki E et al. Concanavalin-Ainduced and spontaneous suppressor cell activities in peripheral blood lymphocytes and spleen cells from gastric cancer patients. Cancer 1983; 52: 1624–31.

    CAS  PubMed  Google Scholar 

  583. Toivanen A, Granberg I, Nordman E. Lymphocyte sub-populations in patients with breast cancer after postoperative radiotherapy. Cancer 1984; 54: 2919–23.

    CAS  PubMed  Google Scholar 

  584. Tom BH, Macek CM, Subramanian C et al. In vitro expression of suppressogenic and enhancing activities in human colon cancer cells. J Biol Response Mod 1984; 3: 435–44.

    CAS  PubMed  Google Scholar 

  585. Tonnesen H, Knigge U, Bulow S et al. Effect of cimetidine on survival after gastric cancer. Lancet 1988; 29: 990–2.

    Google Scholar 

  586. Treurniet-Donker AD, Meischke-de Jongh ML, van Putten WLJ. Levamisole as adjuvant immunotherapy in breast cancer. Cancer 1987; 59: 1590–3.

    CAS  PubMed  Google Scholar 

  587. Tsang KY, Fudenberg HH, Pan JF et al. An in vitro study on the effects of isoprinosine on immune responses in cancer patients. Int J Immunopharmacol 1983; 5: 481–90.

    CAS  PubMed  Google Scholar 

  588. Tsuyuguchi I, Shiratsuchi H, Fukuoka M. T-lymphocyte subsets in primary lung cancer. Jpn J Clin Oncol 1987; 17: 13–17.

    CAS  PubMed  Google Scholar 

  589. Uchida A, Kolb R, Micksche M. Generation of suppressor cells for natural killer activity in cancer patients after surgery. J Natl Cancer Inst 1982; 68: 735–41.

    CAS  PubMed  Google Scholar 

  590. Uchida A, Mickskche M. Generation of suppressor cells for natural killer (NK) activity in cancer patients after surgery. Cancer Immunol Immunother 1981; 10: 203–10.

    Google Scholar 

  591. Uchida A, Hoshino T. Clinical studies on well-mediated immunity in patients with malignant disease. I. Effects of immunotherapy with OK-432 on lymphocyte subpopulation and phytomitogen responsiveness in vitro. Cancer 1980; 45: 476–83.

    CAS  PubMed  Google Scholar 

  592. Umeda T, Yokoyama H, Kobayashi K et al. Subsets of T-lymphocytes of patients with malignancies of the urogenital tract. Cell Mol Biol 1979; 25: 95–9.

    CAS  Google Scholar 

  593. Unger SW, Bernhard MI, Pace RC, Wanego HJ. Monocyte dysfunction in human cancer. Cancer 1983; 51: 669–74.

    CAS  PubMed  Google Scholar 

  594. Uracz W, Mytar B, Zembala M et al. Activated monocytes in gastric cancer patients. II. Suppressor and cytostatic activity in vitro. J Cancer Res Clin Oncol 1982; 104: 307–13.

    CAS  PubMed  Google Scholar 

  595. Van Rijswijk REN, DeMeijer A, Bob Sybesma JPH, Kater

    Google Scholar 

  596. L. Five-year survival in Hodgkin’s disease. The prospective value of immune status at diagnosis. Cancer 1986; 57: 1489–96.

    Google Scholar 

  597. Van-Stolen K, Wiernick PH, Schiffer CA, Schimpff SC. Evaluation of levamisole as an adjuvant to chemotherapy for treatment of ANLL. Cancer 1983; 51: 1576–80.

    Google Scholar 

  598. Vanhaelen CPJ, Fisher RI. Increased sensitivity of T-cells to regulation by normal suppressor cells persists in longterm survivors with Hodgkin’s disease. Am J Med 1982; 72: 385–90.

    CAS  PubMed  Google Scholar 

  599. Vaudaux P, Kiefer B, Forni M et al. Adriamycin impairs phagocytic function and induces morphologic alterations in human neutrophils. Cancer 1984; 59: 400–10.

    Google Scholar 

  600. Venkataraman M, Rao DS, Levin RD, Westerman MP. Suppression of B-lymphocyte function by T-lymphocytes in patients with advanced lung cancer. J Natl Cancer Inst 1985; 74: 37–41.

    CAS  PubMed  Google Scholar 

  601. Verhaegen H, DeCree J, DeCock W et al. Levamisole therapy in patients with colorectal cancer. In: Terry WD, Rosenberg SA, eds. Immunotherapy of Human Cancer. New York: Elsevier/North-Holland, 1982: 225–9.

    Google Scholar 

  602. Vinzenz K, Matejka M, Watzek G et al. Modulation of NK activity in regional lymph nodes by preoperative immunotherapy with OK-432 in patients with cancer of the oral cavity. Cancer Detect Prev Suppl 1987; 1: 463–75.

    CAS  PubMed  Google Scholar 

  603. Von Roenn J, Harris JE, Braun DP. Suppressor cell function in solid-tumor cancer patients. J Clin Oncol 1987; 5: 150–9.

    Google Scholar 

  604. Voogt PJ, van de Velde CJH, Brand A et al. Perioperative blood transfusion and cancer prognosis: different effects of blood transfusion on prognosis of colon and breast cancer patients. Cancer 1987; 59: 836–43.

    CAS  PubMed  Google Scholar 

  605. Vose BM, Vanky F, Argrov S, Klein E. Natural cytotoxicity in man: activity of lymph node and tumor-infiltrating lymphocytes and regional lymphocytes. Eur J Immunol 1977; 7: 753–7.

    Google Scholar 

  606. Wagner DK, Kiwanuka J, Edwards BK et al. Soluble interleukin-2 receptor levels in patients with undifferentiated and lymphoblastic lymphomas: correlation with survival. J Clin Oncol 1987; 5: 1262–74.

    CAS  PubMed  Google Scholar 

  607. Wagner V, Janku O, Wagnerora Metal. The production of complete and incomplete antibodies in patients with neoplastic disease. Neoplasma 1972; 19: 75–87.

    CAS  PubMed  Google Scholar 

  608. Wakasugi H, Kasahara T, Minato N et al. In vivo potentiation of human natural killer cell activity by a streptococcal preparation: interferon and interleukin-2 participation in the stimulation with OK-432. J Natl Cancer Inst 1982; 69: 807–12.

    CAS  PubMed  Google Scholar 

  609. Waller CA, Gill BG, Machennon IC. Enhancement of lymphocyte-mediated cytotoxicity after tumor resection in patients with colorectal cancer. J Natl Cancer Inst 1980; 65: 223–30.

    CAS  PubMed  Google Scholar 

  610. Walter RJ, Danielson JR. Defective monocyte chemotaxis in patients with epidermoid tumors of the head and neck. Arch Otolaryngol 1985; 11: 530–40.

    Google Scholar 

  611. Wanebo HJ, Rao B, Miyazawa N et al. Immune reactivity in primary carcinoma of the lung and its relation to prognosis. J Thorac Cardiovasc Surg 1976; 72: 339–47.

    CAS  PubMed  Google Scholar 

  612. Wanebo HJ, Pace R, Hargett S et al. Production of and response to interleukin-2 in peripheral blood lymphocytes of cancer patients. Cancer 1980; 57: 656–62.

    Google Scholar 

  613. Wanebo HJ, Jun M, Strong E, Oettgen HF. T-cell deficiency in patients with squamous-cell cancer of head and neck. Am J Surg 1975; 130: 445–51.

    CAS  PubMed  Google Scholar 

  614. Wanego HJ, Rao B, Attiyeh F et al. Immune reactivity in patients with colorectal cancer: assessment of biological risk by immunoparameters. Cancer 1980; 45: 1254–63.

    Google Scholar 

  615. Wanebo HJ, Hilal EY, Strong EW et al. Adjuvant trial of levamisole in patients with squamous cancer of the head and neck: a preliminary report. Cancer Res 1978; 68: 324–33.

    CAS  Google Scholar 

  616. Wanebo HJ. Observations on the effects of adjuvant radiation on immune tests of patients with colorectal cancer and head and neck cancer. In: Dubois JB, Serrou B, Rosenfeld C, eds. Immunopharmacologic Effects of Radiation Therapy. New York: Raven Press, 1980: 241–52.

    Google Scholar 

  617. Wanego HJ, Riley T, Katz D et al. Indomethacin-sensitive suppressor-cell activity in head and neck cancer patients. Cancer 1988; 61: 462–74.

    Google Scholar 

  618. Wara WM, Phillips TL, Wara DW et al. Immunosuppression following radiation therapy for carcinoma of the nasopharynx. Am J Roentgenol Radium Ther Nucl Med 1975; 123: 482–5.

    CAS  PubMed  Google Scholar 

  619. Wara WM, Wara DW, Philips TL, Amman AJ. Elevated IgA in cancer of the nasopharynx. Cancer 1975; 35: 1313–15.

    CAS  PubMed  Google Scholar 

  620. Wara WM, Neely MH, Amman AJ, Wara DW. Biological modification of immunologic parameters in head and neck cancer patients with thymosin fraction V. In: Goldstein AL, Chirigos MA, eds. Lymphokines and Thymic Hormones: Their Potential Utilization in Cancer Therapeutics. New York: Raven Press, 1981: 257–62.

    Google Scholar 

  621. Warren RP, McCall CA, Urban RW. Augmentation of natural killer cell activity by ImuVert: a biological response modifier derived from Serratia marcescens. Mol Biother 1989; 1: 145–51.

    CAS  PubMed  Google Scholar 

  622. Wasserman J, Wallgren A, Blomgren H et al. Prognostic relevance of post-irradiation lymphocyte reactivity in breast cancer patients. Cancer 1986; 58: 348–51.

    CAS  PubMed  Google Scholar 

  623. Wasserman J, Blomgren H, Petrini B et al. Effect of radiation therapy and in vitro x-ray exposure on lymphocyte subpopulations and their functions. Am J Clin Oncol 1982; 5: 195–208.

    CAS  PubMed  Google Scholar 

  624. Watanabe Y, Takashi I. Clinical value of immunotherapy for lung cancer by the streptococcal preparation OK-432. Cancer 1984; 53: 248–53.

    CAS  PubMed  Google Scholar 

  625. Webster DJ, Whitehead RH, Richardson G, Hughes LE. Levamisole: a double-blind immunological study. Anticancer Res 1982; 2: 29–32.

    CAS  PubMed  Google Scholar 

  626. Weiden PL, Bean MA, Schultz P. Perioperative blood transfusion does not increase the risk of colorectal cancer recurrence. Cancer 1987; 60: 870–4.

    CAS  PubMed  Google Scholar 

  627. Wells SA Jr, Burdick JF, Christiansen C et al. Demonstration of tumor-associated delayed cutaneous hypersensitivity reactions in lung cancer patients and in patients with carcinoma of the cervix. Natl Cancer Inst Monogr 1973; 37: 197–203.

    PubMed  Google Scholar 

  628. Wells SA Jr, Burdick JF, Christiansen C et al. Demonstration of tumor-associated delayed cutaneous hypersensitivity reactions in lung cancer patients and in patients with carcinoma of the cervix. Natl Cancer Inst Monogr 1973; 37: 197–203.

    PubMed  Google Scholar 

  629. Wells SA Jr, Burdick JF, Joseph WL et al. Delayed cutaneous hypersensitivity reactions to tumor cell antigens and to nonspecific antigens. J Thorac Cardiovasc Surg 1973; 66: 557–62.

    PubMed  Google Scholar 

  630. Weppelmann B, Monkemeir D. The influence of prostaglandin antagonists on radiation therapy of carcinoma of the cervix. Gynecol Oncol 1984; 17: 196–9.

    CAS  PubMed  Google Scholar 

  631. Wesse J, Oldham RK, Tormey DC et al. Immunologic monitoring in carcinoma of the breast. Surg Gynecol Obstet 1977; 145: 209–18.

    Google Scholar 

  632. Wesselius LJ, Wheaton DL, Manahan-Wahl LJ et al. Lymphocyte subsets in lung cancer. Chest 1987; 91: 725–9.

    CAS  PubMed  Google Scholar 

  633. White JE, Chen T, Reed R et al. Limited squamous-cell carcinoma of the lung: a Southwest Oncology Group randomized study of radiation with or without doxorubicin and with or without levamisole immunotherapy. Cancer Treat Rep 1982; 66: 113–20.

    Google Scholar 

  634. Whitehead RH, Thatcher J, Teasdale C et al. T- and B-lymphocytes in breast cancer: stage relationship and abrogation of T-lymphocyte depression by enzyme treatment in vitro. Lancet 1976; 1: 330–3.

    CAS  PubMed  Google Scholar 

  635. Wilkins SA Jr, Olkowskii ZL. Immunocompetence of cancer patients treated with levamisole. Cancer 1977; 39: 487–93.

    PubMed  Google Scholar 

  636. Windle R, Bell PR, Shaw D. Five-year results of a randomized trial of adjuvant 5-fluorouracil and levamisole in colorectal cancer. Br J Surg 1987; 74: 569–72.

    CAS  PubMed  Google Scholar 

  637. Windle R, Wood RFM, Bell PRF. The effect of levamisole on post-operative immunosuppression. Br J Surg 1979; 66: 507–9.

    CAS  PubMed  Google Scholar 

  638. Wleklik MS, Luczak M, Najjajr VA. Tuftsin-induced tumor necrosis activity. Mol Cell Biochem 1987; 75: 169–74.

    CAS  PubMed  Google Scholar 

  639. Wolf GT, Lovett EJ III, Peterson KA et al. Lymphokine production and lymphocyte subpopulations in patients with head and neck squamous carcinoma. Arch Otolaryngol 1984; 110: 731–5.

    CAS  PubMed  Google Scholar 

  640. Wolf GT, Amendola BE, Diaz R et al. Definite vs. adjuvant radiotherapy. Comparative effects on lymphocyte subpopulations in patients with head and neck squamous carcinoma. Arch Otolaryngol 1985; 111: 716–26.

    CAS  PubMed  Google Scholar 

  641. Wybran J, Govaerts P. Levamisole and human lymphocyte surface markers. Clin Exp Immunol 1977; 27: 319–21.

    CAS  PubMed Central  PubMed  Google Scholar 

  642. Wybran J, Serrou B, Belpomme D et al. Immunomodulating of T-cell and NK function by NPT-15392 in cancer patients. A cooperative study by the tumor immunology group. In: Serrou B, Rosenfeld C, Daniels JC, Saunders JP, eds. Current Concepts in Human Immunology and Cancer Immunomodulation. Amsterdam: Elsevier, 1982: 471–8.

    Google Scholar 

  643. Yokoyama H, Umeda T, Kobayashi K et al. Restoration of E-rosette formation by bestatin in patients with bladder cancer. Cancer Res Clin Oncol 1980; 98: 195–201.

    CAS  Google Scholar 

  644. Young RC, Corder MP, Haynes HA, DeVita VT. Delayed hypersensitivity in Hodgkin’s disease. Am J Med 1972; 52: 63–72.

    CAS  PubMed  Google Scholar 

  645. Zabbe C, DeWitte JD, Lozach P et al. Predictive value of T-cell subset derangements in lung cancer. Med Oncol Tumor Pharmacother 1986; 3: 83–5.

    CAS  PubMed  Google Scholar 

  646. Zacharski LR, Linman JW. Lymphocytopenia: its causes and significance. Mayo Clin Proc 1971; 46: 168–73.

    CAS  PubMed  Google Scholar 

  647. Zamkoff KW, Reeves WG, Paolozzi FP et al. Impaired interleukin regulation of the phytohemagglutinin response in Hodgkin’s disease. Clin Immunol Immunopathol 1985; 35: 111–24.

    CAS  PubMed  Google Scholar 

  648. Zamkoff KW, Reeves WQ, Paolozzi FP et al. Impaired interleukin regulation of the phytohemagglutinin response in Hodgkin’s disease. Clin Immunol Immunopathol 1985; 35: 111.

    CAS  PubMed  Google Scholar 

  649. Zanker KS, Blumel G, Lange J et al. Coumarin in malignant melanoma patients: an experimental and clinical study. Drug Exp Clin Res 1984; 10: 767–74.

    Google Scholar 

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Oldham, R.K. (2003). Therapeutic approaches to cancer-associated immune suppression. In: Oldham, R.K. (eds) Principles of Cancer Biotherapy. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2757-0_6

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