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A Review of Recent Studies on Rous Sarcoma Virus (RSV) Emphasizing Virus-Cell-Host Interactions

  • Conference paper
Ergebnisse der Mikrobiologie Immunitätsforschung und Experimentellen Therapie

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 38))

  • 19 Accesses

Abstract

In attempting to review recent research dealing with Rous sarcoma, it is interesting to note the quantity and diversity of investigations reported within the past six years following several decades of relative inactivity in this important area. It is obvious that in order to be of value, this review must be limited to but a few areas of a broad spectrum. Setting such limits is difficult. Selection of topics must be both subjective and arbitrary, and done with the full realization that literature of interest and importance will be omitted altogether. We admittedly have also been influenced by our own research interests, and by our reluctance to stray from areas of our own personal experience. It is the intent of this review to evaluate and integrate recent findings concerning interactions between Rous sarcoma virus (RSV) and its host, both as cell and as organism. This subject will be approached from the following five viewpoints: a) Morphological and viral aspects of tumor pathogenesis, b) The relative roles of the tumor cell and the virus in tumor induction, c) Factors of host resistance to infection with RSV, d) The effects of humoral antibody upon infection and the subsequent development of malignant disease, and e) Experimental chemotherapy of virus-induced Rous sarcoma. No attempt will be made to review numerous studies concerned with the kinetics and characteristics of RSV infection in vitro (8),(35), (38), (39),(65), (74), (84–87),(104–107), (112), the studies on adaptation of the virus to growth in mammalian species (55),(64), (91), (101–103), or the electron microscopic studies on ultrastructural aspects of RSV infection (30), (46–49), that have been recently reviewed by other investigators.

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References

  1. Adams, E., and V. GroupÉ: A macrofocus assay for Rous sarcoma virus (Rsv) in chicken embryo cells. Virology 21, 271–273 (1963).

    Google Scholar 

  2. Andrewes, C. H.: The immunological relationship of fowl tumors with different histological structure. J. Path. Bact. 34, 91–107 (1931).

    Article  Google Scholar 

  3. Andrewes, C. H.: The occurrence of neutralizing antibodies for Rous sarcoma virus in the sera of young “normal” chicks. J. Path. Bact. 48, 225–227 (1939).

    Article  Google Scholar 

  4. Bader, J. P.: Production of interferon by chick embryo cells exposed to Rous sarcoma virus. Virology 16, 436–443 (1962).

    Article  CAS  PubMed  Google Scholar 

  5. Bang, F. B., and R. Haley: The appearance and disappearance of antibodies to Rous virus in normal chickens. J. nat. Cancer Inst. 20, 329–338 (1958).

    CAS  PubMed  Google Scholar 

  6. Bang, F. B., and M. Foard: Flocks of chickens free from antibody to Rous virus. J. nat. Cancer Inst. 30, 457–466 (1963).

    CAS  PubMed  Google Scholar 

  7. Bergs, V. V., and V. GroupÉ: Critical factors in successful recovery of Rous sarcoma virus from turkey tumors. Science 134, 192–193 (1961).

    Google Scholar 

  8. Bergs, V. V., and V. GroupÉ: Effect of antiviral antibody on virus-cell interactions in turkey Rous sarcoma cells. J. nat. Cancer Inst. 29, 723–737 (1962).

    Google Scholar 

  9. Bergs, V. V., and V. GroupÉ: Role of humoral antibody and infecting dose in the recovery of Rous sarcoma virus from turkey tumor cells in tissue culture. J. nat. Cancer Inst. 29, 739–748 (1962).

    Google Scholar 

  10. Bergs, V. V., and V. GroupÉ: Low malignancy of Rous sarcoma cells as evidenced by poor transplantability in turkeys. Science 139, 922–923 (1963).

    Google Scholar 

  11. Bielka, H., and A. Graffi: The significance of nucleic acids for the development of the Rous virus. Naturwissenschaften 45, 320 (1958).

    Article  CAS  Google Scholar 

  12. BoRsos, T., and F. B. Bang: Quantitation of hemorrhagic lesions in the chick embryo produced by the Rous tumor virus. Virology 4, 385–386 (1957).

    Article  CAS  PubMed  Google Scholar 

  13. Brandly, C. A., H. E. Moses, and E. L. Jungherr: Transmission of antiviral activity via the egg and the role of congenital passive immunity to Newcastle disease in chickens. Amer. J. vet. Res. 7, 333–342 (1946).

    CAS  PubMed  Google Scholar 

  14. Bryan, W. R.: Quantitative studies on the latent period of tumors induced with subcutaneous injections of the agent of chicken tumor I. I. Curve relating dosage of agent and chicken response. J. nat. Cancer Inst. 6, 225–237 (1946).

    CAS  Google Scholar 

  15. Bryan, W. R., D. Calnan, and J. B. Moloney: Biological studies on the Rous sarcoma virus. Iii. The recovery of virus from experimental tumors in relation to initiating dose. J. nat. Cancer Inst. 16, 317–335 (1955).

    CAS  PubMed  Google Scholar 

  16. Burmester, B. R.: Routes of natural infection in avian lymphomatosis. Ann N Y Acad. Sci. 68, 487–495 (1957).

    Article  CAS  PubMed  Google Scholar 

  17. Burmester, B. R., A. K. Fontes, and W. G. Walter: Contact transmission of Rous sarcoma. J. nat. Cancer Inst. 25, 307–313 (1960).

    CAS  PubMed  Google Scholar 

  18. Burmester, B. R., A. K. Fontes, N. F. Waters, W. R. Bryan, and V. GroupÉ: The response of several inbred lines of white leghorns to inoculation with the virus of strain Rpl 12 visceral lymphomatosis-erythroblastosis, and of Rous sarcoma. Poultry Sci. 39, 199–215 (1960).

    Google Scholar 

  19. Burmester, B. R., A. K. Fontes: Personal communication, 1964.

    Google Scholar 

  20. Carr, J. G.: The relation between age, structure, and agent content of Rous No. 1 sarcomas. Brit. J. exp. Path. 24, 133–137 (1943).

    CAS  Google Scholar 

  21. Carr, J. G.: Prolonged antibody production following recovery of fowls from Rous No. 1 sarcoma. Brit. J. exp. Path. 24, 138–140 (1943).

    CAS  Google Scholar 

  22. Carr, J. G.: Experiments on the inhibitor occurring in Rous No. 1 sarcomas. Brit. J. exp. Path. 25, 56–62 (1944).

    Google Scholar 

  23. Crawford, L. V., and E. M. Crawford: The properties of Rous sarcoma virus purified by density gradient centrifugation. Virology 13, 227–232 (1961).

    Article  CAS  PubMed  Google Scholar 

  24. Crittenden, L. B., W. Okazaki, and R. Reamer: Genetic resistance to Rous sarcoma virus in embryo cell cultures and embryos. Virology 20, 541–544 (1963).

    Article  CAS  PubMed  Google Scholar 

  25. Crittenden, L. B., W. Okazaki, and R. Reamer: Personal communication, 1964.

    Google Scholar 

  26. Dhaliwal, S. S.: Resistance of the chorio-allantoic membrane of chick embryos to Rous sarcoma and MH2 reticuloendothelioma viruses. J. nat. Cancer Inst. 30, 323–336 (1963).

    CAS  PubMed  Google Scholar 

  27. Dougherty, R. M., J. A. Stewart, and H. R. Morgan: Quantitative studies of the relationships between infecting dose of Rous sarcoma virus, antiviral immune response, and tumor growth in chickens. Virology 11, 349–370 (1960).

    Article  CAS  PubMed  Google Scholar 

  28. Dougherty, R. M., and H. R. Morgan: Comparative studies in Rous sarcoma with virus, tumor cells, and chick embryo cells transformed in vitro by virus. II. Response of normal and immunized chicks. J. exp. Med. 115, 245–251 (1962).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  29. Dougherty, R. M., P. J. Simons, and F. C. Chesterman: Biological properties of three variants of Rous sarcoma virus. J. nat. Cancer Inst. 31, 1285–1307 (1963).

    CAS  PubMed  Google Scholar 

  30. Dourmasiikin, R. R., and P. J. SMoxs: The ultrastructure of the Rous sarcoma virus. J. Ultrastruct. Res. 5, 505–522 (1961).

    Article  Google Scholar 

  31. Dulbecco, R.: Induction of tumors in vitro with viruses. Nat. Cancer Inst. Monogr. 4, 355–361 (1960).

    CAS  PubMed  Google Scholar 

  32. Dunkel, V. C.: Antibody response in turkeys infected with Rous sarcoma virus (Rsv). M. S. Thesis, Rutgers Univ. 1959.

    Google Scholar 

  33. Dunkel, V. C., F. J. Rauscher, and V. GroupÉ: Further studies on Rous sarcoma virus (Rsv). Experiences with virus-host-tumor interactions in turkeys. Nat. Cancer Inst. Monogr. (in press) (1964).

    Google Scholar 

  34. Duran-Reynals, F.: Neutralization of tumor viruses by the blood of normal fowls of different ages. Yale J. Biol. Med. 13, 61–76 (1940).

    Google Scholar 

  35. Ephrussi, B., and H. M. Temin: Infection of chick iris epithelium with the Rous sarcoma virus in vitro. Virology 11, 547–552 (1960).

    Article  CAS  PubMed  Google Scholar 

  36. Epstein, M. A.: Composition of the Rous virus nucleoid. Nature (Lond.) 181, 1808 (1958).

    Article  CAS  Google Scholar 

  37. Fink, M. A., and F. J. Rauscher: A simple method for the preparation of potent chicken anti-Rous sarcoma virus serum. J. nat. Cancer Inst. 26, 519–522 (1961).

    CAS  PubMed  Google Scholar 

  38. Freeman, G.: Focus formation by Japanese quail cells infected with Rous sarcoma virus. J. nat. Cancer Inst. 31, 761–767 (1963).

    CAS  PubMed  Google Scholar 

  39. GoldÉ, A., and P. Vicier: Growth of Rous sarcoma virus and cells in nonconfluent chick embryo monolayers. Virology 15, 36–46 (1961).

    Article  PubMed  Google Scholar 

  40. GoldÉ, A., and P. Vicier: Kinetic study of inhibition of growth of Rous sarcoma virus and cells by 5-fluorouracil in vitro. Virology 20, 420–432 (1963).

    Article  PubMed  Google Scholar 

  41. GroupÉ, V., F. J. Rauscher, and W. R. Bryan: Modification of tumor response to Rous sarcoma virus (Rsv) by hydrocortisone. Proc. Soc. exp. Biol. (N.Y.) 91, 113–117 (1956).

    Google Scholar 

  42. GroupÉ, V., F. J. Rauscher, and W. R. Bryan: Suppression and modification of virus-induced Rous sarcoma in chicks by xerosin. Science 123, 1073–1074 (1956).

    Google Scholar 

  43. GroupÉ, V., F. J. Rauscher, and W. R. Bryan: “Nonviral” tumors produced in turkeys by Rous sarcoma virus. Science 125, 694–695 (1957).

    Google Scholar 

  44. GroupÉ, V., F. J. Rauscher, and W. R. Bryan: Factors contributing to production of “virus-free” tumors in turkeys by Rous sarcoma virus. Science 129, 1022–1023 (1959).

    Google Scholar 

  45. Gye, W. E., and W. J. Purdy: The cause of cancer. London: Cassel Co., Ltd. 1931.

    Google Scholar 

  46. Haguenau, F.: Significance of ultrastructure in virus-induced tumors. Nat. Cancer Inst. Monogr. 4, 211–249 (1960).

    CAS  PubMed  Google Scholar 

  47. Haguenau, F., and J. W. Beard: The avian sarcoma-leukosis complex; Its biology and ultrastructure. In: Tumors induced by viruses: Ultrastructural studies. New York: Academic Press 1962.

    Google Scholar 

  48. Haguenau, F., H. Febvre, and J. Arnoult: Mode de formation intracellulare du virus du sarcome de Rous. Etude ultrastructurale. J. Microscopie 1, 445–454 (1962).

    Google Scholar 

  49. Heine, U., G. DE THÉ, H. Isiguro, and J. W. Beard: Morphologic aspects of Rous sarcoma virus elaboration. J. nat. Cancer Inst. 29, 211–223 (1962).

    CAS  PubMed  Google Scholar 

  50. Johnson, I. S., L. A. Baker, and H. F. Wright: Possible utility of the Rous sarcoma for antitumor screening. Ann N Y Acad. Sci. 76, 861–869 (1958).

    Article  CAS  PubMed  Google Scholar 

  51. Johnson, I. S., L. A. Baker, and H. F. Wright: The utility of the Rous sarcoma virus for detection of antiviral activity. Antibiot. and Chemother. 8, 113–121 (1958).

    CAS  Google Scholar 

  52. Johnson, I. S., L. A. Baker, and H. F. Wright: Further studies on the utility of the Rous sarcoma virus for the detection of antiviral activity. Antibiot. Ann. 967–971 (1957/58).

    Google Scholar 

  53. Jungherr, E. L., and N. L. Terrell: Naturally acquired passive immunity to infectious bronchitis in chicks. Amer. J. vet. Res. 9, 201–205 (1948).

    Google Scholar 

  54. Kenzy, S. G., and P. V. Neuzil: Studies in avian neoplasia. II. The incidence of Rous virus neutralizing antibodies in serum collected from flocks experiencing losses due to lymphomatosis. Amer. J. vet. Res. 14, 123–128 (1953).

    CAS  PubMed  Google Scholar 

  55. Kuwata, T.: Studies on the growth of Rous sarcoma and its variant strain in cortisone-treated hamsters. Cancer Res. 20, 170–177 (1960).

    CAS  PubMed  Google Scholar 

  56. Levine, M.: The cytology of the tumor cell in the Rous chicken sarcoma. Amer. J. Cancer 36, 276–302, 386–430; 37, 69–107 (1939).

    Google Scholar 

  57. Levinthal, J., B. Takacs, and M. D. Eaton: Polyoma infection of newborn mice studied with fluorescent antibody. Proc. Amer. Ass. Cancer Res. 3, 339 (1962).

    Google Scholar 

  58. Levinthal, J., M. Jakobovits, and M. D. Eaton: Polyoma disease and tumors in mice: The distribution of viral antigen detected by immunofluorescence. Virology 16, 314–319 (1962).

    Article  CAS  PubMed  Google Scholar 

  59. Linder, O., and E. Klein: Skin and tumor grafting in coisogenic resistant lines of mice and their hybrids. J. nat. Cancer Inst. 24, 707–720 (1960).

    CAS  PubMed  Google Scholar 

  60. Loomis, L. N., and A. W. Pratt: The histogenesis of Rous sarcoma I induced by partially purified virus. J. nat. Cancer Inst. 17, 101–121 (1956).

    CAS  PubMed  Google Scholar 

  61. Mendle, L., and M. Pollard: Antibody response to Rous sarcoma virus. Tex. Rep. Biol. Med. 17, 218–223 (1959).

    CAS  PubMed  Google Scholar 

  62. MoRgan, H. R., and A. P. Andrese: Malignancy in vivo of chick embryo cells infected with Rous sarcoma virus in vitro. Experentia (Basel) 17, 309–310 (1961).

    Google Scholar 

  63. MoRgan, H. R., and A. P. Andrese: Comparative studies in Rous sarcoma with virus, tumor cells, and chick embryo cells transformed in vitro by virus. Iii. Malignancy in vivo of cells transformed in vitro by virus. J. exp. Med. 116, 329–336 (1962).

    Google Scholar 

  64. Munroe, J. S., and W. F. Windle: Tumors induced in primates by chicken sarcoma virus. Science 140, 1415–1416 (1963).

    Article  CAS  PubMed  Google Scholar 

  65. Nankervis, G. A., and H. R. Morgan: Infection of chick cells with Rous sarcoma virus in vitro. Virology 9, 708 (1959).

    Article  CAS  PubMed  Google Scholar 

  66. Okazaki, W, H. G. Purchase, T. N. Fredrickson, and B. R. Burmester: Modification of complement fixation test for estimation of Rous sarcoma virus antibodies in turkey and chicken serums. Proc. Soc. exp. Biol. (N.Y.) 111, 377–380 (1962).

    Article  CAS  Google Scholar 

  67. Fienta, R. J., E. H. Bernstein, and V. GroupÉ: Experiences with virus-induced Rous sarcoma as a model in experimental therapy. Cancer Chemother. Rep. (U.S.P.H.S.) No 31, 25–39 (1963).

    Google Scholar 

  68. PoNTÉN, J.: Homologous transfer of Rous sarcoma by cells. J. nat. Cancer Inst. 29, 1147–1159 (1962).

    Google Scholar 

  69. PoNTÉN, J.: Chromosome analysis of three virus-associated chicken tumors: Rous sarcoma, erythroleukemia, and Rpl 12 lymphoid tumor. J. nat. Cancer Inst. 30, 897–921 (1963).

    Google Scholar 

  70. Prince, A. M.: Quantitative studies on Rous sarcoma virus. I. The titration of Rous sarcoma virus on the chorio-allantoic membrane of the chick embryo. J. nat. Cancer Inst. 20, 147–158 (1958).

    CAS  Google Scholar 

  71. Prince, A. M.: Quantitative studies on Rous sarcoma virus. II. Mechanism of resistance of chick embryos to chorio-allantoic inoculation of Rous sarcoma virus. J. nat. Cancer Inst. 20, 843–850 (1958).

    CAS  PubMed  Google Scholar 

  72. Prince, A. M.: Quantitative studies on Rous sarcoma virus. IV. An investigation of the nature of “noninfective” tumors induced by low doses of virus. J. nat. Cancer Inst. 23, 1361–1381 (1959).

    CAS  PubMed  Google Scholar 

  73. Prince, A. M.: Quantitative studies on Rous sarcoma virus. V. An analysis of the mechanism of virulence of the Bryan ’’high titer“ strain of Rsv. Virology 11, 371–399 (1960).

    Article  CAS  PubMed  Google Scholar 

  74. Prince, A. M.: Quantitative studies on Rous sarcoma virus. VI. Clonal analysis of in vitro infections. Virology 11, 400–424 (1960).

    Article  CAS  PubMed  Google Scholar 

  75. Rabin, H., C. F. A. Heijen, M. FoArd, and F. B. Bang: Attempts to obtain virus-free Rous tumors in tissue culture. J. nat. Cancer Inst. 30, 467–476 (1963).

    CAS  PubMed  Google Scholar 

  76. Rauscher, F. J., and V. GroupÉ: Further studies on non-infective tumors in turkeys produced by Rous sarcoma virus. Proc. Amer. Ass. Cancer Res. 3, 55 (1959).

    Google Scholar 

  77. Rauscher, F. J., and V. GroupÉ: Studies on noninfective tumors produced in turkeys by Rous sarcoma virus. J. nat. Cancer Inst. 25, 141–160 (1960).

    Google Scholar 

  78. Rauscher, F. J., and V. GroupÉ: Importance of the infecting dose on growth patterns of Rous sarcoma virus (Rsv) in chick brain. J. nat. Cancer Inst. 25, 1391–1404 (1960).

    Google Scholar 

  79. Rauscher, F. J., M. A. Fink, and J. P. Kvedar: Enhancement of host response to subliminal doses of Rous sarcoma virus by Freund’S adjuvant. J. nat. Cancer Inst. 30, 645–659 (1963).

    Google Scholar 

  80. Rauscher, F. J.: Personal communication, 1963.

    Google Scholar 

  81. Rich, M., E. H. Stonehill, and M. L. Eidinoff: Growth inhibition of chick-embryo cells by some 5-fluorinated pyrimidines: Effect on Rous sarcoma virus infection. J. nat. Cancer Inst. 25, 1355–1363 (1960).

    CAS  PubMed  Google Scholar 

  82. Rous, P.: A transmissable avian neoplasm. (Sarcoma of the common fowl.) J. exp. Med. 12, 696–705 (1910).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  83. Rous, P.: A sarcoma of thé fowl transmissable by an agent seperable from the tumor cells. J. exp. Med. 13, 397–411 (1911).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  84. Rubin, H., and H. M. Temin: Infection with the Rous sarcoma virus in vitro. Fed. Proc. 17, 994–1003 (1958).

    CAS  PubMed  Google Scholar 

  85. Rubin, H., and H. M. Temin: An analysis of the assay of Rous sarcoma cells in vitro by the infective center technique. Virology 10, 29–49 (1960).

    Article  CAS  PubMed  Google Scholar 

  86. Rubin, H., and H. M. Temin: Growth of Rous sarcoma virus in chick embryo cells following irradiation of host cells or free virus. Virology 11, 28–47 (1960).

    Article  CAS  PubMed  Google Scholar 

  87. Rubin, H., and H. M. Temin: The suppression of morphological alterations in cells infected with Rous sarcoma virus. Virology 12, 14–31 (1960).

    Article  CAS  PubMed  Google Scholar 

  88. Rubin, H., and H. M. Temin: A virus in chick embryos which induces resistance in vitro to infection with Rous virus. Proc. nat. Acad. Sci. (Wash.) 46, 1105–1119 (1960).

    Article  CAS  Google Scholar 

  89. Rubin, H., and H. M. Temin: The nature of a virus-induced cellular resistance to Rous sarcoma virus. Virology 13, 200–206 (1961).

    Article  CAS  PubMed  Google Scholar 

  90. Rubin, H., H. M. Temin, and P. K. Vogt: An avian leukosis virus associated with stocks of Rous sarcoma virus. Virology 17, 184–194 (1962).

    Article  CAS  PubMed  Google Scholar 

  91. Rychlikova, M., and J. Svoboda: Effects of anti-Rous sarcoma virus sera on a hemorrhagic disease of rats. Virology 10, 545–547 (1960).

    Article  CAS  PubMed  Google Scholar 

  92. Schechtman, A. M., and P. F. Knight: Transfer of proteins from the yolk to the chick embryo. Nature (Lond.) 176, 786–787 (1955).

    Article  CAS  Google Scholar 

  93. Scholler, J., F. S. Philips, S. S. Sternberg, and J. J. Bittner: A comparative study of chemotherapeutic agents in spontaneous mammary adenocarcinomas of mice and in transplants of recent origin. Cancer (Philad.) 9, 240–251 (1956).

    Article  CAS  Google Scholar 

  94. Scholler, J., and J. J. Bittner: Further studies of chemotherapeutic agents in spontaneous mammary adenocarcinomas of mice and in transplants of recent origin. Cancer Res. 18, 464–468 (1958).

    CAS  PubMed  Google Scholar 

  95. Sigel, M. M., and N. B. Bleecher: Interference of influenza virus with Rous sarcoma virus (Rsv). Proc. Amer. Ass. Cancer Res. 3, 361 (1962).

    Google Scholar 

  96. Simons, P. J., and R. M. Dougherty: Antigenic variants of Rous sarcoma virus. Virology 15, 200–201 (1961).

    Article  CAS  PubMed  Google Scholar 

  97. Simons, P. J., and R. M. Dougherty: Antigenic characteristics of three variants of Rous sarcoma virus. J. nat. Cancer Inst. 31, 1275–1283 (1963).

    CAS  PubMed  Google Scholar 

  98. Spencer, H. J., and V. GroupÉ: Pathogenesis of virus-induced Rous sarcoma. I. Distribution of virus and tumor foci in chicks and turkeys. J. nat. Cancer Inst. 29, 397–419 (1962).

    Google Scholar 

  99. Spencer, H. J., and V. GroupÉ: Pathogenesis of virus-induced Rous sarcoma. II. Dynamics of tumor development and viral growth patterns in chicks. J. nat. Cancer Inst. 29, 421–441 (1962).

    Google Scholar 

  100. Stenkvist, B., and J. PontÉN: Growth curves, histology, and virus titers in Rous sarcomas. A comparison between progressively growing and regressing tumors. Acta path. microbiol. stand. 58, 273–282 (1963).

    Article  CAS  Google Scholar 

  101. Svet-Molpavsky, G. J.: The pathogenicity of Rous sarcoma virus for mammals. Acta virol. 2, 1 (1958).

    Google Scholar 

  102. Syboda, J.: Presence of chicken tumor virus in the sarcoma of the adult rat inoculated after birth with Rous sarcoma tissue. Nature (Lond.) 186, 980 (1960).

    Google Scholar 

  103. Syboda, J.: The tumorigenic action of Rous sarcoma in rats and the permanent production of Rous virus by the induced rat sarcoma XC. Folia biol. 7, 46–60 (1961).

    Google Scholar 

  104. Temin, H. M., and H. Rubin: Characteristics of an assay for Rous sarcoma virus and Rous sarcoma cells in tissue culture. Virology 6, 669–688 (1958).

    Article  CAS  PubMed  Google Scholar 

  105. Temin, H. M., and H. Rubin: A kinetic study of infection in chick embryo cells in vitro by Rous sarcoma virus. Virology 8, 209–222 (1959).

    Article  CAS  PubMed  Google Scholar 

  106. Temin, H. M., and H. Rubin: The control of cellular morphology in embryonic cells infected with the Rous sarcon a virus. Virology 10, 182–197 (1960).

    Article  CAS  PubMed  Google Scholar 

  107. Temin, H. M., and H. Rubin: Mixed infection with two types of Rous sarcoma virus. Virology 13, 158–163 (1961).

    Article  CAS  PubMed  Google Scholar 

  108. Thomas, E. D., C. A. Ashley, H. L. Lochte, A. Jaretzki, O. D. Sahler, and J. W. Ferrebee: Homografts of Bone marrow in dogs after lethal total-body radiation. Blood 14, 720–736 (1959).

    CAS  PubMed  Google Scholar 

  109. Vicier, P.: Recherches quantitatives sur le sarcome du Rous. Croissance de sarcomes dermiques et anticorps neutralisants. Bull. du Cancer 45, 460–475 (1958).

    Google Scholar 

  110. Vicier, P.: Reliability of titration of Rous sarcoma virus by the count of the pocks produced on the egg chorio-allantoic membrane. Virology 8, 41–59 (1959).

    Article  Google Scholar 

  111. Vicier, P., and A. GoldÉ: Growth curve of Rous sarcoma virus on chick embryo cells in vitro. Virology 8, 60–79 (1959).

    Article  Google Scholar 

  112. Vogt, P. K., and H. Rubin: Localization of infectious virus and viral antigen in chick fibroblasts during successive stages of infection with Rous sarcoma virus. Virology 13, 528–544 (1961).

    Article  CAS  PubMed  Google Scholar 

  113. Waters, N. F., and A. K. Fontes: Genetic response of inbred lines of chicknes to Rous sarcoma virus. J. nat. Cancer Inst. 25, 351–357 (1960).

    CAS  PubMed  Google Scholar 

  114. Waters, N. F., and B. R. Burmester: Mode of inheritance of resistance to Rous sarcoma virus in chickens. J. nat. Cancer Inst. 27, 655–661 (1961).

    CAS  PubMed  Google Scholar 

  115. Weil, R., A. Bendich, and C. M. Southam: Attempts to extract infective nucleic acid of Rous sarcoma virus. Proc. Soc. exp. Biol. (N.Y.) 104, 670–673 (196C).

    Google Scholar 

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Authors and Affiliations

  1. Medical Research Laboratories, The Mary Imogene Bassett Hospital, Cooperstown, New York, USA

    Herbert J. Spencer

  2. Institute of Microbiology, Rutgers, the State University, New Brunswick, New Jersey, USA

    Vincent Groupé

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  1. Herbert J. Spencer
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  2. Vincent Groupé
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Editors and Affiliations

  1. Philadelphia, USA

    W. Henle

  2. Düsseldorf, Deutschland

    W. Kikuth

  3. San Francisco, USA

    K. F. Meyer

  4. Hamburg, Deutschland

    E. G. Nauck

  5. Basel, Schweiz

    J. Tomcsik

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Spencer, H.J., Groupé, V. (1964). A Review of Recent Studies on Rous Sarcoma Virus (RSV) Emphasizing Virus-Cell-Host Interactions. In: Henle, W., Kikuth, W., Meyer, K.F., Nauck, E.G., Tomcsik, J. (eds) Ergebnisse der Mikrobiologie Immunitätsforschung und Experimentellen Therapie. Current Topics in Microbiology and Immunology, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-42622-7_8

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