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Erworbene Bindegewebserkrankungen

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Braun-Falco’s Dermatologie, Venerologie und Allergologie

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Zusammenfassung

Atrophie der Haut trifft für eine Vielzahl von erworbenen Erkrankungen zu und zeigt sich durch unterschiedliche Ausprägungen der Verminderung von Komponenten der extrazellulären Matrix mit folglicher Atrophie der Dermis und sekundär auch der Epidermis und der Subkutis. Die dermale und/oder subkutane Atrophie kann sowohl fokal als auch diffus ausgebildet sein. Dermale Atrophie führt zum ausgeprägten Verlust von Kollagenfibrillen oder zum Verlust von Proteoglykanen und der elastischen Fasern, neben einer Verminderung von Glykoproteinen. Eine alleinige Atrophie der Epidermis ist selten, häufig tritt sie in Kombination mit der dermalen Atrophie auf. Fehlfunktion und Depletion adulter Stammzellen, ein begrenztes proliferatives Potenzial der dermalen Zellen durch Reaktion auf Schädigung und Stress (beispielsweise der UV-Schädigung) sowie Beeinträchtigung der Angiogenese und neurogenen Versorgung tragen zur dermalen Atrophie bei. Die wahrscheinlich stärkste Ausbildung einer Atrophie wird bei der Acrodermatitis chronica atrophicans beobachtet, der Spätphase einer Infektion mit Borrelia burgdorferi.

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Authors and Affiliations

  1. Universitätsklinik und Poliklinik für Dermatologie und Allergologie, Universitätklinikum Ulm, Ulm, Deutschland

    Karin Scharffetter-Kochanek & Evgenia Makrantonaki

Authors
  1. Karin Scharffetter-Kochanek
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  2. Evgenia Makrantonaki
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Correspondence to Karin Scharffetter-Kochanek .

Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Allergologie, Universitätsklinikum München, München, Germany

    Gerd Plewig

  2. Klinik und Poliklinik für Dermatologie und Allergologie, Universitätsklinikum München, München, Germany

    Thomas Ruzicka

  3. Klinik für Dermatologie, Venerologie und Allergologie, J.W.Goethe-Universität, Frankfurt, Germany

    Roland Kaufmann

  4. Klinik für Dermatologie und Allergologie, Universitätsklinikum Marburg, Marburg, Germany

    Michael Hertl

Section Editor information

  1. Klinik für Dermatologie und Allergologie, Universitätsklinikum Marburg, Marburg, Deutschland

    Michael Hertl

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Scharffetter-Kochanek, K., Makrantonaki, E. (2018). Erworbene Bindegewebserkrankungen. In: Plewig, G., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco’s Dermatologie, Venerologie und Allergologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49544-5_52

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  • DOI: https://doi.org/10.1007/978-3-662-49544-5_52

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