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Akne und Rosazea

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Braun-Falco’s Dermatologie, Venerologie und Allergologie

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Zusammenfassung

Akne und Rosazea zählen zu den häufigsten entzündlichen Hauterkrankungen, die eine konsequente Behandlung erfordern. Aktuelle pathogenetische Erkenntnisse erklären neue präventive und innovative Therapienansätze. Bei Acne vulgaris wurden Ernährungsfaktoren als wichtige Auslöser gesichert wie vermehrter Konsum von Milch und Kohlenhydraten, die den mTORC1-Signalweg und damit die Talgproduktion steigern. Endoplasmatischer Retikulum-Stress erklärt die klinischen Triggerfaktoren der Rosazea und erlaubt ein neues Verständnis der Rosazea. Die Acne inversa ist keine Akne im eigentlichen Sinn, sondern ist eine Entzündung terminaler Haarfollikel (dissecting terminal hair folliculitis). Primär besteht eine erhöhte Fragilität des Akroinfundibulums infolge verminderter Notch-Signale sowie eine Verbindung zu autoinflammatorischen Prozessen. Die Kenntnis dieser neuen Zusammenhänge ermöglicht moderne und zielgerichtete Therapien dieser häufigen, psychosozial oft stark belastenden Hautkrankheiten.

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Authors and Affiliations

  1. Abteilung Dermatologie, Umweltmedizin und Gesundheitstheorie, Universität Osnabrück, Am Finkenhügel 7a, 49076, Osnabrück, Deutschland

    Bodo Melnik

  2. Hautarztpraxis, Gütersloh, Deutschland

    Bodo Melnik

  3. Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteiner Str. 29, 80802, München, Deutschland

    Wenchieh Chen

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  1. Bodo Melnik
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Correspondence to Bodo Melnik .

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Editors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Allergologie, Universitätsklinikum München, München, Germany

    Gerd Plewig

  2. Klinik und Poliklinik für Dermatologie und Allergologie, Universitätsklinikum München, München, Germany

    Thomas Ruzicka

  3. Klinik für Dermatologie, Venerologie und Allergologie, J.W.Goethe-Universität, Frankfurt, Germany

    Roland Kaufmann

  4. Klinik für Dermatologie und Allergologie, Universitätsklinikum Marburg, Marburg, Germany

    Michael Hertl

Section Editor information

  1. Klinik und Poliklinik für Dermatologie und Allergologie, Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland

    Thomas Ruzicka

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Melnik, B., Chen, W. (2018). Akne und Rosazea. In: Plewig, G., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco’s Dermatologie, Venerologie und Allergologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49544-5_71

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