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D-penicillamine in rheumatoid arthritis: fixed versus variable regimes

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Inflammation: Mechanisms and Treatment

Part of the book series: Inflammation: Mechanisms and Treatment ((FTIN,volume 4))

Abstract

D-penicillamine is of proven therapeutic value in the treatment of rheumatoid arthritis1, although the increased incidence of side effects associated with high dose regimes (greater than 1 g/per day) has encouraged clinicians to examine the response to lower doses.

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References

  1. Multicenter Trial Group (1973). Controlled trial of D-pencillamine in severe rheumatoid arthritis. Lancet, 1, 275

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  2. Dixon, A. S.J., Davies, J., Dormandy, T. L., Hamilton, E. B.D., Holt, P. J. L., Mason, R. M., Thompson, M., Weber, J. C. P. and Zutshi, D. W. (1975). Synthetic D-penicillamine in rheumatoid arthritis: double-blind controlled study of a high and low dosage regimen. Ann. Rheum. Dis., 34, 416

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  6. Ritchie, D. M., Boyle, J. A., McInnes, J. R., Jasani, K. M., Dalabos, T. C., Grieveson, P. and Buchanan, W. W. (1968). Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q. J. Med., 147, 393

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Authors and Affiliations

  1. UK

    D. R. Blake, E. F. J. Ring, R. C. Bucknall & P. A. Bacon

Authors
  1. D. R. Blake
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  2. E. F. J. Ring
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  3. R. C. Bucknall
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  4. P. A. Bacon
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Editor information

Editors and Affiliations

  1. Department of Experimental Pathology and Rheumatology, St Bartholomew’s Hospital, London, UK

    D. A. Willoughby (Professor) (Professor)

  2. Department of Pharmacology, Hôpital Cochin, Paris, France

    J. P. Giroud (Professor) (Professor)

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© 1980 MTP Press Limited

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Blake, D.R., Ring, E.F.J., Bucknall, R.C., Bacon, P.A. (1980). D-penicillamine in rheumatoid arthritis: fixed versus variable regimes. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_28

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  • DOI: https://doi.org/10.1007/978-94-010-9423-8_28

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9425-2

  • Online ISBN: 978-94-010-9423-8

  • eBook Packages: Springer Book Archive

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