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Enhanced Osteogenesis: Systemic Consequence of Traumatic Brain Injury

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Shock, Sepsis, and Organ Failure
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Abstract

Already in 1918, Dejerine and Ceillier [9] described for the first time the appearance of abundant osseous neoformations near joints and bones in patients with injuries of the spinal cord. Calandriello in 1964 [7] and Roberts in 1968 [28] were the first authors to describe the phenomenon in patients with traumatic brain injury (TBI). The advantage of this phenomenon is early consolidation of the fractures, while an extreme disadvantage is extensive periarticular calcification that could, in spite of the spontaneous ending of the process, lead to complete ankylosis of the affected joint (Figs. 1, 2).

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References

  1. Anderson DK, Means ED (1983) Lipid peroxidation in spinal cord: FeCl2 induction and protection with antioxidants. Neurochem Pathol 1:249–264

    CAS  Google Scholar 

  2. Bellomo G, Maggi E, Poli M, Agosta FG, Bollati P, Finardi G (1995) Autoantibodies against oxidatively modified low-density lipoproteins in NIDDM. Diabetes 44:60–66

    Article  CAS  PubMed  Google Scholar 

  3. Bidner SM (1990) Evidence for a humoral mechanism for enhanced osteogenesis after head injury. J Bone Joint Surg [Am] 72:1144–1149

    CAS  Google Scholar 

  4. Borović S, Žarković N, Wildburger R, Tatzber F, Jurin M (1995) Post-traumatic differences in titer of autoantibodies against oxidised low density lipoproteins (oLDL) in the sera of patients with traumatic bone fractures and brain injury. Period Biol 97:289–293

    Google Scholar 

  5. Braughler JM, Hall ED (1989) Central nervous system trauma and stroke. I. Biochemical considerations of oxygen radical formation and lipid peroxidation. Free Radic Biol Med 6:289–301

    Article  CAS  PubMed  Google Scholar 

  6. Burgeson RE (1988) New collagens, new concepts (Review). Annu Rev Cell Biol 4:551–557

    Article  CAS  PubMed  Google Scholar 

  7. Calandriello B (1964) Callus formation in severe brain injuries. Bull Hosp Jt Dis Orthop Inst 25:170–175

    CAS  Google Scholar 

  8. Chaudry IH, Ayala A, Meldrum A, Ertel W (1993) Hemorrhage-induced alterations in cell mediated immune function. In: Faist E, Meakins J, Schildberg FW (eds) Host defense dysfunction in trauma, shock and sepsis. Springer, Berlin Heildelberg New York, pp 149–160

    Chapter  Google Scholar 

  9. Dejerine ME, Ceillier MA (1918) Para-ostéo-arthropathies des paraplégiques par lésion médullaire. Ann Med 5:497

    Google Scholar 

  10. Diduch DR, Coe MR, Joyner C, Owen ME, Balian G (1993) Two cell lines from bone marrow that differ in terms of collagen synthesis, osteogenic characteristics and matrix mineralization. J Bone Joint Surg [Am] 75:92–105

    CAS  Google Scholar 

  11. Eber B, Schumacher M, Tatzber F, Kaufmann P, Lupha O, Esterbauer H, Klein W (1994) Autoantibodies to oxidized low density lipoproteins in restonosis following coronary angioplasty. Cardiology 84:310–315

    Article  CAS  PubMed  Google Scholar 

  12. Esterbauer H, Waeg G, Puhl H (1993) Lipid peroxidation and its role in atherosclerosis. Br Med Bull 49:566–576

    CAS  PubMed  Google Scholar 

  13. Frostegard J, Wu R, Giscombe R, Holm G, Lefvert AK, Nilsson J (1992) Induction of T-cell activation by oxidized low density lipoprotein. Arterioscler Thromb 12:461–467

    Article  CAS  PubMed  Google Scholar 

  14. Garret LR, Boyce BF, Oreffo ROC, Bonewski L, Poser J, Mundy GR (1990) Oxygen-derived free radicals stimulate osteoclastic bone resporption in rodent bone in vitro and in vivo. J Clin Invest 85:632–639

    Article  Google Scholar 

  15. Göktürk E, Turgut A, Baycu C, Günal I, Seber, S, Gülbas Z (1995) Oxygen-free radicals impair fracture healing in rats. Acta Orthop Scand 66:473–475

    Article  PubMed  Google Scholar 

  16. Gotto AM Jr (ed) (1987) Plasma lipoproteins. Elsevier, Amsterdam

    Google Scholar 

  17. Hall ED, Braughler JM (1989) Central nervous system trauma and stroke. II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation. Free Radic Biol Med 6:289–301

    Article  PubMed  Google Scholar 

  18. Huber LA, Böck G, Jürgens G, Trail KN, Schönitzer D, Wick G (1990) Increased expression of high affinity LDL receptors on human T-blasts. Int Arch Allergy Appl Immunol 93:205–211

    Article  CAS  PubMed  Google Scholar 

  19. Joerring S, Jensen LT, Andersen GR, Johansen JS (1992) Types I and III procollagen extension peptides in serum respond to fracture in humans. Arch Orthop Trauma Surg 111:265–267

    Article  CAS  PubMed  Google Scholar 

  20. Junger WG, Hoyt DB, Redl H, Liu FC, Loomis WH, Davies J, Schlag G (1995) Tumor necrosis factor antibody treatment of septic baboons reduces the production of sustained T-cell suppressive factors. Shock 3:173–178

    Article  CAS  PubMed  Google Scholar 

  21. Jürgens G, Xu Q, Huber LA, Böck G, Howanietz H, Wick G, Trail KN (1989) Promotion of lymphocyte growth by high density lipoproteins (HDL). J Biol Chem 264:8549–8556

    PubMed  Google Scholar 

  22. Kawaguchi H, Pilbeam CC, Harrison JR, Raisz LG (1995) The role of prostaglandins in the regulation of bone metabolism. Clin Orthop 313:36–46

    PubMed  Google Scholar 

  23. Miller-Graziano CL, Szabo G, Koyds K, Metha B (1993) Interactions of immunopathological mediators (tumor necrosis factor α, -β, prostaglandin E2) in traumatized individuals. In: Faist E, Meakins J, Schildberg FW (eds) Host defense dysfunction in trauma, shock and sepsis. Springer, Berlin Heidelberg New York, pp 637–650

    Chapter  Google Scholar 

  24. Parums DV, Brown DL, Mitchinson MJ (1990) Serum antibodies to oxidised LDL and ceroid in chronic periaartitis. Arch Pathol Lab Med 114:383–387

    CAS  PubMed  Google Scholar 

  25. Raisz LG (1988) Bone metabolism and its hormonal regulation: an update. Triangle 27:5–10

    Google Scholar 

  26. Redl H, Gasser H, Hallstrom S, Schlag G (1993) Radical related cell injury. In: Schlag G, Redl H (eds) Pathophysiology of shock, sepsis, and organ failure. Springer, Berlin Heildelberg New York, pp 92–110

    Chapter  Google Scholar 

  27. Renfree KJ, Banovac K, Hornicek FJ, Lebwhol NH (1994) Evaluation of serum osteoblast mitogenic activity in spinal cord and head injury in patients with acute heterotopic ossification. Spine 19:740–746

    Article  CAS  PubMed  Google Scholar 

  28. Roberts PH (1968) Heterotopic ossification complicating paralysis of intracranial origin. J Bone Joint Surg [Br] 50:70–77

    Google Scholar 

  29. Sadrzadeh SMH, Eaton JW (1992) Hemoglobin-induced oxidant damage to the central nervous system. In: Moslaen MT, Smith CV (eds) Free radical mechanisms of tissue injury. CRC, Boca Raton, pp 24–34

    Google Scholar 

  30. Salonen JT, Ylä-Hertuala S, Yamamoto R, Butler S, Korpela H, Salonen R, Nyssönnen K, Palinski W, Witzum JL (1992) Autoantibody against oxidised LDL and progression of carotid atherosclerosis. Lancet 339:883–887

    Article  CAS  PubMed  Google Scholar 

  31. Schlag G, Redl H, Baharami S, Davies J, Smuts P, Marzi I (1993) Trauma and cytokines. In: Schlag G, Redl H, Traber DL (eds) Shock, sepsis, and organ failure. Springer, Berlin Heidelberg New York, pp 128–156 (Third Wiggers Bernard Conference-Cytokine Network)

    Google Scholar 

  32. Schnai E, Lamprey JM, Viljoen MJ, Joffe BI, Seftel HC (1987) The early biochemical and hormonal profile in patients with long bone fractures at risk of fat embolism syndrome. J Trauma 27:309–311

    Article  Google Scholar 

  33. Schumacher M, Eber B, Tatzber F, Kaufmann P, Halwachs G, Fruhwald FM, Zweiker R, Esterbauer H, Klein W (1995) Transient reduction of autoantibodies against oxidized LDL in patients with acute myocardial infarction. Free Radic Biol Med 18:1087–1091

    Article  CAS  PubMed  Google Scholar 

  34. Schutze S (1993) Humoral and neural mediators of systemic response to surgery. Dan Med Bull 40:365–377

    Google Scholar 

  35. Sobus KML, Alexander MA, Harcke HT (1993) Undetected musculosceletal trauma in children with traumatic brain injury or spinal cord injury. Arch Phys Med Rehabil 74:902–904

    Article  CAS  PubMed  Google Scholar 

  36. Spiegel RJ, Schaefer EJN, Magrath IT, Edwards BK (1982) Plasma lipid alteration in leukemia and lymphoma. Am J Med 72:775–782

    Article  CAS  PubMed  Google Scholar 

  37. Trail KN, Huber LA, Wick G, Jürgens G (1990) Lipoprotein interactions with T cells: an update. Immunol Today 11:411–417

    Article  Google Scholar 

  38. Virella G, Virella I, Leman RB, Pryor MB, Lopes-Virella MV (1993) Anti-oxidised low-density lipoprotein antibodies in patients with coronary heart disease and normal healthy volunteers. Int J Clin Lab Res 23:95–101

    Article  CAS  PubMed  Google Scholar 

  39. Waterfall AH, Singh G, Fry JR, Marsden CA (1995) Detection of the lipid peroxidation product malondyaldehide in the rat brain in vivo. Neurosci Lett 200:69–72

    Article  CAS  PubMed  Google Scholar 

  40. Wildburger R, Žarković N (1995) Enhanced osteogenesis in patients with traumatic brain injury (Editorial). Period Biol 97:281–288

    Google Scholar 

  41. Wildburger R, Žarković N, Dobnig H, Petek W, Hofer HP (1994) Post-traumatic dynamic change of carboxyterminal propeptide of type I procollagen, alkaline phosphatase and its isoenzymes as predictors for enhanced osteogenesis in patients with severe head injury. Res Exp Med 194:247–259

    Article  CAS  Google Scholar 

  42. Wildburger R, Žarković N, Egger G, Petek W, Žarković K, Hofer HP (1994) Basic fibroblast growth factor (bFGF) immunoreactivity as a possible link between head injury and impaired bone fracture healing. Bone Miner 27:183–192

    Article  CAS  PubMed  Google Scholar 

  43. Wildburger R, Žarković N, Petek W, Dobnig H, Leopold-Wildburger U, Schweighofer F, Hofer HP (1995) A possible early quantitative prediction of bone fracture callus volume according to the post-traumatic increase in the serum alkaline phosphatase and procollagen I. Med Sci Res 23:219–223

    Google Scholar 

  44. Wildburger R, Tonković G, Žarković N (1995) Posttraumatske promjene vrijednosti hormona u serumu: Prolaktin kao veza izmedu kraniocerebralne ozljede i fenomena pojacane osteogeneze. Lijec Vjesn 117 [Suppl 1]: 13

    Google Scholar 

  45. Wildburger R, Žarković N, Egger G, Petek W, Mainitzer A, Borovic S, Žarković K, Li L, Stipancic I, Trbojević-Čepe M, Čvoriščeć D, Doko M (1995) Comparison of the values of basic fibroblast growth factor determined by an immunoassay in the sera of patients with traumatic brain injury and enhanced osteogenesis and the effects of the same sera on the fibroblast growth in vitro. Eur J Clin Chem Clin Biochem 33:693–698

    CAS  PubMed  Google Scholar 

  46. Wildburger R, Žarković N, Borovic S, Žarković K, Stipancic I, Kejla Z, Golubic J, Li L, Tonkovic G, Skorić T, Jurin M (1995) The effects of sera of injured patients on the growth of human peripheral blood mononuclear cells: possible involvement of the immune system in the phenomenon of enhanced osteogenesis in patients with traumatic brain injury (TBI). Period Biol 97 [Suppl 1]:58

    Google Scholar 

  47. Wildburger R, Žarković N, Petek W, Egger G, Leopold U, Schweighofer F (1996) Hypertrophe Kallusformation und Schädel-Hirn-Trauma: Frühdiagnostik und das Verhalten des basischen Fibroblastenwachstumsfaktors. Unfallchirurg 99:17–23

    CAS  PubMed  Google Scholar 

  48. Williams TJ, Peck MJ (1977) Role of prostaglandin-mediated vasodilatation in inflammation. Nature 270:530–531

    Article  CAS  PubMed  Google Scholar 

  49. Xu Q, Jürgens G, Huber LA, Böck G, Wolf H, Wick G (1992) Lipid utilization by human peripheral blood lymphocytes correlates to their high density lipoprotein binding site activity. Biochem J 285:105–112

    CAS  PubMed  Google Scholar 

  50. Zollner H, Schaur RJ, Esterbauer H (1991) Biological activities of 4-hydroxyalkenals. In: Sies H (ed) Oxidative stress. Academic, London, pp 337–369

    Google Scholar 

  51. Žarković N, Salzer B, Hrženjak M, Ilić Z, Pifat G, Stipančić I, Vučcković I, Jurin M (1991) The effects of gallium arsenide laser irradiation and partial hepatectomy on murine skin wound healing and lipoprotein composition. Period Biol 93:359–361

    Google Scholar 

  52. Žarković N, Pifat G, Salzer B (1992) The influence of liver regeneration and tumor growth on serum lipoprotein composition in mice. Period Biol 94:53–58

    Google Scholar 

  53. Žarković N, Ilic Z, Jurin M, Schaur RJ, Puhl H, Esterbauer H (1993) Stimulation of HeLa cell growth by physiological concentrations of 4-hydroxynonenal. Cell Biochem Funct 11:279–286

    Article  PubMed  Google Scholar 

  54. Žarković N, Schaur RJ, Puhl H, Jurin M, Esterbauer H (1994) Mutual dependence of growth modifying effects of 4-hydroxynonenal and fetal calf serum in vitro. Free Radic Biol Med 16:877–884

    Article  PubMed  Google Scholar 

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© 1997 Springer-Verlag Berlin Heidelberg

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Wildburger, R., Zarkovic, N., Borovic, S., Zarkovic, K., Kejla, Z. (1997). Enhanced Osteogenesis: Systemic Consequence of Traumatic Brain Injury. In: Schlag, G., Redl, H., Traber, D. (eds) Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60698-4_15

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  • DOI: https://doi.org/10.1007/978-3-642-60698-4_15

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