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Basic Aspects of Receptor Biochemistry pp 181–188Cite as

(3,4-Dihydroxyphenylimino)-2-Imidazoline (DPI) and Its Action at Noradrenergic and Dopaminergic Receptors in the Nucleus Accumbens of Rats: Mesolimbic Catecholamine Receptors and Hyperactivity

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Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 18))

Summary

Bilateral administration of ergometrine into the nucleus accumbens of rats pretreated 1–3 min earlier with intra-accumbens injections of noradrenaline, phenylephrine, clonidine and phentolamine has been found to produce a normal ergometrine-induced hyperactivity. In contrast, low doses of dopamine and (3,4-dihydroxyphenylimino)-2-imidazoline (DPI) and only high doses of clonidine and phentolamine have been found to attenuate the ergometrine response. These data together with the finding that phentolamine is unable to alter DPI’s ability to suppress the ergometrine response provide direct evidence that the latter DPI effect is certainly not due to its ability to act as an agonist at α-NE receptors within the nucleus accumbens of rats.

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Authors and Affiliations

  1. Department of Pharmacology, University of Nijmegen, P.O.B. 9101, NL-6500 HB, Nijmegen, The Netherlands

    Dr. A. R. Cools

  2. Department of Pharmacology, University of Nijmegen, Nijmegen, The Netherlands

    S. K. Oosterloo

Authors
  1. Dr. A. R. Cools
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  2. S. K. Oosterloo
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, New York University Medical Center, New York, N.Y., USA

    Menek Goldstein

  2. Ludwig Boltzmann-Institut für Klinische Neurobiologie und Neurologische Abteilung, Krankenhaus der Stadt Wien-Lainz, Wien, Austria

    Kurt Jellinger

  3. Ludwig Boltzmann-Institut für Klinische Neurobiologie, Krankenhaus der Stadt Wien-Lainz, Wien, Austria

    Peter Riederer

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© 1983 Springer-Verlag Wien

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Cools, A.R., Oosterloo, S.K. (1983). (3,4-Dihydroxyphenylimino)-2-Imidazoline (DPI) and Its Action at Noradrenergic and Dopaminergic Receptors in the Nucleus Accumbens of Rats: Mesolimbic Catecholamine Receptors and Hyperactivity. In: Goldstein, M., Jellinger, K., Riederer, P. (eds) Basic Aspects of Receptor Biochemistry. Journal of Neural Transmission, vol 18. Springer, Vienna. https://doi.org/10.1007/978-3-7091-4408-4_17

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  • DOI: https://doi.org/10.1007/978-3-7091-4408-4_17

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-4410-7

  • Online ISBN: 978-3-7091-4408-4

  • eBook Packages: Springer Book Archive

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