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Naunyn Schmiedebergs Archiv für Pharmakologie pp 1899–1912Cite as

Zum Mechanismus der 2 -Propanoloxydation

Interferenzversuche mit niederen aliphatischen Alkoholen in vivo und an der isoliert perfundierten Rattenleber

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Summary

The elimination of 2-propanol from the blood of rats as well as from the isolated perfused rat liver is inhibited by ethanol and 1-propanol, whereas methanol and tert. butanol have no effect on the elimination of 2-propanol. Vice versa, 2-propanol delays ethanol elimination. 2-propanol has no influence on the elimination of 1-propanol in the concentration range examined. The results show that 2-propanol is metabolized by ADH. The change in the kinetics of the elimination of ethanol caused by 2-propanol and 1-propanol from zero to first and higher orders demonstrates a competition for ADH.

Auszugsweise vorgetragen auf der Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft 1969.

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Author information

Authors and Affiliations

  1. Institut für Pharmakologie und Toxikologie, Universität Würzburg, Deutschland

    U. Abshagen

  2. Institut für Klinische Pharmakologie im Klinikum Steglitz, Freien Universität Berlin, 1000, Berlin 45, Hindenburgdamm 30, Deutschland

    Prof. Dr. N. Rietbrock

Authors
  1. U. Abshagen
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  2. Prof. Dr. N. Rietbrock
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Editor information

Editors and Affiliations

  1. Gießen, Deutschland

    E. Habermann

  2. Berlin, Deutschland

    H. Herken

  3. Frankfurt/M., Deutschland

    P. Holtz

  4. Graz, Österreich

    F. Lembeck

  5. Würzburg, Deutschland

    U. Trendelenburg

  6. Ulm, Deutschland

    L. Heilmeyer

  7. Göttingen, Deutschland

    L. Lendle

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© 1969 Springer-Verlag Berlin Heidelberg

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Abshagen, U., Rietbrock, N. (1969). Zum Mechanismus der 2 -Propanoloxydation. In: Habermann, E., et al. Naunyn Schmiedebergs Archiv für Pharmakologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39718-3_340

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  • DOI: https://doi.org/10.1007/978-3-662-39718-3_340

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-38809-9

  • Online ISBN: 978-3-662-39718-3

  • eBook Packages: Springer Book Archive

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