Summary
Between 1982 and February 1996 11 patients underwent liver transplantation for irresectable neuroendocrine hepatic metastases. The operative mortality was one of 11, while two patients died due to sepsis respectively tumor recurrence 7 and 68 months after transplantation. Eight patients are alive with a median survival of 55 months (range from 10 days to 8.5 years). In three patients there is no evidence of tumor and the longest disease-free survival is 102 months after LTx.
These results suggest that liver transplantation represents a justified treatment for irresectable hepatic metastases arising from neuroendocrine tumors.
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Literatur
O’Grady JG, Poison RT, Rolles K, Calne RY, Williams R (1988) Liver transplantation for malignant disease: results in 93 consecutive patients. Ann Surg 267:373–379
Pichlmayr R, Weimann A, Ringe B (1994) Indications for liver transplantation in hepatobiliary malignancy. Hepatology 20:33–40
Makowka L, Tzakis AG, Mazzaferro V, Teperman L, Demetris A, Iwatsuki S, Starzl TE (1989) Transplantation of the liver for metastatic endocrine tumors of the intestine and pancreas. Surg Gynecol Obstet 168:107–111
Arnold JC, O’Grady JG, Bird GL, Calne RY, Williams R (1989) Liver transplantation for primary and secondary hepatic apudoma. Br J Surg 76:248–249
Ahlman H, Westberg G, Wängberg B, Nilsson O, Tylen U, Schersten T, Tisell LE (1996) Treatment of liver metastases of carcinoid tumors. World J Surg 20:196–202
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© 1996 Springer-Verlag Berlin Heidelberg
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Lang, H., Oldhafer, K.J., Schlitt, H.J., Scheumann, G.F.W., Ringe, B., Pichlmayr, R. (1996). Ist die Lebertransplantation als chirurgisches Therapiekonzept bei Metastasen neuroendokriner Tumoren gerechtfertigt?. In: Hartel, W. (eds) Wahrung des Bestandes, Wandel und Fortschritt der Chirurgie. Langenbecks Archiv für Chirurgie, vol 1996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80295-9_107
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DOI: https://doi.org/10.1007/978-3-642-80295-9_107
Publisher Name: Springer, Berlin, Heidelberg
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