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Self-Administration of Drugs

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Psychic Dependence

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 4))

Abstract

After several months of agonizing over the subject matter of my presentation today I finally decided to depart from my usual approach to the topic of drug self-administration experiments in laboratory animals. This departure was prompted by several factors: 1. a number of review articles have been written in recent years which systematically cover much of the research in this area (Schuster and Thompson, 1969; Schuster, 1970; Schuster and Johanson, 1972)), 2. the presence of a number of investigators in this symposia who will be presenting various aspects of this research in greater detail than would be possible in the time alloted to me. Because of this I have chosen to be a bit presumptious and to share with you my reflections on some of the assumptions, problems and strengths of this research. In no sense will I attempt to systematically cover the literature, but rather, I have selected a few main issues which I feel to be of importance.

This research was supported by NIMH Grant MH-11,052 awarded to Ch. R. Schuster, Ph. D.

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References

  • Bykov, K. M.: Translated and edited by Horsley Gantt: The Cerebral Cortex and the Internal Organs. New York: Chemical Publ. Co. Inc. 1957.

    Google Scholar 

  • Clark, R., Schuster, C. R., Brady, J. V.: Instramental Conditioning of Jugular Self-infusion in the Rhesus Monkey. Science 133, 1928–1930 (1961).

    Article  Google Scholar 

  • Conger, J. J.: The Effects of Alcohol on Conflict Behavior in the Albino Rat. Quart. j. Stud. Alcohol 12, 1–29 (1951)

    CAS  Google Scholar 

  • Goldberg, S. R., Hoffmeister, F., Schlichting, U. U., Wuttke, W.: Aversive Properties of Nalorphine and Naloxone in Morphine-dependent Rhesus Monkeys. J. Pharmacol. exp. Ther. 179, 268–276 (1972).

    Google Scholar 

  • Headlee, C. P., Corrocx, H. W., Nichols, J. R.: Apparatus and Technique Involved in a Laboratory Method of Detecting the Addictiveness of Drugs. J. Amer. pha.rm. Ass. 44, 229–231 (1955).

    Article  CAS  Google Scholar 

  • Hoffmeister, R., Schlichting, U. U.: Reinforcing Properties of Some Opiates and Opioids in Rhesus Monkeys with Histories of Cocaine and Codeine Self-Administration. Psychopharmacologia (Berl.) 23, 55–74 (1972).

    Article  CAS  Google Scholar 

  • Johanson, C. E.: The Use of Animal Models for the Study of Drug Dependence. In Research Advances in Alcohol and Drug Problems. New York: J. Wiley and Sons (in press).

    Google Scholar 

  • Kelleher, R. T., Gollub, L. R.: A Review of Positive Conditioned Reinforcement. J. exp. Anal. Behay. 5, 543–597 (1962).

    Article  CAS  Google Scholar 

  • Lindesmith, A. R.: The Addict and the Law. Bloomington: Indiana University Press 1965.

    Google Scholar 

  • Schlichting, U U., Hoffmeister, F.: Positive and Negative Reinforcing Properties of Weak Morphine Antagonists in Physically Dependent and Non-dependent Rhesus Monkeys. Naunyn-Schmiedebergs Arch. Pharmak. Suppl. 270, R 123 (1971).

    Google Scholar 

  • Schuster, C. R., Brady, J. V.: The Discriminative Control of a Food-reinforced Operant by Interoceptive Stimulation. Pavlov J. higher nerv. Activ. 14, 448 (1964).

    CAS  Google Scholar 

  • Spragg, S.D. S.: Morphine Addiction in Chimpanzees. Comp. Psychol. Managr. 15, No. 7 (1940).

    Google Scholar 

  • Thompson, T. A.: Self-administration of and Behavioral Dependence on Drugs. Ann. Rev. Pharmacol. 9, 483–502 (1969).

    Article  PubMed  Google Scholar 

  • Thompson, T. A.: Psychological Approaches to Opiate Dependence and Self-administration by Laboratory Animals. Fed. Proc. 29, 2–5 (1970).

    Google Scholar 

  • Thompson, T., Schuster, C. R.: Morphine Self-administration, Food-reinforced and Avoidance Behaviors in Rhesus Monkeys. Psychopharmacologia (Berl.) 5, 87–94 (1964).

    Article  CAS  Google Scholar 

  • Wendel, H. Q.: Pentazocine Dependence in Medical Practice. Committee on Problems of Drug Dependence. 282 (1971).

    Google Scholar 

  • Woods, J. H., Schuster, C. R.: Reinforcement Properties of Morphine, Cocaine, and SPA as a Function of Unit Dose. Intern. J. Addict. 3, 231–237 (1968).

    Google Scholar 

  • Yanagita, T., Deneau, G. A., Seevers, M. N.: Evaluation of Pharmocologic Agents in Monkey by Long Term Intravenous Self or Programmed Administration. Excerpta Medica Internatl. Congress Series 87, 453 (1965).

    Google Scholar 

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© 1973 Springer-Verlag

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Schuster, C.R. (1973). Self-Administration of Drugs. In: Goldberg, L., Hoffmeister, F. (eds) Psychic Dependence. Bayer-Symposium, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87987-6_10

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  • DOI: https://doi.org/10.1007/978-3-642-87987-6_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-87989-0

  • Online ISBN: 978-3-642-87987-6

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