Abstract
Local recruitment of polymorphonuclear leukocytes (PMNs) to inflammatory sites is essential to the host in its defence against injury. The activation of directed migration of cells (Chemotaxis) along a chemical gradient is determined by a variety of attractants such as serum factors1, particularly a fragment of the fifth component of complement2, bacterial metabolites3, cell derived materials from sensitized lymphocytes4, or PMNs and denatured proteins5. Recently Schiffman et al. 6 have shown that small synthetic N-formyl-methionyl peptides, which may be related to natural bacterial leukoattractants, induce leukocyte Chemotaxis. Williams et al. 7 with human PMNs and Aswanikumar et al. 8, with rabbit PMNs have demonstrated that membrane receptors appear to mediate Chemotaxis induced by both natural bacterial peptides and formylated synthetic peptides.
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Roch-Arveiller, M., Abita, J.P., Bradshaw, D., Giroud, J.P. (1980). Modification of Chemotaxis and peptide binding during pathophysiological state of polymorphonuclear leukocytes. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_58
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DOI: https://doi.org/10.1007/978-94-010-9423-8_58
Publisher Name: Springer, Dordrecht
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