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Surgical Management of Aortic Pathology pp 561–566Cite as

Genetics of Marfan Syndrome and Loeys-Dietz Syndrome

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Abstract

Marfan syndrome (MFS) and Loeys-Dietz syndrome (LDS) are two clinically related aortic aneurysm conditions. LDS shows significant clinical overlap with MFS as regards its vascular and skeletal features, including aortic root aneurysm, arachnodactyly, scoliosis, and pectus deformity. In this chapter, we will review the current knowledge of the genetic basis of both disorders.

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Authors and Affiliations

  1. Center for Medical Genetics, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium

    Aline Verstraeten & Bart Loeys

Authors
  1. Aline Verstraeten
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  2. Bart Loeys
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Correspondence to Bart Loeys .

Editor information

Editors and Affiliations

  1. Fmr Royal Brompton Hospital, London, UK

    Olaf H. Stanger

  2. Royal Brompton Hospital, London, UK

    John R. Pepper

  3. Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA

    Lars G. Svensson

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Verstraeten, A., Loeys, B. (2019). Genetics of Marfan Syndrome and Loeys-Dietz Syndrome. In: Stanger, O., Pepper, J., Svensson, L. (eds) Surgical Management of Aortic Pathology. Springer, Vienna. https://doi.org/10.1007/978-3-7091-4874-7_38

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  • DOI: https://doi.org/10.1007/978-3-7091-4874-7_38

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-4872-3

  • Online ISBN: 978-3-7091-4874-7

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