Abstract
The genetic relationships of the gag and pol genes of all retroviruses are approximately the same and the strategy for expression of the protein products of these genes is also strongly conserved (Weiss et al., 1982) (e.g. Figure 1). The gag and pol genes are adjacent and in many cases the 3′ end of gag and the 5′ end of pol overlap by up to a few hundred nucleotides. Where there is an overlap pol is generally in the -1 translational phase with respect to gag. Both genes are expressed from the full length genomic RNA to produce two primary translation products, a GAG precursor protein and a GAG:POL fusion precursor protein. The production of the fusion protein is achieved by the gag and pol reading frames being brought into translational phase. For several years it was assumed that this translational shift was mediated by a splice and the absence of any evidence for this was explained by proposing that the splice was small and therefore hard to detect (Weiss et al., 1 982). However, in 1985 two pieces of data suggested that the splicing hypothesis was wrong. First, in the retrovirus-like yeast transposon Ty it was shown that frameshifting between the TYA gene, a gag analogue, and the TYB gene, a pol analogue, was not due to splicing (Mellor et al., 1985; Clare and Farabaugh, 1985).
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Keywords
- Bovine Leukemia Virus
- Mouse Mammary Tumor Virus
- Equine Infectious Anemia Virus
- Rous Sarcoma Virus
- Ribosomal Frameshifting
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 1990 Springer-Verlag Berlin Heidelberg
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Kingsman, A.J., Wilson, W., Kingsman, S.M. (1990). HIV pol Expression via a Ribosomal Frameshift. In: McCarthy, J.E.G., Tuite, M.F. (eds) Post-Transcriptional Control of Gene Expression. NATO ASI Series, vol 49. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75139-4_58
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DOI: https://doi.org/10.1007/978-3-642-75139-4_58
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