Skip to main content
SpringerLink
Log in
Book cover

Funktionsdiagnostik in Endokrinologie, Diabetologie und Stoffwechsel pp 55–69Cite as

Nebenschilddrüse

  • Chapter
  • First Online:

  • 3858 Accesses

Zusammenfassung

Erläutert werden alle relevanten Funktionstests mit ausführlicher Darstellung von Indikationen, Kontraindikationen, Nebenwirkungen, Testvorbereitung, Rahmenbedingungen, konkreten Handlungsanleitung der eigentlichen Testdurchführung sowie der Interpretation der Testergebnisse. Es werden immer konkrete Normbereiche und Cut-off-Werte angegeben, auch für besondere Situationen (Geschlecht, Alter, BMI, Pubertätsphasen, Zyklusphasen, akute Erkrankungen, Medikamente etc.). Ein besonderes Merkmal ist die Betonung der Testvorbereitung, -durchführung und -interpretation sowie des interdisziplinären Charakters. Nebenschilddrüsendiagnostik ist biochemisch sehr anspruchsvoll. Neben den Kalzium- und Phosphat-Werten in Serum und Urin erfolgt eine ausführliche Darstellung zum Parathormon. Der Casanova-Test wird erläutert. Sowohl die Halsvenenkatheterisierung als auch die intraoperative PTH-Bestimmung sind von hoher praktischer Bedeutung, ebenso wie die Beurteilung eines Operationserfolgs anhand nationaler und internationaler Kriterien.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Literatur

  1. D’Amour P, Brossard JH, Rousseau L, Roy L, Gao P, Cantor T (2003) Amino-terminal form of parathyroid hormone (PTH) with immunologic similarities to hPTH(1-84) is overproduced in primary and secondary hyperparathyroidism. Clin Chem 49:2037–2044

    Article  PubMed  Google Scholar 

  2. Fraser WD, Ahmad AM, Vora JP (2004) The physiology of the circadian rhythm of parathyroid hormone and its potential as a treatment for osteoporosis. Curr Opin Nephrol Hypertens 13:437–444

    Article  CAS  PubMed  Google Scholar 

  3. Holmes DT, Levin A, Forer B, Rosenberg F (2005) Preanalytical influences on DPC IMMULITE 2000 intact PTH assays of plasma and serum from dialysis patients. Clin Chem 51:915–917

    Article  CAS  PubMed  Google Scholar 

  4. Glendenning P, Musk AA, Taranto M, Vasikaran SD (2002) Preanalytical factors in the measurement of intact parathyroid hormone with the DPC IMMULITE assay. Clin Chem 48:566–567

    CAS  PubMed  Google Scholar 

  5. Haden ST, Brown EM, Hurwitz S, Scott J, El-Hajj Fuleihan G (2000) The effects of age and gender on parathyroid hormone dynamics. Clin Endocrinol (Oxf) 52:329–338

    Article  CAS  Google Scholar 

  6. Lopez I, Aguilera-Tejero E, Felsenfeld AJ, Estepa JC, Rodriguez M (2002) Direct effect of acute metabolic and respiratory acidosis on parathyroid hormone secretion in the dog. J Bone Miner Res 17:1691–1700

    Article  CAS  PubMed  Google Scholar 

  7. Lopez I, Rodriguez M, Felsenfeld AJ, Estepa JC, Aguilera-Tejero E (2003) Direct suppressive effect of acute metabolic and respiratory alkalosis on parathyroid hormone secretion in the dog. J Bone Miner Res 18:1478–1485

    Article  CAS  PubMed  Google Scholar 

  8. Cholst IN, Steinberg SF, Tropper PJ, Fox HE, Segre GV, Bilezikian JP (1984) The influence of hypermagnesemia on serum calcium and parathyroid hormone levels in human subjects. N Engl J Med 310:1221–1225

    Article  CAS  PubMed  Google Scholar 

  9. Sokoll LJ, Wians FH Jr, Remaley AT (2004) Rapid intraoperative immunoassay of parathyroid hormone and other hormones: a new paradigm for point-of-care testing. Clin Chem 50:1126–1135

    Article  CAS  PubMed  Google Scholar 

  10. Riss P, Kaczirek K, Bieglmayer C, Niederle B (2007) PTH spikes during parathyroid exploration – a possible pitfall during PTH monitoring? Langenbecks Arch Surg 392:427–430

    Article  PubMed  Google Scholar 

  11. Carneiro DM, Solorzano CC, Nader MC, Ramirez M, Irvin GL (2003) Comparison of intraoperative iPTH assay (QPTH) criteria in guiding parathyroidectomy: which criterion is the most accurate? Surgery 134:973–979; discussion 979–981

    Article  PubMed  Google Scholar 

  12. Zettinig G, Kurtaran A, Prager G, Kaserer K, Dudczak R, Niederle B (2002) ‚Suppressed‘ double adenoma – a rare pitfall in minimally invasive parathyroidectomy. Horm Res 57:57–60

    CAS  PubMed  Google Scholar 

  13. Reidel MA, Schilling T, Graf S, Hinz U, Nawroth P, Buchler MW, Weber T (2006) Localization of hyperfunctioning parathyroid glands by selective venous sampling in reoperation for primary or secondary hyperparathyroidism. Surgery 140:907–913; discussion 913

    Article  PubMed  Google Scholar 

  14. Jones JJ, Brunaud L, Dowd CF, Duh QY, Morita E, Clark OH (2002) Accuracy of selective venous sampling for intact parathyroid hormone in difficult patients with recurrent or persistent hyperparathyroidism. Surgery 132:944–950; discussion 950–941

    Article  PubMed  Google Scholar 

  15. Udelsman R, Aruny JE, Donovan PI, Sokoll LJ, Santos F, Donabedian R, Venbrux AC (2003) Rapid parathyroid hormone analysis during venous localization. Ann Surg 237:714–719; discussion 719–721

    PubMed  PubMed Central  Google Scholar 

  16. Baker SB, Worthley LI (2002) The essentials of calcium, magnesium and phosphate metabolism: part I. Physiology. Crit Care Resusc 4:301–306

    CAS  PubMed  Google Scholar 

  17. Thomas L (2008) Labor und diagnose, 7. Aufl. TH-Books, Frankfurt am Main, S 350–353

    Google Scholar 

  18. Payne RB, Carver ME, Morgan DB (1979) Interpretation of serum total calcium: effects of adjustment for albumin concentration on frequency of abnormal values and on detection of change in the individual. J Clin Pathol 32:56–60

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Pak CY, Oata M, Lawrence EC, Snyder W (1974) The hypercalciurias. Causes, parathyroid functions, and diagnostic criteria. J Clin Invest 54:387–400

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Strewler GJ (2000) The physiology of parathyroid hormone-related protein. N Engl J Med 342:177–185

    Article  CAS  PubMed  Google Scholar 

  21. Hiraki A, Ueoka H, Bessho A, Segawa Y, Takigawa N, Kiura K, Eguchi K, Yoneda T, Tanimoto M, Harada M (2002) Parathyroid hormone-related protein measured at the time of first visit is an indicator of bone metastases and survival in lung Karzinoma patients with hypercalcemia. Cancer 95:1706–1713

    Article  CAS  PubMed  Google Scholar 

  22. Dumon JC, Jensen T, Lueddecke B, Spring J, Barle J, Body JJ (2000) Technical and clinical validation of an immunoradiometric assay for circulating parathyroid hormone-related protein. Clin Chem 46:416–418

    CAS  PubMed  Google Scholar 

  23. Ratcliffe WA, Norbury S, Heath DA, Ratcliffe JG (1991) Development and validation of an immunoradiometric assay of parathyrin-related protein in unextracted plasma. Clin Chem 37:678–685

    CAS  PubMed  Google Scholar 

  24. Burtis WJ, Brady TG, Orloff JJ, Ersbak JB, Warrell RP Jr, Olson BR, Wu TL, Mitnick ME, Broadus AE, Stewart AF (1990) Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer. N Engl J Med 322:1106–1112

    Article  CAS  PubMed  Google Scholar 

  25. Tang JCY, Washbourne CJ, Galitzer H, Hiemstra T, Meek C, Chipchase A, Fraser D (2013) The Ellsworth-howard-test revisited. Bone Abstr 1:PP129

    Google Scholar 

  26. Mahaffee DD et al (1982) Magnesium promotes both parathyroid hormone secretion and adenosine 3′,5′-monophosphate production in rat parathyroid tissues and reverses the inhibitory effects of calcium on adenylate cyclase. Endocrinology 110:487–495

    Article  CAS  PubMed  Google Scholar 

  27. Rodriguez-Ortiz ME et al (2014) Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration. Nephrol Dial Transplant 29:282–289

    Article  CAS  PubMed  Google Scholar 

  28. Casanova D et al (1991) Secondary hyperparathyroidism: diagnosis of site of recurrence. World J Surg 15:546–549; discussion 549–550

    Article  CAS  PubMed  Google Scholar 

  29. Schlosser K et al (2004) Assessing the site of recurrence in patients with secondary hyperparathyroidism by a simplified Casanova autograftectomy test. World J Surg 28:583–588

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Innere Medizin III, Universitätsklinikum Gießen und Marburg (UKGM), Standort Giessen, Giessen, Deutschland

    Andreas Schäffler & Thomas Karrasch

  2. Lehrstuhl für Geriatrie, Universitätsklinikum Aachen, Universität Aachen, Aachen, Deutschland

    Cornelius Bollheimer

  3. Abteilung für Innere Medizin, Caritas Krankenhaus St. Josef, Regensburg, Regensburg, Deutschland

    Roland Büttner

  4. Klinik für Allgemeine Innere Medizin und Geriatrie, Krankenhaus der Barmherzigen Brüder, Regensburg, Deutschland

    Christiane Girlich

  5. Institut für Klinische Chemie und Laboratoriumsmedizin, Klinikum der Universität Regensburg, Regensburg, Deutschland

    Charalampos Aslanidis

  6. Institut für Pathologie, Klinikum der Universität Regensburg, Regensburg, Deutschland

    Wolfgang Dietmaier

  7. Medizinische Klinik und Poliklinik I, Universitätsklinikum Würzburg, Würzburg, Deutschland

    Margarita Bala

  8. Abteilung für Innere Medizin, Klinikum Bogen, Bogen, Deutschland

    Viktoria Guralnik

  9. Klinik und Poliklinik für Innere Medizin I, Klinikum der Universität Regensburg, Regensburg, Deutschland

    Sylvia Schneider

Authors
  1. Andreas Schäffler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cornelius Bollheimer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Roland Büttner
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Christiane Girlich
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Charalampos Aslanidis
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Wolfgang Dietmaier
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Margarita Bala
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Viktoria Guralnik
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Thomas Karrasch
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Sylvia Schneider
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Andreas Schäffler .

Editor information

Editors and Affiliations

  1. Medizinische Klinik und Poliklinik III, Universitätsklinikum Gießen und Marburg (UKGM), Standort Gießen, Gießen, Germany

    Andreas Schäffler

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer-Verlag GmbH Deutschland

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Schäffler, A. et al. (2018). Nebenschilddrüse. In: Schäffler, A. (eds) Funktionsdiagnostik in Endokrinologie, Diabetologie und Stoffwechsel. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-55914-7_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-55914-7_6

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-55913-0

  • Online ISBN: 978-3-662-55914-7

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation