Skip to main content

Antidiabetika

  • Chapter
  • First Online:
Pharmakologie und Toxikologie
  • 31k Accesses

Zusammenfassung

Die Behandlung des Diabetes mellitus zielt zum einen auf die Vermeidung der akuten Folgen einer erhöhten Blutglucosekonzentration. Zum anderen stellt sie eine Prophylaxe gegen die bei länger bestehendem Diabetes sich entwickelnden teilweise gravierenden Langzeitfolgen dar. Im vorliegenden Kapitel werden die physiologischen und pathophysiologischen Grundlagen der Stoffwechselregulation durch Insulin und die zur Behandlung des Diabetes verfügbaren Pharmaka dargestellt. Der praktische Einsatz von Antidiabetika wird am Beispiel der Behandlung des Typ-2-Diabetes-mellitus verdeutlicht.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 89.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Weiterführende Literatur

  • Anders HJ, Davis JM, Thurau K (2016) Nephron protection in diabetic kidney disease. N Engl J Med 375:2096–2098

    Article  Google Scholar 

  • Ashcroft FM, Rorsman P (2012) Diabetes mellitus and the beta cell: the last ten years. Cell 148:1160–1171

    Article  CAS  Google Scholar 

  • Atkinson MA, Eisenbarth GS, Michels AW (2014) Type 1 diabetes. Lancet 383:69–82

    Article  Google Scholar 

  • Campbell JE, Drucker DJ (2013) Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab 17:819–837

    Article  CAS  Google Scholar 

  • Davies MJ, D’Alessio DA, Fradkin J, Kernan WN, Mathieu C, Mingrone G, Rossing P, Tsapas A, Wexler DJ, Buse JB (2018) Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care

    Google Scholar 

  • Diabetes Prevention Program Research Group (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393–403

    Article  Google Scholar 

  • DiMeglio LA, Evans-Molina C, Oram RA (2018) Type 1 diabetes. Lancet 391:2449–2462

    Article  Google Scholar 

  • Drucker DJ (2013) Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls. Diabetes 62:3316–3323

    Article  CAS  Google Scholar 

  • Holman RR, Sourij H, Califf RM (2014) Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes. Lancet 383:2008–2017

    Article  CAS  Google Scholar 

  • Johnson AM, Olefsky JM (2013) The origins and drivers of insulin resistance. Cell 152:673–684

    Article  CAS  Google Scholar 

  • Kahn SE, Cooper ME, Del Prato S (2014) Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet 383:1068–1083

    Article  CAS  Google Scholar 

  • Madiraju AK, Erion DM, Rahimi Y et al (2014) Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature 510:542–546

    Article  CAS  Google Scholar 

  • Riddle MC, Gerstein HC, Holman RR, Inzucchi SE, Zinman B, Zoungas S, Cefalu WT (2018) A1C targets should be personalized to maximize benefits while limiting risks. Diabetes Care 41:1121–1124

    Article  Google Scholar 

  • Rorsman P, Braun M (2013) Regulation of insulin secretion in human pancreatic islets. Annu Rev Physiol 75:155–179

    Article  CAS  Google Scholar 

  • Samuel VT, Shulman GI (2016) The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. J Clin Invest 126:12–22

    Article  Google Scholar 

  • Scheen AJ (2018) Cardiovascular effects of new oral glucose-lowering agents: DPP-4 and SGLT-2 Inhibitors. Circ Res 122:1439–1459

    Article  CAS  Google Scholar 

  • Tonneijck L, Muskiet MH, Smits MM, van Bommel EJ, Heerspink HJ, van Raalte DH, Joles JA (2017) Glomerular hyperfiltration in diabetes: mechanisms, clinical significance, and treatment. J Am Soc Nephrol 28:1023–1039

    Article  CAS  Google Scholar 

  • Tornio A, Niemi M, Neuvonen PJ et al (2012) Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications. Trends Pharmacol Sci 33:312–322

    Article  CAS  Google Scholar 

  • van Bommel EJ, Muskiet MH, Tonneijck L, Kramer MH, Nieuwdorp M, van Raalte DH (2017) SGLT2 inhibition in the diabetic kidney-from mechanisms to clinical outcome. Clin J Am Soc Nephrol 12:700–710

    Article  Google Scholar 

  • Zaykov AN, Mayer JP, DiMarchi RD (2016) Pursuit of a perfect insulin. Nat Rev Drug Discov 15:425–439

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Stefan Offermanns .

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Offermanns, S. (2020). Antidiabetika. In: Pharmakologie und Toxikologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58304-3_54

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-58304-3_54

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-58303-6

  • Online ISBN: 978-3-662-58304-3

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics