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DNA-Schäden: Erkennung, Reparatur und Nachweisverfahren

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Der Experimentator Zellbiologie

Part of the book series: Experimentator ((EXPERIMENTATOR))

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Zusammenfassung

Dieses Kapitel ist thematisch eher eng gefasst, da es sich nur mit der DNA-Struktur, der Signalübertragung der Schadenserkennung, der DNA-Reparatur und den Nachweisverfahren für unterschiedliche DNA-Schäden befasst. Der Schwerpunkt ist bewusst so gewählt, weil die Integrität des DNA-Moleküls von fundamentaler Bedeutung für das Zellüberleben ist. Idealerweise soll nur intakte DNA bei der Zellteilung an die Tochterzellen weitergegeben werden, allerdings wirken ständig schädigende chemische und physikalische Noxen auf die Erbsubstanz ein, was die Zelle dazu zwingt, sich fortwährend mit den entstandenen Schäden auseinanderzusetzen. Die Kenntnis über die Struktur des DNA-Moleküls ist von grundlegender Bedeutung für das Verständnis der zellulären Schadensantwort und der Reparaturmechanismen.

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Authors and Affiliations

  1. Jülich, Deutschland

    Sabine Schmitz

  2. Kiel, Deutschland

    Christine Desel

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  1. Sabine Schmitz
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  2. Christine Desel
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Schmitz, S., Desel, C. (2018). DNA-Schäden: Erkennung, Reparatur und Nachweisverfahren. In: Der Experimentator Zellbiologie. Experimentator. Springer Spektrum, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-56111-9_7

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