Abstract
Inflammation represents a localized or systemic response against tissue or cell injury, which, on the one hand, is essential among cell defense mechanisms and, on the other, is involved in a broad spectrum of diseases. According to the initiating event, the inflammatory response may involve, or not, an antigenspecific immune response. In the first case, the initiating agent is generally a microorganism or an antigen of unknown origin, while in the latter, cells may respond to injurious physical agents (foreign bodies, burns, radiations, trauma) or toxic chemicals. Lymphocytes are classically involved in the specific immune response, and phagocytes in its non-specific counterpart.
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Keywords
- Major Histocompatibility Complex
- Heat Shock Protein
- Major Histocompatibility Complex Class
- Hsp70 Family
- Major Histocompatibility Complex Allele
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References
Anderton SM, van der Zee R, Prakken B, Noordzij A, van Eden W (1995) Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis. J Exp Med 181:943–952
Arnaout MA (1990) Leukocyte adhesion molecules deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory response. Immunol Rev 114:145–180
Arrigo AP (1990) TNF induces the rapid phosphorylation of the mammalian hsp28. Mol Cell Biol 10:1276–1280
Bachelet M, Chouaid C., Havet N, Masliah J, Barre A, Housset B, Vargaftig B (1992) Modulation of arachidonic acid metabolism and cyclic AMP content of human alveolar macrophages. Eicosanoids 5:185–190
Bachelet M, Mariéthoz E, Banzet N, Souil E, Pinot F, Polla CZ, Durand P, Bouchaert I, Polla BS (1998) Flow cytometry is a rapid and reliable method for evaluating heat shock protein 70 expression in human monocytes. Cell Stress & Chap 3:168–176
Baeuerle PA, Baltimore D (1996) NF-κB: ten years later. Cell 87:13–20
Baldwin AS Jr (1996) The NF-κB and κB proteins: new discoveries and insights. Annu Rev Immunol 14:649–681
Barazzone C., Kantengwa S, Suter S, Polla BS (1996). Phagocytosis of Pseudomonas aeruginosa fails to elicit heat shock protein expression in human monocytes. Inflammation 20:243–262
Bonta IL, Parnham MJ (1982) Immunomodulatory antiinflammatory functions of E-type prostaglandins. Minireview with emphasis on macrophage-mediated effects. Int J Immunopharmacol 4:103–109
Born W, Hall L, Dallas A, Boymel J, Shinnick T, Young D, Brennan P, O’Brien R (1990) Recognition of a peptide antigen by heat shock reactive γδ T lymphocytes. Science 249:67–69
Botzier C., Kolb H-J, Isseis RD, Multhoff G (1996) Noncytotoxic alkyl lysophospholipid treatment increases sensitivity of leukemic K562 cells to lysis by natural killer (NK) cells. Int J Cancer 65:633–638
Buttke TM, Sandstrom PA (1994) Oxidative stress as a mediator of apoptosis. Immunol Today 15:7–10
Chopp M (1993) The roles of heat shock proteins and immediate early genes in central nervous system normal function and pathology. Curr Opin Neurol Neurosurg 6:6–10
Chouchane L, Bowers S, Sawasdikosol S, Simpson RM, Kindt TJ (1994) Heat shock proteins expressed on the surface of human T cell leukemia virus Type I-infected cell lines induce autoantibodies in rabbits. J Infect Dis 169:253–259
Christie P, Jacquier-Sarlin M, Janin A, Bousquet J, Polla BS (1995) Heat Shock proteins in eosinophilic inflammation. In: Van Eden W, Young DB (eds) Stress proteins in medicine. Dekker, New York, pp 479–493
Cohen IR, Young DB (1991) Autoimmunity, microbial immunity and the immunological homunculus. Immunol Today 12:105–110
Corrigan CJ, Kay AB (1992) Asthma. Role of T-lymphocytes and lymphokines. Br Med Bull 48:72–84
DiCesare S, Poccia F, Mastino A, Colizzi V (1992) Surface expressed heat shock proteins by stressed or human immunodeficiency virus (HlV)-infected lymphoid cells represent the target for antibody-dependent cellular cytotoxicity. Immunol 76:341–343
Dix DJ, Allen JW, Collins BW (1996) Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis and male infertility. Proc Natl Acad Sci USA 93:3264–3268
Favatier F, Bornman L, Hightower LE, Günther E, Polla BS (1997). Variation in hsp gene expression and Hsp polymorphism: do they contribute to differential disease susceptibility and stress tolerance?. Cell Stress Chap 2:141–155
Fajac I, Roisman GL, Lacronique J, Polla BS, Dusser DJ (1997) Bronchial gamma-delta T-lymphocytes and expression of heat shock proteins in mild asthma. Eur Respir J 10:633–638
Fincato G, Polentarutti N, Sica A, Mantovani A, Colotta F (1991) Expression of a heat-shock inducible gene of the HSP70 family in human myelomonocytic cells: regulation by bacterial products and cytokines. Blood 77:579–586
Haire RN, Peterson MS, O’Leary JJ (1988) Mitogen activation induces the enhanced synthesis of two heat-shock proteins in human lymphocytes. J Cell Biol 106:883–891
Helqvist S, Polla BS, Johannasen J, Nerup J (1991) Heat shock proteins induction in rat pancreatic islets by recombinant human interleukin 1 ß. Diabetologia 34:150–156
Hennet T, Richter C., Peterhans E (1993) Tumor necrosis factor-alpha induces Superoxide anion generation in mitochondria of L929 cells. Biochem J 289:587–592
Heufelder AE, Wenzel BE, Bahn RS (1992) Cell surface localization of a 72 kilodalton heat shock protein in retroocular fibroblasts from patients with Graves’ ophthalmopathy. J Clin Endocrinol Metab 74:732–736
Hightower LE, Guidon PT (1989) Selective release from cultured mammalian cells of heat shock (stress) proteins that resemble glia-axon transfer proteins. J Cell Physiol 138:257–266
Himeno K, Hisaeda H (1996) Contribution of 65-kDa heat shock protein induced by gamma and delta T cells to protection against Toxoplasma gondii infection. Immunol Res 15:258–264
Hisaeda H, Nagasawa H, Maeda K, Maekawa Y, Ishikawa H, Ito Y, Good RA, Himeno K (1995) γδ T cells play an important role in expression of hsp65 and in acquiring protective immune responses against infection with Toxoplasma gondii. J Immunol 155:244–249
Hisaeda H, Sakai T, Nagasawa H, Ishikawa H, Yasutomo K, Maekawa Y, Himeno K (1996a) Contribution of extrathymic γδ T cells to the expression of heat shock protein and to protective immunity in mice infected with Toxoplasma gondii. Immunol 88:551–557
Hisaeda H, Sakai T, Ishikawa H, Maekawa Y, Yasutomo K, Nagasawa H, Himeno K (1996b) Mechanisms of Hsp65 expression induced by γδ T cells in murine Toxoplasma gondii infection. Pathobiology 64:198–203
Hisaeda H, Sakai T, Ishikawa H, Maekawa Y, Yasumoto K, Good RA, Himeno K (1997) Heat shock protein 65 induced by γδ T cells prevents apoptosis of macrophages and contributes to host defense in mice infected with Toxoplasma gondii. J Immunol 159:2375–2381
Hisaeda H, Himeno K (1997) The role of host-derived heat shock protein in immunity against Toxoplasma gondii infection. Parasitology Today 13:465–468
Holtzman M (1991) Arachidonic acid metabolism, Am Rev Resp Dis 143:188–203
Ishikawa H, Hisaeda Y, Maekawa Y, Himeno K (1997) Expression of heat shock proteins in host macrophages correlates with a protective potential against infection with Leishmania major in mice. Parasitology International 46:263–270
Jäättelä M, Saksela K, Saksela E (1989) Heat shock protects WEHI-164 target cells from the cytolysis by tumor necrosis factor a and β. Eur J Immunol 19:1413–1417
Jäättelä M (1993) Overexpression of major heat shock protein hsp70 inhibits tumor necrosis factor-induced activation of phospholipase A2. J Immunol 151:4286–4294
Jacquier-Sarlin MR, Fuller K, Dinh-Xuan AT, Richard M-J, Polla BS (1994) Protective effects of hsp70 in inflammation. Experientia 50:1031–1038
Jacquier-Sarlin MR, Jornot L, Polla BS (1995) Differential expression and regulation of hsp70 and hsp90 by phorbol esters and heat shock. J Biol Chem 270:14094–14099
Jacquier-Sarlin MR, Polla BS (1996) Dual regulation of heat-shock transcription factor (HSF) activation and DNA-binding activity by H2O2: role of thioredoxin. Biochem J 318:187–199
Kantengwa S, Donati YRA, Clerget M, Maridonneau-Parini I, Sinclair F, Mariéthoz E, Perin M, Rees ADM, Slosman DO, Polla BS (1991) Heat shock proteins: an autoprotective mechanism for inflammatory cells?. Semin Immunol 3:49–56
Kantengwa S, Polla BS (1993) Phagocytosis of Staphylococcus aureus induces a selective stress response in human monocytes-macrophages (mϕ): modulation by mϕ differentiation and by iron. Infect Immun 61:1281–1287
Kaufmann SH (1994) Heat shock proteins and autoimmunity: a critical appraisal. Int Arch Allergy Immunol 103:317–322
Koller M, König W (1990) Arachidonic acid metabolism in heat-shock treated human leukocytes. Immunology 70:458–464
Köller M, Hensler T, Konig B, Prevost G, Alouf J, Konig W (1993) Induction of heat shock proteins by bacterial toxins, lipid mediators and cytokines in human leukocytes. Int J Med Microbiol Virol Parasitol Infect Dis 278:365–376
Leonard EJ, Yoshimura T (1990) Neutrophil attractant/activation protein-1 (NAP-1 [interleukin 8]). Am J Res Cell Mol Biol 2:479–481
Liochev SI, Fridovich I (1997) How does Superoxide dismutase protect against tumor necrosis factor: a hypothesis informed by effect of Superoxide on “free” iron. Free Radiat Biol Med 23:668–671
Long EO, Colonna M, Lanier LL (1996) Inhibitory MHC class I receptors on NK and T cells: a standard nomenclature. Immunol Today 17:100–111
Lurquin C., Van Pel A, Mariamé B, De Plaen E, Szikora J-P, Janssens J, Reddehase MJ, Lejeune J, Boon T (1989) Structure of the gene tum-transplantation antigen P91 A: the mutated exon encodes a peptide recognized with Ld by cytolytic cells. Cell 58:293–303
Margulis BA, Sandier S, Eizirik DL, Welsh N, Welsh M (1991) Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1β-induced impaired β-cell function. Diabetes 40:1418–1422
Mariéthoz E, Tacchini-Cottier F, Jacquier-Sarlin M, Sinclair F, Polla B S (1994) Exposure of monocytes to heat shock does not increase class II expression but modulates antigen-dependent T cell responses. Int Immunol 6:925–930
Marietta MA (1989) Nitric oxide: biosynthesis and biological significance. Trends Biochem Sci 14:488–492
Mehlen P, Schulze-Osthoff K, Arrigo A-P (1996a) Small stress proteins as novel regulators of apoptosis. J Biol Chem 271:16510–16514
Mehlen P, Kretz-Romy C., Preville X, Arrigo A-P (1996b) Human hsp27, Drosophila hsp27 and human αβ-crystallin expression-mediated increase in glutathione is essential for the protection activity of these proteins against TNFα-induced cell death. EMBO J 15:2695–2706
Misumi Y, Miki K, Takatsuki A, Tamura G, Ikehara Y (1986) Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes. J Biol Chem 261:11398–11403
Moliterno R, Valdivia L, Pan F, Duquesnoy RJ (1995) Heat shock protein reactivity of lymphocytes isolated from heterotopic rat cardiac allografts. Transplantation 59:598–604
Moretta L, Ciccone E, Poggi A, Mingari MC., Moretta A (1994). Ontogeny, specific functions and receptors of human natural killer cells. Immunol Lett 40:83–88
Mountz JD, Wu J, Cheng J, Zhou T (1994) Autoimmune disease. A problem of defective apoptosis. Arthritis Rheum 37:1415–1420
Multhoff G, Botzler C., Wiesnet M, Müller E, Meier T, Wilmanns W, Issels RD (1995a) A stress inducible 72-kDa heat shock protein (HSP72) is expressed on the surface of human tumor cells, but not in normal cells. Int J Cancer 61:272–279
Multhoff G, Botzler C., Wiesnet M, Eissner G, Issels RD (1995b) CD3-large granular lymphocytes recognize a heat-inducible immunogenic determinant associated with the 72-kD heat shock protein on human sarcome cells. Blood 86:1374–1382
Multhoff G, Hightower LE (1996) Cell surface expression of heat shock proteins and the immune response. Cell Stress Chap 1:167–176
Multhoff G, Botzler C., Jennen L, Schmidt J, Ellwart J, Issels R (1997) Heat shock protein 72 on tumor cells. A recognition structure for natural killer cells. J Immunol 158:4341–4350
Munk ME, Schoel B, Modrow S, Karr RW, Young RA, Kaufmann SHE (1989) T lymphocytes from healthy individuals with specificity to self epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein. J Immunol 143:2844–2879
Muthukrishnan L, Warder E, McNeil PL (1991) Basic fibroblast growth factor is efficiently released from a cytosolic storage site through plasma membrane disruptions of endothelial cells. J Cell Physiol 148:1–16
Nagasawa H, Oka M, Maeda K, Chai J-G, Hisaeda H, Ito Y, Good RA, Himeno K (1992) Induction of heat shock protein closely correlates with protection against Toxoplasma gondii infection. Proc Natl Acad Sci USA 89:3155–3158
Nagasawa H, Hisaeda H, Maekawa Y, Fujioka H, Ito Y, Aikawa M, Himeno K (1994) γδ T cells play a crucial role in expression of 65000 MW heat shock protein in mice immunized with Toxoplasma antigen. Immunol 83:347–352
O’Brien RL, Fu Y, Cranfill R, Dallas A, Ellis C., Reardon C., Lang J, Carding S, Kubo R, Born W (1992) Heat shock protein 60-reactive γδ cells: a large, diversified T-lymphocyte subset with highly focused specificity. Proc Natl Acad Sci USA 89:4348–4352
Ohtsuka K, Nakamura H, Sato C (1986) Intracellular distribution of 73,000 and 72,000 dalton heat shock protein in HeLa cells. Int J Hyperthermia 2:267–751
Pinhasi-Kimhi O, Michalovitz D, Ben-Zeev A, Oren M (1986) Specific interaction between the p53 cellular tumor antigen and major heat shock proteins. Nature 320:182–184
Polla BS, De Rochemonteix B, Junod AF, Dayer J-M (1985) Effects of LTB4 and Ca++ ionophore A23187 on the release by human alveolar macrophages of factors controlling fibroblast functions. Biochem Biophys Res Commun 129:560–567
Polla BS, Healy AM, Wojno WC., Krane SM (1987) Hormone la,25-dihydroxyvitamin D3 modulates heat shock response in monocytes. Am J Physiol 252:C640–C649
Polla BS (1988) A role for heat shock proteins in inflammation, Immunol Today 9:134–137
Polla BS, Mariéthoz E, Hubert D, Barazzone C (1995a) Heat-shock proteins in host-pathogen interactions: implications for cystic fibrosis. Trends Microbiol 10:392–396
Polla BS, Stubbe H, Kantengwa S, Maridonneau-Parini I, Jacquier-Sarlin MR (1995b) Differential induction of stress proteins and functional effects of heat shock in human phagocytes. Inflammation 19:323–377
Polla BS, Kantengwa S, Frans D, Salvioli S, Franceschi C., Marsac C., Cossarizza A (1996) Mitochondria are selective targets for the protective effects of heat shock against oxidative injury. Proc Natl Acad Sci USA 93:6458–6463
Pratt WB (1993) The role of heat shock proteins in regulating the function, folding and trafficking of the glucocorticoid receptor. J Biol Chem 268:21455–21458
Rauslton JE, Davis CH, Schmiel DH, Morgan MW, Wyrik PB (1993) Molecular characterization and outer membrane association of a Chlamydia trachomatis protein related to the hsp70 family of proteins. J Biol Chem 268:23139–23147
Richter C., Schweitzer M, Cossarizza A, Franceschi C (1996) Control of apoptosis by cellular ATP levels. FEBS Lett 378:107–110
Rosales C., Juliano RL (1995) Signal transduction by cell adhesion receptors in leukocytes. J Leukocyte Biol 57:189–198
Rosen GM, Pou S, Ramos CL, Cohen MS, Britigan BE (1995) Free radicals and phagocytic cells. FASEB J 9:200–209
Rossi A, Elia G, Santoro MG (1997) Inhibition of nuclear factor kB by prostaglandin Al: an effect associated with heat shock transcription factor activation. Proc Natl Acad Sci USA 94:746–750
Samali A, Cotter TG (1996) Heat shock proteins increase resistance to apoptosis. Exp Cell Res 223:163–170
Santoro MG (1997) Antiviral activity of cyclopentenone prostanoids. Trends Microbiol 5:276–281
Santoro MG, Garaci E, Amici C (1989) Prostaglandins with antiproliferative activity induce the synthesis of a heat shock protein in human cells. Proc Natl Acad Sei USA 86:8407
Savill J (1994) Apoptosis in disease. Eur J Clin Invest 24:715–773
Schuler D, Szende B, Borsi JD, Marton T, Bocsi J, Magyarossy E, Koos R, Csoka M (1994) Apoptosis as a possible way of destruction of lymphoblasts after glucocorticoid treatment of children with acute lymphoblastic leukemia. Pediatr Hematol Oncol 11:641–664
Springer TA (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301–314
Srivastava PK (1994) Heat shock proteins in immune response to cancer: the fourth paradigm. Experientia 50:1054–1060
Takenaka IM, Hightower LE (1992) Transforming growth factor βl rapidly induces Hsp70 and Hsp90 molecular chaperones in cultured chicken embryo cells. J Cell Physiol 152:568–577
Tamura Y, Tsuboi N, Sato N, Kikuchi K (1993) 70 kDa heat shock cognate protein is a transformation-associated antigen and a possible target for the host’s anti-tumor immunity. J Immunol 151:5516–5524
Tauber AI (1987) Protein knase C and the activation of the human neutrophil NADPH-oxidase. Blood 69:711–720
Vanbuskirk AM, DeNagel DC., Guagliardi LE, Brodsky FM, Pierce CK (1991) Cellular and subcellular distribution of PBP72/74, a peptide-binding protein that plays a role in antigen processing. J Immunol 146:500–506
Van-den Eynde B, Lethe B, Van Pel A, De Plaen E, Boon T (1991) The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice. J Exp Med 173:1373–1384
Vignola AM, Chanez P, Polla BS, Vic P, Godard P, Bousquet J (1995) Increased expression of heat shock protein 70 on airway cells in asthma and chronic bronchitis. Am J Res Cell Mol Biol 13:683–694
Villar J, Edelson JD, Post M, Mullen BM, Slutsky AS (1993) Induction of heat stress proteins is associated with decreased mortality in an animal model of acute lung injury. Am Rev Respir Dis 147:177–181
Udono H, Levey DL, Srivastava PK (1994) Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8+ T cells in vivo. Proc Natl Acad Sci USA 91:3077–3081
Ward PA, Markd RM (1989) The acute inflammatory reaction. Curr Opin Immunol 2:5–9
Watson F, Robinson J, Edwards SW (1990) Protein kinase C-dependent and-independent activation of the NADPH oxidase of human neutrophils. J Biol Chem 256:7432–7439
Winfield J, Jarjour W (1991) Do stress proteins play a role in arthritis and autoimmu-nity?. Immunol Rev 121:193–220
Wong HR, Ryan M, Wispé JR (1997) Stress response decrease NF-κB nuclear translocation and increases IκBα expression in A549 cells. J Clin Invest 99:2428–2433
Yoshino I, Goedegebuure PS, Peoples GE, Lee KY, Eberlein TJ (1994) Human tumor infiltrating CD4+ T cells react to B cell lines expressing heat shock protein 70. J Immunol 153:4149–4158
Young RA, Elliott TJ (1989) Stress proteins, infection, and immune surveillance. Cell 59:5–8
Zugel U, Schoel B, Yamamoto S, Hengel H, Morein B, Kaufmann SH (1995) Crossrecognition by CD8 T cell receptor alpha beta cytotoxic T lymphocytes of peptides in the self and the mycobacterial hsp60 which share intermediate sequence homology. Eur J Immunol 25:451–458
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Bachelet, M., Multhoff, G., Vignola, M., Himeno, K., Polla, B.S. (1999). Heat Shock Proteins in Inflammation and Immunity. In: Latchman, D.S. (eds) Stress Proteins. Handbook of Experimental Pharmacology, vol 136. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58259-2_13
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