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Naunyn Schmiedebergs Archiv für Pharmakologie pp 1188–1205Cite as

Die Rolle von Noradrenalin bei der Temperaturwirkung der Narkose The Role of Noradrenaline for the Temperature Effect of Anaesthesia

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Zusammenfassung

Vor einigen Jahren haben Prof. Myers und ich die Theorie aufgestellt, daß eine Funktion der im Hypothalamus vorkommenden Monoamine darin bestehe, Änderungen der Körpertemperatur herbeizuführen (Feldberg u. Myers, 1963, 1964a). Wenn diese Theorie richtig ist, ergibt sich die Frage: welche Temperaturänderungen beruhen auf dem Freiwerden dieser Monoamine?

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Literatur

  • Amin, A.N., T.B.B. Crawford, and J.H. Gaddum: The distribution of substance P and 5-hydroxytryptamine in the central nervous system of the dog. J. Physiol. (Lond.) 126, 596–618 (1954).

    CAS  Google Scholar 

  • Andén, N.E., A. Dahlström, K. Fuxe, and K. Larsson: Mapping out of catecholamine and 5-hydroxytryptamine neurons innervating the telencephalon and diencephalon. Life Sci. 4, 1275–1279 (1965).

    Article  PubMed  Google Scholar 

  • Anderson, B., M. Jobin, and K. Olsson: Serotonin and temperature control. Acta physiol. scand. 67, 50–56 (1966).

    Article  Google Scholar 

  • Banerjee, U., W. Feldberg, and V.J. Lotti: Effect on body temperature of morphine and ergotamine injected into the cerebral ventricles of cats. Brit. J. Pharmacol. 32, 523–538 (1968).

    CAS  PubMed  Google Scholar 

  • Bligh, J.: Effects on temperature of monoamines injected into the lateral ventricles of sheep. J. Physiol. (Lond.) 185, 46–47 P (1966).

    Google Scholar 

  • Bogdanski, D.F., H. Weissbach, and S. Udenfriend: The distribution of serotonin, 5-hydroxytryptophan decarboxylase and monoamine oxidase in brain. J. Neurochem. 1, 272–278 (1957).

    Article  CAS  PubMed  Google Scholar 

  • Brittain, R.T., and S.L. Handley: Temperature changes produced by the injection of catecholamines and 5-hydroxytryptamine into the cerebral ventricles of the conscious mouse. J. Physiol. (Lond.) 192, 805–813 (1967).

    CAS  Google Scholar 

  • Brodie, B.B., S. Spector, and P.A. Shore: Interaction of monoamine oxidase inhibition with physiological and biochemical mechanisms in brain. Ann. N.Y. Acad. Sci. 80, 609–614 (1959).

    Article  CAS  PubMed  Google Scholar 

  • Carlsson, A., B. Falck, and N. Hillarp: Cellular localization of brain mono-amines. Acta physiol. scand. 56, Suppl. 196 (1962).

    Google Scholar 

  • Carmichael, E.A., W. Feldberg, and K. Fleischhauer: Methods for perfusing different parts of the cat’s cerebral ventricles with drugs. J. Physiol. (Lond.) 173, 354–367 (1964).

    CAS  Google Scholar 

  • Cooper, K.E., W.I. Cranston, and A.J. Honour: Effects of intraventricular and intrahypothalamic injection of noradrenaline and 5-HT on body temperature in conscious rabbits. J. Physiol. (Lond.) 181, 852–864 (1965).

    CAS  Google Scholar 

  • Dahlström, A., and K. Fuxe: Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta physiol. scand. 26, Suppl. 232 (1964).

    Google Scholar 

  • Euler, U.S. von, E. Lindner u. S.O. Myrin: Über die fiebererregende Wirkung des Adrenalins. Acta physiol. scand. 5, 85–96 (1943).

    Article  Google Scholar 

  • Feldberg, W.: The monoamines of the hypothalamus as mediators of temperature responses. In: Recent advances in pharmacology, ed. J.M. Robson and R.S. Stacey, 4th Ed. London: Churchill 1968.

    Google Scholar 

  • — R.F. Hellon, and V.J. Lotti: Temperature effects produced in dogs and monkeys by injections of monoamines and related substances into the third ventricle. J. Physiol. (Lond.) 191, 501–515 (1967).

    CAS  Google Scholar 

  • — and R.D. Myers: Effects on temperature of monoamines injected into the cerebral ventricles of anaesthetized dogs. J. Physiol. (Lond.) 186, 413–423 (1966).

    Google Scholar 

  • —, and V.J. Lotti: Body temperature responses in cats and rabbits to the monoamine oxidase inhibitor tranylcypromine. J. Physiol. (Lond.) 190, 203–220 (1967a).

    CAS  Google Scholar 

  • — Temperature responses to monoamines and an inhibitor of MAO injected into the cerebral ventricles of rats. Brit. J. Pharmacol. 31, 152–161 (1967b).

    CAS  PubMed  Google Scholar 

  • —, and R.D. Myers: A new concept of temperature regulation by amines in the hypothalamus. Nature (Lond.) 200, 1325 (1963).

    Article  CAS  Google Scholar 

  • — Effects on temperature of amines injected into the cerebral ventricles. A new concept of temperature regulation. J. Physiol. (Lond.) 173, 226–237 (1964a).

    CAS  Google Scholar 

  • — Temperature changes produced by amines injected into the cerebral ventricles during anaesthesia. J. Physiol. (Lond.) 175, 464–478 (1964b).

    CAS  Google Scholar 

  • — Changes in temperature produced by microinjections of amines into the anterior hypothalamus of cats. J. Physiol. (Lond.) 177, 239-245 (1965a).

    Google Scholar 

  • — Hypothermia produced by chloralose acting on the hypothalamus. J. Physiol. (Lond.) 179, 509–517 (1965b).

    CAS  Google Scholar 

  • — Appearance of 5-hydroxytryptamine and an unidentified pharmacologically active lipid acid in effluent from perfused cerebral ventricles. J. Physiol. (Lond.) 184, 837–855 (1965c).

    Google Scholar 

  • Findlay, J.D., and D. Robertshaw: The mechanism of body temperature changes induced by intraventricular injections of adrenaline, noradrenaline and 5-hydroxytryptamine in the ox (Bos taurus). J. Physiol. (Lond.) 189, 329–336 (1967).

    CAS  Google Scholar 

  • Funderburk, W.H., K.F. Finger, A.B. Drakontides, and J.A. Schneider: EEG and biochemical findings with MAO inhibitors. Ann. N.Y. Acad. Sci. 96, 289–302 (1962).

    Article  CAS  PubMed  Google Scholar 

  • Gaddum, J.H., and N.J. Giarman: Preliminary studies on the biosynthesis of 5-hydroxytryptamine. Brit. J. Pharmacol. 11, 88–92 (1956).

    CAS  PubMed  Google Scholar 

  • Koe, B.K., and A. Weissman: p-Chlorophenylalanine: a specific depletor of brain serotonin. J. Pharmacol. exp. Ther. 154, 499–516 (1966).

    CAS  PubMed  Google Scholar 

  • Koella, W.P., A. Feldstein, and J.S. Szichman: The effect of para-chloro-phenylalanine on the sleep of cats. Elctroenceph. clin. Neurophysiol. 25, 481–490 (1968).

    Article  CAS  Google Scholar 

  • Kuntzman, R., P.A. Shore, D. Bogdanski, and B.B. Brodie: Microanalytical procedures for fluorometric assay of brain Dopa-5-HTP decarboxylase, nor-epinephrine and serotonin, and a detailed mapping of decarboxylase activity in brain. J. Neurochem. 6, 226–232 (1961).

    Article  CAS  Google Scholar 

  • Myers, R.D.: Release of chemical factors from the diencephalic region of the unanaesthetized monkey during changes in body temperature. J. Physiol. (Lond.) 188, 50–51 (1967a).

    Google Scholar 

  • — Transfusion of cerebrospinal fluid and tissue bound chemical factors between the brains of conscious monkeys: a new neurobiological assay. Physiol. Behav. 2, 373–377 (1967b).

    Article  Google Scholar 

  • Myers, R.D.: The significance of transmitter substances for hypothalamic temperature regulation. Proc. XXIV Internat. Congr. Physiol. Sci. 6, 285–286 (1968).

    Google Scholar 

  • — A. Kawa, and D. Beleslin: Evoked release of 5-HT and NEFA from the hypothalamus of the monkey during thermoregulation. Experientia (Basel) 25 (in press) (1969).

    Google Scholar 

  • —, and L.G. Sharpe: Temperature in the monkey: transmitter factors released from the brain during thermoregulation. Science 161, 572–573 (1968 a).

    Article  CAS  PubMed  Google Scholar 

  • — Chemical activation of ingestive and other hypothalamic regulatory mechanisms. Physiol. Behav. 3, 987–995 (1968).

    Article  CAS  Google Scholar 

  • Ruckebusch, Y., M.L. Geivel, et J.P. Laplace: Variations interspécifiques des modifications de la température centrale liées a l’injection cérébro-ventriculaire de catécholamines et de 5-hydroxytryptamine. C.R. Soc. Biol. (Paris) 159, 1748 (1965).

    CAS  Google Scholar 

  • J.P. Laplace: — Effects comportementaux et électrographiques de l’injection cérébro-ventriculaire de catécholamines chez le mouton. Thérapie 21, 483–491 (1966).

    CAS  PubMed  Google Scholar 

  • Spectoe, S.: Monoamine oxidase in control of brain serotonin and norepinephrine content. Ann. N.Y. Acad. Sci. 107, 856–861 (1963).

    Article  Google Scholar 

  • Summers, R.J.: Effects of MAO inhibitors on the hypothermia produced in cats by halothane. Brit. J. Pharmac. (in press) (1969).

    Google Scholar 

  • Udenfriend, S., and C.R. Creveling: Location of dopamine betaoxidase in brain. J. Neurochem. 4, 350–352 (1959).

    Article  CAS  PubMed  Google Scholar 

  • —, and H. Weissbach: Turnover of 5-hydroxytryptamine (Serotonin) in tissues. Proc. Soc. exp. Biol. (N.Y.) 97, 748–751 (1958).

    Article  CAS  Google Scholar 

  • Vane, J.R.: A sensitive method for the assay of 5-hydroxytryptamine. Brit. J. Pharmacol. 12, 344–349 (1957).

    CAS  PubMed  Google Scholar 

  • Vogt, M.: The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs. J. Physiol. (Lond.) 123, 451–481 (1954).

    CAS  Google Scholar 

  • — Catecholamines in brain. Pharmacol. Rev. 11, 483–489 (1959).

    CAS  PubMed  Google Scholar 

  • Weiner, N.: The distribution of monoamine oxidase and succinic oxidase in brain. J. Neurochem. 6, 79–86 (1960).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. National Institute for Medical Research, Mill Hill, London, N.W. 7, England

    Professor Dr. W. Feldberg

Authors
  1. Professor Dr. W. Feldberg
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Editor information

Editors and Affiliations

  1. Gießen, Deutschland

    E. Habermann

  2. Berlin, Deutschland

    H. Herken

  3. Frankfurt/M., Deutschland

    P. Holtz

  4. Graz, Österreich

    F. Lembeck

  5. Würzburg, Deutschland

    U. Trendelenburg

  6. Ulm, Deutschland

    L. Heilmeyer

  7. Göttingen, Deutschland

    L. Lendle

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© 1969 Springer-Verlag Berlin Heidelberg

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Feldberg, W. (1969). Die Rolle von Noradrenalin bei der Temperaturwirkung der Narkose The Role of Noradrenaline for the Temperature Effect of Anaesthesia. In: Habermann, E., et al. Naunyn Schmiedebergs Archiv für Pharmakologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39718-3_181

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  • DOI: https://doi.org/10.1007/978-3-662-39718-3_181

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-38809-9

  • Online ISBN: 978-3-662-39718-3

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