Abstract
From the drug scene it is well known that the consumption of cannabis is often combined with the abuse of other drugs. Unpredictable interaction effects, in particular an increase in toxicity might be the consequence of such combinations. Experimental work on this subject is rare and only shows that crude cannabis preparations and some of its constituents enhance the barbiturate sleeping time and some amphetamine-effects in small rodents. In view of these sparse results we felt that interaction studies between cannabis extracts or their constituents and other drugs would be of particular interest.
Supported in part by a grant of the Bundesministerium für Jugend, Familie und Gesundheit.
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References
Aramaki, H., Tomiyasu, N., Yoshimura, H., Tsukamoto, H.: Forensic chemical study on marihuana. I. A detection method of the principal constituents by thin-layer and gaschromatographies. Chem. pharm. Bull. 16, 822–826 (1968).
Cohen, G. M., Peterson, D. W., Mannering, G. J.: Interactions of d °-Tetrahydrocannabinol with the hepatic microsomal drug metabolizing system. Life Sci. 10, I, 1207–1215 (1971).
Fernandes, M., Coper, H.: Sympos. on the Chem. and Biol. Activ. of Cannabis: The role of vehicles in cannabis application and interaction between cannabis and central active drugs. Acta pharm. Suec. 8, 692–693 (1971).
Nash, T.: The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. Biochem. J. 55, 416–421 (1953).
Paton, W. D. M., Pertwee, R. G.: Effect of cannabis and certain of its constituents on pento- barbitone sleeping time and phenazone metabolism. Brit. J. Pharm. 44, 250–261 (1972).
Rating, D., Honecker, H., Broermann, I., Strauss, S.: Hexobarbitone sleeping time and amphetamine motility after subchronic tetrahydrocannabinol treatment. Acta Pharmacologica et Toxicologica 29, Suppl. 4, 1971 X XV Scandinavian Pharmacological Meeting, Copenhagen, 1971.
Remmer, H., Schenkmann, I., Estabrook, R. U., Sasame, H., Gillette, I. R., Narasimukulu, S., Cooper, D. Y., Rosenthal, O.: Drug interaction with hepatic microsomal cytochrome. Molec. Pharm. 3, 113–123 (1967).
Schenkmann, J. B., Remmer, H., Estabrook, R. W.: Spectral studies of drug interaction with hepatic microsomal cytochrome. Molec. Pharm. 3, 113–123 (1967).
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Coper, H., Fernandes, M. (1973). Interaction between Cannabis and Other Drugs. In: Goldberg, L., Hoffmeister, F. (eds) Psychic Dependence. Bayer-Symposium, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87987-6_16
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DOI: https://doi.org/10.1007/978-3-642-87987-6_16
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