Abstract
Retroviruses have been associated with neurological disease in man. Recently, Kaprowski et al. [1] reported that outbreaks of mutliple sclerosis (MS) in Key West, Florida, and in Sweden seem to be associated with increased antibody for human retroviruses. In addition, homology studies under nonstringent conditions using CSF cells derived from MS patients reacted with human T-cell leukemia virus (HTLV)-I antigen. During the past 10 years more than ten different possible agents have been suggested as causes of MS [2]. These agents include a number of recognized viruses such as measles, canine distemper, scrapie agent, coronaviruses, and agents of unclear classification such as the MSAA (multiple sclerosis associated agent), bone marrow agent, and chimpanzee agent. We report here our studies of retrovirus antibody in a large number of sera and CSF collected from MS patients, matched controls, and patients with other neurological diseases (OND) prior to AIDS becoming a serious disease.
Chapter PDF
References
Koprowski H, DeFreitas EC, Harper ME, Sandberg-Wollheim M, Sheremata WA, Robert-Guroff M, Saxinger CW, Feinberg MB, Wong-Staal F, and Gallo RC (1985) Multiple sclerosis and human T-cell lymphotropic retroviruses. Nature 318:154–160
Sever JL, Madden DL (1979) Viruses that do not cause multiple sclerosis. In: Boese A (ed). Search for the cause of multiple sclerosis and other chronic diseases of the central nervous system. First International Symposium of Hertie Foundation in Frankfurt/Main, 414–424
Gessain A, Bavia F, Vernant JC et al. (1985) Antibodies to human ? lymphotropic virus type 1 in patients with tropical spastic parapresis. Lancet ii: 407–10
Roman G, Spencer PS, Schoenberg BS (1985) Tropical myeloneuropathies: the hidden endemics. Neurology 35:1158–1170
Epstein LG, Shaver LR, Cho Eun-Sook, Myenhofer M (1985) HTLV-III/LAV the retrovirus particles in the brains of patients with AIDS encephalopathy. AIDS Research 1:447–454
Ho DD, Rota TR, Schooby RT, Kaplen JC, Allan JD, Gropman JE, Resnick L, Felsentein D, Andrews CA, Hinsch MS. Isolation of HTLV-III from cerebrospinal fluid and nerve tissue of patients with neurological syndromes related to the acquired immunodeficiency syndrome. J Engl J Med 313:1493–1497
Hauser SL, Aubert JS, Burks JS, Kerns C, Lyon-Caln T, de The G, Brakic M (1986) Analysis of human ? lymphotropic virus sequences in multipls sclerosis tissue. Nature 322:176–177
Karpas A, Kampf U, Siden A, Koch M, Poser S (1986) Lack of evidence for involvement of known human retroviruses in multiple sclerosis. Nature 322:177–8
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Madden, D.L. et al. (1988). Serological Studies of Patients with Multiple Sclerosis, controls, and Patients with Other Neurological Diseases: Antibodies to HTLV-I, HTLV-II, HIV, and STLV-III. In: Cazzullo, C.L., Caputo, D., Ghezzi, A., Zaffaroni, M. (eds) Virology and Immunology in Multiple Sclerosis: Rationale for Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73032-0_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-73032-0_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73034-4
Online ISBN: 978-3-642-73032-0
eBook Packages: Springer Book Archive