Skip to main content
SpringerLink
Log in

Biomarkers of Acute Aortic Syndrome

  • Chapter
  • First Online:
Surgical Management of Aortic Pathology

  • 1671 Accesses

Abstract

Acute aortic syndrome (acute aortic dissection, AAD; intramural hematoma, IMH; and penetrating atherosclerotic ulcer, PAU) is a disease entity which possesses high mortality rate during the acute phase even in the current era. AAD, especially, has a broad variety of symptoms at onset, and frequently its diagnosis is delayed resulting in worse prognosis. Development and improvement of biomarkers have been pursued to enable the early diagnosis of AAD at “point of care” for immediate decision for further imaging or discrimination from other diseases such as coronary artery disease or pulmonary embolism.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Hagan PG, Nienaber CA, Isselbacher EM, Bruckman D, Karavite DJ, Russman PL, Evangelista A, et al. The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease. JAMA. 2000;283:897–903.

    Article  CAS  Google Scholar 

  2. Suzuki T, Katoh H, Tsuchio Y, Hasegawa A, Kurabayashi M, Ohira A, Hiramori K, et al. Diagnostic implications of elevated levels of smooth-muscle myosin heavy-chain protein in acute aortic dissection. The smooth muscle myosin heavy chain study. Ann Intern Med. 2000;133:537–41.

    Article  CAS  Google Scholar 

  3. Suzuki T, Katoh H, Kurabayashi M, Yazaki Y, Nagai R. Biochemical diagnosis of aortic dissection by raised concentrations of creatine kinase BB-isozyme. Lancet. 1997;350:784–5.

    Article  CAS  Google Scholar 

  4. Suzuki T, Distante A, Zizza A, Trimarchi S, Villani M, Salerno Uriarte JA, de Luca Tupputi Schinosa L, et al. International registry of acute aortic dissection substudy on biomarkers I. Preliminary experience with the smooth muscle troponin-like protein, calponin, as a novel biomarker for diagnosing acute aortic dissection. Eur Heart J. 2008;29:1439–45.

    Article  CAS  Google Scholar 

  5. Suzuki T, Distante A, Eagle K. Biomarker-assisted diagnosis of acute aortic dissection: how far we have come and what to expect. Curr Opin Cardiol. 2010;25:541–5.

    Article  Google Scholar 

  6. Shinohara T, Suzuki K, Okada M, Shiigai M, Shimizu M, Maehara T, Ohsuzu F. Soluble elastin fragments in serum are elevated in acute aortic dissection. Arterioscler Thromb Vasc Biol. 2003;23:1839–44.

    Article  CAS  Google Scholar 

  7. Sangiorgi G, Trimarchi S, Mauriello A, Righini P, Bossone E, Suzuki T, Rampoldi V, Eagle KA. Plasma levels of metalloproteinases-9 and -2 in the acute and subacute phases of type A and type B aortic dissection. J Cardiovasc Med (Hagerstown). 2006;7:307–15.

    Article  Google Scholar 

  8. Chung AW, Yang HH, Radomski MW, van Breemen C. Long-term doxycycline is more effective than atenolol to prevent thoracic aortic aneurysm in Marfan syndrome through the inhibition of matrix metalloproteinase-2 and -9. Circ Res. 2008;102:e73–85.

    Article  CAS  Google Scholar 

  9. Stein PD, Hull RD, Patel KC, Olson RE, Ghali WA, Brant R, Biel RK, Bharadia V, Kalra NK. D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism: a systematic review. Ann Intern Med. 2004;140:589–602.

    Article  Google Scholar 

  10. Eggebrecht H, Naber CK, Bruch C, Kroger K, von Birgelen C, Schmermund A, Wichert M, Bartel T, Mann K, Erbel R. Value of plasma fibrin D-dimers for detection of acute aortic dissection. J Am Coll Cardiol. 2004;44:804–9.

    Article  CAS  Google Scholar 

  11. Suzuki T, Distante A, Zizza A, Trimarchi S, Villani M, Salerno Uriarte JA, Luca Tupputi D, Schinosa L, et al. Diagnosis of acute aortic dissection by D-dimer: the international registry of Acute Aortic Dissection Substudy on Biomarkers (IRAD-Bio) experience. Circulation. 2009;119:2702–7.

    Article  Google Scholar 

  12. Watanabe H, Horita N, Shibata Y, Minegishi S, Ota E, Kaneko T. Diagnostic test accuracy of D-dimer for acute aortic syndrome: systematic review and meta-analysis of 22 studies with 5000 subjects. Sci Rep. 2016;6:26893.

    Article  CAS  Google Scholar 

  13. Asha SE, Miers JW. A systematic review and meta-analysis of D-dimer as a rule-out test for suspected acute aortic dissection. Ann Emerg Med. 2015;66:368–78.

    Article  Google Scholar 

  14. Gorla R, Erbel R, Kahlert P, Tsagakis K, Jakob H, Mahabadi AA, Schlosser T, Eggebrecht H, Bossone E, Janosi RA. Diagnostic role and prognostic implications of D-dimer in different classes of acute aortic syndromes. Eur Heart J Acute Cardiovasc Care. 2017;6(5):379–88. https://doi.org/10.1177/2048872615594500.

    Article  PubMed  Google Scholar 

  15. Ohlmann P, Faure A, Morel O, Kindo M, Jesel L, Radulescu B, Billaud P, et al. Lower circulating Sta-Liatest D-Di levels in patients with aortic intramural hematoma compared with classical aortic dissection. Crit Care Med. 2009;37:899–901.

    Article  Google Scholar 

  16. Erbel R, Aboyans V, Boileau C, Bossone E, Bartolomeo RD, Eggebrecht H, Evangelista A, et al. Guidelines ESCCfP. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The task force for the diagnosis and treatment of aortic diseases of the European Society of Cardiology (ESC). Eur Heart J. 2014;35:2873–926.

    Article  Google Scholar 

  17. Makita S, Ohira A, Tachieda R, Itoh S, Moriai Y, Yoshioka K, Niinuma H, Nakamura M, Hiramori K. Behavior of C-reactive protein levels in medically treated aortic dissection and intramural hematoma. Am J Cardiol. 2000;86:242–4.

    Article  CAS  Google Scholar 

  18. Sakakura K, Kubo N, Ako J, Wada H, Fujiwara N, Funayama H, Ikeda N, et al. Peak C-reactive protein level predicts long-term outcomes in type B acute aortic dissection. Hypertension. 2010;55:422–9.

    Article  CAS  Google Scholar 

  19. Kuehl H, Eggebrecht H, Boes T, Antoch G, Rosenbaum S, Ladd S, Bockisch A, Barkhausen J, Erbel R. Detection of inflammation in patients with acute aortic syndrome: comparison of FDG-PET/CT imaging and serological markers of inflammation. Heart. 2008;94:1472–7.

    Article  CAS  Google Scholar 

  20. Anzai A, Shimoda M, Endo J, Kohno T, Katsumata Y, Matsuhashi T, Yamamoto T, et al. Adventitial CXCL1/G-CSF expression in response to acute aortic dissection triggers local neutrophil recruitment and activation leading to aortic rupture. Circ Res. 2015;116:612–23.

    Article  CAS  Google Scholar 

  21. Matt P, Schoenhoff F, Habashi J, Holm T, Van Erp C, Loch D, Carlson OD, et al. Circulating transforming growth factor-beta in Marfan syndrome. Circulation. 2009;120:526–32.

    Article  CAS  Google Scholar 

  22. Suzuki T, Trimarchi S, Sawaki D, Grassi V, Costa E, Rampoldi V, Nagai R, Eagle K. Circulating transforming growth factor-beta levels in acute aortic dissection. J Am Coll Cardiol. 2011;58:775.

    Article  Google Scholar 

  23. Mallat Z, Ait-Oufella H, Tedgui A. The pathogenic transforming growth factor-beta overdrive hypothesis in aortic aneurysms and dissections: a mirage? Circ Res. 2017;120:1718–20.

    Article  CAS  Google Scholar 

  24. Son BK, Sawaki D, Tomida S, Fujita D, Aizawa K, Aoki H, Akishita M, et al. Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma. Nat Commun. 2015;6:6994.

    Article  CAS  Google Scholar 

  25. Ju X, Ijaz T, Sun H, Ray S, Lejeune W, Lee C, Recinos A 3rd, et al. Interleukin-6-signal transducer and activator of transcription-3 signaling mediates aortic dissections induced by angiotensin II via the T-helper lymphocyte 17-interleukin 17 axis in C57BL/6 mice. Arterioscler Thromb Vasc Biol. 2013;33:1612–21.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Leicester, Leicester, UK

    Toru Suzuki

  2. University Hospitals of Leicester NHS Trust, Leicester, UK

    Toru Suzuki

  3. Department of Cardiovascular Sciences, Cardiovascular Research Centre, Glenfield General Hospital, University of Leicester, Leicester, UK

    Toru Suzuki

  4. INSERM U955-Biomedical Research of Mondor Institute, University of Paris East Créteil-Henri Mondor Hospital, Paris, France

    Daigo Sawaki

Authors
  1. Toru Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Daigo Sawaki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Toru Suzuki .

Editor information

Editors and Affiliations

  1. Fmr Royal Brompton Hospital, London, UK

    Olaf H. Stanger

  2. Royal Brompton Hospital, London, UK

    John R. Pepper

  3. Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA

    Lars G. Svensson

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer-Verlag GmbH Austria, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Suzuki, T., Sawaki, D. (2019). Biomarkers of Acute Aortic Syndrome. In: Stanger, O., Pepper, J., Svensson, L. (eds) Surgical Management of Aortic Pathology. Springer, Vienna. https://doi.org/10.1007/978-3-7091-4874-7_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-4874-7_16

  • Published:

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-4872-3

  • Online ISBN: 978-3-7091-4874-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation