Abstract
From the variety of X-polysomic conditions described in man in recent years, one remarkable rule emerged: the number of sex chromatin bodies always equals the number of X-chromosomes present minus one. The dosage compensation mechanism which nullifies the genetic disparity between the male and the female also serves to minimize the detrimental consequences of X-polysomy. But when this rule is viewed against the broad background of knowledge of the whole infraclass Eutheria, it becomes just a small portion of the grand scheme of dosage compensation. In this chapter, it will be shown that the dosage compensation mechanism is universal to all the placental mammals in a qualitative as well as a quantitative sense in that the aim is to preserve only one original X in the functional state in each diploid somatic cell under all the normal and abnormal conditions.
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References
Carr, D. H., and M. L. Barr: An XXXX sex chromosome complex in two mentally defective females. Canad. med. Ass. J. 84, 131–137 (1961).
De Grouchy, J., M. Arthuis, C. Salmon, M. Lamy et S. Thieffry: Le syndrome du cri du chat une nouvelle observation. Anal. Génétique 7, 13–16 (1964).
Edwards, J. H., D. G. Harnden, A. H. Cameron, M. Crosse, and O. H. Wolff: A new trisomic syndrome. Lancet 1, 787 (1960).
Ferguson-Smith, M. A., A. W. Johnston, and S. D. Handmaker: Primary amentia and micro-orchidism associated with an XXXY sex-chromosome constitution. Lancet 2, 184–187 (1960).
Ford, C. E., D. W. Jones, P. E. Polani, J. C. Almeida, and J. H. Briggs: A sex chromosome anomaly in a case of gonadal dysgenesis (Turner’s syndrome). Lancet 1, 711–713 (1959).
Fraccaro, M., D. Ixxos, J. Lindsten, and K. Kaijser: A new type of chromosomal abnormality in gonadal dysgenesis. Lancet 2, 1144–1145 (1960).
Galton, M., and S. F. Holt: DNA replication patterns of the sex chromosomes in somatic cells of the Syrian hamster. Cytogenetics 3, 97–111 (1964).
Galton, M., K. Benirschke, and S. Ohno: Sex chromosomes of the chinchilla: Allocycly and duplication sequence in somatic cells and behavior in meiosis. Chromosoma (Berl.) 16, 668–680 (1965).
Galton, M., and S. F. Holt: Asynchronous replication of the mouse sex chromosomes. Exp. Cell Res. 37, 111–116 (1965).
German, J. L.: DNA synthesis in human chromosomes. Trans. N. Y. Acad. Sci. 24, 395–407 (1962).
Gilbert, C. W., S. Muldal, L. G. Lajtha, and J. Rowley: Time-sequence of human chromosome duplication. Nature 195, 869–873 (1962).
Grumbach, M. M., P. A. Marks, and A. Morishima: Erythrocyte glucose6-phosphate dehydrogenase activity and X-chromosome polysomy. Lancet 1, 1330–1331 (1962).
Huang, C. C., and L. C. Strong: Chromosomes of the African mouse. J. Hered. 53, 95–99 (1962).
Jacobs, P. A., A. G. Baikie, W. M. Court-Brown, T. N. Macgregor, M. Maclean, and D. G. Harnden: Evidence for the existence of the human “super female”. Lancet 2, 423–425 (1959).
Jacobs, P. A., and J. A. Strong: A case of human intersexuality having a possible XXY sex-determining mechanism. Nature 183, 302 (1959).
Jacobs, P. A., D. G. Harnden, W. M. Court-Brown, J. Goldstein, H. G. Close, T. N. Macgregor, N. Maclean, and J. A. Strong: Abnormalities involving the X-chromosome in women. Lancet 1, 1213–1216 (1960).
Jacobs, P. A., D. G. Harnden, K. E. Buckton, W. M. Court-Brown, M. J. King, J. A. Mcbride, T. N. Macgregor, and N. Maclean: Cytogenetics studies in primary amenorrhoea. Lancet 1, 1183–1188 (1961).
Lejeune, J., M. Gautier and R. Turpin: Etude des chromosomes somati- ques de neuf enfants mongoliens. C. R. Acad. Sci. 248, 1721–1722 (1959).
Miller, O. J., W. R. Breg, R. D. Schmickel, and W. Tretter: A family with an XXXXY male, a leukemic male and two 21-trisomic mongoloid females. Lancet II, 78–79 (1961).
Muldal, S., C. W. Gilbert, L. G. Lajtha, J. Lindsten, J. Rowley, and M. Fraccaro: Tritiated thymidine incorporation in an isochromosome for the long arm of the X chromosome in man. Lancet I, 861–863 (1963).
Ohno, S., W. Beçak, and M. L. Beçak: X-autosome ratio and the behavior pattern of individual X-chromosomes in placental mammals. Chromo-soma 15, 14–30 (1964).
Ohno, S., C. Stenius, and L. Christian: The XO as the normal female of the creeping vole (Microtus oregoni). In: Chromosomes today, Vol. I, pp. 182–187. Eds. C. D. Darlington and K. R. Lewis. Edinburgh and London: Oliver and Boyd 1966.
Patau, K., D. W. Smith, E. Therman, S. L. Inhorn, and H. P. Wagner: Multiple congenital anomaly caused by an extra autosome. Lancet I, 790–793 (1960).
Sachs, L., and M. Danon: Diagnosis of the sex chromosomes in human tissues. Genetica 28, 201–216 (1956).
Saksela, E., and P. S. Moorhead: Enhancement of secondary constrictions and the heterochromatic X in human cells. Cytogenetics 1, 225–244 (1962).
Taylor, J. H.: Asynchronous duplication of chromosomes in cultured cells of Chinese hamster. J. Biophys. Biochem. Cytol. 7, 455–464 (1960).
Wolf, U., G. Flinspach, R. Böhm und S. Ohno: DNS-Reduplikationsmuster bei den Riesen-Geschlechtschromosomen von Microtus agrestis. Chromosoma16, 609–617 (1965).
Wolf, U., und D. Hepp: DNS-Reduplikationsmuster der somatischen Chromosomen von Cricetus cricetus (L.). Chromosoma (Berl.) 18, 438–448 (1966).
Yerganian, G.: Chromosomes of the Chinese Hamster, Cricetulus griseus. I. The normal complement and identification of sex chromosomes. Cytologia 24, 66–75 (1959).
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Ohno, S. (1966). The Conservation of the Original X and Dosage Compensation in the Face of X-polysomy. In: Sex Chromosomes and Sex-Linked Genes. Monographs on Endocrinology, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-88178-7_10
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DOI: https://doi.org/10.1007/978-3-642-88178-7_10
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