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Altered responses to 5-hydroxytryptamine in hypertension and other cardiovascular disorders

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Cardiovascular Pharmacology of 5-Hydroxytryptamine

Abstract

5-Hydroxytryptamine (5-HT; serotonin) can either cause vasodilatation or vasoconstriction with resulting increases in blood flow and decreases in blood pressure or vice versa [1]. This complexity can be explained by the interaction of the monoamine with different receptors within the vascular wall. On the one hand, activation of endothelial receptors by 5-HT will cause the release of a short-lived vasodilatator substance (EDRF: endothelium derived relaxing factor) and activation of 5-HT receptors on the adrenergic nerve endings will result in a decreased liberation of noradrenaline [2–7]. The receptors involved in these actions of 5-HT leading to vasodilatation belong to the 5-HT1-like type [4, 7–9]. On the other hand, 5-HT can cause vasoconstriction by activation of 5-HT2 receptors on the vascular smooth muscle cells [10–12]. Whether a particular vascular bed will respond to 5-HT with a vasodilatation or a vasoconstriction will ultimately depend upon a balance between factors which determine which of the two receptor systems can play a dominating role. It is the aim of this chapter to specifically review the evidence of pathological changes favouring the 5-HT2 receptor mediated vasoconstriction.

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Authors
  1. J. M. Van Nueten
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  2. W. J. Janssens
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  3. P. A. J. Janssen
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  2. Department of Physiology, University of Wales, College of Cardiff, Cardiff, UK

    D. I. Wallis

  3. Department of Pharmacology, Duphar B.V, Weesp, The Netherlands

    W. Wouters  & P. Bevan  & 

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© 1990 Springer Science+Business Media Dordrecht

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Van Nueten, J.M., Janssens, W.J., Janssen, P.A.J. (1990). Altered responses to 5-hydroxytryptamine in hypertension and other cardiovascular disorders. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_23

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  • DOI: https://doi.org/10.1007/978-94-009-0479-8_23

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6701-0

  • Online ISBN: 978-94-009-0479-8

  • eBook Packages: Springer Book Archive

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