Abstract
Enterotropic mouse hepatitis virus (MHV) infection is usually subclinical, with no gross lesions. Neonatal mice suffer high mortality when the virus is first introduced to a naive breeding population. They become dehydrated, with soiling of the perineum with yellow, pasty feces. Their stomachs are usually empty, and intestines are thin-walled, flaccid, and contain watery yellow digesta and gas. Juvenile mice are less severely affected, but are often runted with pot bellies and oily-appearing hair. Careful examination of weaning-age or adult mice may reveal dark, sticky feces and opaque, thickened segments of bowel. Livers, if affected, have few to many small, pale or hemorrhagic foci (see “Mouse Hepatic Virus Infection, Liver, Mouse,” this volume; Barthold 1986; Barthold and Smith 1984; Barthold et al. 1982,1993; Broderson et al. 1976; Hierholzer et al. 1979; Ishida and Fujiwara 1979; Ishida et al. 1978; Kraft 1962, 1966). Athymic nude mice infected with enterotropic MHV may have segmental thickening of the cecum and ascending colon, with enlargement of mesenteric lymph nodes (Barthold et al. 1985; Ward et al. 1977).
Chapter PDF
Similar content being viewed by others
References
Barthold SW (1986) Mouse hepatitis virus biology and epizoo-tiology. In: Bhatt PN, Jacoby RO, Morse HC III, New AE (eds) Viral and mycoplasmal infections of laboratory rodents: effects on biomedical research, chap 25. Academic, Orlando, pp 571–601
Barthold SW, Smith AL (1984) Mouse hepatitis virus s&m-related patterns of tissue tropism in suckling mice. Arch Virol 81:103–112
Barthold SW, Smith AL (1989) Virus strain specificity of challenge immunity to coronavirus. Arch Virol 104:187–196
Barthold SW, Smith AL, Lord PF, Bhatt PN, Jacoby RO, Main AL (1982) Epizootic coronaviral typhlocolitis in suckling mice. Lab Anim Sci 32:376–383
Barthold SW, Smith AL, Povar ML (1985) Enterotropic mouse hepatitis virus infection in nude mice. Lab Anim Sci 35:613–618
Barthold SW, Beck DS, Smith AL (1988) Mouse hepatitis virus and host determinants of vertical transmission and mater-nally-derived passive immunity in mice. Arch Virol 100:171–183
Barathold SW, Beck DS, Smith AL (1993) Enterotropic coronavirus (mouse hepatitis virus) in mice: influence of host age and strain on infection and disease. Lab Anim Sci 43:276–284
Biggers DC, Kraft LM, Sprinz H (1964) Lethal intestinal virus infection of mice (LIVIM). An important new model for study of the response of the intestinal mucosa to injury. Am J Pathol 45:413–122
Broderson JR, Murphy FA, Hierholzer JC (1976) Lethal enteritis in infant mice caused by mouse hepatitis virus. Lab Anim Sci 26:824
Hierholzer JC, Broderson JR, Murphy FA (1979) New strain of mouse hepatitis virus as the cause of lethal enteritis in infant mice. Infect Immun 24:508–522
Homberger FR (1992) Maternally-derived passive immunity to enterotropic mouse hepatitis virus. Arch Virol 122:133–141
Homberger FR, Barthold SW (1992) Passively acquired challenge immunity to enterotropic coronavirus in mice. Arch Virol 126:35–43
Homberger FR, Barthold SW, Smith AL (1992) Duration and strain specificity of immunity to enterotropic mouse hepatitis virus. Lab Anim Sci 42:347–351
Ishida T, Fujiwara K (1979) Pathology of diarrhea due to mouse hepatitis virus in the infant mouse. Jpn J Exp Med 49:33–41
Ishida T, Fujiwara K (1982) Maternally derived immune resistance to fatal diarrhea in infant mice due to mouse hepatitis virus. Jpn J Exp Med 52:231–235
Ishida T, Taguchi F, Lee Y-S, Yamada A, Tamura T, Fujiwara K (1978) Isolation of mouse hepatitis virus from infant mice with fatal diarrhea. Lab Anim Sci 28:269–276
Kraft LM (1962) An apparently new lethal virus disease of infant mice. Science 137:282–283
Kraft LM (1966) Epizootic diarrhea of infant mice and lethal intestinal virus infection of infant mice. Natl Cancer Inst Monogr 20:55–61
Ward JM, Collins MJ, Parker JC (1977) Naturally occurring mouse hepatitis virus infection in the nude mouse. Lab Anim Sci 27:372–376
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Barthold, S.W. (1997). Mouse Hepatitis Virus Infection, Intestine, Mouse. In: Jones, T.C., Popp, J.A., Mohr, U. (eds) Digestive System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60473-7_58
Download citation
DOI: https://doi.org/10.1007/978-3-642-60473-7_58
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64421-4
Online ISBN: 978-3-642-60473-7
eBook Packages: Springer Book Archive