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Inflammation: Mechanisms and Treatment pp 543–546Cite as

Different susceptibilities to 4-hydroperoxycyclophosphamide of T cell sub-sets involved in delayed-type hypersensitivity of mice to sheep red blood cells

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Part of the book series: Inflammation: Mechanisms and Treatment ((FTIN,volume 4))

Abstract

It has been amply shown that cyclophosphamide (Cy), in addition to its immunosuppressive properties, enhances the cellular immune response to heterologous red blood cells, and both elimination by Cy of B cells and suppressor T cells (Ts cells) have been postulated as the underlying mechanism1–3. 4-hydroperoxycyclophosphamide (4-HPCy) is a derivative of Cy which in contrast to Cy acts on lymphocytes in vitro since the compound in aqueous solution is converted to 4-hydroxycyclophosphamide, the naturally occurring metabolite of Cy4.

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References

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Authors
  1. S. H. E. Kaufmann
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  2. H. Hahn
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  3. T. Diamantstein
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Editor information

Editors and Affiliations

  1. Department of Experimental Pathology and Rheumatology, St Bartholomew’s Hospital, London, UK

    D. A. Willoughby (Professor) (Professor)

  2. Department of Pharmacology, Hôpital Cochin, Paris, France

    J. P. Giroud (Professor) (Professor)

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© 1980 MTP Press Limited

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Kaufmann, S.H.E., Hahn, H., Diamantstein, T. (1980). Different susceptibilities to 4-hydroperoxycyclophosphamide of T cell sub-sets involved in delayed-type hypersensitivity of mice to sheep red blood cells. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_78

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  • DOI: https://doi.org/10.1007/978-94-010-9423-8_78

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9425-2

  • Online ISBN: 978-94-010-9423-8

  • eBook Packages: Springer Book Archive

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