Summary
The vaccine strategies available for control of emerging encephalitides range in a continuum from traditional approaches to those utilizing new technologies. In this report, we explore the use of live attenuated vaccines where the attenuating mutations have been selected in a rational way to improve attenuation without sacrificing effectiveness. A strategy for paired lethal and resuscitating mutations is presented that will greatly reduce the possibility of reversion to virulence. Finally, we describe an example of a vaccine vector system that could be rapidly adapted for use against these virus diseases as they emerge.
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Keywords
- Drain Lymph Node
- Sindbis Virus
- Baby Hamster Kidney Cell
- Venezuelan Equine Encephalitis Virus
- Equine Arteritis Virus
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Johnston, R.E., Davis, N.L. (2004). Future vaccines against emerging encephalitides. In: Calisher, C.H., Griffin, D.E. (eds) Emergence and Control of Zoonotic Viral Encephalitides. Archives of Virology. Supplementa, vol 18. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0572-6_19
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DOI: https://doi.org/10.1007/978-3-7091-0572-6_19
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-20454-2
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