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In Kenntnis späterer intra-/extrathorakaler Rezidivmanifestationen auch nach sogenannter radikaler Operation: Wann sind (neo-)adjuvante Maßnahmen indiziert?

In the Light of Expected Intra-/Extrathoracic Relapses Even upon So-Called Radical Surgery: When Are (Neo-) Adjuvant Strategies Indicated?

  • Conference paper
Wahrung des Bestandes, Wandel und Fortschritt der Chirurgie

Part of the book series: Langenbecks Archiv für Chirurgie ((KONGRESSBAND,volume 1996))

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Summary

Due to the high rate of loco-regional relapses as well as distant metastases, and additional chemotherapy with or without concomitant radiotherapy after the potentially curative surgery appears reasonable in stage II and higher stages of non-small cell lung cancer. Adjuvant radiotherapy can reduce the rate of local relapses in N2 tumours. The influence of this regimen on survival remains to be established. Also, preliminary results from prospective randomized studies investigating adjuvant and preoperative chemotherapy seem to demonstrate a positive effect. These therapeutic strategies currently cannot yet be recommend outside clinical studies.

Zusammenfassung

Wegen der hohen Rate lokoregionärer Rezidive und Fernmetastasen erscheint eine ergänzende Chemotherapie und/oder Radiotherapie zur potentiell kurativen Operation ab Stadium II beim nicht-kleinzelligen Bronchialkarzinom sinnvoll. Die adjuvante Radiotherapie vermag die Rate lokaler Rezidive bei N2-Tumoren zu reduzieren. Der Einfluß dieser Maßnahme auf die Überlebensdauer ist noch unklar. Vorläufige Ergebnisse aus prospektiv randomisierten Studien zur adjuvanten und präoperativen Chemotherapie berechtigen trotz Hinweisen auf einen positiven Effekt noch nicht zum allgemeinen Einsatz dieses Verfahrens außerhalb klinischer Studien.

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Literatur

  1. Bloedorn FG, Cowley RA, Cuccia CA, Mercado R, Jr (1961) Combined therapy: Irradiation and surgery in the treatment of bronchogenic carcinoma. Am J Roentgenol 85:875–885

    Google Scholar 

  2. Choi NC (1991) Controversies in the role of postoperative radiotherapy in stages II and III a resected non-small cell lung carcinoma. Int J Rad Oncol Biol Phys 20:1137–1141

    Article  CAS  Google Scholar 

  3. Damstrup L, Skovgaard Poulsen H (1994) Review of the curative role of radiotherapy in the treatment of non-small cell lung cancer. Lung Cancer 11:153–178

    Article  CAS  PubMed  Google Scholar 

  4. Drings P, Manegold C (1994) Stand der Chemotherapie beim nicht-kleinzelligen Bronchialkarzinom. Strahlenther Onkol 170:495–506

    CAS  PubMed  Google Scholar 

  5. Friedland DM, Comis RL (1995) Perioperative therapy of non-small cell lung cancer: A Review of adjuvant and neoadjuvant approaches. Sem Oncol 22:571–581

    CAS  Google Scholar 

  6. Goldberg EM, Glicksman AS, Khan FR, Nickson JJ (1970) Mediastinoscopy for assessing mediastinal spread in clinical staging of carcinoma of the lung. Cancer 25:347–353

    Article  CAS  PubMed  Google Scholar 

  7. Goldstraw P (1996) Neoadjuvant (preoperative induction) therapy in non-small cell lung cancer: A surgeon’s view. In: Zatloukal P, Petruzelka L, Gregor A (Eds) Lung Cancer Current Topics. Scien-tia Medica Ltd, Publishing House, Prag, pp 47–52

    Google Scholar 

  8. Hofmann PC, Weimann DS, Bitran JD (1982) Surgical resection in patients with stage III MO, non small cell lung carcinoma of the lung. Proc Amer Soc Clin Oncol 1:147A–C571

    Google Scholar 

  9. Holmes EC, Gail M (1986) Surgical adjuvant therapy for stage II and stage III adenocarcinoma and large-cell, undifferentiated carcinoma. J Clin Oncol 4:710–715

    CAS  PubMed  Google Scholar 

  10. Johnson DH (1990) Chemotherapy for unresectable non-small cell lung cancer. Semin Oncol 17:22–29

    Google Scholar 

  11. Kenis Y (1980) Surgical adjuvant chemotherapy in non-small cell carcinoma of the lung. Int J Radiat Oncol Biol Phys 6:1075–1077

    Article  CAS  PubMed  Google Scholar 

  12. Kirsh MM, Sloan H (1982) Mediastinal metastases in bronchogenic carcinoma: influence of postoperative irradiation, cell type, and location. Ann Thorac Surg 33:459–463

    Article  CAS  PubMed  Google Scholar 

  13. Martini N, Flehinger BJ, Bains MS, Cormack P (1985) Management of stage III disease. Alternative approaches to the management of mediastinal adenopathy. In: Delrue NC, Eschapasse H (Eds) International trends in general thoracic surgery. Lung Cancer. Saunder WB, Philadelphia, pp 108–120

    Google Scholar 

  14. Naruke T, Goya T, Tsuchiya R, Suemasu K (1988) The importance of surgery to non-small cell carcinoma of lung with mediastinal lymph node metastasis. Non-Thorac Surg 46:603–610

    Article  CAS  Google Scholar 

  15. Niiranen A, Niitamo-Korhonen S, Kouri M, Assendelft A, Maatson K, Pyrrhönen S (1992) Adjuvant Chemotherapy after radical surgery for non-small-cell lung cancer: A randomized study. J Clin Oncol 10:1927–1932

    CAS  PubMed  Google Scholar 

  16. Ohta M, Tsuchiya R, Shimoyama M (1993) Adjuvant chemotherapy for completely resected stage III non-small cell lung cancer: results of a randomized prospective study. J Thorac Cardiovasc Surg 106:703–708

    CAS  PubMed  Google Scholar 

  17. Payne DG (1994) Adjuvant radiotherapy on operable (stage I-III a) non-small cell lung cancer (NSCLC). Lung Cancer 11:45–46

    Article  Google Scholar 

  18. Pisters KMW, Kris MG, Gralla RJ, Hilaris B, McCormack PM, Bains MS, Martini N (1994) Randomized trial comparing postoperative chemotherapy with vindesine and cisplatin plus thoracic irradiation with irradiation alone in stage III (N2) non-small cell lung cancer. J. Surgic Oncol 56: 236–241

    Article  CAS  Google Scholar 

  19. Splinter TAW (1996) The current role of chemotherapy in non-small cell lung cancer. In: Zatloukal P, Petruzelka L, Gregor A (Eds) Lung Cancer Current Topics. Scientia Medica Ltd Publishing House, Prag, pp 83–92

    Google Scholar 

  20. Stewart IA, Pihnon JP für Non-small Cell Cancer Cooperative Group (1995) Chemotherapy in non-small cell lung cancer: a metaanalyses using updated data on individual patients from 52 randomised clinical trials. Brit med J 311:899–909

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Thoraxklinik Heidelberg-Rohrbach, Amalienstraße 5, D-69126, Heidelberg, Deutschland

    P. Drings

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  1. P. Drings
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Editor information

Editors and Affiliations

  1. Deutschen Gesellschaft für Chirurgie, Steinhölzle 16, D-89197, Westerstetten-Vorderdenkental, Deutschland

    W. Hartel (Generalsekretär) (Generalsekretär)

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© 1996 Springer-Verlag Berlin Heidelberg

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Drings, P. (1996). In Kenntnis späterer intra-/extrathorakaler Rezidivmanifestationen auch nach sogenannter radikaler Operation: Wann sind (neo-)adjuvante Maßnahmen indiziert?. In: Hartel, W. (eds) Wahrung des Bestandes, Wandel und Fortschritt der Chirurgie. Langenbecks Archiv für Chirurgie, vol 1996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80295-9_212

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  • DOI: https://doi.org/10.1007/978-3-642-80295-9_212

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61617-7

  • Online ISBN: 978-3-642-80295-9

  • eBook Packages: Springer Book Archive

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