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Influence of colchicine derivatives on lysosomal enzyme release from polymorphonuclear leukocytes and intracellular levels of cAMP after phagocytosis of monosodium urate crystals

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Inflammation: Mechanisms and Treatment

Part of the book series: Inflammation: Mechanisms and Treatment ((FTIN,volume 4))

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Abstract

Colchicine and its analogues belong to the group of microtubular inhibitors1. Microtubules are involved in the transport of extracellular material wrapped in vesicles towards lysosomes. Drug-induced tubulostasis may lead to reduced digestion of phagocytozed material and could prevent metabolic transformation of this material. These events possibly play a role in the inhibition of the generation of inflammatory mediators2. Colchicine does not stabilize isolated lysosomes3 and so its primary action on polymorphonuclear functions (release of lysosomal enzymes and chemotactic factors, motility etc.) is possibly mediated through its anti-microtubular activity4.

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Authors and Affiliations

  1. Czechoslovakia

    Daniela Mikulíková & Karel Trnavský

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  1. Daniela Mikulíková
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  2. Karel Trnavský
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Editors and Affiliations

  1. Department of Experimental Pathology and Rheumatology, St Bartholomew’s Hospital, London, UK

    D. A. Willoughby (Professor) (Professor)

  2. Department of Pharmacology, Hôpital Cochin, Paris, France

    J. P. Giroud (Professor) (Professor)

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© 1980 MTP Press Limited

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Mikulíková, D., Trnavský, K. (1980). Influence of colchicine derivatives on lysosomal enzyme release from polymorphonuclear leukocytes and intracellular levels of cAMP after phagocytosis of monosodium urate crystals. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_118

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  • DOI: https://doi.org/10.1007/978-94-010-9423-8_118

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9425-2

  • Online ISBN: 978-94-010-9423-8

  • eBook Packages: Springer Book Archive

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