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Disorders of the energy pathway and the metabolic intermediate pool

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Biochemical Neurology

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Abstract

Neural tissue obtains almost all its energy from the oxidative metabolism of glucose. The whole human brain consumes about 50 ml of oxygen per minute, some 20% of the body’s total oxygen requirement under basal conditions. This oxygen is required to provide energy by oxidatively metabolizing the 72 mg per minute of glucose that the brain takes up over the same time interval1. In certain circumstances acetyl groups (CH3.CO—) and keto acids (R′—CO—R″—COOH), derived respectively from fatty acids by β-oxidation and from amino acids by oxidative deamination, can be used to provide energy. Energy is stored in the form of high energy phosphate (adenosine triphosphate, i.e. ATP). Skeletal muscle can make more extensive use of fatty acids as an energy source than can neural tissue.

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  1. Department of Medicine, University of Queensland, Brisbane, Australia

    M. J. Eadie

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  1. M. J. Eadie
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  2. J. H. Tyrer
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© 1983 M. J. Eadie and J. H. Tyrer

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Eadie, M.J., Tyrer, J.H. (1983). Disorders of the energy pathway and the metabolic intermediate pool. In: Biochemical Neurology. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0896-8_2

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  • DOI: https://doi.org/10.1007/978-94-017-0896-8_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-017-0898-2

  • Online ISBN: 978-94-017-0896-8

  • eBook Packages: Springer Book Archive

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