Abstract
Biology, for the clinician, has classically encompassed the study of the life and growth of cells and organisms; death has been perceived as a pathologic process to be prevented. But over the past few years, our perception of cell death has undergone a major transformation [1]. It is now recognized that cells do not have an absolute and unchangeable lifespan, but rather that cell survival can change in response to environmental stimuli. Moreover, a moment’s reflection will confirm that for a host of normal biologic processes, controlled cellular death is not only inevitable, but critical to normal development. During embryogenesis, the formation of mature organs is dependent on the controlled remodeling of tissues resulting, for example, in the formation of interdigital web spaces or the canalization of the gastrointestinal tract. Deletion of autoreactive T cells during immune maturation is essential to prevent autoimmune disease; other tissues such as blood cells, and epithelial cells of the skin, or gastrointestinal tract are constantly formed and shed during life. The programmed death of cells is called apoptosis.
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References
Hetts SE (1998) To die or not to die: an overview of apoptosis and its role in disease. JAMA 279:300–307
Majno G, Joris I (1995) Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 146:3–15
Ellis RE, Yuan J, Horvitz HR (1991) Mechanisms and function of cell death. Ann Rev Cell Dev Biol 7:663–698
Yuan J, Horvitz HR (1990) The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. Dev Biol 138:33–41
Hengartner MO, Ellis RE, Horvitz HR (1992) Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 356:494–499
Yang E, Korsmeyer SJ (1996) Molecular thanatopsis: A discourse on the Bcl-2 family and cell death. Blood 88:386–401
Yang J, Liu XS, Bhalla K et al (1997) Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science 275:1129–1132
Yuan J, Shaham S, Ledoux S et al (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin lb converting enzyme. Cell 75:641–652
Alnemri ES (1997) Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteases. J Cell Biochem 64:33–42
Alnemri ES, Livingston DJ, Nicholson DW et al (1996) Human ICE/CED-3 protease nomenclature. Cell 87:171
Nagata S, Golstein P (1995) The Fas death factor. Science 267:1449–1456
Griffith TS, Brunner T, Fletcher SM et al (1995) Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270:1189–1192
Takahashi T, Tanaka M, Brannan CI et al (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76:969–976
Rieux-Laucat F, Le Deist F, Hivroz C et al (1995) Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 268:1347–1349
Boldin MP, Goncharov TM, Goltsev YV et al (1996) Involvement of MACH, a novel MORTI/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death. Cell 85:803–815
Wallach D, Boldin M, Varfolomeev E et al (1997) Cell death induction by receptors of the TNF family: towards a molecular understanding. FEBS Lett 410:96–106
Woods KM, Chapes SK (1993) Three distinct cell phenotypes of induced-TNF cytotoxicity and their relationship to apoptosis. J Leuk Biol 53:37–44
Savill JS, Wyllie AH, Henson JE et al (1989) Macrophage phagocytosis of aging neutrophils in inflammation. J Clin Invest 83:865–875
Teodorczyk-Injeyan JA, Cembrznska-Nowak M, Lalani S et al (1995). Immune deficiency following thermal trauma is associated with apoptotic cell death. J Clin Immunol 15:318–328
Nakanishi T, Nishi Y, Sato EF et al (1998) Thermal injury induces thymocyte apoptosis in rats. J Trauma 44:143–148
Oka M, Hirazawa K, Yamamoto K et al (1996) Induction of Fas-mediated apoptosis on circulating lymphocytes by surgical stress. Ann Surg 223:434–440
Feldman G (1997) Liver apoptosis. J Hepatol 26:1–11
Galle PR (1997) Apoptosis in liver disease. J Hepatol 27:405–412
Galle PR, Hofmann WJ, Walczak H et al (1995) Involvement of the CD95(APO-1/Fas) receptor and ligand in liver damage. J Exp Med 182:1223–1230
Strand S, Hofmann WJ, Grambihler A et al (1998) Hepatic failure and liver cell damage in acute Wilson’s disease involve CD95 (APO-1/Fas) mediated apoptosis. Nature Med 4:588–593
Lacronique V, Mignon A, Fabre M et al (1996) Bcl-2 protects against lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nature Med 2:80–86
Haendeler J, Messmer UK, Brune B et al (1996) Endotoxin shock leads to apoptosis in vivo and reduces bcl-2. Shock 6:405–409
Gobe GC, Axelsen RA, Searle JW (1990) Cellular events in experimental unilateral ischemic renal atrophy and in regeneration after contralateral nephrectomy. Lab Invest 56:770–779
Buttyan R, Gobe G (1997) Apoptosis in the mammalian kidney: incidence, effectors, and molecular control in normal developmental and disease states. Adv Pharmacol 41:369–381
Mahida YR, Makh S, Hyde S et al (1996) Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment. Gut 38:337–347
Ray CA, Black RA, Kronheim SR et al (1992) Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. Cell 69:597–604
Leopardi R, Roizman B (1996) The herpes simplex virus major regulatory protein ICP4 blocks apoptosis induced by the virus or by hyperthermia. Cell Biol 93:9583–9587
Badley AD, McElhinny JA, Leibson PJ et al (1996) Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes. J Virol 70:199–206
Bone RC, Balk RA, Cerra FB et al (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 101:1644–1655
Beal AL, Cerra FB (1994) Multiple organ failure syndrome in the 1990’s. Systemic inflammatory response and organ dysfunction. JAMA 271:226–233
Weiss SJ (1989) Tissue destruction by neutrophils. N Engl J Med 320:365–376
Fujishima S, Aikawa N (1995) Neutrophil-mediated tissue injury and its modulation. Intensive Care Med 21:277–285
Lee A, Whyte MKB, Haslett C et al (1993) Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators. J Leuk Biol 54:283–288
Marshall JC, Watson RWG (1997) Programmed cell death (apoptosis) and the resolution of systemic inflammation. Can J Surg 40:169–174
Watson RWG, Rotstein OD, Nathens AB et al (1997) Neutrophil apoptosis is modulated by endothelial transmigration and adhesion molecule engagement. J Immunol 158:945–953
Ognibene FP, Martin SE, Parker MM (1986) Adult respiratory distress syndrome in patients with severe neutropenia. N Engl J Med 315:547–551
Windsor ACJ, Mullen PG, Fowler AA et al (1993) Role of the neutrophil in adult respiratory distress syndrome. Br J Surg 80:10–17
Steinberg KP, Milberg JA, Martin TR et al (1994) Evolution of bronchoalveolar cell populations in the adult respiratory distress syndrome. Am J Respir Crit Care Med 150:113–122
Miller EJ, Cohen AB, Nagao S et al (1992) Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality. Am Rev Respir Dis 146:427–432
Chollet-Martin S, Jourdain B, Gibert C et al (1996) Interactions between neutrophils and cytokines in blood and alveolar spaces during ARDS. Am J Respir Crit Care Med 154:594–601
Baldwin SR, Grum CM, Boxer LA et al (1986) Oxidant activity in expired breath of patients with adult respiratory distress syndrome. Lancet 1:11–14
Schilero GJ, Oropello J, Benjamin E (1995) Impairment in gas exchange after granulocyte colony stimulating factor (G-CSF) in a patient with the adult respiratory distress syndrome. Chest 107:276–278
Verhoef G, Boogaerts M (1991) Treatment with granulocyte-macrophage colony-stimulating factor and the adult respiratory distress syndrome. Am J Hematol 36:285–287
Weiland JE (1986) Lung neutrophils in adult respiratory distress syndrome. Clinical and pathologic significance. Am Rev Respir Dis 133:218–225
Cox GJ, Crossley J, Xing Z et al (1995) Macrophage engulfment of apoptotic neutrophils contributes to the resolution of acute pulmonary inflammation in vivo. Am J Respir Cell Mol Biol 12:232–237
Watson RWG, Rotstein OD, Parodo J et al (1997) Impaired apoptotic death signaling in inflammatory lung neutrophils is associated with decreased expression of interleukin lb converting enzyme family proteases (caspases). Surgery 122:163–172
Matute-Bello G, Liles WC (1997) Neutrophil apoptosis in acute respiratory distress syndrome. Am J Respir Crit Care Med 156:1969–1977
Steinberg KP, Milberg JA, Martin TR et al (1994) Evolution of bronchoalveolar cell populations in the adult respiratory distress syndrome. Am J Respir Crit Care Med 150:113–122
Cox G (1996) IL-10 enchances resolution of pulmonary inflammation in vivo by promoting apoptosis of neutrophils. Am J Physiol 271: L566–L571
Chitnis D, Dickerson C, Munster AM et al (1996) Inhibition of apoptosis in polymorphonuclear neutrophils from burn patients. J Leuk Biol 59:835–839
Ertel W, Keel M, Infanger M et al (1998) Circulating mediators in serum of injured patients with septic complications inhibit neutrophil apoptosis through up-regulation of protein tyrosine phosphorylation. J Trauma 44:767–776
Jimenez MF, Watson RWG, Parodo J et al (1997) Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome (SIRS). Arch Surg 132:1263–1270
Rouquet N, Pages JC, Molina T et al (1996) ICE inhibitor YVAD-cmk is a potent therapeutic agent against in vivo liver apoptosis. Curr Biol 6:1192–1195
Watson RWG, Rotstein OD, Parodo J et al (1998) The interleukin-1 beta converting enzyme (caspase-1) inhibits neutrophil apoptosis through processing of interleukin-1. J Immunol
Lu Q, Mellgren RL (1996) Calpain inhibitors and serine protease inhibitors can produce apoptosis in HL-60 cells. Arch Biochem Biophys 334:175–181
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Rouzati, A.H., Taneja, R., Marshall, J.C. (1999). Apoptosis (Programmed Cell Death) and the Resolution of Acute Inflammation. In: Baue, A.E., Berlot, G., Gullo, A., Vincent, JL. (eds) Sepsis and Organ Dysfunction. Springer, Milano. https://doi.org/10.1007/978-88-470-2248-5_10
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DOI: https://doi.org/10.1007/978-88-470-2248-5_10
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