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The central antihypertensive action of 5-hydroxytryptamine: The location of site of action

  • Chapter
Cardiovascular Pharmacology of 5-Hydroxytryptamine

Abstract

A great number of studies indicate that 5-hydroxytryptamine (5-HT) acts as a neurotransmitter or neuromodulator at sites in the CNS. Fluorescence histochemical and immunohistochemical studies have shown that 5-HT containing neurones originating in the brainstem project to a number of forebrain structures as well as to specific regions of mid brain, hind brain and spinal cord [1–8]. Furthermore, electrophysiological investigations have demonstrated both inhibitory and excitatory effects of 5-HT on spinal and brainstem neurones (see reviews [9–11]). From the many studies cited in these reviews it is clear that 5-HT neurones project to regions of the CNS intimately involved in cardiovascular regulation and that 5-HT could have excitatory or inhibitory actions at these sites. Sites which are of particular interest are the preoptic/anterior hypothalamus, the ventrolateral medulla and the dorsal medulla.

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Authors
  1. J. H. Coote
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Editors and Affiliations

  1. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  2. Department of Physiology, University of Wales, College of Cardiff, Cardiff, UK

    D. I. Wallis

  3. Department of Pharmacology, Duphar B.V, Weesp, The Netherlands

    W. Wouters  & P. Bevan  & 

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Coote, J.H. (1990). The central antihypertensive action of 5-hydroxytryptamine: The location of site of action. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_19

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  • DOI: https://doi.org/10.1007/978-94-009-0479-8_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6701-0

  • Online ISBN: 978-94-009-0479-8

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