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Effect of tumour growth on inflammatory macrophages

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Part of the book series: Inflammation: Mechanisms and Treatment ((FTIN,volume 4))

Abstract

Studies in many laboratories have led to the speculation that macrophages probably play a significant role in host defence against neoplasia. It has been shown both in vitro and in vivo that macrophages can destroy tumour cells via different pathways, specific1 or otherwise2. On the other hand it has been demonstrated that patients with neoplasms have a depressed monocyte chemotactic responsiveness3 and that macrophage accumulation in response to inflammatory stimuli is impaired during growth of experimental tumours4,5.

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References

  1. Alexander, P. (1976). The functions of the macrophage in malignant disease. Ann. Rev. Med., 27, 207

    Article  PubMed  CAS  Google Scholar 

  2. Zbar, B., Bernstein, I. D., Bartlett, G. L., Hanna, N. G., and Rapp H. J. (1972). Immunotherapy of cancer: regression of intradermal tumors and prevention of growth of lymph node metastases after intralesional injection of living mycobacterium bovis. J. Natl. Cancer Inst., 49, 119

    PubMed  CAS  Google Scholar 

  3. Snyderman, R., Seigler, H. F. and Meadows, L. (1977). Abnormalities of monocyte Chemotaxis in patients with melanoma; effects of immunotherapy and tumor removal. J. Natl. Cancer Inst., 58, 37

    PubMed  CAS  Google Scholar 

  4. Snyderman, R., Pike, M. C, Blaylock, B. L. and Weinstein, P. (1976). Effects of neoplasms on inflammation: depression of macrophage accumulation after tumor implantation. J. Immunol., 116, 585

    PubMed  CAS  Google Scholar 

  5. Normann, S. J., Schardt, M. and Sorkin, E. (1979). Cancer progression and monocyte inflammatory dysfunction: relationship to tumour excision and metastasis. Int. J. Cancer, 23, 110

    Article  PubMed  CAS  Google Scholar 

  6. Normann, S.J. and Schardt, M. (1978). A macrophage inflammation test using subcutaneous nitrocellulose filters. J. Reticuloendothial Soc., 23, 153

    CAS  Google Scholar 

  7. Normannn, S.J. and Schardt, M. (1978).A cancer related macrophage dysfunction in inflamed tissues. J. Reticuloendothelial Soc., 24, 147–159

    Google Scholar 

  8. Nolibe, D., Masse, R., and Lafuma, J. (1980). The effect of neonatal thymectomy upon lung cancers induced in rats by 239 plutonium dioxide. Radiat Res. (In press)

    Google Scholar 

  9. Normann, S. J. and Cornelius, J. (1978). Concurrent depression of tumor macrophage infiltration and systemic inflammation by progressive cancer growth. Cancer Res., 38, 3453

    PubMed  CAS  Google Scholar 

  10. Gauci, C. L., Wrathmell, A. and Alexander, P. (1975). The origin and role of blood born monocytes in rats with transplanted myelogenous leukemia. Cancer Lett. 1, 33

    Article  PubMed  CAS  Google Scholar 

  11. Jamasbi, R. J., Nettesheim, P. and Kennel S.J. (1978). Demonstration of cellular and humoral immunity to transplantable carcinomas derived from the respiratory tract of rats. Cancer Res., 38, 261

    PubMed  CAS  Google Scholar 

  12. Ruco, L. P. and Meltzer, M.S. (1978). Macrophage activation for tumor cytotoxicity: increased lymphokine responsiveness of peritoneal macrophages during acute inflammation. J. Immunol, 120, 1054

    PubMed  CAS  Google Scholar 

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© 1980 MTP Press Limited

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Nolibe, D., Masse, R., Giroud, J.P. (1980). Effect of tumour growth on inflammatory macrophages. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_97

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  • DOI: https://doi.org/10.1007/978-94-010-9423-8_97

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9425-2

  • Online ISBN: 978-94-010-9423-8

  • eBook Packages: Springer Book Archive

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