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Tissue hypoxia

  • Chapter
Applied Physiology in Clinical Respiratory Care

Part of the book series: Developments in Critical Care Medicine and Anaesthesiology ((DCCA,volume 1))

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Abstract

The overall adverse effects of tissue hypoxia are determined by the degree of fall in oxygen delivery to tissue and the complex changes that occur both in the tissue and in the microcirculation that supplies the tissue. The latter can be considered an adaptation to hypoxia. In this chapter, we will consider the biochemistry and physiology of tissue hypoxia and adaptation mechanisms.

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References

  1. Acker H: The meaning of tissue PO2 and local blood flow for the chemoreceptive process of the carotid body. Fed Proc 39: 2641–2647, 1980.

    CAS  PubMed  Google Scholar 

  2. Acker H, Pietruschka: Meaning of the type I cell for the chemorecptive process. An electrophysiological study on cultured type I cells of the carotid body. In: Acker H, Fidone S, Pallot D, Eyzaquirre C, Lubbers D, Torrence RW (eds) Chemoreceptions in the carotid body. New York: Springer-Verlag, 1977, pp 9–98.

    Google Scholar 

  3. Atkinson DE: Adenine nucleotides as stoichiometric coupling agents in metabolism and as regulatory modifiers. In: Vogel HJ (ed) Metabolic pathways. New York: Academic Press, 1971, pp 1–21.

    Google Scholar 

  4. Bachelard HS, Lewis LD, Monten U, Siesjö BK: Mechanisms activating glycolysis in the brain in arterial hypoxia. J Neurochem 22: 395–401, 1974.

    CAS  PubMed  Google Scholar 

  5. Bushford CL, Barlow CH, Chance B, Haselgrove J: The oxidation-reduction state of cytochrome oxidase in freeze-trapped gerbil brains. FEBS Lett 113: 78–80, 1980.

    Google Scholar 

  6. Berglund L, Hamble E: Kinetic properties of pig pyruvate kinases type A from kidney and type M from muscle. Arch Biol Chem Biophys 195: 347–361, 1979.

    CAS  Google Scholar 

  7. Berne RM: The role of adenosine in the regulation of coronary blood flow. Circ Res 47:807– 313, 1980.

    CAS  PubMed  Google Scholar 

  8. Berne RM, Foley DH, Watkinson WP, Miller WL, Winn HR, Rubio R: Role of adenosine as a mediator of metabolic vasodilation in the heart and brain: a brief overview and update. Physiological and regulatory functions of adenosine and adenine nucleotides. In: Baer HP, Drummond GI (eds) New York: Raven, 1979, pp 117–126.

    Google Scholar 

  9. Bloxham DP, Lardy HA: Phophofructokinase. In: Boyer PD (ed) The enzymes, 3rd edn, vol 8, part A. New York: Academic Press, 1973, pp 239–278.

    Google Scholar 

  10. Bourdeau-Martini J, Honig CR: Control of coronary intercapillary distance: effect of arterial PCO2 and pH. Microvasc Res 6: 286–296, 1973.

    CAS  PubMed  Google Scholar 

  11. Bourdeau-Martini J, Odoroff CL, Honig CR: Dual effect of oxygen on magnitude and uniformity of coronary intercapillary distance. Am J Physiol 226: 800–810, 1974.

    CAS  PubMed  Google Scholar 

  12. Burger RM, Lowenstein JM: 5 nucleotidase from smooth muscle of small intestine and from brain, inhibition by nucleotides. Biochemistry 14: 2362–2366, 1975.

    Google Scholar 

  13. Burt CT, Cohen SM, Barany M: Analysis of intact tissue with 31 P NMR. Annu Rev Biophys Bioenerg 8: 1–25, 1979.

    CAS  Google Scholar 

  14. Burt TC, Glonek T, Barany M: Analysis of phosphate metabolites, the intracellular pH, and the state of adenosine triphosphate in intact muscle by phosphorus nuclear magnetic resonance. J Biol Chem 251: 2584–2591, 1976.

    CAS  PubMed  Google Scholar 

  15. Chance B: Molecular basis of O2 affinity for cytochrome oxidase. In: Jobsis FF (ed) Oxygen and physiological function. Dallas: Professional Information Library, 1976, pp 14–15.

    Google Scholar 

  16. Chance B: Pyridine nucleotide as an indicator of the oxygen requirements for energy-linked functions of mitochondria. Circ Res [Suppl1] 38: 131–138, 1976.

    Google Scholar 

  17. Chance B, Barlow C, Nakase Y, Takeda H, Mayevsky A, Fischetti R, Graham N, Sorge J: Heterogeneity of oxygen delivery in normoxic and hypoxic states: a fluorometer study. Am J Physiol 235: H809–H820, 1978.

    CAS  PubMed  Google Scholar 

  18. Chance B, Haselgrove J, Barlow C: Redox gradients in oxygen delivery to tissue. Adv Physiol Sci 25: 13–17, 1981.

    CAS  Google Scholar 

  19. Chance B, Maitra PK: Determination of the intracellular phosphate potential of ascites cells by reversed electron transfer. In: Wright B (ed) Control mechanisms in respiration and Fermentation. Ronald Press, 1963, pp 307–332.

    Google Scholar 

  20. Chance B, Oshnio N, Sugano T, Mayevsky A: Basic principles of tissue oxygen determination from mitochondrial signals. In: Bicher HI, Bruley DF (eds) Oxygen transport to tissue-I. New York: Plenum, 1974, pp 277–292.

    Google Scholar 

  21. Chance B, Quistorff B: Study of tissue oxygen gradients by single and multiple indicators. In: Silver IA, Erecinska M, Bicher HI (eds) Oxygen transport to tissue-III. New York: Plenum, 1978, pp 331–338.

    Google Scholar 

  22. Chance B, Saronio C, Leigh JS: Functional intermediates in the reaction of membrane-bound cytochrome oxidase with oxygen. J Biol Chem 250: 9226–9237, 1975.

    CAS  PubMed  Google Scholar 

  23. Chance B, Schoener B, Oshino R, Itshak F, Nakase Y: Oxidation-reduction ratio studies of mitochondria in freeze-trapped samples. J Biol Chem 254: 4764–4771, 1979.

    CAS  PubMed  Google Scholar 

  24. Chance B, Williams GR: The respiratory chain and oxidative phosphorylation. Adv Enzymol 17: 65–134, 1956.

    CAS  Google Scholar 

  25. Clark BJ, Coburn RF: Mean myoglobin PO2 during exercise and at maximal oxygen uptake. J Appl Physiol 39: 135–144, 1975.

    CAS  PubMed  Google Scholar 

  26. Cobbold A, Folkow B, Kjellmer I, Mellander S: Nervous and local cherqical control of precapillary sphincters in skeletal muscle as measured by changes in filtration coefficient. Acta Physiol Scand 57: 180–192, 1963.

    CAS  PubMed  Google Scholar 

  27. Coburn RF, Forman HJ: Carbon monoxide hypoxia. In: Handbook of respiration. Bethesda: American Physiological Society, (in press) 1982.

    Google Scholar 

  28. Coburn RF, Grubb B, Aronson RD: Effect of cyanide on oxygen tension-dependent mechanical tension in rabbit aorta. Circ Res 44: 368 – 378, 1979.

    CAS  PubMed  Google Scholar 

  29. Coburn RF, Mayers LB: Myoglobin O2 tension determined from measurement of carboxy- myoglobin in skeletal muscle. Am J Physiol 220: 66–74, 1971.

    CAS  PubMed  Google Scholar 

  30. Coburn RF, Pendleton M: Effects of norepinephrine on oxygenation of resting skeletal muscle. Am J Physiol 5: H307–313, 1979.

    Google Scholar 

  31. Coburn RF, Ploegmakers, Gondrie P, Abboud R: Myocardial myoglobin oxygen tension. Am J Physiol 224: 870–876, 1973.

    CAS  PubMed  Google Scholar 

  32. Crisp DM, Pogson CI: Glycolytic and gluconeogenic enzyme activities in parenchymal and nonparenchymal cells from mouse liver. Biochem J 126: 1009–1023, 1972.

    CAS  PubMed  Google Scholar 

  33. Davis JM: Synaptosomal tyrosine hydroxylation. Affinity for oxygen. J Neurochem 28:1043 -1050, 1977.

    Google Scholar 

  34. Davis JM, Carlson A: The effect of hypoxia on monoamine synthesis levels and metabolism in rat brain. J Neurochem 21: 783–790, 1973.

    CAS  PubMed  Google Scholar 

  35. Dawson MJ, Gadian DG, Wilkie DR: Mechanical relaxation rate and metabolism studied in fatiguing muscle by phosphorus nuclear magnetic resonance. J Physiol 299: 464–484, 1980.

    Google Scholar 

  36. De Haan EJ, Croot GSP, Scholte HR, Tager JM, Wit-Peeters EM: Biochemistry of muscle mitchondria. In: Bourne GH (ed) The structure and function of muscle, 2nd edn, vol 3. New York: Academic Press, 1973, pp 417–469.

    Google Scholar 

  37. Diwan JJ, Lehrer PH: Effects on mitochondrial K flux of pH, K concentration, and N-ethyl maleimide. Membr Biochem 1: 43–60, 1978.

    CAS  PubMed  Google Scholar 

  38. Dóra F, Chance B, Kovach AGB, Silver IA: Carbon monoxide-induced localized toxic anoxia in the brain cortex. J Appl Physiol 41: 480–488, 1976.

    Google Scholar 

  39. Duhm M: Effects of high altitude (arterial PO2) and displacements of the O2 dissociation curve of blood on peripheral oxygen extraction and PO2. In: Brendel W, Zink RA (eds) High altitude physiology and medicine. Topics in environmental physiology and medicine. Heidelberg: Springer, 1980.

    Google Scholar 

  40. Duran WN, Renkin EM: Oxygen consumption and blood flow in resting mammalian skeletal miscle. Am J Physiol 226: 173–177, 1974.

    CAS  PubMed  Google Scholar 

  41. Erecinska M, Stubbs M, Miyata Y, Ditre CM, Wilson DF: Regulation of cellular metabolism by intracellular phosphate. Biochem Biophys Acta 462: 20–35, 1977.

    CAS  PubMed  Google Scholar 

  42. Ernster L, Kuylensterna B: Outer membrane of mitochondria. In: Racker E (ed) Membrane of mitochondria and chloroplasts. New York: Van Nostrand Reinhold, 1970, pp 172–212.

    Google Scholar 

  43. Eyzaguirre C, Fidone SJ: Transduction mechanism in carotid body; glomus cells, putative neurotransmitters and nerve endings. Am J Physiol 239 [Cell Physiol 8]: C135–C152, 1980.

    CAS  PubMed  Google Scholar 

  44. Eyzaguirre C, Fitzgerald RS, Lahiri S, Zapata P: Arterial chemoreceptors. In: Handbook of respiration. Bethesda: American Physiological Society press, (in press) 1982.

    Google Scholar 

  45. Fay FS: Guinea pig ductus arteriosus. I. Cellular and metabolic basis for oxygen sensitivity. Am J Physiol 221: 470–479, 1971.

    CAS  PubMed  Google Scholar 

  46. Fay FS, Nair P, Whalen WJ: Mechanism of oxygen induced contraction of ductus arteriosus. In: Reivich M, Coburn RF, Lahiri S, Chance B (eds) Tissue hypoxia and ischemia. New York: Plenum, 1977, pp 123–134.

    Google Scholar 

  47. Fay FS, Jobsis FF: Guinea pig ductus arteriosus. III. Light absorption changes during response to O2. Am J Physiol 223: 588–595, 1972.

    CAS  PubMed  Google Scholar 

  48. Fini C, Minelli A, Floridi A, Ipata PL: Effect of nucleoside di- and triphosphates and MgCC2 on the activity of 5’ nucleotidase from bull seminal plasma. Experientia 31: 399–401, 1975.

    CAS  PubMed  Google Scholar 

  49. Fisher DB, Kaufman S: The inhibition of phenylalanine and tyrosine hydroxlases by high oxygen levels. J Neurochem 19: 1359–3165, 1972.

    CAS  PubMed  Google Scholar 

  50. Fitch CD, Chevli R, Jellinek M: Phosp ho creatine does not inhibit rabbit muscle phosphofru- ctokinase or pyruvate kinase. J Biol Chem 254: 11357–11359, 1979.

    CAS  PubMed  Google Scholar 

  51. Franke H, Barlow CH, Chance B: Fluorescence of pyridine nucleotide and flavoproteins as an indicator of substrate oxidation and oxygen demand of the isolated perfused rat kidney. J Biochem 12: 269–275, 1980.

    CAS  Google Scholar 

  52. Gadian DG, Hoult DI, Radda GK, Seeley PJ, Chance B, Barlow C: Phosphorus nuclear magnetic resonance studies on normoxic and ischemic cardiac tissue. Proc Natl Acad Sci USA 73: 4446–4448, 1976.

    CAS  PubMed  Google Scholar 

  53. Gayeski TEJ, Honig CR: Myoglobin saturation and calculated PO2 in single cells of resting gracilis muscles. Adv Exp Med Biol 94: 77–94, 1977.

    CAS  PubMed  Google Scholar 

  54. Ginsburg MD, Orela L, Wrobel-Kuhl K, Reivich M: Mitochondrial metabolism following bilateral cerebral ischemia in the gerbil. Ann Neurol 1: 519–527, 1977.

    Google Scholar 

  55. Gonzalez CY, Kwok Y, Gibb J, Fidone S: Effects of hypoxia on tyrosine hydroxylase activity in rat carotid body. J Neurochem 33: 713–719, 1979.

    CAS  PubMed  Google Scholar 

  56. Granger HJ, Goodman AH, Granger DN: Role of resistance and exchange vessels in local microvascular control of skeletal muscle oxygenation in the dog. Circ Res 38: 379–385, 1976.

    CAS  PubMed  Google Scholar 

  57. Hellstrand P, Johansson B, Norberg K: Mechanical electrical and biochemical effects of hypoxia and substrate removal on spontaneously active vascular smooth muscle. Acta Physiol Scand 100: 69–83, 1977.

    CAS  PubMed  Google Scholar 

  58. Hempel FG, Jobsis FF, La Manna JL, Rosenthal MR, Saltzman HA: Oxidation of cerebral cytochrome aa3 by oxygen plus carbon dioxide at hyperbaric pressures. J Appl Physiol (Respir Environ Exerc Physiol) 43: 873–879, 1977.

    CAS  Google Scholar 

  59. Henderson J: Regulation of adenosine metabolism. In: Bauer HP, Drummond GI (eds) Physiological and regulatory functions of adenosine and adenine nucleotides. New York: Raven, 1979, pp 315–322.

    Google Scholar 

  60. Henquell L, Honig CR: Capillary spacing around coronary venules suggests that diffusion distance is controlled by local tissue PO2. Microvasc Res 15: 363–366, 1978.

    CAS  PubMed  Google Scholar 

  61. Hossman KA, Keilhues P: Reversibility of ischemic brain damage. Arch Neurol 29: 375–384, 1975.

    Google Scholar 

  62. Itoh R, Usami C, Nishino T, Tsushima K: Kinetic properties of cytosol 5’ nucleotidase from chicken liver. Biochem Biophys Acta 526: 154–162, 1978.

    CAS  PubMed  Google Scholar 

  63. Jobsis FF: What is a molecular oxygen sensor? What is a transduction process? In: Reivich M, Coburn R, Lahiri S, Chance B (eds) Hypoxia and ischemia. New York: Plenum, 1977, pp 3–18.

    Google Scholar 

  64. Jobsis FF, Keizer JH, La Manna JC, Rosenthal M: Reflective spectrophotometry of cytochrome aa3 in vivo. J Appl Physiol (Respir Environ Exerc Physiol) 43: 858–872, 1977.

    CAS  Google Scholar 

  65. Johannsson H, Siesjo BK: Cerebral blood flow and oxygen consumption in the rat in hypoxic hypoxia. Acta Physiol Scand 93: 269–276, 1975.

    CAS  PubMed  Google Scholar 

  66. Jones DP, Mason HS: Gradients of O2 concentration in hepatocytes. J BiolChem 253:4874 -4880,1978.

    Google Scholar 

  67. Kety SS: Determinants of tissue oxygen tension. Fed Proc 16: 666–670, 1953.

    Google Scholar 

  68. Kleinert HD, Scales JL, Weiss HR: Effects of carbon monoxide or low oxygen gas mixture inhalation cn regional oxygenation, blood flow, and small vessel blood content of the rabbit heart. Pfluegers Arch Eur J Physiol 383: 105–111, 1980.

    CAS  Google Scholar 

  69. Kessler M, Hoper J, Lubbers DW, Ti S: Local factors affecting regulation of microflow, O2 uptake and energy metabolism. Adv Physiol Sci 25: 155–162, 1981.

    CAS  Google Scholar 

  70. Kontos HA, Wei EP, Raper AJ, Rosenblum WI, Navari RM, Patterson JLJr: Role of tissue hypoxia in local regulation of cerebral microcirculation. Am J Physiol 234: H582–H591, 1978.

    Google Scholar 

  71. Krogh A: The anatomy and physiology of capillaries. New York: Hafner, 1959.

    Google Scholar 

  72. Kovach AGB, Dora E: Redox state and vascular volume changes in the cat brain cortex during CBF autoregulation. Adv Physiol Sci 25: 145–154, 1981.

    CAS  Google Scholar 

  73. Krebs HA: The Pasteur effect and the relations between respiration and fermentation. Essays Biochem 8: 1–34, 1972.

    CAS  PubMed  Google Scholar 

  74. Lahiri S, Mulligan E, Nishino T, Mokashi A, Davies RO: Relative responses of aortic body and carotid body chemoreceptors to carboxyhemoglobinemia. J Appl Physiol 50: 580–586, 1981.

    CAS  PubMed  Google Scholar 

  75. LaNone KF, Bryla J, Bassett DJP: Energy-driven aspartate efflux from heart and liver mitochondria. J Biol Chem 249: 7514–7521, 1974.

    Google Scholar 

  76. Land JM, Booth RFG, Berger R, Clark JB: Development of mitochondrial energy metabolism in rat brain. Biochem J 164: 339–348, 1977.

    CAS  PubMed  Google Scholar 

  77. Lardy HA, Tonsky PW, Johnson D: Antibiotics as tools for metabolic studies. IV. Comparative effectiveness of oligomycin A, B, and C and ratomycin as inhibitors of phosphoryl transfer reactions in mitochondria. Biochemistry 4: 552–560, 1965.

    CAS  PubMed  Google Scholar 

  78. Lipmann F: Metabolic generation and utilization of phosphate bond energy. Adv Enzymol 1: 99–162, 1941.

    CAS  Google Scholar 

  79. Martini J, Honig CR: Direct measurement of intercapillary distance in beating rat heart in situ under various conditions of O2 supply. Microvasc Res 1: 244–256, 1969.

    CAS  PubMed  Google Scholar 

  80. McLaughlin AC, Takeda H, Chance B: Rapid ATP assays in perfused mouse liver by 31P NMR. Proc Natl Sci USA 76: 5445–5449, 1979.

    CAS  Google Scholar 

  81. Mela L: Mechanism and physiological significance of calcium transport across mammalian mitochondrial membranes. Curr Top Memb Trans 9: 321–366, 1979.

    Google Scholar 

  82. Mela L, Goodwin CW, Miller LD: In vivo control of mitochondrial concentrations and activity by oxygen. Am J Physiol 231: 1811–1816, 1976.

    CAS  PubMed  Google Scholar 

  83. Mela L, Goodwin CW, Miller LD: Correlation of mitochondrial cytochrome concentration and activity to oxygen availability in the newborn. Biochem Biophys Res Commun 64: 384–390, 1975.

    CAS  PubMed  Google Scholar 

  84. Mela L: Mitochondrial function in cerebral ischemia and hypoxia. Comparison of inhibitory and adaptive responses. Neurol Res 1: 51–63, 1979.

    CAS  PubMed  Google Scholar 

  85. Mills E, Jöbsis FF: Mitochondrial respiratory chain of carotid body and chemoreceptor response to changes in oxygen tension. J Neurophysiol 35: 405–428, 1972.

    CAS  PubMed  Google Scholar 

  86. Mulligan E, Lahiri S, Storey BT: Carotid body O2 chemoreception and mitochondrial oxidative phosphorylation. J Appl Physiol (Respir Environ Exerc Physiol) 51: 438–446, 1981.

    CAS  Google Scholar 

  87. Myers WW, Honig CR: Number and distribution of capillaries as determinants of myocardial oxygen tension. Am J Physiol 207: 653–660, 1964.

    CAS  PubMed  Google Scholar 

  88. Nayler WG, Poole-Wilson PA, Williams A: Hypoxia and calcium. J MolCell Cardiol 11:683– 706, 1979.

    Google Scholar 

  89. Needleman P, Key SL, Isakson PC, Kulkarni PS: Relationship between oxygen tension, coronary vasodilation and prostaglandin biosynthesis in the isolated rabbit heart. Prostaglandins 9: 123–134, 1975.

    CAS  PubMed  Google Scholar 

  90. Newby AC: Role of adenosine deaminase, ecto-(5″ nucleotidase) and ecto- (non-specific phosphatase) in cyanide-induced adenosine monophosphate catabolism in rat polymorphonuclear leucocytes. Biochem J 186: 907–918, 1980.

    CAS  PubMed  Google Scholar 

  91. Newby-Schmidt B, Roberts RJ, Bhatnager RK: Regional effects of carbon monoxide and hypoxia on catecholamines in the rat brain. Neurotoxicology 1: 533–540, 1980.

    CAS  Google Scholar 

  92. Nischiki K, Erecinska M, Wilson DF: Effect of amytal on metabolism of perfused rat heart: relationship between glycolysis and oxidative phosphorylation. Am J Physiol 237:C221- C230, 1979.

    Google Scholar 

  93. Nishiki K, Erecinska M, Wilson DF: Energy relationships between cytosolic metabolism and mitochondrial respiration in rat heart. Am J Physiol 234: C73–C81, 1978.

    CAS  PubMed  Google Scholar 

  94. Nishiki K, Erecinska M, Wilson DF, Cooper S: Evaluation of oxidative phosphorylation in hearts from euthyroid, hypothyroid, and hyperthyroid rats. Am J Physiol 235:C212- C219, 1978.

    Google Scholar 

  95. Norberg K, Siesjo BK: Cerebral metabolism in hypoxia. I. Pattern of activation of glycolysis: a re-evaluation. Brain Res 86: 31–44, 1975.

    CAS  PubMed  Google Scholar 

  96. Nordstron CH, Rehncrona S, Siesjo BK: Reconstitution of cerebral energy state after complete and incomplete ischemica of 30 min. duration. Acta Physiol Scand 97: 270–272, 1976.

    Google Scholar 

  97. 95.0ntko JA: Genesis of liver mitochondria in the neonatal rat. Life Sci 5: 817–825, 1966.

    Google Scholar 

  98. Oshino N, Jamieson D, Chance B: The properties of hydrogen peroxide production under hyperbaric and hypoxia conditions of perfused rat liver. Biochem J 146: 53–60, 1975.

    CAS  PubMed  Google Scholar 

  99. Oshino N, Sugano T, Oshino R, Chance B: The redox behavior of mitochondrial cytochrome oxidase during aerobioanaerobic transition and its relation to ATP hydrolysis. Biochim Biophys Acta 14: 201–214, 1974.

    Google Scholar 

  100. Park CD, Mela R, Wharton R, Reilly J, Fishbein P, Aberdeen E: Cardiac mitochondrial activity in acute and chronic cyanosis. J Surg Res 14: 139–146, 1973.

    CAS  PubMed  Google Scholar 

  101. Pilkis SJ, El-Maghrabi MR, Pilkis J, Claus TH, Cumming DA: Fructose 2, 6-biphosphate. A new activator of phosphofructokinase. J Biol Chem 256: 3171–3174, 1981.

    CAS  PubMed  Google Scholar 

  102. Pilkis SJ, El-Maghrabi MR, Pilkis J, Claus T: Inhibition of fructose 1, 6-biphosphatase by fructose 2, 6-biphosphate. J BiolChem 256: 3619–3622, 1981.

    CAS  PubMed  Google Scholar 

  103. Pittman RN, Quinn JV: A physicochemical model of adenosine’s role in hypoxic relaxation of isolated vascular smooth muscle. Microvasc Res 17: S37, 1979.

    Google Scholar 

  104. Podgorski GT, Longmuir IS, Knopp JA, Benson DM: Use of an encapsulated fluorescent probe to measure intracellular PO2. J Cell Physiol 107: 329–333, 1981.

    CAS  PubMed  Google Scholar 

  105. Poel WE: Effect of anoxic anoxia on myoglobin concentration in striated muscle. Am J Physiol 156: 44–51, 1949.

    CAS  PubMed  Google Scholar 

  106. Quistorff B, Chance B: Two and three dimensional analysis on brain oxygen delivery. In: Jobsis FF (ed) Oxygen and physiological function. Dallas: Professional Information Library, 1976, pp 100–110.

    Google Scholar 

  107. Rehncrona S, Mela L, Chance B: Cerebral energy state, mitochondrial function, and redox state measurements in transient ischemia. Fed Proc 38: 2489–2492, 1979.

    CAS  PubMed  Google Scholar 

  108. Rehncrona S, Mela L, Siesjo BK: Recovery of brain mitochondrial function in the rat after complete and incomplete cerebral ischemia. Stroke 10: 437–446, 1979.

    CAS  PubMed  Google Scholar 

  109. Renkin EM, Rosell S: The influence of sympathetic adrenergic vasoconstrictor nerves on transport of diffusible solute from blood to tissues in skeletal muscle. Acta Physiol Scand 54: 223–240, 1962.

    CAS  PubMed  Google Scholar 

  110. Riggs TE, Shafer AW, Guenther CA: Acute changes in oxyhemoglobin affinity: effect on oxygen transport and utilization. J Clin Invest 52:2660- 2663, 1973.

    Google Scholar 

  111. Roulet MJ, Coburn RF: Oxygen-induced contraction in the guinea pig neonatal ductus arteriosus. Circ Res 49: 897–1002, 1981.

    Google Scholar 

  112. Rubio R, Belardinelli L, Thompson CI, Berne RM: Cardiac adenosine: electrophysiological effects, possible significance in cell function and mechanisms controlling its release. In: Bauer HP, Drummond GI (eds) Physiological and regulatory functions of adenosine and adenine nucleotides. New York: Raven, 1979, pp 167–182.

    Google Scholar 

  113. Rubio R, Berne RM: Release of adenosine by the normal myocardium in dogs and its relationship to the regulation of coronary resistance. Circ Res 225: 407–415, 1969.

    Google Scholar 

  114. Rubio R, Berne RM, Dobson JG Jr: Sites of adenosine production in cardiac and skeletal muscle. Am J Physiol 225: 938–958, 1973.

    CAS  PubMed  Google Scholar 

  115. Rubio R, Wiedmeier VT, Berne RM: Relationship between coronary flow and adenosine production and release. J Mol Cell Cardiol 6: 561–566, 1974.

    CAS  PubMed  Google Scholar 

  116. Scarpa A, Brinley FJ: In situ measurements of free cytosolic magnesium ions. Fed Proc 40: 2626–2652, 1981.

    Google Scholar 

  117. Schrader J, Schutz W: Sites of adenosine production in the hypoxic heart. Fed Proc 38: 1037, 1979.

    Google Scholar 

  118. Schultz JS, Goddard JD, Suchdeo SR: Facilitated transport via carrier-mediated diffusion in membranes. Part I. Mechanistic aspects, experimental systems and characteristic regimes. A I Chi J 20: 417–445, 1974.

    CAS  Google Scholar 

  119. Shepherd AP: Intestinal O2 consumption and 86Rb extraction during arterial hypoxia. Am J Physiol 234: E248–E251, 1978.

    CAS  PubMed  Google Scholar 

  120. Sies H: Peroxisomal enzymes and oxygen metabolism in liver. In: Reivich M. Coburn R, Lahiri S, Chance B (eds) Tissue hypoxia and ischemia. New York: Plenum, 1977, pp 51–66.

    Google Scholar 

  121. Sies H: Oxygen gradients during hypoxic steady states in liver. Urate oxidase and cytochrome oxidase as intracellular O2 indicators. Hoppe Seylers Z Physiol Chem 358:1O21-1032, 1977.

    Google Scholar 

  122. Sies H: Cytochrome oxidase and urate oxidase as intracellular O2 indicators in studies of O2 gradients during hypoxia in liver. In: Silver IA, Erecinska M, Bicher HI (eds) Oxygen transport to tissue -III. New York: Plenum, 1978, pp 561–566.

    Google Scholar 

  123. Siesjo BK: Brain energy metabolism. New York: John Wiley and Sons, 1978.

    Google Scholar 

  124. Siliprandi N, Rugolo M, Siliprandi D, Toninello A, Zoccarato F: Interaction between calcium and phosphate eyeing in rat liver mitochondria and related cation movements. In: Quagliariello E (ed) Function and molecular aspects of biomembrane transport. Amsterdam: Elsevier/ North Holland, 1979, pp 147–155.

    Google Scholar 

  125. Siliprandi N, Rugolo M, Siliprandi D, Toninello A, Zoccarato F: Induction of Mg2+ efflux and Ca2+ cycling in rat liver mitochondria by inorganic phosphate and oxidizing agents. In: Lee CP, Schatz G, Ernster L, Membrane bioenergetics. Reading MA: Addison-Wesley, 1979, pp 533–545.

    Google Scholar 

  126. Sillau AH, Banchero N: Effect of hypoxia on the capillarity of guinea pig skeletal muscle. Proc Soc Exp Biol Med 160: 368–373, 1979.

    CAS  PubMed  Google Scholar 

  127. Simon LM, Robin ED, Phillips JR, Acevedo J, Axline SG, Theodore J: Enzymatic basis for bioenergetic differences of alveolar versus peritoneal macrophages and enzyme regulation by molecular O2. J Clin Invest 50: 443–448, 1977.

    Google Scholar 

  128. Simon M, Robin ED, Raffin R, Theodore J, Douglass WHJ: Bioenergetic pattern of isolated type II pneumocytes in air and during hypoxia. J Clin Invest 61: 1232–1239, 1978.

    CAS  PubMed Central  PubMed  Google Scholar 

  129. Slater EC: Application of inhibitors and uncouplers for a study of oxidative phosphorylation. Methods Enzymol 10: 48–57, 1967.

    CAS  Google Scholar 

  130. Smith HE, Paige E: Ultrastructural changes in rabbit heart mitochondria during the perinatal period. Neonatal transition to aerobic metabolism. Dev Biol 57: 109–117, 1977.

    CAS  PubMed  Google Scholar 

  131. Somlyo AP, Somlyo AV: Effects and subcellular distribution of magnesium in smooth and striated muscle. Fed Proc 40: 2667–2671, 1981.

    CAS  PubMed  Google Scholar 

  132. Srere AJ, Brister NW, Anthony A: Microsphere measurement of myocardial capillary bed in hypoxic rats. Experientia 36: 842–843, 1980.

    Google Scholar 

  133. Stainsly WN, Otis AB: Blood flow, blood oxygen tension and O2 transport in skeletal muscle. Am J Physiol 206: 858–866, 1964.

    Google Scholar 

  134. Stalcup AS, Lipset JS, Woan JM, Leuenberger P, Mellins RB: Inhibition of angiotensin converting enzyme activity in cultured cells by hypoxia. J Clin Invest 63: 966–976, 1980.

    Google Scholar 

  135. Stanley KK, Edwards MR, Lubzio J: Subcellular distribution and movement of 5’ nucleotidase in rat cells. Biochem J 186: 59–69, 1980.

    CAS  PubMed  Google Scholar 

  136. Starlinger H, Lubbers DW: Oxygen consumption of the isolated carotid body tissue (cat). Pfluegers Arch 366: 61–66, 1976.

    CAS  Google Scholar 

  137. Steenbergen C, Deleeuw G, Barlow C, Chance B, Williamson JR: Heterogeneity of the hypoxic state in perfused rat heart. Circ Res 41: 606–615, 1977.

    CAS  PubMed  Google Scholar 

  138. Storey BT, Kayne FJ: Energy metabolism of spermatoza. V. The Emb den-Meyer ho f pathway of glycolysis: activities of pathway enzymes in hypotonically treated rabbit epididymal spermatozoa. Fertil Steril 26: 1257–1265, 1975.

    CAS  PubMed  Google Scholar 

  139. Stuart BH, Chance B: NADH brain surface scanning and 3-D computer display. Brain Res 76: 473–479, 1974.

    CAS  PubMed  Google Scholar 

  140. 138.Suchdeo SR, Goddard JD, Schultz JS: An analysis of the competitive diffusion of O2 and CO through hemoglobin solutions. Adv Exp Med Biol 37: 951–961, 1973.

    Google Scholar 

  141. 139.Sugano T, Oshino N, Chance B: Mitochondrial functions under hypoxic conditions. The steady states of cytochrome c reduction and of energy metabolism. Biochim Biophys Acta 347: 340–358, 1974.

    Google Scholar 

  142. Sullivan JM, AlpersJB: In vitro regulation of rat heart 5’ nucleotidase by adenine nucleotides and magnesium. J Biol Chem 246: 3057–3063, 1971.

    Google Scholar 

  143. Szadon P, Bairey N, Oparil S: Effect of acute hypoxia on pulmonary conversion of angiotensin I to angiotensin II in dogs. Circ Res 46: 221–226, 1980.

    Google Scholar 

  144. Tamura M, Oshino N, Chance B, Silver IA: Optical measurements of intracellular oxygen concentration of rat heart in vitro. Arch Biochem Biophys 191: 8–22, 1978.

    CAS  PubMed  Google Scholar 

  145. Tamura M, Oshino N, Chance B: The myoglobin probed optical studies of myocardial energy metabolism. In: Silver IA, Erecinska M, Bicher HI (eds) Oxygen transport to tissue -III. New York: Plenum, 1978, pp 561–566.

    Google Scholar 

  146. Thews G: Implications to physiology and pathology of oxygen diffusion at the capillary level. In: Schade JP, McMenemey WH (eds) Selective vulnerability of the brain in hypoxia. Oxford: Blackwell, 1963, pp 27–35.

    Google Scholar 

  147. Thews G: The theory of oxygen transport and its application to gaseous exchange in the lung. In: Lubbers DW, Luft EC, Thews G, Witzleb E (eds) Oxygen transport in blood and tissue. Stuttgart: Georg Thieme, 1968, pp 1–20.

    Google Scholar 

  148. Thomas MF, Penney DG: Hematologic responses to carbon monoxide and altitude: a comparative study. J Appl Physiol (Respir Environ Exercise Physiol) 43: 364–369, 1977.

    Google Scholar 

  149. Van Den Berghe G, Van Pottelsberghe C, Hers H: A kinetic study of the soluble 5’-nucleotidase of rat liver. Biochem J 162: 611–616, 1977.

    PubMed  Google Scholar 

  150. Van Shaftingen E, Jett M, Hue J, Hers HG: Control of liver 6-phosphofructokinase by fructose 2, 6-biphosphate and effectors. Proc Natl Acad Sci USA 78: 3483–3486, 1981.

    Google Scholar 

  151. Van Schaftingen E, Hers HG: Phosphofructokinase 2. The enzyme that forms fructase 2, 6-biphosphate from fructose 6-phosphate and ATP. Biochem Res Commun 101: 1078–1084, 1981.

    Google Scholar 

  152. Warshaw JB: Cellular energy metabolism during fetal development. IV Fatty acid activation, acyl transfer and fatty acid oxidation during development of the chick and the rat. Dev Biol 28: 537–544, 1972.

    Google Scholar 

  153. Weibel ER: Oxygen demand and the size of respiratory structures in mammals. In: Wood SC, Lenfant C (eds) Evolution of respiratory processes. A comparative approach. New York: Marcel Dekker, 1979, pp 289–340.

    Google Scholar 

  154. Whalen WJ, Nair P: Some factors affecting tissue PO2 in the carotid body. J Appl Physiol 39: 562–566, 1975.

    CAS  PubMed  Google Scholar 

  155. Whalen WJ, Buerk D, Thuning C, Kanoy BE Jr, Duran WN: Tissue PO2, VO2, venous PO2 and perfusion pressure in resting dog gracilis muscle perfused at constant flow. Adv Exp Med Biol 75: 639–653, 1977.

    Google Scholar 

  156. White RR, Mela L, Bacalzo LV, Olofsson K, Miller LD: Hepatic ultrastructure in endotoxemia, hemorrhage, and hypoxia: emphasis on mitochondrial changes. Surgery 73: 524–534, 1973.

    Google Scholar 

  157. Wilks SS, Tomashefski JF, Clark RT Jr: Physiological effects of chronic exposure monoxide. J Appl Physiol 14: 305–310, 1959.

    CAS  PubMed  Google Scholar 

  158. Williamson JR, Safer B, La None KF, Smith CM, Walatys E: Mitochondrial-cytosolic interactions in cardiac tissue: role of the malate-aspartate cycle in the removal of glycolytic NADH from the cytosol. In: Davies DD (ed) Proc Soc Exp Biol Symp no. 27. Cambridge: Cambridge University Press, 1973, pp 241–281.

    Google Scholar 

  159. Wilson DF, Owen C, Mela L, Wiener L: Control of mitochondrial respiration by the phosphate potential. Biochem Biophys Res Commun 53: 326–334.

    Google Scholar 

  160. Wittenberg BA, Wittenberg JB: Role of myoglobin in the oxygen supply to red skeletal muscle. J BiolChem 240: 9038–9043, 1975.

    Google Scholar 

  161. Wittenberg JB: Myoglobin facilitated diffusion: a role of myoglobin in O2 entry into muscle. Physiol Rev 50: 559–636, 1970.

    CAS  PubMed  Google Scholar 

  162. Wood JD, Watson WJ, Decker AJ: The effect of hypoxia on brain gamma aminobutyric acid levels. J Neurochem 15: 603–608, 1968.

    CAS  PubMed  Google Scholar 

  163. Wyman J: Facilitated diffusion and the possible role of myoglobin as a transport mechanism. J Biol Chem 241: 115–121, 1966.

    CAS  PubMed  Google Scholar 

  164. Zoccarato F, Rugolo M, Siliprandi D, Siliprandi N: Correlated effluxes of adenine nucleotides, Mg2+ and Ca2+ induced in rat-liver mitochondria induced by external Ca2+ and phosphate. Eur J Biochem 114: 195–199, 1981.

    CAS  PubMed  Google Scholar 

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Authors
  1. R. F. Coburn
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  2. B. T. Storey
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Editors and Affiliations

  1. Thorax Center, Academic Hospital Dijkzicht, Erasmus University, PO Box 1738, 3000 DR, Rotterdam, The Netherlands

    Omar Prakash M.D.

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Coburn, R.F., Storey, B.T. (1982). Tissue hypoxia. In: Prakash, O. (eds) Applied Physiology in Clinical Respiratory Care. Developments in Critical Care Medicine and Anaesthesiology, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7567-5_29

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  • DOI: https://doi.org/10.1007/978-94-009-7567-5_29

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