Abstract
Rheumatoid arthritis is characterized by an influx of both polymorphonuclear (PMN) and mononuclear leukocytes into various inflammatory sites1,2. These infiltrating cells are, in part, responsible for a number of pathological events resulting ultimately in protease release and connective tissue catabolism. Over the past 10 years a number of in vivo models of leukocyte infiltration have been described3–5. Most have been aimed at PMN accumulation and the effects of pharmacological agents on this process. In the current studies, a model of macrophage accumulation was developed; in addition, the effects of steroidal and non-steroidal anti-inflammatories and anti-rheumatic agents were determined.
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Ackerman, N., Tomolonis, A., Miram, L., Kheifets, J., Martinez, S., Carter, A. (1980). Effect of pharmacological agents on macrophage accumulation. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_48
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DOI: https://doi.org/10.1007/978-94-010-9423-8_48
Publisher Name: Springer, Dordrecht
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