Abstract
Migraine is regarded as an episodic syndrome characterised by usually unilateral headache, nausea, vomiting and photophobia, sometimes preceded by certain premonitory aura symptoms. Despite a large number of investigations over the years, the multifactorial pathogenesis of migraine still remains ill understood. However, amongst a host of biogenic substances implicated in the pathophysiology of migraine, none seems to have a better claim than 5-hydroxytryptamine (5-HT) [1–6].
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References
Lance JW (1982): Mechanism and management of headache . London: Butterworth.
Anthony M (1987): Amine metabolism in migraine, pp. 303–329 in: Blau JN (ed), Migraine, Clinical, therapeutic, conceptual and research aspects . London: Chapman & Hall.
Richardson BP, Engel G, Buchheit K-H, Hoyer D, Kalkman H, Markstein R, Thomson C (1986): Defective serotonergic transmission: A possible cause of migraine and a basis for the efficacy of ergot compounds in the treatment of attacks, pp. 9–21 in: Lance JW (ed), Recent trends in the management of migraine . Aulendorf: Editio Cantor.
Fozard JR (1987): 5-HT: the enigma variations. Trends Pharmacol Sci 8: 501–506.
Saxena PR (1987): The arteriovenous anastomoses and veins in migraine research, pp. 581–596 in: Blau JN (ed), Migraine – Therapeutic, Conceptual and Research Aspects . Amsterdam: Elsevier.
Raskin NH (1988): Headache, 2nd Ed., New York: Churchill Livingstone.
Sicuteri F, Testi H, Anselmi B (1961): Biochemical investigations in headache: Increase in hydroxyindoleacetic acid excretion during migraine. Int. Arch Allergy 19: 55–58.
Curran DA, Hinterberger H, Lance JW (1965): Total plams serotonin, 5-hydroxyindole- acetic acid and p-hydroxy-m-methoxy-mandelic acid excretion in normal and migrainous subjects. Brain 88: 997–1010.
Curzon G, Theaker P, Phillips B (1966): Excretion of 5-hydroxyindoleacetic acid (5-HIAA) in migraine. J Neurol Neurosurg Psychiatry 32: 85–90.
Ferrari MD, Odink J, Tapparelli C, Van Kempen MJ, Pennings EJM, Bruyn GW (1989): Serotonin metabolism in migraine. Neurology 39: 1239–1242.
Somerville BW (1965): Platelet-bound and free serotonin levels in jugular and forearm venous blood during migraine. Neurology 26 : 41–45.
Tandon RN, Sur BK, Nath K (1969): Effect of reserpine injections in migrainous and normal control subjects, with estimations of urinary 5-hydroxyindole acetic acid. Neurology 19: 1073–1079.
Del Bene E, Anselmi B, Del Bianco PL, Fanciullacci M, Galli P, Salmon S, Sicuteri F (1977): Fenfluramine headache: a biochemical and monoamine receptorial human study, pp. 101–109 in: Sicuteri F (ed), Headache: New Vistas . Florence: Biomedical press.
Syvalahti E, Kangasniemi P, Ross B (1979): Migraine headache and blood serotonin levels after administration of zimelidine, a selective inhibitor of serotonin uptake. Curr ther Res 25: 299–310.
MacDonald RA (1956): A study of 356 carcinoids of the gastrointestinal tract. A report of four new cases of the carcinoid syndrome. Am J Med 21: 867–878.
Edvinsson L, Denguerce A, Duverger D, MacKenzie ET, Scatton B (1983): Central serotonergic nerves project to the pial vessels of the brain. Nature 306: 55–57.
Dhall U, Cowan T, Haven AJ, Burnstock G (1988): Effect of oestrogen and progesterone on noradrenergic nerves and on nerves showing serotonin-like immunoreactivity in the basilar artery of the rabbit. Brain Res 422: 335–339.
Owman C, Chang J-Y, Hardebo JE (1989): Presence of serotonin in adrenergic nerves of the brain circulation: its role in sympathetic neurotransmission and regulation of cerebral vessel wall. Ch. XVI, This book.
Bradley PB, Engel G, Feniuk W, Fozard JR, Humphrey PPA, Middlemiss DN, Mylecharane EJ, Richardson BP, Saxena PR (1986): Proposals for the classification and nomenclature of functional 5-hydroxytryptamine receptors. Neuropharmacology 25: 563–576.
Humphrey PPA, Feniuk W (1988): Pharmacological characterization of functional neuronal receptors for 5-hydroxytryptamine, pp. 3–19 in: Nobin A, Owman C, Arneklo- Nobin B (eds), Neuronal messengers in vascular function . Amsterdam: Elsevier Science Publication.
Saxena PR, Ferrari M (1989): 5-Hydroxytryptamine1-like receptor agonists and migraine: Possible impact on the pathophysiology of migraine. Trends Pharmacol Sci 10: 200–204.
Fozard JR (1989): 5-HT in migraine: Evidence from 5-HT receptor antagonists for a neuronal aetiology, In press, in: Sandler M (ed), Migraine . London: Oxford University Press.
Loisy C, Beorchia S, Centzone V, Fozard JR, Schechter PJ, Tell GP (1985): Effects on migraine headache of MDL 72222, an antagonist at neuronal 5-HT receptors. Double- blind, placebo-controlled study. Cephalalgia 5:79–82.
Humphrey PPA, Feniuk W, Perren MJ (1989): 5-HT in migraine: evidence with 5-HT1- like receptor agonists for a vascular aetiology, in press in: Sandler M (ed), Migraine . London: Oxford University Press.
Humphrey PPA, Apperley E, Feniuk W, Perren MJ (1989): A rational approach to identifying a fundamentally new drug in the treatment of migraine. Ch. XXXVII, This book.
Saxena PR, Bom AH, Verdouw PD (1989): Characterization of 5-hydroxytryptamine receptors in the cranial vasculature. Cephalalgia 9 (Suppl. 9): 15–22.
Saxena PR, Verdouw PD (1982): Redistribution by 5-hydroxytryptamine of carotid arterial blood at the expense of arteriovenous blood flow. J Physiol 332: 501–520.
Bom AH, Verdouw PD, Saxena PR (1989): Carotid haemodynamics in pigs during infusions of 8-OH-DPAT: Reduction in arteriovenous shunting is mediated by 5-hydroxytryptamine1-like receptors. Br J Pharmacol 96: 125–132.
Bom AH, Verdouw PD, Saxena PR (1989): Reduction of cephalic arteriovenous shunting by ergotamine is not mediated by 5-HT1-like or 5-HT2 receptors. Br J Pharmacol 97: 383–390.
Meyer JS, Hata T, Imai A (1987): Evidence supporting a vascular pathogenesis of migraine and cluster headache, pp. 265–302 in: Blau JN (ed), Migraine — Therapeutic, Conceptual and Research Aspects . Amsterdam: Elsevier.
Lauritzen M, Olesen J (1987): Leão’s spreading depression, pp. 387–402 in: Blau JN (ed), Migraine – Therapeutic, Conceptual and Research Aspects , Amsterdam: Elsevier.
Drummond PD, Lance JW (1983): Extracranial vascular changes and the source of pain in migraine headaches. Ann. Neurol 13: 32–37.
Heyck H (1969): Pathogenesis of migraine. Res. Clin. Stud. Headache 2: 1–28.
Sherman JL (1963): Normal arteriovenous anastomoses. Medicine 92: 247–267.
Rowbotham GF, Little E (1965): New concepts on the aetiology and vascularization of meningiomata; the mechanisms of migraine; the chemical process of the cerebrospinal fluid; and the formations of the collections of blood or fluid in the subdural space. Br J Surg 52: 21–24.
Rowbotham GF, Little E (1965): New concepts on the aetiology and vascularization of meningiomata; the mechanisms of migraine; the chemical process of the cerebrospinal fluid; and the formations of the collections of blood or fluid in the subdural space. Br J Surg 52: 21–24.
Brand J, Hadoke M, Perrin VL (1987): Placebo-controlled study of a selective 5-HT1- like agonist, AH25086B, in relief of acute migraine. Cephalalgia 1 (Suppl. 6): 402.
Doenicke A, Brand J, Perrin VL (1988): Possible benefit of GR43175, a novel 5-HT1- like receptor agonist, for the treatment of severe migraine. Lancet 1: 1309–1311.
Perrin VL, Färkkilä M, Goasguen J, Doenicke A, Brand J, Tfelt-Hansen P (1989): Overview of initial clinical studies with intravenous and oral GR43175 in acute migraine. Cephalalgia 9 (Suppl. 9): 63–72.
Perrin VL (1985): Clinical pharmacokinetics of ergotamine in migraine and cluster headache. Clin Pharmacokin 10: 334–352.
Lataste X (1988): 5-HT3 antagonists as antimigraine compounds. Abstract, Int. Congr., Cardiovascular Pharmacology of 5-HT , Oct 4–7, Amsterdam, p. 46.
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Saxena, P.R. (1990). 5-Hydroxytryptamine and migraine. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_36
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DOI: https://doi.org/10.1007/978-94-009-0479-8_36
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