Skip to main content

Preliminary report on the effect of a new derivative of acetyl salicylic acid on tissue-algogen component due to damaging stimulation of cutis

  • Chapter
  • 40 Accesses

Part of the book series: Inflammation: Mechanisms and Treatment ((FTIN,volume 4))

Abstract

A derivative of acetyl salicylic acid recently synthesized, acid 5-(2,4-difluorenil)-salicylate (diflunisal), seems to be endowed with an elevated anti-phlogistic and analgesic activity1–4.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hannah, J., Ruyle, W.V., Kelly, K., Matzuk, A. R., Holtz, W.J., Witzel, B.E., Winter, C.A., Silber, C. A. and Shen, T.Y. (1970). Flufenisal, a novel salicylate. Joint Conf. Chem. Inst. Can. Am. Chem. Soc., 18

    Google Scholar 

  2. Shen, T. Y. (1972). Perspectives in non-steroidal anti inflammatory agents. Agnew. Chem. II, 460

    Google Scholar 

  3. Patrono, C., Ciabattoni, G., Grego, F. and Grossi Belloni, D. (1976). Comparative evaluation of the inhibitory effects of aspirin-like drugs on prostaglandin production by human platelets and synovial tissue. In Samuelsson, B. and Paoletti, R. (eds.) Advances in Prostaglandin and Thromboxane Research, p. 125

    Google Scholar 

  4. Tempero, K. F., Cirillo, V.J. and Steelman, S. L. (1977). Diflunisal: a review of the pharmacokinetic and pharmacodynamic properties, drug interaction and special tolerability studies in humans. Br. J. Clin. Pharmacol., 4, 31S

    Google Scholar 

  5. Galletti, R., Marra, N. and Vecchiet, L. (1960). Studio analitico dei fenomeni reattivi cutanei conseguenti a stimolazione con neve carbonica in soggetti normali. Estratto da “Lo Sperimentale”

    Google Scholar 

  6. Lewis, T. (1942). Pain. (New York: Macmillan)

    Google Scholar 

  7. Lunedei, A. (1948). Relazione 49 Cong. Soc. It. Med. Int., Pozzi, L. (ed.) Roma

    Google Scholar 

  8. Arcangeli, P. and Galletti, R. (1974). Endogenous pain producing substances. In Bonica, J. J., Procacci, P. and Pagni, C. A. (eds.) Recent advances in pain. (Springfield C.C. Thomas)

    Google Scholar 

  9. Vecchiet, L., Matassi, L., Buzzelli, G., Fini, F. and Branzi, G. C. (1968). Rilievisull’attività tissulo-algogena del plasma dopo la voro muscolare. La Set. Medica, 56, 823

    Google Scholar 

  10. Keele, C.A. and Armstrong, D. (1964). Substances producing pain and itch. (London: Arnold)

    Google Scholar 

  11. Vecchiet, L., Galletti, R., Matassi, L., Chiarini, P. and Buzzelli, G. (1973). Il ruolo del kininogeno nella riattivazione della flogosi sperimentale da cantaridina. Clin. Ter., 67, 339

    Google Scholar 

  12. Vecchiet, L., Galletti, R., Chiarini, P. and Fabrizi, L. (1973). Rapporti tra dolore ed aumento della permeabilità dei microvasi nel quadro della flogosi sperimentale da cantaridina. Clin. Ter., 667, 521

    Google Scholar 

  13. Roth, G. J., Stanford, N. and Majerus, P. W. (1975). Acetylation of prostaglandin-synthetase by aspirin. Proc. Natl. Acad. Sci (USA)., 72, 3073

    Article  CAS  Google Scholar 

  14. Majerus, P. W. and Stanford, N. (1977). Comparative effects of aspirin and diflunisal on prostaglandin-synthetase from human platelets and sheep seminal vesicles. Br. J. Clin. Pharmacol., 4, 15S

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1980 MTP Press Limited

About this chapter

Cite this chapter

Vecchiet, L., Pontano, O., Obletter, G., Carratelli, L. (1980). Preliminary report on the effect of a new derivative of acetyl salicylic acid on tissue-algogen component due to damaging stimulation of cutis. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_31

Download citation

  • DOI: https://doi.org/10.1007/978-94-010-9423-8_31

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9425-2

  • Online ISBN: 978-94-010-9423-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics