Abstract
The brain-gastrointestinal tridecapeptide neurotensin (NT) has been shown to affect the contractility of a variety of gastrointestinal smooth muscle preparations in vitro [1]. In particular, it has been reported that NT contracts rat fundus smooth muscle strips [2]. Rharmacological experiments and structure activity studies have suggested that this effect was myogenic in nature and involved an interaction of NT with specific smooth muscle receptors [3]. In the present paper we provide direct evidence for the existence of such receptors from radioligand binding studies using 125I-Trp11-NT as the labelled ligand and highly purified rat fundus smooth muscle plasma membranes at the source of NT receptors.
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References
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Kitabgi, P., Kwan, CY., Fox, J.E.T. (1984). Characterization of 125I-Trp11-Neurotensin Binding to Rat Fundus Smooth Muscle Plasma Membranes. In: Roman, C. (eds) Gastrointestinal Motility. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9352-1_87
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DOI: https://doi.org/10.1007/978-94-010-9352-1_87
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-9354-5
Online ISBN: 978-94-010-9352-1
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