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Feedback Control of Pineal Function by Reproductive Hormones—A Neuroendocrine Paradigm

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Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 13))

Summary

Secretions from the pineal gland participate in the control of reproductive function. In turn gonadal steroids, gonadotrophins and prolactin modify pineal metabolic activity and change the rate of synthesis of pineal hormones. This article reviews the major observations made regarding the pineal gland and its innervating neurons as target tissues for reproductive steroid and hypophyseal hormones.

Established Investigator. Comisión Nacional de Estudios Geo-Heliofísicos. Argentina.

Research Fellow. Consejo Nacional de Investigaciones Científicas y Técnicas. Argentina.

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References

  • Antón-Tay, F.: Pineal-brain relationships. In: The Pineal Gland (Woistenholme, G. E. W., Knight, J., eds.), pp. 213–227. London: Churchill. 1971.

    Google Scholar 

  • Antón-Tay, F., Wurtman, R. J.: Regional uptake of 3H-melatonin from blood and cerebrospinal fluid by rat brain. Nature 221, 474–475 (1969).

    Article  PubMed  Google Scholar 

  • Axelrod, J.: The pineal gland: a neurochemical transducer. Science 184, 1341–1348 (1974).

    Article  CAS  PubMed  Google Scholar 

  • Banerjee, S., Kerr, V., Winston, M., Kelleher, J. K., Margulis, L.: Melatonin: inhibition of microtubule-based oral morphogenesis in Stentor coeruleus J. Protozool. 19, 108–112 (1972).

    Article  CAS  Google Scholar 

  • Benson, B.: Current status of pineal peptides. Neuroendocrinology 24, 241–258 (1977).

    Article  CAS  PubMed  Google Scholar 

  • Cady, P., Dillman, R. O.: Influence of catechol and indole amines upon pineal uptake of thyroxine. Neuroendocrinology 8, 228–234 (1971).

    Article  CAS  PubMed  Google Scholar 

  • Cardinali, D. P.: Melatonin and the endocrine role of the pineal organ. In: Current Topics in Experimental Endocrinology (James, V. H. T., Martini, L., eds.), Vol. 2, pp. 107–128. New York: Academic Press. 1974.

    Google Scholar 

  • Cardinali, D. P.: Nuclear receptor estrogen complex in the pineal gland. Modulation by sympathetic nerves. Neuroendocrinology 24, 336–346 (1977).

    Google Scholar 

  • Cardinali, D. P., Freire, F.: Melatonin effects on brain. Interaction with microtubule protein, inhibition of fast axoplasmic flow and induction of crystaloid and tubular formations in the hypothalamus. Mol. Cell. Endocrinol. 2, 317–330 (1975).

    Article  CAS  PubMed  Google Scholar 

  • Cardinali, D. P., Freire, F., Nagle, C. A., Rosner, J. M.: Effects of environmental lighting, superior cervical ganglionectomy, and adrenergic drugs on microtubule protein levels of the rat hypothalamus. Neuroendocrinology 19, 44–53 (1975 a).

    Article  CAS  PubMed  Google Scholar 

  • Cardinali, D. P., Gomez, E., Rosner, J. M.: Changes in 3H-leucine incorporation into pineal proteins following estradiol or testosterone administration: involvement of the sympathetic superior cervical ganglion. Endocrinology 98, 849–858 (1976 a).

    Article  CAS  PubMed  Google Scholar 

  • Cardinali, D. P., Hyyppä, M. T., Wurtman, R. J.: Fate of intracisternally-injected melatonin in the rat brain. Neuroendocrinology 12, 30–40 (1973 a).

    Article  CAS  PubMed  Google Scholar 

  • Cardinali, D. P., Nagle, C. A., Denari, J. H., Bedes, G. D. P., Rosner, J. M.: Lack of effects of light on the rat pineal in organ culture. Gen. comp. Endocr. 21, 573–577 (1973 b).

    Article  CAS  PubMed  Google Scholar 

  • Cardinali, D. P., Nagle, C. A., Freire, F., Rosner, J. M.: Effects of melatonin on neurotransmitter uptake and release by synaptosome-rich homogenates of the rat hypothalamus. Neuroendocrinology 18, 72–85 (1975 b).

    Article  CAS  PubMed  Google Scholar 

  • Cardinali, D. P., Nagle, C. A., Gomez, E., Rosner, J. M.: Norepinephrine turnover in the rat pineal gland. Acceleration by estradiol and testosterone. Life Sci. 16, 1717–1724 (1975 c).

    Article  CAS  PubMed  Google Scholar 

  • Cardinali, D. P., Nagle, C. A., Rosner, J. M.: Incorporation of 3H-leucine into proteins in the hypothalamus and anterior hypophysis. Effects of pinealectomy, superior cervical sympathectomy and continuous exposure to light or darkness. Neuroendocrinology 16, 74–83 (1974 a).

    Article  CAS  PubMed  Google Scholar 

  • Cardinali, D. P., Nagle, C. A., Rosner, J. M.: Effects of estradiol on melatonin and protein synthesis in the rat pineal organ. Hormone Res. 5, 304–310 (1974 b).

    Article  CAS  PubMed  Google Scholar 

  • Cardinali, D. P., Nagle, C. A., Rosner, J. M.: Changes in the pineal indole metabolism and plasma progesterone levels during the estrous cycle in ewes. Steroids Lipids Res. 5, 308–315 (1974 c).

    CAS  PubMed  Google Scholar 

  • Cardinali, D. P., Nagle, C. A., Rosner, J. M.: Metabolic fate of androgens in the pineal organ. Uptake, binding to cytoplasmic proteins and conversion of testosterone into 5α-reduced metabolites. Endocrinology 95, 179–187 (1974 d).

    Article  CAS  PubMed  Google Scholar 

  • Cardinali, D. P., Nagle, C. A., Rosner, J. M.: Aromatization of androgens to estrogens by the rat pineal gland. Experientia 30, 1022–1023 (1974 e).

    Article  Google Scholar 

  • Cardinali, D. P., Nagle, C. A., Rosner, J. M.: Gonadal steroids as modulators of the function of the pineal gland. Gen. comp. Endocr. 26, 50–53 (1975 d).

    Article  CAS  PubMed  Google Scholar 

  • Cardinali, D. P., Nagle, C. A., Rosner, J. M.: Control of estrogen and androgen receptors in the rat pineal gland by catecholamine transmitter. Life Sci. 16, 81–91 (1975 e).

    Article  PubMed  Google Scholar 

  • Cardinali, D. P., Nagle, C. A., Rosner, J. M.: Gonadotropin-and prolactin-induced increase of rat pineal hydroxyindole-O-methyl transferase. Involvement of the sympathetic nervous system. J. Endocrinol. 68, 341 to 342 (1976 b).

    Article  CAS  PubMed  Google Scholar 

  • Cardinali, D. P., Nagle, C. A., Rosner, J. M.: Pineal gonads relationships. Nature of the feedback mechanism at the level of the pineal gland. In: Neuroendocrine Regulation of Fertility (Anand Kumar, T. C., ed.), pp. 206–214. Basel: Karger. 1976 c.

    Google Scholar 

  • Cardinali, D. P., Vacas, M. I.: Progesterone-induced decrease of pineal protein synthesis in rats. Possible participation in estrous-related changes of pineal function. J. Neural Transm. (1978, in press).

    Google Scholar 

  • Cardinali, D. P., Wurtman, R. J.: Control of melatonin synthesis in the pineal organ. In: Frontiers of Pineal Physiology (Altschule, M. D., ed.), pp. 12–41. Cambridge, Mass.: The MIT Press. 1975.

    Google Scholar 

  • Clark, J. H., Peck, E. J.: Nuclear retention of receptor-oestrogen complex and nuclear acceptor sites. Nature 260, 635–637 (1976).

    Article  CAS  PubMed  Google Scholar 

  • David, G. F. X., Umberkoman, B., Kumar, K., Anand Kumar, T. C.: Neuro-endocrine significance of the pineal. In: Brain-Endocrine Interaction II (Knigge, K., Scott, D., Kobayashi, Y., Ishii, T., eds.), pp. 365–375. Basel: Karger. 1975.

    Google Scholar 

  • Deguchi, T.: Role of the beta-adrenergic receptor in the elevation of adenosine cyclic 3′, 5′-monophosphate and induction of serotonin N-acetyltransferase in rat pineal glands. Mol. Pharmacol. 9, 184–190 (1973).

    CAS  PubMed  Google Scholar 

  • Deguchi, T., Axelrod, J.: Supersensitivity and subsensitivity of the beta-adrenergic receptor in pineal gland regulated by catecholamine transmitter. Proc. natl. Acad. Sci. U.S.A. 70, 2411–2414 (1973).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Demoulin, A., Hudson, B., Franchimont, P., Legros, J. J.: Arginine vasotocin does not affect gonadotrophin secretion in vitro. J. Endocrinol. 72, 105–106 (1977).

    Article  CAS  PubMed  Google Scholar 

  • Deussen-Schmitter, M., Garweg, G., Schwabedal, P. E., Wartenberg, H.: Simultaneous changes of the perivascular contact area and HIOMT activity in the pineal organ after bilateral adrenalectomy in the rat. Anat. Embryol. 149, 297–305 (1976).

    Article  CAS  PubMed  Google Scholar 

  • Dunaway, J. E.: Alterations in the timing of PMS-induced ovulation following pinealectomy. Neuroendocrinology 5, 281–289 (1969).

    Article  CAS  PubMed  Google Scholar 

  • Duraiswami, S., Franchimont, P., Boucher, S., Thieblot, M.: Immunoreactive luteinizing hormone-releasing hormone (LH-RH) in the bovine pineal gland. Horm. Metab. Res. 8, 232–233 (1976).

    Article  CAS  PubMed  Google Scholar 

  • Ebels, I., Prop, N.: A study on the effects of melatonin on the gonads, the estrous cycle, and the pineal organ of the rat. Acta Endocrinol. (Kbh.) 49, 567–577 (1965).

    CAS  Google Scholar 

  • Eränkö, O., Rechardt, L., Eränkö, L., Cunningham, A.: Light and electron microscopic histochemical observations on cholinesterase-containing sympathetic nerve fibres in the pineal body of the rat. Histochem. J. 2, 479–489 (1970).

    Article  PubMed  Google Scholar 

  • Fiske, V. M., Huppert, L. C.: Melatonin action on pineal varies with photo-period. Science 162, 279 (1968).

    Article  CAS  PubMed  Google Scholar 

  • Fiske, V. M., Pound, J., Putnam, J.: Effect of light on the weight of the pineal organ in hypophysectomized, gonadectomized, adrenalectomized or thiouracil-fed rats. Endocrinology 71, 130–131 (1962).

    Article  CAS  PubMed  Google Scholar 

  • Freire, F., Cardinali, D. P.: Effects of melatonin treatment and environmental lighting on the ultrastructural appearance, melatonin synthesis, norepinephrine turnover and microtubule protein content of the rat pineal gland. J. Neural Transm. 37, 237–257 (1975).

    Article  CAS  PubMed  Google Scholar 

  • Hanukoglu, I., Karavolas, H. J., Goy, R. W.: Progesterone metabolism in the pineal gland, brain stem, thalamus and corpus callosum of the femaie rat. Brain Res. 125, 313–324 (1977).

    Article  CAS  PubMed  Google Scholar 

  • Hedlund, L., Lishko, M. M., Rollag, M. D., Niswender, G. D.: Melatonin: daily cycle in plasma and cerebrospinal fluid of calves. Science 195, 686–687 (1977).

    Article  CAS  PubMed  Google Scholar 

  • Herbert, J.: Initial observations on pinealectomized ferrets kept for long periods in either daylight or artificial illumination. J. Endocrinol. 55, 591–597 (1972).

    Article  CAS  PubMed  Google Scholar 

  • Hoffmann, J. C., Cullin, A. M.: Effects of pinealectomy and constant light on the estrous cycle of female rats. Neuroendocrinology 17, 167–174 (1975).

    Article  Google Scholar 

  • Hoffmann, K.: Testicular involution in short photoperiods inhibited by melatonin. Naturwissenschaften 61, 364–365 (1974).

    Article  CAS  PubMed  Google Scholar 

  • Hoffmann, K., Kuederling, I.: Antigonadal effects of melatonin in pinealectomized Djungarian hamsters. Naturwissenschaften 64, 339–340 (1977).

    Article  CAS  PubMed  Google Scholar 

  • Houssay, A. B., Barceló, A. C.: Effect of estrogens and progesterone upon the biosynthesis of melatonin by pineal gland. Experientia 28, 478–479 (1972).

    Article  CAS  PubMed  Google Scholar 

  • Hyyppä, M. T., Cardinali, D. P., Baumgarten, H., Wurtman, R. J.: Rapid accumulation of 3H-serotonin in brains of rats receiving 3H-tryptophan. Effects of 5, 6-dihydroxytryptamine or female sex hormones. J. Neural Transm. 34, 111–124 (1973a).

    Article  PubMed  Google Scholar 

  • Hyyppä, M. T., Cardinali, D. P., Wurtman, R. J.: Sex-dependent increase in pineal hydroxyindole-O-methyl transferase activity after a single intraventricular injection of 6-hydroxydopamine to newborn rats. Neuroendocrinology 12, 274–283 (1973 b).

    Google Scholar 

  • Ilinerova, H.: Effect of estradiol on the activity of serotonin-N-aeetyltransferase in the rat epiphysis. Endocrinol. Exp. (Bratisl.) 9, 141–148 (1975).

    Google Scholar 

  • Jackson, I. M. D., Saperstein, R., Reichlin, S.: Thyrotropin releasing hormone (TRH) in pineal and hypothalamus of the frog: effect of season and illumination. Endocrinology 100, 97–100 (1977).

    Article  CAS  PubMed  Google Scholar 

  • Kao, L. W. L., Weisz, J.: Release of gonadotrophin-releasing hormone (GnRH) from isolated, perifused medial basal hypothalamus by melatonin. Endocrinology 100, 1723–1726 (1977).

    Article  CAS  PubMed  Google Scholar 

  • Kappers, J. A.: Innervation of the pineal organ: Phylogenese aspects and comparison of the neural control of the mammalian pineal with that of other neuroendocrine systems. In: Subcellular Organization and Function in Endocrine Tissues (Heller, H., Lederis, K., eds.), pp. 27–48. London: Cambridge University Press. 1971.

    Google Scholar 

  • Kinson, G. A., Peat, F.: The influence of illumination, melatonin and pinealectomy on testicular function in the rat. Life Sci. 10 (part I), 259–269 (1971).

    Article  CAS  Google Scholar 

  • Klein, D. C., Weller, J. L.: Melatonin synthesis: adenosine-3′-5′-monophos-phate and norepinephrine stimulate N-acetyltransferase. Science 168, 978–980 (1970).

    Google Scholar 

  • Lerner, A. B., Case, J. D.: Pigment cell regulatory factors. J. invest. Dermatol. 32, 211–221 (1959).

    Article  CAS  PubMed  Google Scholar 

  • Luttge, W. G., Wallis, C. G.: In vitro accumulation and saturation of 3H-progestins in selected brain regions and in the adenohypophysis, uterus and pineal of the female rat. Steroids 22, 493–502 (1973).

    Article  CAS  PubMed  Google Scholar 

  • Lynch, H. J., Ho, M., Wurtman, R. J.: The adrenal medulla may mediate the increase in pineal melatonin synthesis induced by stress but not that caused by exposure to darkness. J. Neural Transm. 40, 87–98 (1977).

    Article  CAS  PubMed  Google Scholar 

  • Marks, B., Wu, T. K., Goldman, H.: Soluble estrogen binding protein in the rat pineal gland. Res. Comm. Chem. Pathol. Pharmacol. 3, 1089–1103 (1972).

    Google Scholar 

  • Nagle, C. A., Cardinali, D. P., Laborde, N. P., Rosner, J. M.: Sex-dependent changes in rat retinal hydroxyindole-O-methyl transferase. Endocrinology 94, 294–297 (1974).

    Article  CAS  PubMed  Google Scholar 

  • Nagle, C. A., Neuspiller, N., Cardinali, D. P., Rosner, J. M.: Uptake and effects of 17β-estradiol on pineal hydroxyindole-O-methyl transferase (HIOMT) activity. Life Sci. 11 (part II), 1105–1116 (1972).

    Article  Google Scholar 

  • Neill, J. D., Smith, M. S.: Pituitary-ovarian interrelationships in the rat. In: Current Topics in Experimental Endocrinology (James, V. H. T., Martini, L., eds.), Vol. 2, pp. 73–106. New York: Academic Press. 1974.

    Google Scholar 

  • Nir, I., Kaiser, N., Hirschmann, N., Sulman, F.: The effect of 17β-estradiol on pineal metabolism. Life Sci. 9, 851–858 (1970).

    Article  CAS  Google Scholar 

  • O’Dea, R. F., Zatz, M.: Catecholamine-stimulated cyclic GMP accumulation in the rat pineal: apparent presynaptic site of action. Proc. natl. Acad. Sci. U.S.A. 73, 3398–3402 (1976).

    Article  PubMed Central  PubMed  Google Scholar 

  • Pavel, S., Calb, M., Georgescu, M.: Reversal of the effects of pinealectomy on the pituitary prolactin content in mice by very low concentration of vasotocin injected into the third ventricle. J. Endocrinol. 66, 289–290 (1975).

    Article  CAS  PubMed  Google Scholar 

  • Pellegrino de Iraldi, A., Rodriguez de Lores Arnaiz, G.: Neural regulation of acetylcholinesterase in the superior cervical ganglia and the pineal gland of the rat. Brain Res. 113, 435–440 (1976).

    Article  CAS  Google Scholar 

  • Preslock, J. P.: Regulation of pineal enzymes by photoperiod, gonadal hormones and melatonin in Coturnix quail. Horm. Res. 7, 108–117 (1976).

    Article  CAS  PubMed  Google Scholar 

  • Quay, W. B.: Pineal Chemistry. Springfield: C. C Thomas. 1974.

    Google Scholar 

  • Reiter, R. J.: The Pineal. 1977. Montreal: Eden Press. 1977.

    Google Scholar 

  • Reiter, R. J., Blask, D. E., Johnson, L. Y., Rudeen, P. K., Vaughan, M. K., Waring, P. J.: Melatonin inhibition of reproduction in the male hamster: its dependency on time of day of administration and on an intact and sympathetically innervated pineal gland. Neuroendocrinology 22, 107 to 116 (1976).

    Article  CAS  PubMed  Google Scholar 

  • Reiter, R. J., Vaughan, M. K.: Pineal antigonadotrophic substances. Polypeptides and indoles. Life Sci. 21, 159–172 (1977).

    Article  CAS  Google Scholar 

  • Reiter, R. J., Vaughan, M. K., Blask, D. E., Johnson, L. Y.: Melatonin: its inhibition of pineal antigonadotrophic activity in male hamsters. Science 185, 1169–1171 (1974).

    Article  CAS  PubMed  Google Scholar 

  • Reiter, R. J., Vaughan, M. K., Vaughan, G. M., Sorrentino, S., jr., Donofrio, R. J.: The pineal as an organ of internal secretion. In: Frontiers of Pineal Physiology (Altschule, M. D., ed.), pp. 54–174. Cambridge, Mass.: The MIT Press. 1975.

    Google Scholar 

  • Relkin, R.: Relative efficacy of pinealectomy and amygdaloid lesions in advancing puberty. Endocrinology 88, 415–418 (1971).

    Article  CAS  PubMed  Google Scholar 

  • Relkin, R.: The Pineal. Montreal: Eden Press. 1976.

    Google Scholar 

  • Romero, J. A., Zatz, M., Axelrod, J.: Beta-adrenergic stimulation of pineal N-acetyltransferase: adenosine 3′, 5′-cyclic monophosphate stimulates both RNA and protein synthesis. Proc. natl. Acad. Sci. U.S.A. 72, 2107–2111 (1975 a).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Romero, J. A., Zatz, M., Kebabian, J. W., Axelrod, J.: Circadian cycles in binding of 3H-alprenol to β-adrenergic receptor sites in rat pineal. Nature 258, 435–436 (1975 b).

    Article  CAS  PubMed  Google Scholar 

  • Ronnekleiv, O. K., Krulich, L., McCann, S. M.: An early morning surge of prolactin in the male rat and its abolition by pinealectomy. Endocrinology 92, 1339–1342 (1973).

    Article  CAS  PubMed  Google Scholar 

  • Ronnekleiv, O. K., McCann, S. M.: Effects of pinealectomy, anosmia and blinding alone or in combination on gonadotropin secretion and pituitary and target gland weight in intact and castrated male rats. Neuroendocrinology 19, 97–114 (1975).

    Article  CAS  PubMed  Google Scholar 

  • Sakai, K. K., Marks, B. H.: Adrenergic effects on pineal cell membrane potential. Life Sci. 11 (part I), 285–291 (1972).

    Article  CAS  Google Scholar 

  • Sakai, K. K., Schneider, D., Felt, B., Marks, B. H.: The effect of α-MSH on β-adrenergic receptor mechanisms in the rat pineal. Life Sci. 19, 1145 to 1150 (1976).

    Article  CAS  PubMed  Google Scholar 

  • Scardapane, L., Cardinali, D. P.: Effect of estradiol and testosterone on catechol-O-methyl transferase activity of rat superior cervical ganglion, pineal gland, anterior hypophysis and hypothalamus. J. Neural Transm. 40, 81–86 (1977).

    Article  CAS  PubMed  Google Scholar 

  • Stumpf, W. E., Sar, M., Keefer, D. A., Martinez-Vargas, M. C.: The anatomical substrate of neuroendocrine regulation as defined by auto-radiography with 3H-estradiol, 3H-testosterone, 3H-dihydrotestosterone and 3H-progesterone. In: Neuroendocrine Regulation of Fertility (Anand Kumar, T. C., ed.), pp. 46–56. Basel: Karger. 1976.

    Google Scholar 

  • Trentini, G. P., Gaetani, C. F., Barbieri-Palmieri, F.: The role of sympathetic innervation in pineal-pituitary feedback. Blocking of pineal changes induced in the rat by experimental hypergonadotrophinaemia by chronic treatment with bretylium or guanethidine. Ann. Endocrinol. 34, 261–270 (1973).

    CAS  Google Scholar 

  • Tsang, D., Martin, J. B.: Effect of hypothalamic hormones on the concentration of adenosine 3′, 5′-monophosphate in incubated rat pineal glands. Life Sci. 19, 911–918 (1976).

    Article  CAS  PubMed  Google Scholar 

  • Turek, F. W.: Antigonadal effect of melatonin in pinealectomized and intact male hamsters. Proc. Soc. exp. Biol. Med. 155, 31–34 (1977).

    Article  CAS  PubMed  Google Scholar 

  • Urry, R. L., Dougherty, K. A., Frehn, J. L., Ellis, L. C: Factors other than light affecting the pineal gland. Hypophysectomy, testosterone, dihydro-testosterone, estradiol, cryptorchidism and stress. Amer. Zool. 16, 79–91 (1976).

    CAS  Google Scholar 

  • Vaughan, M. K., Blask, D. E., Vaughan, G. M., Reiter, R. J.: Dose-dependent prolactin releasing activity of arginine vasotocin in intact and pinealectomized, estrogen-progesterone treated adult male rats. Endocrinology 99, 1319–1322 (1976).

    Article  CAS  PubMed  Google Scholar 

  • Wallen, E. P., Yochim, J. M.: Pineal HIOMT activity in the rat: effect of ovariectomy and hormone replacement. Biol. Reprod. 10, 474–479 (1974 b).

    Article  CAS  PubMed  Google Scholar 

  • Weiss, B., Crayton, J.: Gonadal hormones as regulators of pineal adenyl cyclase activity. Endocrinology 87, 527–533 (1970).

    Article  CAS  PubMed  Google Scholar 

  • White, W. F., Hedlund, M. T., Weber, G. F., Rippel, R. H., Johnson, E. S., Wilber, J. F.: The pineal gland: a supplemental source of hypothalamic releasing hormones. Endocrinology 94, 1422–1426 (1974).

    Article  CAS  PubMed  Google Scholar 

  • Wurtman, R. J., Axelrod, J., Potter, L. T.: The uptake of 3H-melatonin in endocrine and nervous tissues and the effects of constant light exposure. J. Pharmacol, exp. Ther. 143, 314–318 (1964).

    CAS  Google Scholar 

  • Wurtman, R. J., Axelrod, J., Snyder, S. H.: Changes in the enzymatic synthesis of melatonin in the pineal during the estrous cycle. Endocrinology 76, 798–800 (1965).

    Article  CAS  PubMed  Google Scholar 

  • Wurtman, R. J., Shein, H. M., Axelrod, J., Larin, F.: Incorporation of 14C-tryptophan into 14C-protein by cultured rat pineals: stimulation by L-norepinephrine. Proc. nati. Acad. Sci. U.S.A. 62, 749–755 (1969).

    Article  CAS  Google Scholar 

  • Zatz, M., O’Dea, R. F.: Regulation of protein kinase in rat pineal: increased Vmax in supersensitive glands. J. cyclic Nucleotide Res. 2, 427–439 (1976).

    CAS  PubMed  Google Scholar 

  • Zweens, J.: Influence of the estrous cycle and ovariectomy on the phospholipid content of the pineal gland in the rat. Nature 197, 1114–1115 (1963).

    Article  CAS  PubMed  Google Scholar 

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Cardinali, D.P., Vacas, M.I. (1978). Feedback Control of Pineal Function by Reproductive Hormones—A Neuroendocrine Paradigm. In: Nir, I., Reiter, R.J., Wurtman, R.J. (eds) The Pineal Gland. Journal of Neural Transmission, vol 13. Springer, Vienna. https://doi.org/10.1007/978-3-7091-4427-5_14

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