Abstract
Most of the non-steroidal anti-inflammatory agents in clinical use today are substituted aromatic organic acids. These agents are endowed with an unfortunately high incidence of toxicity1 which may have to do with unavoidable unwanted side effects of their powerful influence on that pathway of arachi-donic acid metabolism that leads to prostaglandin synthesis.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Dodge, P. W., Brodic, D. and Mitchell, B. D. (1979). Evaluation of the toxicity of antiinflammatory drugs. In Vane, J. R. and Ferreira, S. H. (eds.) Anti-inflammatory Drugs. Vol. 50/11, Chap. 29, p. 280. Berlin: Springer-Verlag.
Majde, J. A. and Gordon, P. (1976). Immunomodulation by l, 2–2-O-isopropylidene-3-O-3’-(N’N’-dimethyl-amino-n-propyl)-D-glucofuranoseSM-1213, a drug with antiviral activity. In Sixteenth Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract, Chicago, Illinois
Files, Greenwich Pharmaceuticals Incorporated. 95 East Putnam Avenue, Greenwich, Connecticut, 06830
Hadden, J.W., Englard, A., Sadlik, J.R., and Hadden, E.M. (1979). The comparative effects of Isoprinosine, Levamisole, Muramyl Dipeptide, and SM-1213 on lymphocyte and macrophage proliferation and activation in vitro. Int. J. Immunopharmacol., 1, 17
Goldlust, M. G., Rich, L. C., and Brown, W. R. (1978). Immune synovitis in rabbits: Effects of differing schedules for intra-articular challenge with antigen. Am. J. Pathol., 91, 329
di Rosa, M., Papadimitriou, J. M., Willoughby, D. A. (1971). A histopathological and pharmacological analysis of the mode of action of nonsteroidal anti-inflammatory drugs. J. Pathol., 105, 239
Pearson, C. M. and Wood, F. E. (1959). Studies of polyarthritis and other lesions induced in rats by injection of Mycobacterial adjuvant. I. General clinical and pathologic characteristics and some modifying factors. Arthritis Rheum., 2, 440
Palmer, R. M. J., Salmon, J. A., Narumiya, S., Higgs, G. A., and Eakins, K. E.(1980). Arachadonic acid metabolism by lipoxygenase in leukocytes of different species and the chemo-kinetic activity of some products. This Volume, Chap. 35
Michelson, A.M. (1974). Is singlet oxygen a substrate for superoxide dismutase? No. FEBS Lett. 44, 97
Ferreira, S. H. and Vane, J. R. (1979). Mode of action of anti-inflammatory agents which are prostaglandin synthetase inhibitors. In Vane, J. R. and Ferreira, S.H. (eds.) Antiinflammatory Drugs. Vol. 50/11, Chap. 31, p. 348. Berlin: Springer-Verlag
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 MTP Press Limited
About this chapter
Cite this chapter
Gordon, P. (1980). Anti-inflammatory actions of an immunomodulator: therafectin 1,2-O-isopropylidene-3-O-3′-(N’, N’-dimethylamino n-propyl)-D-gluco-furanose, HCl. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_20
Download citation
DOI: https://doi.org/10.1007/978-94-010-9423-8_20
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-9425-2
Online ISBN: 978-94-010-9423-8
eBook Packages: Springer Book Archive