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Geriatrische Onkologie pp 313–324Cite as

Ösophaguskarzinom beim alten und geriatrischen Patienten

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Zusammenfassung

Ösophaguskarzinome sind Erkrankungen des Erwachsenen und zeigen eine zunehmende Prävalenz mit steigendem Lebensalter. Plattenepithelkarzinome entstehen vorwiegend auf der Grundlage jahrelangen Tabak- und Alkoholkonsums; Adenokarzinome finden sich assoziiert mit Adipositas und chronischer gastro-ösophagealer Refluxkrankheit. Die kurative Behandlung des Ösophaguskarzinoms erfolgt multimodal in den meist bei Diagnosestellung anzutreffenden lokal fortgeschrittenen Stadien. Die Therapie-assoziierten Risiken sind dabei besonders zu beachten. Ein exzellentes Risikomanagement, gerade bei Begleiterkrankungen und eingeschränkten Organfunktionen ist von großer Wichtigkeit. Dies setzt gerade bei älteren Patienten eine große Erfahrung und Expertise des Zentrums voraus. Die wissenschaftliche Evidenz für die Behandlung von Ösophaguskarzinomen im höheren Lebensalter ist noch dürftig.

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Literatur

  • van Adrichem EJ, Meulenbroek RL et al (2014) Comparison of two preoperative inspiratory muscle training programs to prevent pulmonary complications in patients undergoing esophagectomy: a randomized controlled pilot study. Ann Surg Oncol 21:2353–2360

    PubMed  Google Scholar 

  • Agrelli TF, de Carvalho RM et al (2012) Preoperative ambulatory inspiratory muscle training in patients undergoing esophagectomy. A pilot study. Int Surg 97:198–202

    Article  PubMed  PubMed Central  Google Scholar 

  • Al-Batran SE, Hartmann JT et al (2008) Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: a study of the Arbeitsgemeinschaft Internistische Onkologie. J Clin Oncol 26:1435–1442

    Article  CAS  PubMed  Google Scholar 

  • Al-Batran SE, Pauligk C et al (2013) The feasibility of triple-drug chemotherapy combination in older adult patients with oesophagogastric cancer: a randomised trial of the Arbeitsgemeinschaft Internistische Onkologie (FLOT65+). Eur J Cancer 49:835–842

    Article  PubMed  Google Scholar 

  • Bedenne L, Michel P et al (2007) Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102. J Clin Oncol 25:1160–1168

    Article  CAS  PubMed  Google Scholar 

  • Bellera CA, Rainfray M et al (2012) Screening older cancer patients: first evaluation of the G-8 geriatric screening tool. Ann Oncol 23:2166–2172

    Article  CAS  PubMed  Google Scholar 

  • Biere SS, van Berge Henegouwen MI et al (2012) Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial. Lancet 379:1887–1982

    Article  PubMed  Google Scholar 

  • Bleiberg H, Conroy T et al (1997) Randomised phase II study of cisplatin and 5-fluorouracil (5-FU) versus cisplatin alone in advanced squamous cell oesophageal cancer. Eur J Cancer 33:1216–1220

    Article  CAS  PubMed  Google Scholar 

  • Blom RL, van Heijl M et al (2013) Initial experiences of an enhanced recovery protocol in esophageal surgery. World J Surg 37:2372–2378

    Article  PubMed  Google Scholar 

  • Bozzetti F (2015) Tube feeding in the elderly cancer patient. Nutrition 31:608–609

    Article  PubMed  Google Scholar 

  • Bytzer P, Christensen PB et al (1999) Adenocarcinoma of the esophagus and Barrett’s esophagus: a population-based study. Am J Gastroenterol 94:86–91

    Article  CAS  PubMed  Google Scholar 

  • Cao S, Zhao G et al (2012) Fast-track rehabilitation program and conventional care after esophagectomy: a retrospective controlled cohort study. Support Care Cancer 21:707–714

    Article  PubMed  Google Scholar 

  • Castro C, Bosetti C et al (2014) Patterns and trends in esophageal cancer mortality and incidence in Europe (1980–2011) and predictions to 2015. Ann Oncol 25:283–290

    Article  CAS  PubMed  Google Scholar 

  • Colloca G, Tosato M, Zuccalà G, Bernabei R (2005) Preoperative assessment and risk factors in the surgical treatment of esophageal cancer: the role of age. Rays 30:335–339

    PubMed  Google Scholar 

  • Decoster L, Van Puyvelde K (2015) Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendations. Ann Oncol 26:288–300

    Article  CAS  PubMed  Google Scholar 

  • Dettling DS, van der Schaaf M et al (2013) Feasibility and effectiveness of pre-operative inspiratory muscle training in patients undergoing oesophagectomy: a pilot study. Physiother Res Int 18:16–26

    Article  PubMed  Google Scholar 

  • Ell C, May A et al (2000) Endoscopic mucosal resection of early cancer and high-grade dysplasia in Barrett’s esophagus. Gastroenterology 118:670–677

    Article  CAS  PubMed  Google Scholar 

  • El-Serag HB, Hashmi A et al (2014) Visceral abdominal obesity measured by CT scan is associated with an increased risk of Barrett's oesophagus: a case-control study. Gut 63:220–229

    PubMed  Google Scholar 

  • Ferlay J, Steliarova-Foucher E et al (2013) Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer 49:1374–1403

    Article  CAS  PubMed  Google Scholar 

  • van Hagen P, Hulshof MC et al (2012) Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med 366:2074–2084

    Article  PubMed  Google Scholar 

  • Homs MY, Steyerberg EW et al (2004) Single-dose brachytherapy versus metal stent placement for the palliation of dysphagia from oesophageal cancer: multicentre randomised trial. Lancet 364:1497–1504

    Article  PubMed  Google Scholar 

  • Hurria A, Browner IS et al (2012) Senior adult oncology. J Natl Compr Canc Netw 10:162–209

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hvid-Jensen F, Pedersen L et al (2011) Incidence of adenocarcinoma among patients with Barrett’s esophagus. N Engl J Med 365:1375–1383

    Article  CAS  PubMed  Google Scholar 

  • Inoue J, Ono R et al (2013) Prevention of postoperative pulmonary complications through intensive preoperative respiratory rehabilitation in patients with esophageal cancer. Dis Esophagus 26:68–74

    Article  CAS  PubMed  Google Scholar 

  • Koop H, Fuchs KH et al (2014) S2k-Leitlinie: Gastroösophageale Refluxkrankheit unter Federführung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten, DGVS, AWMF Registrier-Nummer 021–013. Z Gastroenterol 52:1299–1346

    Article  PubMed  Google Scholar 

  • Kosugi S, Sasamoto R, Kanda T, Matsuki A, Hatakeyama K (2009) Retrospective review of surgery and definitive chemoradiotherapy in patients with squamous cell carcinoma of the thoracic esophagus aged 75 years or older. Jpn J Clin Oncol 39:360–366

    Article  PubMed  Google Scholar 

  • Lagergren J, Bergström R et al (1999) Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 340:825–831

    Article  CAS  PubMed  Google Scholar 

  • Li J, Shen Y et al (2015) Is minimally invasive esophagectomy beneficial to elderly patients with esophageal cancer? Surg Endosc 29:925–930

    Article  PubMed  Google Scholar 

  • Lordick F (2012) Optimizing neoadjuvant chemotherapy through the use of early response evaluation by positron emission tomography. Recent Results Cancer Res 196:201–211

    Article  PubMed  Google Scholar 

  • Lordick F, Ott K et al (2007) PET to assess early metabolic response and to guide treatment of adenocarcinoma of the oesophagogastric junction: the MUNICON phase II trial. Lancet Oncol 8:797–805

    Article  PubMed  Google Scholar 

  • Lordick F, Mariette C, Haustermans K, Obermannová R, Arnold D on behalf of the ESMO Guideline Committee (2016) Oesophageal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 27(Sep, suppl 5):v50–v57

    Google Scholar 

  • Lorenzen S, Pauligk C et al (2013) Feasibility of perioperative chemotherapy with infusional 5-FU, leucovorin, and oxaliplatin with (FLOT) or without (FLO) docetaxel in elderly patients with locally advanced esophagogastric cancer. Br J Cancer 108:519–526

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Manzano JG, Luo R, Elting LS, George M, Suarez-Almazor ME (2014) Patterns and predictors of unplanned hospitalization in a population-based cohort of elderly patients with GI cancer. J Clin Oncol 32:3527–3533

    Article  PubMed  PubMed Central  Google Scholar 

  • Mariette C, Meunier B et al (2015) Hybrid minimally invasive versus open oesophagectomy for patients with oesophageal cancer: A multicenter, open-label, randomized phase III controlled trial, the MIRO trial. J Clin Oncol 33(Suppl 3), Abstract 5

    Google Scholar 

  • McLoughlin JM, Lewis JM et al (2013) The impact of age on morbidity and mortality following esophagectomy for esophageal cancer. Cancer Control 20:144–150

    Article  PubMed  Google Scholar 

  • Miyata H, Yamasaki M et al (2015) Clinical outcome of esophagectomy in elderly patients with and without neoadjuvant therapy for thoracic esophageal cancer. Ann Surg Oncol 22:794–801

    Article  Google Scholar 

  • Oakley B, Lamb C et al (2016) Achieving long term survival in oesophagectomy patients aged over 75. Ann Med Surg (Lond) 9:15–21

    Article  Google Scholar 

  • Pech O, May A et al (2014) Long-term efficacy and safety of endoscopic resection for patients with mucosal adenocarcinoma of the esophagus. Gastroenterology 146:652–660

    Article  PubMed  Google Scholar 

  • Phoa KN, van Vilsteren FG et al (2014) Radiofrequency ablation vs endoscopic surveillance for patients with Barrett esophagus and low-grade dysplasia: a randomized clinical trial. JAMA 311:1209–1217

    Article  CAS  PubMed  Google Scholar 

  • Phoa KN, Pouw RE et al (2016) Multimodality endoscopic eradication for neoplastic Barrett oesophagus: results of an European multicentre study (EURO-II). Gut 65:555–562

    Article  CAS  PubMed  Google Scholar 

  • Popa MA, Wallace KJ, Brunello A, Extermann M, Balducci L (2014) Potential drug interactions and chemotoxicity in older patients with cancer receiving chemotherapy. J Geriatr Oncol 5:307–314

    Article  PubMed  PubMed Central  Google Scholar 

  • Puntambekar S, Kenawadekar R et al (2013) Minimally invasive esophagectomy in the elderly. Indian J Surg Oncol 4:326–331

    Article  PubMed  PubMed Central  Google Scholar 

  • Rice DC, Correa AM et al (2005) Preoperative chemoradiotherapy prior to esophagectomy in elderly patients is not associated with increased morbidity. Ann Thorac Surg 79:391–397

    Article  PubMed  Google Scholar 

  • Rustgi AK, El-Serag HB (2014) Esophageal carcinoma. N Engl J Med 371:2499–2509

    Article  PubMed  Google Scholar 

  • Schoppmeyer K, Golsong J et al (2007) Antireflux stents for palliation of malignant esophagocardial stenosis. Dis Esophagus 20:89–93

    Article  CAS  PubMed  Google Scholar 

  • Shaheen NJ, Sharma P et al (2009) Radiofrequency ablation in Barrett’s esophagus with dysplasia. N Engl J Med 360:2277–2288

    Article  CAS  PubMed  Google Scholar 

  • Stahl M, Stuschke M et al (2005) Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus. J Clin Oncol 23:2310–2317

    Article  PubMed  Google Scholar 

  • Stahl M, Walz MK et al (2009) Phase III comparison of preoperative chemotherapy compared with chemoradiotherapy in patients with locally advanced adenocarcinoma of the esophagogastric junction. J Clin Oncol 27:851–856

    Article  CAS  PubMed  Google Scholar 

  • Steyerberg EW, Neville BA et al (2006) Surgical mortality in patients with esophageal cancer: development and validation of a simple risk score. J Clin Oncol 24:4277–4284

    Article  PubMed  Google Scholar 

  • Waddell T, Verheij M et al (2013) Gastric cancer: ESMO-ESSO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 24(Suppl 6):vi57–vi63

    Article  PubMed  Google Scholar 

  • Wilke H, Muro K et al (2014) Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial. Lancet Oncol 15:1224–1235

    Article  CAS  PubMed  Google Scholar 

  • Won E, Ilson DH (2014) Management of localized esophageal cancer in the older patient. Oncologist 19:367–374

    Article  PubMed  PubMed Central  Google Scholar 

  • Wouters MW, Wijnhoven BP et al (2008) High-volume versus low-volume for esophageal resections for cancer: the essential role of case-mix adjustments based on clinical data. Ann Surg Oncol 15:80–87

    Article  PubMed  Google Scholar 

  • Yamamoto M, Yamasaki M, Sugimoto K, Maekawa Y, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Rakugi H, Mori M, Doki Y. Risk Evaluation of Postoperative Delirium Using Comprehensive Geriatric Assessment in Elderly Patients with Esophageal Cancer. World J Surg 40(11):2705–2712

    Google Scholar 

  • Yamana I, Takeno S et al (2015) Is the geriatric nutritional risk index a significant predictor of postoperative complications in patients with esophageal cancer undergoing esophagectomy? Eur Surg Res 55:35–42

    Article  PubMed  Google Scholar 

  • Zhu HD, Guom JH et al (2014) Conventional stents versus stents loaded with (125)iodine seeds for the treatment of unresectable oesophageal cancer: a multicentre, randomised phase 3 trial. Lancet Oncol 15:612–619

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. University Cancer Center Leipzig (UCCL), University Medicine Leipzig, Liebigstr. 20, Haus 4, 04103, Leipzig, Deutschland

    Florian Lordick

  2. Klinik und Poliklinik für Visceral-, Transplantations-, Thorax- und Gefäßchirurgie, Universitätsklinikum Leipzig, Liebigstr. 20, 04103, Leipzig, Deutschland

    Ines Gockel

  3. Klinik und Poliklinik für Gastroenterologie und Rheumatologie, Universitätsklinikum Leipzig, Liebigstr. 18, 04103, Leipzig, Deutschland

    Joachim Mössner

Authors
  1. Florian Lordick
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  2. Ines Gockel
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  3. Joachim Mössner
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Corresponding author

Correspondence to Florian Lordick .

Editor information

Editors and Affiliations

  1. II. Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany

    Matthias Ebert

  2. II. Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany

    Nicolai Härtel

  3. Klinik für Innere Medizin II, Universitätsklinikum Jena, Jena, Germany

    Ulrich Wedding

Section Editor information

  1. Interdisziplinäres Tumorzentrum, Universitätsmedizin Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland

    Nicolai Härtel

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Lordick, F., Gockel, I., Mössner, J. (2018). Ösophaguskarzinom beim alten und geriatrischen Patienten. In: Ebert, M., Härtel, N., Wedding, U. (eds) Geriatrische Onkologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48727-3_24

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  • DOI: https://doi.org/10.1007/978-3-662-48727-3_24

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  • Print ISBN: 978-3-662-48726-6

  • Online ISBN: 978-3-662-48727-3

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