Abstract
While epidemiologic and serologic evidence suggests a viral etiology of multiple sclerosis (MS), virus isolations have yet to be confirmed. Our laboratory has possibly isolated a coronavirus from two MS patients. Virus was isolated from two of nine MS patients’ brains at autopsy. This paper reports the isolation methods, the attempts to identify the virus as a coronavirus, and a preliminary serologic survey investigating the presence of antibody to this virus in MS and control populations.
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References
Tanaka R, Iwasaki Y, Koprowski, HJ (1976) Intracisternal virus-like particles in brain of a multiple sclerosis patient. J Neurol Sci 28:121
Weiner LP (1973) Pathogenesis of demyelination induced by a mouse hepatitis virus (JHM virus). Arch Virol 28:298
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© 1980 Springer-Verlag Berlin Heidelberg
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Burks, J.S., De Vald, B., Jankovsky, L., Gerdes, J. (1980). A Possible Coronavirus Isolation from Multiple Sclerosis Autopsy Material. In: Bauer, H.J., Poser, S., Ritter, G. (eds) Progress in Multiple Sclerosis Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67554-6_9
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DOI: https://doi.org/10.1007/978-3-642-67554-6_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-67556-0
Online ISBN: 978-3-642-67554-6
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