Summary
Molecular biological markers that influence prognosis should be considered in the optimization of therapy for disseminated forms of neuroblastoma. Some of these markers include: N-myc amplification, deletion of lp36, ploidy, and trk expression. Neuroblastoma without N-myc amplification and high trk expression show a favorable outcome and would enable a more gentle chemotherapy treatment. Neuroblastomas with N-myc amplification and lack of trk expression behave extremely unfavorably and require an even more intensive treatment.
Zusammenfassung
Zur Optimierung der Therapie des dessiminierten Neuroblastoms sollten die molekularbiologischen Merkmale der Tumore, die die Prognose beeinflussen, berücksichtigt werden. Zu diesen Faktoren zählen: N-myc-Amplifikation, 1p36-Deletion, Ploidie und trk-Expression. Neuroblastome ohne N-myc-Amplifikation und hoher trk-Ex-pression haben eine günstige Prognose und können mit einer schonenderen Chemotherapie behandelt werden. Neuroblastome mit N-myc-Amplifikation und fehlender trk-Expression verhalten sich extrem ungünstig und bedürfen einer noch intensiveren Behandlung.
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Literatur
Berthold F, Hunnenman DH, Käser H, Harms D, Bertram U, Erttmann R, Schilling FH, Treuner J, Zieschang J (1991) Neuroblastoma screening: Arguments from retrospective analysis of three German neuroblastoma trials. Am J Ped Hem Onc 13:8–13
Favrot MC, Combaret V, Lasset C (1993) CD44 — A new prognostic marker for neuroblastoma. N Engl J Med 329:1965
Look AT, Hayes FA, Shuster JJ, Douglass EC, Castleberry RP, Bowman LC, Smith EI, Brodeur GM (1991) Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study. J Clin Oncol 9:581 – 591
Nakagawara A, Arima-Nakagawara M, Scavarda NJ, Azar CG, Cantor AB, Brodeur GM (1993) Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma. N Engl J Med 328:847–852
O’Dorisio MS, Chen F, O’Dorisio TM, Wray D, Qualman SJ (1994) Characterization of somatostatin receptors on human neuroblastoma tumors. Cell Growth Differ 5:1–8
Schleiermacher G, Peter M, Michon J, Hugot JP, Vielh P, Zucker JM, Magdelenat H, Thomas G, De-lattre O (1994) Two distinct deleted regions on the short arm of chromosome 1 in neuroblastoma. Genes Chromosom Cancer 10:275–281
Schwab M (1991) Enhanced expression of the cellular oncogene MYCN and progression of human neuroblastoma. Adv Enzyme Regul 31:329–338
Seeger RC, Brodeur GM, Sather H, Dalton A, Siegel SE, Wong KY, Hammond D (1985) Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 313:1111–1116
Tanaka T, Slamon DJ, Shimada H, Shimoda H, Fujisawa T, Norioka I, Seeger RC (1991) A significant association of Ha-ras p21 in neuroblastoma cells with patient prognosis. Cancer 68:1296–1302
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© 1996 Springer-Verlag Berlin Heidelberg
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Girgert, R., Treuner, J., Schweizer, P. (1996). Molekularbiologische Merkmale des Neuroblastoms als Grundlage eines Therapiekonzepts. In: Hartel, W. (eds) Wahrung des Bestandes, Wandel und Fortschritt der Chirurgie. Langenbecks Archiv für Chirurgie, vol 1996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80295-9_282
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DOI: https://doi.org/10.1007/978-3-642-80295-9_282
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