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Drug immunoconjugates

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Book cover Principles of Cancer Biotherapy

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Abstract

Monoclonal antibodies and their immunoconjugates represent one of the first practical methods for the selective treatment of cancer [42]. Monoclonal antibody technology now allows for the generation of antibodies or ‘cocktails’ of antibodies that have some selectivity for cancer tissue as compared with the normal tissue oforigin. These antibodies can be tested as unconjugated antibody alone or in conjunction with effector cells. The ‘signal strength’ of the antibody may be made more powerful by conjugating antibody to drugs, toxins, biologicals, and radioisotopes with different mechanisms of action and different levels of potency. This chapter will focus on the use of drug immunoconjugates for cancer treatment.

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  1. Malek Safa
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  2. Kenneth A. Foon
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  3. Robert K. Oldham
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  1. Singleton Oncology Center, Florida State University College of Medicine, 116 Mimosa Avenue, 31792, Thomasville, GA, USA

    Robert K. Oldham MD

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Safa, M., Foon, K.A., Oldham, R.K. (2003). Drug immunoconjugates. In: Oldham, R.K. (eds) Principles of Cancer Biotherapy. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2757-0_12

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