Summary
The antihypertensive effects of oxprenolol, an adrenoceptive beta-receptor blocking agent, hydralazine or a combination of both compounds were compared in intact and adrenal demedullated rats. Blood pressure in the conscious animal was measured according to the method of Gerold, et al., and in the anaesthetized rat according to the method of Byrom and Wilson.
Although oxprenolol had no influence on blood pressure in the intact rat, an antihypertensive effect was seen in conscious or anaesthetized, demedullated animals. The antihypertensive effect of hydralazine was more pronounced in conscious, intact rats than in conscious, demedullated rats, while its effect was similar in anaesthetized, intact or demedullated rats.
An antagonism of the effect of hydralazine by oxprenolol was seen in intact, but not in demedullated animals. In the conscious, demedullated animal oxprenolol enhanced the antihypertensive effect of hydralazine.
It can be concluded that adrenal catecholamines play a major role in reflex adjustment to a fall in blood pressure and that this effect can be enhanced by adrenergic beta-receptor blockade.
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Brunner, H., Hedwall, P.R. (1969). Bedeutung der Nebennierenkatecholamine für die reflektorische kardiovasculäre Gegenregulation bei renal hypertonischen Ratten. In: Habermann, E., et al. Naunyn Schmiedebergs Archiv für Pharmakologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39718-3_338
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DOI: https://doi.org/10.1007/978-3-662-39718-3_338
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