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Glycopeptid-resistente Enterokokken in deutschen Krankenhäusern 1998

Glycopeptide-resistantenterococci in German hospitals in 1998

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Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz

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Zusammenfassung

Es wurden 92 Stämme Glycopeptid-resistenter Enterokokken (GRE) von 80 Patienten aus 31 Krankenhäusern in elf Bundesländern analysiert. GRE wurden vorrangig in den intensivmedizinischen Bereichen (allgemeine, chirurgische, internistische, pädiatrische, onkologische ITS-Stationen), aber auch in Nephrologie/Dialyse- oder Neurologie/Orthopädie-Abteilungen isoliert. Dabei war die Dominanz von VanA-E. faecium-Stämmen zu beobachten (n=81; 88,0%), weiterhin wurden Stämme von E. faecalis (VanA; n=4; 4,4%), E. faecium (VanB; n=1; 1,1%) sowie E. gallinarum (VanC1; n=6;6,5%) gefunden. Die 81 VanA-Stämme von E. faecium zeigten folgende Resistenzquoten gegen weitere Antibiotika: Erythromycin, Ciprofloxacin (jeweils 93,8%), Ampicillin, Oxytetracyclin (je 88,9%), Rifampicin (79,0%), Trimethoprim/Sulfamerazin (61,7%), Chloramphenicol (18,9%), Fusidinsäure (12,3%), Quinupristin/Dalfopristin (7,4%);Gentamicin (46,9%) und Streptomycin (37,0%), auch kombiniert mit Ampicillinresistenz (9,9-35,8%). Bei einigen dieser VanA-Stämme war die Resistenz gegen Teicoplanin in-vitro nicht vollständig exprimiert. Gleiche Makrorestriktionsmuster von E. faecium-Ausbruchsstämmen (VanA-Typ) aus Krankenhäusern in verschiedenen Bundesländern deuteten auf eine intra- und interhospitale Verbreitung eines definierten GRE-Stammes. Analysen der Plasmid- und Plasmidrestriktionsmuster dieser Isolate zeigten jedoch deutliche Unterschiede. Dies bedeutet, daß E. faecium-Isolate mit gleichem Makrorestriktionsmuster nicht unbedingt identisch sein müssen.

Summary

Ninety-two strains of glycopeptide-resistant enterococci (GRE) from 80 patients of 31 hospitals in 11 federal states were analyzed. They were primarily isolated in intensive care units (general, surgical, internistic, pediatric, oncological ones), but also in nephrologic/dialysis or neurologic/orthopaedic wards. A dominance of Van A type E. faecium strains was observed (n=81; 88.0%). In addition, strains of E. faecalis (VanA; n=4; 4.4%), E. faecium (VanB; n=1; 1.1%), and E. gallinarum (VanC1, n=6; 6.5%) were found. The 81 VanA strains of E. faecium possessed the following resistances to other antibiotics: erythromycin, ciprofloxacin (both 93.8%), ampicillin, oxytetracycline (both 88.9%), rifampicin (79.0%), trimethoprim/sulfameracin (61.7%), chloramphenicol (18.9%), fusidic acid (12.3%), quinupristin/dalfopristin (7.4%);gentamicin (46.9%) and streptomycin (37.0%), also together with ampicillin resistance (9.9–35.8%). In some of these VanA type strains resistance to teicoplanin cannot be completely expressed in-vitro. Macrorestriction analysis of E. faecium outbreak isolates (VanA type) from hospitals in different federal states indicated an intra- and inter-hospital spread of a defined strain. However, heterogeneous plasmid and plasmid restriction patterns showed that these strains were not completely identical.

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Authors and Affiliations

  1. Robert Koch-Institut, Postfach 65 02 80, D-13303, Berlin, Deutschland

    Dr. Ingo Klare, C. Konstabel, D. Badstübner, G. Werner & W. Witte

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  1. Dr. Ingo Klare
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  2. C. Konstabel
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  3. D. Badstübner
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  4. G. Werner
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  5. W. Witte
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Klare, I., Konstabel, C., Badstübner, D., Werner, G., Witte, W. (1999). Glycopeptid-resistente Enterokokken in deutschen Krankenhäusern 1998. In: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-38283-7_154

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  • DOI: https://doi.org/10.1007/978-3-662-38283-7_154

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