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The Mechanism of Action of Pentagastrin on Circular Muscle from Canine Gastric Corpus

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Gastrointestinal Motility
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Abstract

Gut peptides and neurotransmitters induce contraction of gastrointestinal smooth muscle by interacting with specific receptors. Occupation of these receptors produces an increase in the concentration of cellular calcium, resulting in contraction of the smooth muscle cell (1). However, in most instances the mechanisms underlying peptide-induced contraction of gastrointestinal smooth muscle are poorly understood.

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References

  1. Bolton, T. B. (1974). Mechanisms of action of transmitters and other substances on smooth muscle. Physiol.Rev. 59, 606–718

    Google Scholar 

  2. Gabella, G. (1979). Smooth muscle cell junctions and structural aspects of contraction. Br.Med.Bull. 35, 213–218

    PubMed  CAS  Google Scholar 

  3. Collins, S. M. and Gardner, J.D. (1982). Cholecystokinin-induced contraction of dispersed smooth muscle cells. Am.J.Physiol. 243, G497 - G504

    PubMed  CAS  Google Scholar 

  4. Bitar, K. N., Zfass, A. M. and Makhlouf, G.M. (1979). Interaction of acetylcholine and cholecystokinin with dispersed smooth muscle cells. Am.J.Physiol. 237, E172 - E176

    PubMed  CAS  Google Scholar 

  5. Hahne, W. H., Jensen, R. T., Lemp, G. F. and Gardner, J.D. (1981). Proglumide and benzotript:members of a new class of cholecystokinin receptor antagonists. Proc.Natl.Acad.Sci. USA, 78, 6304–6308

    Article  PubMed  CAS  Google Scholar 

  6. Daniel, E. E., Crankshaw, D. and Kwan, C.Y. (1979). Intracellular sources of calcium for activation of smooth muscle. In:Kalsner, S. (ed). Trends in Autonomic Pharmacology. PP 443–484. ( Urban and Schwarzenberg Inc. Germany )

    Google Scholar 

  7. Triggle, D. J. and Swamy, C. F. (1980). Pharmacology of agents that affect calcium:agonists and antagonists. Chest 78 Suppl., 174–179

    Google Scholar 

  8. Morgan, K. G. and Szurszewski, J. H. (1980). Mechanisms of phasic and tonic actions of pentagastrin on canine gastric smooth muscle. J.Physiol. 301, 229–242

    PubMed  CAS  Google Scholar 

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© 1984 MTP Press Limited

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Collins, S.M. (1984). The Mechanism of Action of Pentagastrin on Circular Muscle from Canine Gastric Corpus. In: Roman, C. (eds) Gastrointestinal Motility. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9352-1_83

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  • DOI: https://doi.org/10.1007/978-94-010-9352-1_83

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9354-5

  • Online ISBN: 978-94-010-9352-1

  • eBook Packages: Springer Book Archive

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