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Central neuronal responses and 5-hydroxytryptamine receptors

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Cardiovascular Pharmacology of 5-Hydroxytryptamine

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Abstract

Most evidence for a role of 5-hydroxytryptamine (5-HT) in hypertension points to an action on the blood vessel wall [1] but many compounds acting on 5-HT receptors also penetrate the blood-brain barrier and central neuronal receptors to 5-HT significantly affect sympathetic outflows [2, 3]. Undoubtedly, the central actions at 5-HT receptors of some antihypertensive agents are of relevance to their therapeutic actions. Until recently the actions of 5-HT on central neurones have been ill defined and controversial due to the lack of a proper framework of receptor definition and a lack of drugs which discriminate between receptor types. Selective agonists and antagonists have been developed in the last decade and the proposed classification of 5-HT receptor types by Bradley et al. [4] has enabled studies of central functional receptors to 5-HT. However, lack of selective antagonists at the 5-HT1-like receptor continues to inhibit proper definition of 5-HT actions in the CNS.

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Authors
  1. M. H. T. Roberts
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  2. M. Davies
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Editors and Affiliations

  1. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  2. Department of Physiology, University of Wales, College of Cardiff, Cardiff, UK

    D. I. Wallis

  3. Department of Pharmacology, Duphar B.V, Weesp, The Netherlands

    W. Wouters  & P. Bevan  & 

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Roberts, M.H.T., Davies, M. (1990). Central neuronal responses and 5-hydroxytryptamine receptors. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_13

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  • DOI: https://doi.org/10.1007/978-94-009-0479-8_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6701-0

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