Abstract
Perfluorochemicals (PFC’s) dissolve large volumes of oxygen (35–52 vol. %) and carbon dioxide (135–160 vol. %) and are chemically and biochemically inert. These properties have made them candidates for blood substitutes and other therapeutic applications requiring oxygen delivery to tissues. In this paper, the history of PFC’s in medicine and the requirements for a successful commercial emulsion are briefly reviewed. The practical aspects and current status of the production of a safe, shelf stable, small particle size, high PFC content emulsion are reviewed and recent advances in the field such as new PFC’s, novel surfactants, new clinical trials and recent regulatory approvals are presented.
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© 1992 Springer Science+Business Media Dordrecht
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Kaufman, R.J. (1992). Perfluorochemical Emulsions as Blood Substitutes. In: Sjöblom, J. (eds) Emulsions — A Fundamental and Practical Approach. NATO ASI Series, vol 363. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2460-7_14
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DOI: https://doi.org/10.1007/978-94-011-2460-7_14
Publisher Name: Springer, Dordrecht
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